Day: October 18, 2022

HPLC of Formula: 826-36-8On March 15, 2021, Ye, Jian; Dai, Jiangdong; Wang, Lulu; Li, Chunxiang; Yan, Yongsheng; Yang, Guoyu published an article in Journal of Colloid and Interface Science. The article was 《Investigation of catalytic self-cleaning process of multiple active species decorated macroporous PVDF membranes through peroxymonosulfate activation》. The article mentions the following:

Currently, carbon-based catalysts integrated with macroporous catalytic membrane have aroused considerable attention for environmental remediation because of its practicability and high efficiency. Herein, nitrogen doped carbon nanotube hybrids (Fe-Co@NC-CNTs) decorated with multiple active species (Fe3Co7/CoFe2O4@Fe/Co-N-C) were designed through N-mol. assisted pyrolysis of bimetallic (Fe/Co) metal-organic frameworks, and then immobilized on poly(vinylidene fluoride) (PVDF) membrane to construct macroporous Fe-Co@NC-CNTs/PVDF catalytic membrane via directional freezing technique, where active sites were efficiently exposed for oxidants and target pollutants. As expected, Fe-Co@NC-CNTs/PVDF membrane successfully achieved almost 100% bisphenol A (BPA) degradation after 40 min via PMS activation, which was significantly overperformed the majority of conventional carbon-based catalysts. Besides, we found that Fe-Co@NC-CNTs/PVDF membrane not only exhibited ideal catalytic and self-cleaning property in humic acid (HA)-BPA coexistence system, but also maintained the excellent reusability and ultrahigh water flux (10464.45 L m-2 h-1) even after 5 cycles. Notably, in EPR anal. and quenching experiments, it was found that sulfate radicals (SO4·- and ·OH) and singlet oxygen (1O2) participated the degradation process while 1O2 made a major contribution. More significantly, this study is very meaningful for the development of novel catalytic self-cleaning membranes with PMS activation. The experimental part of the paper was very detailed, including the reaction process of Triacetonamine(cas: 826-36-8HPLC of Formula: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.HPLC of Formula: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: TriacetonamineOn September 5, 2020 ,《Diatomite supported hierarchical 2D CoNi3O4 nanoribbons as highly efficient peroxymonosulfate catalyst for atrazine degradation》 was published in Applied Catalysis, B: Environmental. The article was written by Dong, Xiongbo; Ren, Bangxing; Zhang, Xiangwei; Liu, Xiaorui; Sun, Zhiming; Li, Chunquan; Tan, Ye; Yang, Shanshan; Zheng, Shuilin; Dionysiou, Dionysios D.. The article contains the following contents:

Reactive oxygen radicals generated by peroxymonosulfate (PMS) activation exhibit great potential to treat refractory pollutants of emerging concern; however, mass production of efficient, cost-effective catalysts for PMS activation is a long-term goal for its widespread practical application. A CoNi3O4/diatomite hybrid was prepared via vertically oriented growth of two dimensional (2D) CoNi3O4 nanoribbons of at. layer-thickness on a cost-effective diatomite template. Distinct from stacked CoNi3O4, the CoNi3O4/diatomite composite has abundant exposed edges, sharp corners, and open diffusion channels. Abundant exposed edges and sharp corners create more open space and active sites for PMS activation. Open diffusion channels accelerate PMS and pollutants migration. Such properties provide CoNi3O4/diatomite hybrid excellent PMS activation efficiency. Sulfate radical played the dominant role in atrazine degradation, and superoxide radical contributed to reversible redox cycle of Co2+/Co3+ and Ni2+/Ni3+. This work provided a strategy for cost-effective mass production of Fenton-like 2D catalysts. In the experiment, the researchers used Triacetonamine(cas: 826-36-8Recommanded Product: Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Recommanded Product: Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Bryan, Marian C.; Drobnick, Joy; Gobbi, Alberto; Kolesnikov, Aleksandr; Chen, Yongsheng; Rajapaksa, Naomi; Ndubaku, Chudi; Feng, Jianwen; Chang, Willy; Francis, Ross; Yu, Christine; Choo, Edna F.; DeMent, Kevin; Ran, Yingqing; An, Le; Emson, Claire; Huang, Zhiyu; Sujatha-Bhaskar, Swathi; Brightbill, Hans; DiPasquale, Antonio; Maher, Jonathan; Wai, John; McKenzie, Brent S.; Lupardus, Patrick J.; Zarrin, Ali A.; Kiefer, James R. published an article in Journal of Medicinal Chemistry. The title of the article was 《Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors》.Related Products of 39546-32-2 The author mentioned the following in the article:

A series of pyrazolopyrimidine inhibitors of IRAK4 were developed from a high-throughput screen (HTS). Modification of an HTS hit led to a series of bicyclic heterocycles with improved potency and kinase selectivity but lacking sufficient solubility to progress in vivo. Structure-based drug design, informed by cocrystal structures with the protein and small-mol. crystal structures, yielded a series of dihydrobenzofurans. This semisatd. bicycle provided superior druglike properties while maintaining excellent potency and selectivity. Improved physicochem. properties allowed for progression into in vivo experiments, where lead mols. exhibited low clearance and showed target-based inhibition of IRAK4 signaling in an inflammation-mediated PK/PD mouse model. In the experiment, the researchers used many compounds, for example, Piperidine-4-carboxamide(cas: 39546-32-2Related Products of 39546-32-2)

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Related Products of 39546-32-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Hayashi, Shigeo; Hirao, Akiko; Imai, Aki; Nakamura, Hiroshi; Murata, Yoshinori; Ohashi, Katsuyo; Nakata, Eriko published an article on February 11 ,2009. The article was titled 《Novel Non-Peptide Nociceptin/Orphanin FQ Receptor Agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, Synthesis, and Structure-Activity Relationship of Oral Receptor Occupancy in the Brain for Orally Potent Antianxiety Drug》, and you may find the article in Journal of Medicinal Chemistry.Application In Synthesis of (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate The information in the text is summarized as follows:

An endogenous heptadecapeptide, nociceptin/orphanin FQ (N/OFQ), and a G-protein-coupled receptor, N/OFQ peptide (NOP) receptor [or opioid-receptor-like-1 (ORL1) receptor], have been described in terms of its structure, distribution, and pharmacol. Thus, the N/OFQ and NOP receptor are located in the central nervous systems in humans, primates, and rodents, and are involved in the integration of the emotional components in the brain; e.g., N/OFQ displays anxiolytic activity in the brain. For identifying orally potent anxiolytic, drug-design studies were performed with a series of 1,2-disubstituted benzimidazole derivatives, which resulted in the identification of various chemotypes of highly potent NOP selective full agonists in vitro with high or moderate NOP receptor occupancy in the mice brain per os such as 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole (MCOPPB), the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. The experimental part of the paper was very detailed, including the reaction process of (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate(cas: 194726-40-4Application In Synthesis of (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate)

(R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate(cas: 194726-40-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Application In Synthesis of (R)-1-tert-Butyl 3-ethyl piperidine-1,3-dicarboxylate

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 1971,European Journal of Pharmacology included an article by Jung, Annemarie; Luellmann, Heinz; Ziegler, Albrecht. Electric Literature of C8H15NO2. The article was titled 《Attempt to correlate kinetic data of the drug receptor interaction with the chemical structures of cholinomimetic agents》. The information in the text is summarized as follows:

The chem. structures of cholinomimetic agents, such as acetylcholine (I) [51-84-3]; carbachol [51-83-2]; muscarine [300-54-9]; different esters of secondary, tertiary, or quaternary arecaidines or Δ3-pyrrolinecarboxylic acids; and the acetates of pyrrolidinol and pyrrolidinecarbinol, and their association and dissociation rate constants could be used to estimate their ability to bind with the receptor sites of isolated guinea pig atria. The ability to bind, as well as the kinetic constants, was dependant on the number of C-atoms at the N, the length of the ester side chain, the conformation for the heterocyclic ring system, and the position of the ester group. The influence of structural characteristics of the cholinergics on their properties was different from that on the parameters that determine their binding ability. The results came from multiple reactions, including the reaction of Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8Electric Literature of C8H15NO2)

Methyl 1-methylpiperidine-3-carboxylate(cas: 1690-72-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Electric Literature of C8H15NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Nomoto, Yuji; Obase, Hiroyuki; Takai, Haruki; Hirata, Tadashi; Teranishi, Masayuki; Nakamura, Joji; Kubo, Kazuhiro published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Studies on cardiotonic agents. I. Synthesis of some quinazoline derivatives》.Electric Literature of C13H16N2O The author mentioned the following in the article:

A series of quinazoline derivatives with various 4-heterocyclylpiperidino groups at the 4-position was synthesized and tested for cardiotonic activity in anesthetized dogs. E.g., reaction of 6-acetamido-4-chloro-7-methoxyqinazoline and 4-(2-oxo-1-imidazolidinyl)piperidine gave quinazoline derivative I. Among them, several 6,7-dimethoxyquinazoline derivatives showed potent cardiotonic activity. In the part of experimental materials, we found many familiar compounds, such as 3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1Electric Literature of C13H16N2O)

3-(Piperidin-4-yl)indolin-2-one(cas: 72831-89-1) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Electric Literature of C13H16N2O

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Takajo, Tokuko; Kurihara, Yoshinori; Iwase, Kodai; Miyake, Daiki; Tsuchida, Kazunori; Anzai, Kazunori published their research in Chemical & Pharmaceutical Bulletin on February 29 ,2020. The article was titled 《Basic investigations of singlet oxygen detection systems with ESR for the measurement of singlet oxygen quenching activities》.Reference of Triacetonamine The article contains the following contents:

Singlet oxygen (1O2) is highly oxidative and exerts strong cytotoxic effects. We tried to establish the best combination of a singlet oxygen generation system and a detection method with ESR, for measurement of the quenching activities of various substances. The photosensitizing reaction of rose bengal or thermal decomposition of 4-methyl-1,4-etheno-2,3-benzodioxin-1(4H)-propanoic acid (endoperoxide, EP) was used for the generation of 1O2, and a sterically hindered secondary amine, 2,2,6,6-tetramethyl-4-piperidone (TEMPD) or 2,2,6,6-tetramethyl-4-piperidinol (TEMP-OH), was used as the 1O2 detection probe. These secondary amines were oxidized by 1O2 to form stable nitroxide radicals, which were detectable by ESR. TEMPD was found to be readily oxidized by air, causing large background signals in comparison with TEMP-OH. The ESR signal obtained by the irradiation of rose bengal with visible light in the presence of TEMP-OH consisted of two kinds of nitroxide radical overlapping. In contrast, only a single nitroxide signal was observed when TEMP-OH was reacted with 1O2 generated from EP. Therefore, the best combination should be EP as the 1O2 generator and TEMP-OH as the detection probe. When using this combination, we found that the concentrations of some organic solvents such as DMSO and acetonitrile should be kept constant for reliable quantification, because the concentrations of organic solvents affect the ESR signal intensity. The results came from multiple reactions, including the reaction of Triacetonamine(cas: 826-36-8Reference of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Reference of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Zhou, Chan; Zhu, Lei; Deng, Lin; Zhang, Haojie; Zeng, Hanxuan; Shi, Zhou published their research in Separation and Purification Technology on December 1 ,2021. The article was titled 《Efficient activation of peroxymonosulfate on CuS@MIL-101(Fe) spheres featured with abundant sulfur vacancies for coumarin degradation: Performance and mechanisms》.Quality Control of Triacetonamine The article contains the following contents:

For improving the catalytic activity and recyclability of CuS in Fenton-like reaction processes, novel sulfur vacancies-enriched CuS@MIL-101(Fe) was constructed, characterized, and examined as heterogeneous catalysts for activating peroxymonosulfate (PMS) to degrade coumarin (COU). Thanks to the redox pairs of Fe3+/Fe2+, Cu+/Cu2+, S2-/S2-2/S0/sulfate species, copper-iron synergistic effect and sulfur vacancies, the CuS@MIL-101(Fe) realized a complete removal of COU (30μM) in 10 min with reaction rate constant of 0.577 min-1, which was 11.1 and 17.0 times of CuS and MIL-101(Fe), resp. The effect of various exptl. conditions (i.e., initial pH, CuS@MIL-101(Fe) dosage, PMS concentration, and background anions) on COU degradation was discussed, and the stability and versatility of CuS@MIL-101(Fe) was studied as well. Radical scavenging experiments and ESR (EPR) spectroscopy identified ·OH and 1O2 as the main reactive oxygen species (ROS). Finally, the possible mechanism of higher COU degradation efficiency in the CuS@MIL-101(Fe) activated PMS system and the degradation pathways were also deeply explored. Consequently, this work provided a novel insight into construction of sulfur vacancies-enriched heterogeneous catalysts for efficiently activating PMS for refractory organic pollutants elimination.Triacetonamine(cas: 826-36-8Quality Control of Triacetonamine) was used in this study.

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Quality Control of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2013,Watanabe, Kazushi; Kakefuda, Akio; Yasuda, Minoru; Enjo, Kentaro; Kikuchi, Aya; Furutani, Takashi; Naritomi, Yoichi; Otsuka, Yukio; Okada, Minoru; Ohta, Mitsuaki published 《Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: A novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitor》.Bioorganic & Medicinal Chemistry published the findings.Computed Properties of C7H15NO The information in the text is summarized as follows:

Type 5 17β-hydroxysteroid dehydrogenase (17β-HSD5), also known as aldo-keto reductase 1C3 (AKR1C3), is a member of the aldo-keto reductase superfamily of enzymes and is expressed in the human prostate. One of the main functions of 17β-HSD5 is to catalyze the conversion of the weak androgen, androstenedione, to the potent androgen, testosterone. The concentration of intraprostatic 5α-dihydrotestosterone (DHT) in patients following chem. or surgical castration has been reported to remain as high as 39% of that of healthy men, with 17β-HSD5 shown to be involved in this androgen synthesis. Inhibition of 17β-HSD5 therefore represents a promising target for the treatment of castration-resistant prostate cancer (CRPC). To investigate this, we conducted high-throughput screening (HTS) and identified compound (I), which displayed a structure distinct from known 17β-HSD5 inhibitors. To optimize the inhibitory activity of compound (I), we first introduced a primary alc. group. We then converted the primary alc. group to a tertiary alc., which further enhanced the inhibitory activity, improved metabolic stability, and led to the identification of compound (II). Oral administration of compound II to castrated nude mice bearing the CWR22R xenograft resulted in the suppression of androstenedione (AD)-induced intratumoral testosterone production Compound II also demonstrated good isoform selectivity, minimal inhibitory activity against either CYP or hERG, and enhanced pharmacokinetic and physicochem. properties. After reading the article, we found that the author used 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Computed Properties of C7H15NO)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Computed Properties of C7H15NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2015,Chakka, Sai Kumar; Kalamuddin, Mohammad; Sundararaman, Srividhya; Wei, Lianhu; Mundra, Sourabh; Mahesh, Radhakrishnan; Malhotra, Pawan; Mohmmed, Asif; Kotra, Lakshmi P. published 《Identification of novel class of falcipain-2 inhibitors as potential antimalarial agents》.Bioorganic & Medicinal Chemistry published the findings.Related Products of 622-26-4 The information in the text is summarized as follows:

Falcipain-2 is a papain family cysteine protease and an emerging antimalarial drug target. A pseudo-tripeptide scaffold I was designed using in silico screening tools and the three dimensional structures of falcipain-2, falcipain-3, and papain. This scaffold was investigated at four positions, T1, T2, T3, and T3′, with various targeted substitutions to understand the structure-activity relationships. Inhibitor synthesis was accomplished by first obtaining the appropriate dipeptide precursors with common structural components. The pyrrolidine moiety introduced interesting rotamers in a number of synthesized mols., which was confirmed using high-temperature 1H NMR spectroscopy. Among the synthesized compounds, three inhibited falcipain-2 activity with inhibition constants (Ki) of 1.8±1.1, 0.2±0.1 and 7.0±2.3 μM, resp. A group of mols. with a pyrrolidine moiety at the T2 position also potently inhibited falcipain-2 activity (Ki = 0.4±0.1, 2.5±0.5, 3.3±1.1, 7.5±1.9, and 4.6±0.7 μM, resp.). Overall, compound I exhibited potent antiparasitic activity (IC50 = 0.9±0.1 μM), corresponding with its inhibitory activity against falcipain-2, with a Ki of 1.1±0.1 μM. Two other compounds inhibited the growth of the drug resistant parasite Dd2 with better efficacy, and compound I exhibited a 7- to 12-fold higher potency against Dd2 and MCamp isolates, than the laboratory strain (3D7). These data suggest that this novel series of compounds should be further investigated as potential antimalarial agents. In the experimental materials used by the author, we found 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Related Products of 622-26-4)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Related Products of 622-26-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem