Day: October 11, 2022

Application of 109384-19-2In 2021 ,《Development of autotaxin inhibitors: A series of tetrazole cinnamides》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Thomson, Christopher G.; Le Grand, Darren; Dowling, Mark; Beattie, David; Elphick, Lucy; Faller, Michael; Freeman, Mark; Hardaker, Elizabeth; Head, Victoria; Hemmig, Rene; Hill, Johan; Lister, Andrew; Pascoe, David; Rieffel, Sebastien; Shrestha, Binesh; Steward, Oliver; Zink, Florence. The article contains the following contents:

A series of inhibitors of autotaxin (ATX) have been developed from a high throughput screening hit, 1a (I), which shows an alternative binding mode to known catalytic site inhibitors. Selectivity over the hERG channel and microsomal clearance were dependent on the lipophilicity of the compounds, and this was optimized by reduction of clogD while maintaining high affinity ATX inhibition. Compound 15a (II) shows good oral exposure, and concentration dependent inhibition of formation of LPA in vivo, as shown in pharmacokinetic-pharmacodynamic (PK/PD) experimentstert-Butyl 4-hydroxypiperidine-1-carboxylate(cas: 109384-19-2Application of 109384-19-2) was used in this study.

tert-Butyl 4-hydroxypiperidine-1-carboxylate(cas:109384-19-2) is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.Application of 109384-19-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Related Products of 826-36-8On September 15, 2020 ,《Activation of persulfate for tetracycline degradation using the catalyst regenerated from Fenton sludge containing heavy metal: Synergistic effect of Cu for catalysis》 was published in Chemical Engineering Journal (Amsterdam, Netherlands). The article was written by Shen, Minxian; Huang, Zhujian; Luo, Xuewen; Ma, Yujia; Chen, Chengyu; Chen, Xian; Cui, Lihua. The article contains the following contents:

Fenton reaction is widely used as a unique oxidation method for industrial wastewater treatment; however, it generates a massive amount of Fe sludge, which mostly contains other hazardous heavy metal wastes which can harm the environment and humans. This work proposed a sustainable method to eliminate side effects of the Fenton reaction and to transform Cu-containing Fenton sludge into an efficient catalyst for peroxymonosulfate (PMS) activation for tetracycline (TC) degradation The existence of Cu, which can increase sludge O2 vacancies, was attributed to the activation efficiency compared to Fe sludge with no Cu. X-ray diffraction and XPS results showed Fe is present as α-Fe2O3 and γ-Fe2O3; Cu mostly exists as Cu2+. Catalyst and PMS doses, pH, and recycling time effect on PMS reaction was illustrated. OH-, SO4- O2-, and 1O2 were the critical reactive oxygen species. TC decomposes into CO2 and water through six possible pathway processes with these free radicals. Given its sustainable treatment and high catalytic efficiency, dealing with Fe sludge which contains heavy metals serves as a modal practice for harmful wastewater treatment and can be popularized for broader applications. The experimental process involved the reaction of Triacetonamine(cas: 826-36-8Related Products of 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Related Products of 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: 826-36-8On September 1, 2020 ,《Defect-rich carbon based bimetallic oxides with abundant oxygen vacancies as highly active catalysts for enhanced 4-aminobenzoic acid ethyl ester (ABEE) degradation toward peroxymonosulfate activation》 was published in Chemical Engineering Journal (Amsterdam, Netherlands). The article was written by Huang, Zhiyan; Wu, Pingxiao; Liu, Juan; Yang, Shanshan; Chen, Meiqing; Li, Yihao; Niu, Wenchao; Ye, Quanyun. The article contains the following contents:

meeting severe environmental problems, highly efficient, environment-friendly, multiple reusable catalysts are demanding to develop. this work prepared C-based bimetallic oxides with O vacancies for peroxymonosulfate activation to degrade 4-aminobenzoic acid Et ester (ABEE). among different molar ratios of Fe2+ and Mn ions, Fe1Mn1-Fe NC had the optimum catalytic performance. ABEE degradation should have free radical and non-free radical pathways. all sulfate, hydroxyl, and superoxide radicals and singlet oxygen were responsible for efficient ABEE degradation and mineralization. lattice O was the main reactive site for ABEE degradation electron transport provided a good synergistic redox reaction between Fe and Mn and promoted lattice O release. a proposed pathway for ABEE degradation included electrophilic and radical addition, H-abstraction reaction, and diazotization. this work was expected to provide rational design of bimetallic materials with oxygen vacancies for in-situ environmental remediation. In the part of experimental materials, we found many familiar compounds, such as Triacetonamine(cas: 826-36-8Recommanded Product: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Recommanded Product: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Chaturvedula, Prasad V.; Pin, Sokhom; Tholady, George; Conway, Charlie M.; Macor, John E.; Dubowchik, Gene M. published an article in Bioorganic & Medicinal Chemistry Letters. The title of the article was 《Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor》.Related Products of 136624-42-5 The author mentioned the following in the article:

We report the synthesis of rigid spirocyclic systems as conformationally constrained variants of the Ala-Phe-NH2 dipeptide amide C-terminus of the calcitonin gene-related peptide (CGRP). CGRP receptor antagonists containing these moieties displayed potent affinity, functional antagonism and excellent oxidative stability. Structure-activity relationship studies demonstrated the relative importance of hydrogen bond donor/acceptor functionalities and the preferred orientation of an aromatic ring. Antagonists showed potent and full reversal of CGRP-induced dilation of ex vivo human intracranial arteries.4-Amino-1-benzylpiperidine-4-carbonitrile(cas: 136624-42-5Related Products of 136624-42-5) was used in this study.

4-Amino-1-benzylpiperidine-4-carbonitrile(cas: 136624-42-5) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Related Products of 136624-42-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Huang, Zhiyan; Wang, Tenglu; Shen, Minxian; Huang, Zhujian; Chong, Yunxiao; Cui, Lihua published their research in Chemical Engineering Journal (Amsterdam, Netherlands) on August 1 ,2019. The article was titled 《Coagulation treatment of swine wastewater by the method of in-situ forming layered double hydroxides and sludge recycling for preparation of biochar composite catalyst》.HPLC of Formula: 826-36-8 The article contains the following contents:

In order to achieve enhanced treatment of swine wastewater as well as resource recycle, in this work, we applied coagulation treatment on swine wastewater by adding Fe and Mg ions, MgFe layered double hydroxides (LDHs) was yielded during coagulation process and the coagulation sludge was recycled to prepare biochar composite catalyst. The removal rates of total phosphorus (TP) and COD (COD) by Mg-Fe coagulation could achieve 82.55% and 98.51%, which is higher than that by coagulation with individual Mg2+ or individual Fe3+. Finely dispersed MgFe-LDHs flocculation was formed during the coagulation process and was embedded within zoogloea, suspended particles, organic matters, etc. The obtained coagulation sludge was recycled to prepare biochar composite catalyst by oxygen-limited pyrolysis. Redox reaction of iron compounds and electron shuttles capacity of biochar in the catalyst could activate potassium peroxymonosulfate (PMS) to generate ·OH, ·OOH and 1O2, which was responsible for catalysis potential. The as-prepared biochar composite catalyst showed satisfactory catalytic degradation capacity on tylosin and rhodamine B (pH value varied from 3 to 10), and the maximum degradation rate achieved 92.2% for tylosin and 81.9% for rhodamine B (RhB). Coagulation treatment of swine wastewater and in-situ formed layered double hydroxides recycling was suitable in wastewater treatment and resource recycling, of which the degradation rates of RhB were above 83% after five cycling experiments In general, the combined process exhibits great potential for the deep treatment of swine wastewater and resource recycling for sludge. In the part of experimental materials, we found many familiar compounds, such as Triacetonamine(cas: 826-36-8HPLC of Formula: 826-36-8)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.HPLC of Formula: 826-36-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sun, Qianqian; Liu, Bin; Wang, Zhao; Feng, Lili; Zhao, Ruoxi; Dong, Shuming; Dong, Yushan; Zhong, Lei; Gai, Shili; Yang, Piaoping published their research in Chemical Engineering Journal (Amsterdam, Netherlands) on December 1 ,2021. The article was titled 《H2O2/O2 self-supplementing and GSH-depleting Ca2+ nanogenerator with hyperthermia-triggered, TME-responsive capacities for combination cancer therapy》.Application In Synthesis of Triacetonamine The article contains the following contents:

The tumor microenvironment (TME) is complex in composition and unique in nature, and is closely related to the growth, invasion and metastasis of tumor cells. Improving and remodeling the TME to return it to a normalized state can fundamentally disrupt the environment and/or nutrient supply on which tumor cells depend. To achieve this goal, based on the unique physicochem. properties and biol. effects of CaO2, we designed and constructed a Ca2+ nanogenerator (named as CaO2-Cu/ICG@PCM) that enables H2O2/O2 self-supplementation and GSH depletion. The 808 nm laser induces the heat generation of photosensitizer indocyanine green (ICG) to initiate a series of reactions, followed by the production of copper ions, H2O2, O2 and large amounts of Ca2+, which can eventually lead to the combined treatment of photodynamic therapy (PDT), chemodynamic therapy (CDT) and calcium overload. Addnl., the reaction process is accompanied by the generation of Ca(OH)2, which greatly improves the acidic environment of TME and effectively promotes the oxidation process of GSH by H2O2, achieving the purpose of remodeling TME. It is worth mentioning that a large amount of free Ca2+ accumulating in tumor cells can rapidly initiate the process of calcium overload and calcification, which can not only play a role in tumor suppression, but also assist CT imaging to detect the effect of treatment. Thus, CaO2-Cu/ICG@PCM could be a promising candidate for bioimaging and tumor therapy. In the experimental materials used by the author, we found Triacetonamine(cas: 826-36-8Application In Synthesis of Triacetonamine)

Triacetonamine(cas: 826-36-8) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Application In Synthesis of Triacetonamine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Potential multifunctional agents with anti-hepatoma and anti-inflammation properties by inhibiting NF-κB activation》 were Su, Chang-Ming; Hou, Gui-Ge; Wang, Chun-Hua; Zhang, Hong-Qin; Yang, Cheng; Liu, Mei; Hou, Yun. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. Synthetic Route of C6H11NO The author mentioned the following in the article:

Inhibition of NF-κB signalling has been demonstrated as a therapeutic option in treating inflammatory diseases and cancers. Herein, we synthesized novel dissym. 3,5-bis(arylidene)-4-piperidones (BAPs, 83-102 ) and characterized fully. MTT and ELISA assay were performed to screen the anti-hepatoma and anti-inflammation properties. 96(I) showed the most potential bioactivity. I could promote HepG2 apoptosis through up-regulating the expression of C-Caspase-3 and Bax, down-regulating the expression of Bcl-2, while markedly inhibit LPS or TNF-α-induced activation of NF-κB through both inhibiting the phosphorylation of IκBα and p65, and preventing the p65 nuclear translocation to exhibit both anti-hepatoma and anti-inflammatory activities. Mol. docking verified that simulated I can effectively bond to the active site of Bcl-2 and NF-κB/p65 proteins. I inhibited xenografts growth by reducing the expression of TNF-α and Bcl-2 in the tumor tissue. This study suggested that I could be developed as a potential multifunctional agent for treatment of inflammatory diseases and cancers. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Synthetic Route of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Synthetic Route of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Liu, Xiaoxiao; Wei, Wei; Yang, Yunfei; Li, Yujiao; Li, Yao; Xu, Shicheng; Dong, Yanfeng; He, Ronghuan published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《A porous membrane electrolyte enabled by poly(biphenyl piperidinium triphenylmethane) for dendrite-free zinc anode with enhanced cycling life》.Computed Properties of C6H11NO The author mentioned the following in the article:

Aqueous zinc-ion batteries show great advantages as the sustainable energy storage devices, but suffer from inferior cycling life and low energy d. due to the notorious zinc dendrites and possible side reactions in aqueous electrolytes. Herein, we propose a zinc-ions (Zn2+) soaked porous membrane electrolyte (GF/PBPT) by incorporating poly(biphenyl piperidinium triphenylmethane) (PBPT) into glass fiber (GF) via non-solvent-induced phase separation The PBPT was synthesized via a super-acid catalyzed polymerization reaction. The fabricated membrane electrolyte containing PBPT of 42 wt% (GF/PBPT-42%) exhibits suitable pores and reasonable mech. robustness of 4.24 MPa. Moreover, the abundant tertiary amines on PBPT backbones have specific affinity to Zn2+, which benefits the uniform Zn2+ flux through the membrane electrolyte. As a result, the electrolyte of GF/PBPT-42% greatly facilitates dendrite-free Zn anode and enables the Zn/Zn cell to deliver a superior cycling life over 1540 h at 0.5 mA cm-2 at room temperature (RT). In addition to be used in the Zn/Zn cells, the GF/PBPT-42% membrane has been demonstrated its application as the electrolyte in the Zn/MnO2 cell with enhanced cycling stability at both RT and -10 °C. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-piperidone(cas: 1445-73-4Computed Properties of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Computed Properties of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety》 were Song, Mingxia; Yan, Rui; Zhang, Yanhui; Guo, Dongfu; Zhou, Naiming; Deng, XianQing. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. Category: piperidines The author mentioned the following in the article:

Histamine H3 receptors (H3R) antagonists/inverse agonists are becoming a promising therapeutic approach for epilepsy. In this article, novel nonimidazole H3R antagonists/inverse agonists have been designed and synthesized via hybriding the H3R pharmacophore (aliphatic amine with propyloxy chain) with the 1,2,4-triazole moiety as anticonvulsant drugs. The majority of antagonists/inverse agonists prepared here exerted moderate to robust activities in cAMP-response element (CRE) luciferase screening assay. 1-(3-(4-(3-Phenyl-4H-1,2,4-triazol-4-yl)phenoxy)propyl)piperidine () and 1-(3-(4-(3-(4-chlorophenyl)-4H-1,2,4-triazol-4-yl)phenoxy)propyl)piperidine displayed the highest H3R antagonistic activities, with IC50 values of 7.81 and 5.92 nM, resp. Meanwhile, the compounds with higher H3R antagonistic activities exhibited protection for mice in maximal electroshock seizure (MES)-induced convulsant model. Moreover, the protection of against the MES induced seizures was fully abrogated when mice were co-treated with RAMH, a CNS-penetrant H3R agonist, which suggested that the potential therapeutic effect of was through H3R. These results indicate that the attempt to find new anticonvulsant among H3R antagonists/inverse agonists is practicable. In addition to this study using Piperidine-4-carboxamide, there are many other studies that have used Piperidine-4-carboxamide(cas: 39546-32-2Category: piperidines) was used in this study.

Piperidine-4-carboxamide(cas: 39546-32-2) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《A simple, robust and efficient structural model to predict CO2 absorption for different amine solutions: Concern to design new amine compounds》 was published in Journal of Environmental Chemical Engineering in 2020. These research results belong to Raznahan, Mohammad Moein; Riahi, Siavash; Mousavi, Seyed Hamed. Related Products of 622-26-4 The article mentions the following:

The absorption capacity (AC) and absorption rate (AR) are considered as the two main characteristics in choosing the great amine solutions for carbon dioxide absorption. However, selecting the proper amine-based solution on a vast number of exptl. procedures is unaffordable regarding cost and time. Accordingly, studying and modeling amine structures and discovering the relationship between structural parameters and the AC and AR values of amine compounds are of great necessity. The Quant. Structure-Property Relationship (QSPR) method, which is considered as an efficient procedure, is used for predicting carbon dioxide absorption by amine solutions The present study was performed on two different groups of amine solutions, including chained and non-ring-shaped structures for group 1 and major ring-shaped structures for group 2. Then, linear and nonlinear models were applied to create QSPR models, resp. The values of the square of the correlation coefficient (R2) for linear and nonlinear models were 0.753 and 0.985, as well as 0.895 and 0.954 for groups 1 and 2, resp. The results demonstrated that applying a nonlinear model is more efficient and accurate than the linear model for predicting absorption. Further, the prediction of the CO2 absorption value is achievable with high precision for groups 1 and 2 using only 1 and 2 descriptors, resp. In this paper, new amine mols. were designed based on their primary structures and the reported descriptor. Finally, the constructed compounds were found to have better AR and AC compared to initial structures. In the experimental materials used by the author, we found 2-(Piperidin-4-yl)ethanol(cas: 622-26-4Related Products of 622-26-4)

2-(Piperidin-4-yl)ethanol(cas: 622-26-4) can be used to synthese ursolic acid derivatives, spiroimidazolidinone NPC1L1 inhibitors, neurokinin-2 receptor antagonists, antagonists for inhibition of platelet aggregation.Related Products of 622-26-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem