Month: September 2022

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Quality Control of 2403-88-5.

Ma, Jianchao;Zhang, Siyu;Duan, Xiaoguang;Wang, Yuxin;Wu, Danlei;Pang, Jin;Wang, Xin;Wang, Shaobin research published 《 Catalytic oxidation of sulfachloropyridazine by MnO₂: Effects of crystalline phase and peroxide oxidants》, the research content is summarized as follows. Catalytic activation of different oxidants including peroxymonosulfate (PMS), peroxydisulfate (PDS), hydrogen peroxide (H₂O₂) and ozone (O₃) by MnO₂ for degradation of sulfachloropyridazine (SCP) was investigated and the effects of different crystalline phases of MnO₂ including nanowire α-MnO₂, nanorod β-MnO₂, nanofiber γ-MnO₂, and nanosphere δ-MnO₂ on catalytic ozonation of SCP were also studied. The SCP degradation and total organic carbon removal indicated that the oxidation efficiency of the peroxide oxidants followed an order of O3/MnO₂ > PMS/MnO₂ > PDS/MnO₂ > H₂O₂/MnO₂. In catalytic ozonation, SCP degradation rate constants of different MnO₂ phases followed an order of δ-MnO₂ > α-MnO₂ > γ-MnO₂> β-MnO₂. ESR (EPR) suggested that hydroxyl radicals (·OH) and singlet oxygen (¹O₂) might be more significant for SCP degradation than sulfate (SO·^–₄) and superoxide (·O^–₂) radicals. Radical competition experiments demonstrated that ¹O₂ and ·OH contributed to 63.16% and 28.07%, resp., for the catalytic ozonation of SCP. It was also found that more oxygen vacancies, sp. surface area and exposure of MnO₆ edges could facilitate the activation of O₃ for ¹O₂ and ·OH productions and SCP degradation The degradation pathways of SCP could mainly follow the cleavage of S-C or S-N bond and dechlorination, accompanied by hydroxylation and oxidation

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Quality Control of 2403-88-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Formula: C5H11NO.

Ma, Huijun;Qian, Anran;Zheng, Yazhou;Meng, Xin;Wang, Ting;Zhang, Yinyong;Sun, Lulu;Zou, Feng;Zhao, Bomei;Zhang, Shuhua;Zhang, Dan;Yang, Yushe research published 《 Design, Synthesis, and Structure-Activity Relationship Studies of Bisamide Derivatives of Amphotericin B with Potent Efficacy and Low Toxicity》, the research content is summarized as follows. Amphotericin B (AMB, 1) is the most powerful antibiotic in treating potentially life-threatening invasive fungal infections (IFIs), though severe toxicity derived from self-aggregation greatly limits its clin. application. Herein, we applied a bisamidation strategy at the C16-COOH and C3′-NH₂ to improve the therapeutic properties by suppressing self-aggregation. It was found that basic amino groups at the residue of C16 amide were beneficial to activity, while lipophilic fragments contributed to toxicity reduction Addnl., N-methyl-amino acetyl and amino acetyl moieties at C3′ amide could help keep the fungistatic effectiveness. The modification work culminated in the discovery of 36 (I) (ED₅₀ = 0.21 mg/kg), which exerted a 1.5-fold stronger antifungal efficacy than amphamide, the optimal derivative theretofore, in mice, low self-aggregation propensity, and thus low acute toxicity. With the improvement in therapeutic index and good PK profile, 36 is promising for further development as a second-generation polyene antifungal agent.

Formula: C5H11NO, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Recommanded Product: 2,2,6,6-Tetramethyl-4-piperidinol.

Luo, Tao;Peng, Ying;Chen, Long;Li, Jinjun;Wu, Feng;Zhou, Danna research published 《 Metal-free electro-activated sulfite process for As(III) oxidation in water using graphite electrodes》, the research content is summarized as follows. Transition-metal-activated sulfite [S(IV)] processes for water decontamination have recently received intense attention in the field of decontamination by advanced oxidation processes (AOPs). However, the drawback with respect to the secondary metal sludge contamination involved in various AOPs has been argued often. In this work, we developed a novel electro-sulfite (ES) process using stable and low-cost graphite electrodes to address that concern. Arsenite [As(III)] was used as the target compound for removal by the ES process because of its wide presence and high toxicity. Parameters, including cell voltage, S(IV) concentration, solution pH, and water matrix, and the mechanisms for reactions on anode and cathode were investigated in electrolytic cells containing one or two compartments, resp. The results show that the ES process using 1 mM S(IV) and 2 V cell voltage oxidizes 5μM As(III) at a rate of 0.127 min^-1, which is 15-fold higher than mere electrolysis without S(IV) addition (0.008 min^-1) at pH 7. Further studies using radical scavengers and ESR assays demonstrated that oxysulfur radicals (i.e., SO₅^•- and SO₄^•-) and HO^• are responsible for As(III) oxidation in the ES process. However, HO₂^• produced via the oxygen reduction reaction in the EO process plays a major role in As(III) oxidation, which explains the lower reaction rate in the absence of S(IV). The effectiveness of the ES process was moreover evidenced by 60-82% As(III) oxidation in field water within 40 min. Overall, this work realizes the metal-free activation of S(IV) and significantly leverages the S(IV)-based water treatment technologies.

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Recommanded Product: 2,2,6,6-Tetramethyl-4-piperidinol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Auguste Cahours, who named it. Both of them obtained piperidine by reacting piperine with nitric acid. Name: 4-Piperidinol.

Luo, Rongshuang;Wang, Zhongyuan;Luo, Dali;Qin, Yumei;Zhao, Chunshen;Yang, Di;Lu, Tian;Zhou, Zhixu;Huang, Zhuyan research published 《 Design, synthesis, and biological evaluation of novel triazoloquinazolinone derivatives as SHP2 protein inhibitors》, the research content is summarized as follows. A novel series of triazoloquinazolinone derivatives were designed, synthesized, and evaluated for their in vitro biol. activities against the SHP2 protein. Moreover, some compounds were evaluated against A375 cells. The results revealed that target compounds possessed moderate to excellent inhibitory activity against SHP2 protein, whereas compounds , , , , and have strong antiproliferative activity on A375 cells. The compound showed remarkable cytotoxicity against A375 cells and a strong inhibitory effect against SHP2 protein when compared with . The structure-activity relationships (SARs) indicated that electron-donating groups (EDGs) on Ph rings are beneficial for improving the antitumor activity; compounds with a hydroxyl substituent at the 2-position of Ph ring exhibited superior activities than compounds with a substituent at the 4-position. In addition, compound displayed improved physicochem. properties as well as metabolic stability compared to . Our efforts identified as a promising SHP2 protein inhibitor, warranting its further investigation.

Name: 4-Piperidinol, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Application of C9H19NO.

Luo, Haopeng;Zhou, Xin;Chen, Quanyuan;Zhou, Juan research published 《 Removal of 2,4-dichlorophenoxyacetic acid by the boron-nitrogen co-doped carbon nanotubes: Insights into peroxymonosulfate adsorption and activation》, the research content is summarized as follows. B, N co-doped CNTs were synthesized by a simple one-step thermal process and the advanced oxidation processes (AOPs) of 2,4-dichlorophenoxyacetic acid (2,4-D) over the catalyst involved peroxymonosulfate (PMS) activation was investigated. The co-doped catalysts showed higher isoelec. points (IEPs) than those of CNTs and single doped CNTs, facilitating the adsorption of PMS anion (HSO-5) on the catalyst surface, and the AOPs of 2,4-D depended on PMS concentration could be illustrated by the Langmuir-Hinshelwood model. The removal efficiency of 2,4-D over CNTs, CB450, CN450 and CBN450-2 was 20%, 23%, 34% and 68%, resp. The enhancement of catalytic activity was due to the synergistic effect between B and N dopants and both the pyrrolic N and B-N complex played roles in the catalytic reaction. The quenching test and ESR (EPR) results showed that 1O₂ contributed most to the oxidation of 2,4-D and the reaction experienced both the free radical and non-radical pathways. Addnl., the DFT calculation results showed that the adsorption energy of PMS on the surface N dopants decreased by B co-doping, implying that a moderate adsorption energy may facilitate the release of active species generated by PMS activation.

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Application of C9H19NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: C5H5N + 3 H2 → C5H10NH. 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol. HPLC of Formula: 84358-13-4.

Lu, Zhichao;Kumon, Tatsuya;Hammond, Gerald B.;Umemoto, Teruo research published 《 Trifluoromethyl Nonaflate: A Practical Trifluoromethoxylating Reagent and its Application to the Regio- and Stereoselective Synthesis of Trifluoromethoxylated Alkenes》, the research content is summarized as follows. Trifluoromethyl nonafluorobutanesulfonate (nonaflate), TFNf, an easy-to-handle, bench-stable, reactive, and scalable trifluoromethoxylating reagent was developed. TFNf was easily and safely prepared in a simple process in large scale and the nonaflyl part of TFNf could easily be recovered as nonaflyl fluoride after usage and recycled. The synthetic potency of TFNf was showcased with the underexplored synthesis of various trifluoromethoxylated alkenes, through a high regio- and stereoselective hydro(halo)trifluoromethoxylation of alkyne derivatives such as haloalkynes, alkynyl esters, and alkynyl sulfones. The synthetic merits of TFNf were further underscored with a high-yielding and smooth nucleophilic trifluoromethoxylation of alkyl triflates/bromides and primary/secondary alcs.

HPLC of Formula: 84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., 84358-13-4.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. It is a colorless liquid with an odor described as objectionable, and typical of amines. Related Products of 84358-13-4.

Lu, Xiao-Yu;Gao, Ang;Ge, Meng-Yuan;Xia, Ze-Jie;Liu, Qi-Le;Tao, Ting-Hua;Sun, Xiao-Mei research published 《 Stereoconvergent Synthesis of Monofluoroalkenes via Photoinduced Dual Decarboxylative Cross-Coupling of α-Fluoroacrylic Acids with Redox-Active Esters》, the research content is summarized as follows. Herein, a new strategy for the synthesis of monofluoroalkenes via employing α-fluoroacrylic acids and N-hydroxyphthalimide (NHPI) redox-active esters as coupling partners has been developed. This decarboxylative reaction enabled the formation of C(sp²)-C(sp³) bonds to provide a practical and efficient approach for the construction of a variety of monofluoroalkenes, which are key structural motifs in organic chem., under mild reaction conditions. The protocol exhibited excellent functional group compatibility and delivered monofluoroalkene products with excellent Z-stereoselectivity. This work also provides a platform for the modification of complex biol. active mols. containing carboxylic acids.

Related Products of 84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., 84358-13-4.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Name: 4-Piperidinol.

Logvinenko, Ivan G.;Kondratov, Ivan S.;Pridma, Stanislav O.;Tolmachova, Nataliya A.;Morev, Roman N.;Dolovanyuk, Violetta G.;Boretskyi, Andrii L.;Stepaniuk, Roman O.;Trofymchuk, Serhii A.;Muck-Lichtenfeld, Christian;Daniliuc, Constantin G.;Haufe, Gunter research published 《 Synthesis and physical chemical properties of CF₃O-containing secondary amines-Perspective building blocks for drug discovery》, the research content is summarized as follows. Conformational and electronic effects of the trifluoromethoxy group make it attractive to be introduced in biorelevant structures. A mini-library of CF₃O-substituted piperidines, pyrrolidines and azetidines was synthesized in 4-5 steps from com. amino alcs. Comparison of the measured pK_a– and log D_7.4 values of selected regioisomeric CF₃O piperidines with the corresponding CF3- and MeO analogs shows that the effect on the acid/base properties and lipophilicity is rather complex and depends of the substitution position and the conformation of the mols. For the most stable conformers of β-OCF₃ compounds 2-(trifluoromethoxymethyl)piperidine and 3-trifloromethoxypiperidine, DFT calculations and X-ray data for 2-(trifluoromethoxymethyl)piperidine show a favored gauche-arrangement with regard to the amino group.

Name: 4-Piperidinol, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Electric Literature of 84358-13-4.

Liu, Yao;Hao, Mingfeng;Leggett, Alan L.;Gao, Yang;Ficarro, Scott B.;Che, Jianwei;He, Zhixiang;Olson, Calla M.;Marto, Jarrod A.;Kwiatkowski, Nicholas P.;Zhang, Tinghu;Gray, Nathanael S. research published 《 Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13》, the research content is summarized as follows. Genetic depletion of cyclin-dependent kinase 12 (CDK12) or selective inhibition of an analog-sensitive CDK12 reduces DNA damage repair gene expression, but selective inhibition of endogenous CDK12 is difficult. Here, we report the development of MFH290(I), a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-terminal domain (CTD) of RNA-polymerase II (Pol II), and reduces the expression of key DNA damage repair genes. Importantly, these effects were demonstrated to be CDK12-dependent as mutation of Cys-1039 rendered the kinase refractory to MFH290 and restored Pol II CTD phosphorylation and DNA damage repair gene expression. Consistent with its effect on DNA damage repair gene expression, MFH290 augments the antiproliferative effect of the PARP inhibitor olaparib.

84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., Electric Literature of 84358-13-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Application In Synthesis of 2403-88-5.

Liu, Yani;Luo, Jun;Tang, Lin;Feng, Chengyang;Wang, Jiajia;Deng, Yaocheng;Liu, Haoyu;Yu, Jiangfang;Feng, Haopeng;Wang, Jingjing research published 《 Origin of the enhanced reusability and electron transfer of the carbon-coated Mn₃O₄ nanocube for persulfate activation》, the research content is summarized as follows. Manganese oxides and carbon materials are both desirable catalysts for persulfate (PS) advanced oxidation processes in environmental remediation. Nevertheless, manganese oxides suffer from low reusability while carbon materials face the problem of limited catalytic efficiency. For the purpose of making full use of the advantages of the two materials as well as avoiding their shortcomings, carbon-coated Mn₃O₄ composites (Mn₃O₄/C) with a regular nanocube structure were designed to activate PS for the removal of organics, and the catalytic processes were deeply investigated. The catalyst prepared at 400°C with a precursor ratio (glucose/KMnO₄) of 0.5 exhibited the best catalytic performance along with satisfactory reusability owing to the protection of the outer carbon layer. According to exptl. results and d. functional theory calculation, there were van der Waals interaction and a part of the strong attraction between the interface of PS and Mn₃O₄/C, which could be enhanced by inner Mn₃O₄ and thus promoted the electron transfer between PS and carbon shell, and the defective edges of the carbon layer with hydroxyl (C-OH) groups could act as active sites for PS activation. Radical (SO₄^•-, ^•OH) and nonradical (¹O₂) oxidation processes both participated in the degradation of 2,4-dichlorophenol, in which ^•OH was dominating. This study not only proposed a promising catalyst for the degradation of pollutants but also expanded research ideas for future PS activation mechanism studies by integrating the experiment and simulation.

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Application In Synthesis of 2403-88-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem