Day: September 19, 2022

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Reference of 5382-16-1.

Eliwa, Essam M.;Frese, Marcel;Halawa, Ahmed H.;Soltan, Maha M.;Ponomareva, Larissa V.;Thorson, Jon S.;Shaaban, Khaled A.;Shaaban, Mohamed;El-Agrody, Ahmed M.;Sewald, Norbert research published 《 Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR》, the research content is summarized as follows. A metal-free, atom-economy and simple work-up domino amination-Knoevenagel condensation approach to construct new coumarin analogous I [R¹ = pyrrolidin-1-yl, morpholino, (4-hydroxy-1-piperidyl), etc.; R² = cyano, methoxycarbonyl, (1-amino-2,2-dicyano-vinyl)] were described. Further, new formyl and nitro coumarin derivatives II [R¹ = methoxy, pyrrolidin-1-yl, morpholino, etc.; R³ = formyl, nitro] were synthesized via C-N coupling reaction of various cyclic secondary amines and 4-chloro-3-(formyl-/nitro)coumarins resp. The confirmed compounds were screened for their in vitro anti-proliferative activity against KB-3-1, A549 and PC3 human cancer cell lines using resazurin cellular-based assay. Among them, coumarin derivatives I [R¹ = (4-piperidylmethylamino); R² = cyano, methoxycarbonyl] displayed the best anti-cervical cancer potency (KB-3-1) with IC₅₀ values of 15.5 ± 3.54 and 21 ± 4.24μM, resp. Also, I [R¹ = (4-piperidylmethylamino); R² = methoxycarbonyl] showed the most promising cytotoxicity toward A549 with IC₅₀ value of 12.94 ± 1.51μM. As well, II [R¹ = morpholino; R³ = nitro]presented a more significant impact of potency against PC3 with IC₅₀ 7.31 ± 0.48μM. Moreover, I [R¹ = morpholino; R² = cyano] manifested selectivity against PC3 (IC₅₀ = 20.16 ± 0.07μM), while I [R¹ = (4-piperidylmethylamino); R² = cyano] was selective toward KB-3-1 cell line (IC₅₀ = 21 ± 4.24μM). Matching with docking profile, the enzymic assay divulged that I [R¹ = (4-piperidylmethylamino); R² = cyano] was a dual potent single-digit nanomolar inhibitor of VEGFR-2 and EGFR with IC₅₀ values of 24.67 nM and 31.6 nM that were almost equipotent to sorafenib (31.08 nM) and erlotinib (26.79 nM), resp.

Reference of 5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Recommanded Product: 4-Piperidinol.

Elbadawi, Mostafa M.;Eldehna, Wagdy M.;Wang, Wenjie;Agama, Keli K.;Pommier, Yves;Abe, Manabu research published 《 Discovery of 4-alkoxy-2-aryl-6,7-dimethoxyquinolines as a new class of topoisomerase I inhibitors endowed with potent in vitro anticancer activity》, the research content is summarized as follows. Two novel series of 4-alkoxy-2-arylquinolines I (n = 1, 2; R = pyrrolidino, 4-hydroxypiperidino, piperidino, morpholino; X = Cl, CF₃) were designed and synthesized based on SARs of the reported TOP1 inhibitors and structural features required for stabilization of TOP1-DNA cleavage complexes (TOP1ccs). The in vitro anticancer activity of these two series of compounds was evaluated at one dose level using NCI-60 cancer cell lines panel. Compounds with p-substituted Ph at C2 and Pr linker at C4, were the most potent and were selected for assay at five doses level in which they exhibited potent anticancer activity at sub-micromolar level against diverse cancer cell lines. Compound I (Ar = 4-F₃CC₆H₄, 2-furyl, 2-thienyl, etc.; n = 2; R = pyrrolidino) was the most potent with full panel GI₅₀ MG-MID 1.26μM and the most sensitive cancers were colon cancer, leukemia and melanoma. Melanoma (LOX IMVI) was the most sensitive cell line to all tested compounds displaying GI₅₀ and LC₅₀ at sub-micromolar concentration against almost of the tested compounds Few compounds were assayed using TOP1-mediated DNA cleavage assay to evaluate their ability to stabilize TOP1ccs resulting in cancer cell death. The morpholino analogs I (n = 2; R = morpholino; X = Cl, CF₃) exhibited moderate TOP1 inhibitory activity compared to 1μM camptothecin suggesting their use as lead compounds that can be optimized for the development of more potent anticancer agents with potential TOP1 inhibitory activity.

Recommanded Product: 4-Piperidinol, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Auguste Cahours, who named it. Both of them obtained piperidine by reacting piperine with nitric acid. COA of Formula: C11H19NO4.

Duan, Shengzu;Zi, Yujin;Wang, Lingling;Cong, Jielun;Chen, Wen;Li, Minyan;Zhang, Hongbin;Yang, Xiaodong;Walsh, Patrick J. research published 《 α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes》, the research content is summarized as follows. Herein, a unique cascade reaction that enables the preparation of α-branched amines I (R = Me, Ad, oxan-4-ylmethyl, etc.; R¹ = H, Me, Ph; R² = Ph; R¹R² = -(CH₂)₂CH(Ph)(CH₂)₂-; R³ = H, Me; R⁴ = Ph, 4-chlorophenyl, furan-3-yl, etc.) and 3-methyl-1,2,2-triphenylpentan-1-amine bearing aryl or alkyl groups at the β- or γ-positions is reported. The cascade is initiated by reduction of redox active esters II to alkyl radicals. The resulting alkyl radicals are trapped by styrene derivatives, R¹C(R²)=CHR³ leading to benzylic radicals. The persistent 2-azaallyl radicals and benzylic radicals are proposed to undergo a radical-radical coupling leading to functionalized amine products I and 3-methyl-1,2,2-triphenylpentan-1-amine. Evidence is provided that the role of the nickel catalyst is to promote formation of the alkyl radical from the redox active ester and not promote the C-C bond formation. The synthetic method introduced herein tolerates a variety of imines III and redox active esters II, allowing for efficient construction of amine building blocks.

84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., COA of Formula: C11H19NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Category: piperidines.

Dou, Jibo;Cheng, Jie;Lu, Zhijiang;Tian, Ziqi;Xu, Jianming;He, Yan research published 《 Biochar co-doped with nitrogen and boron switching the free radical based peroxydisulfate activation into the electron-transfer dominated nonradical process》, the research content is summarized as follows. In this study, N/B co-doped biochars were employed as metal-free activators of peroxydisulfate (PDS) for tetracycline degradation, more importantly, the roles of dopants and the relative contribution of radical vs nonradical oxidations were comprehensively investigated. Integrating with ESR and kinetics calculations, we showed that co-doping N and B into biochars not only boosted the catalytic activity but also switched the radical PDS-activated process into the electron transfer-dominated nonradical process. Compared with pristine biochar/PDS systems (22%), the nonradical contribution of N/B co-doped biochar/PDS systems increased to 59%, exhibiting outstanding stability and selectivity. Galvanic oxidation tests and theor. simulations unveiled that doped biochars as conductive tunnels accelerate the p.d.-driven electron transfer from the HOMO of pollutants to the LUMO of PDS due to the lower energy gap. This study provided new insights into the critical role of heteroatom-doped carbocatalysts in PDS nonradical activation.

Category: piperidines, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. HPLC of Formula: 2403-88-5.

Dorival-Garcia, Noemi;Galbiati, Fabrizio;Kruell, Ralf;Kovasy, Roman;Dunne, Simon O.;D’Silva, Kyle;Bones, Jonathan research published 《 Identification of additives in polymers from single-use bioprocessing bags by accelerated solvent extraction and ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry》, the research content is summarized as follows. Single-use technologies are increasingly used in biopharmaceutical manufacturing Despite their advantages, these plastic assemblies draw concern because they are a potential source of contamination due to extractable and leachable compounds (E&Ls). Characterizing E&Ls from such materials is a necessary step in establishing their suitability for use. Therefore, there is an urgent need for sensitive methods to identify and quant. assess compounds in plastic materials. Accelerated solvent extraction (ASE) is a powerful technique that can be reliably used for this purpose. In this study, ASE followed by liquid chromatog. and Orbitrap-based High Resolution Accurate Mass (HRAM) mass anal. was found to be an efficient and versatile method for the determination of additives in different multilayer polymer systems from single-use bags. ASE optimization was performed using a design of experiments approach. The type of solvent, temperature, swelling agent addition, static time and number of cycles were the selected variables. Optimum conditions were dependent on the type of plastic film. Et acetate and cyclohexane were selected individually as optimum solvents. Optimum temperatures were 90-100°C. Pressure was set at 1500 psi and extraction time was 30 min in 2 cycles. Swelling agent addition was necessary with polar extraction solvents. More than 100 additives and degradation products were confidently identified by HRAM MS. Correlations between the type and levels of identified additives and the type of polymer system were established. In addition, degradation behavior and pathways for some additives can be addressed.

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., HPLC of Formula: 2403-88-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Reference of 2403-88-5.

Dong, Xiaona;Yang, Xiaoxue;Hua, Sheng;Wang, Ziqian;Cai, Tianming;Jiang, Canlan research published 《 Unraveling the mechanisms for persulfate-based remediation of triphenyl phosphate-contaminated soils: Complicated soil constituent effects on the formation and propagation of reactive oxygen species》, the research content is summarized as follows. The continuous accumulation of tri-Ph phosphate (TPHP) in soil poses a potential threat to human health. Persulfate-based advanced oxidation processes (SR-AOPs) are promising soil remediation technologies. Naturally occurring soil constituents could interact with persulfate (PS) during soil remediation by SR-AOPs. However, the production and transformation of reactive oxygen species (ROS) by synthetic reactions between PS and different soil constituents, as well as their roles in the pollutants degradation, are still largely unknown. This study systematically investigated the generation of ROS and their roles in degradation of TPHP in soil constituents activated PS process and in soil constituents-heat (50 °C) co-activated PS process. Comprehensive studies including ROS identification, ESR anal., and ROS-generated model systems were carried out. An appreciable degradation rate of TPHP (∼21.9%) in soil-PS system and the significant discrepancy in degradation rate (69.0-97.0%) in heat-soil-PS systems with three different soils suggested that soil constituents exhibited complex effects on the activation of PS. The Fe/Mn-minerals in soil effectively activated PS and facilitated TPHP degradation Specially, the iron redox cycle (Fe(II) ↔ Fe(III)) plays a key role in ROS generation. Small mol. soil organic matter (SOM) rapidly consumed the produced ROS which led to their mineralization, while the remaining macromol. SOM became more hydrophilic by interaction with ROS. SO•-4, •OH, and 1O2 played major roles directly in TPHP degradation, while O•-2 could not degrade TPHP directly but might promote TPHP degradation by reducing Fe(III)- to Fe(II)-minerals or converting to other ROS. This study provides new and deeper insights into the interaction between PS and soil constituents and their roles in organic pollutant degradation in contaminated soil using SR-AOPs.

Reference of 2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Auguste Cahours, who named it. Both of them obtained piperidine by reacting piperine with nitric acid. Recommanded Product: 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid.

Dombrowski, Amanda W.;Gesmundo, Nathan J.;Aguirre, Ana L.;Sarris, Katerina A.;Young, Jonathon M.;Bogdan, Andrew R.;Martin, M. Cynthia;Gedeon, Shasline;Wang, Ying research published 《 Expanding the Medicinal Chemist Toolbox: Comparing Seven C(sp²)-C(sp³) Cross-Coupling Methods by Library Synthesis》, the research content is summarized as follows. Despite recent advances in the field of C(sp²)-C(sp³) cross-couplings and the accompanying increase in publications, it can be hard to determine which method is appropriate for a given reaction when using the highly functionalized intermediates prevalent in medicinal chem. Thus a study was done comparing the ability of seven methods to directly install a diverse set of alkyl groups on “drug-like” aryl structures via parallel library synthesis. Each method showed substrates that it excelled at coupling compared with the other methods. When analyzing the reactions run across all of the methods, a reaction success rate of 50% was achieved. Whereas this is promising, there are still gaps in the scope of direct C(sp²)-C(sp³) coupling methods, like tertiary group installation. The results reported herein should be used to inform future syntheses, assess reaction scope, and encourage medicinal chemists to expand their synthetic toolbox.

Recommanded Product: 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., 84358-13-4.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Formula: C9H19NO.

Dintcheva, Nadka Tz;Al-Malaika, Sahar research published 《 Photo-stabilization of biopolymers-based nanocomposites with UV-modified layered silicates》, the research content is summarized as follows. Eco-friendly in-situ stabilized biopolymer nanocomposites based on polyamide 11 (PA11) and polylactic acid (PLA) were prepared by melt mixing in the presence of a modified organo-montmorillonite clay containing a chem.-bound hindered amine UV-stabilizing function, [(UV)OM-MMt]. Characterization of the newly synthesized organo-modifier containing the reactive hindered amine (HAS) UV-stabilizing function [(UV)OM] has confirmed a successful synthesis. The (UV)OM was then introduced into NaMMt through ion exchange reaction to prepare the UV stabilizer-bound organo-modified-MMt, [(UV)OM-MMt]. The in-situ stabilized PA11- and PLA- nanocomposites (PA11-(UV)OM-MMt and PLA-(UV)OM-MMt) were characterized and their photoxidative stabilities (under accelerated weathering conditions) were compared with their nanocomposite analogs containing either the organo-modified MMt (OM-MMt) alone (i.e. without UV-stabilizer) or the OM-MMT containing conventionally added com. hindered amine HAS-UV-stabilizer (Cyasorb UV-3853). It was found that both of the newly prepared in-situ stabilized PA11- and PLA- nanocomposites gave good clay dispersion and have demonstrated a much higher, especially in PLA-nanocomposites, photo-oxidative stability compared to the corresponding nanocomposites but in the absence, or the presence, of the conventionally added HAS-UV-stabilizer.

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Formula: C9H19NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: C5H5N + 3 H2 → C5H10NH. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol. Application In Synthesis of 2403-88-5.

Ding, Haojie;Zhu, Ying;Wu, Yulun;Zhang, Jian;Deng, Huiping;Zheng, Huaili;Liu, Zhen;Zhao, Chun research published 《 In situ regeneration of phenol-saturated activated carbon fiber by an electro-peroxymonosulfate process》, the research content is summarized as follows. Regeneration is required to restore the adsorption performance of activated carbon used as an adsorbent in water purification Conventional thermal and electrochem. regenerations have high energy consumption and poor mineralization of pollutants, resp. In this study, phenol-saturated activated carbon fiber was regenerated in situ using an electro-peroxymonosulfate (E-PMS) process, which mineralized the desorbed contaminants with relatively low energy consumption. The initial adsorbed phenol (81.90%) was mineralized, and only 4.07% of the initial concentration remained in the solution after 6 h of E-PMS regeneration. The phenol degradation was dominated by hydroxyl radical oxidation Adding the PMS in three doses at 2 h intervals improves the regeneration performance from 75% to more than 82%. Regeneration retained 60% of its initial effectiveness even in the 10th cycle with 4.40% of the initial concentration of phenol remaining in the solution These results confirm the E-PMS regeneration process as effective, sustainable, and environmentally friendly for regenerating activated carbon.

Application In Synthesis of 2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Category: piperidines.

Ding, Dahu;Zhou, Liang;Kang, Fuxing;Yang, Shengjiong;Chen, Rongzhi;Cai, Tianming;Duan, Xiaoguang;Wang, Shaobin research published 《 Synergistic adsorption and oxidation of ciprofloxacin by biochar derived from metal-enriched phytoremediation plants: Experimental and computational insights》, the research content is summarized as follows. Biochar is a promising candidate for the adsorptive removal of organic/inorganic pollutants, yet its role in metal-free catalyzed advanced oxidation processes still remains ambiguous. In this work, five biochar samples (PPBKx, where x represents the pyrolysis temperature) were prepared by using metal-enriched phytoremediation plant residue as the feedstock. Notably, PPBK exhibited a high sp. surface area (as high as 1090.7 m² g^-1) and outstanding adsorption capacity toward ciprofloxacin (CIP, as much as 1.51 ± 0.19 mmol g^-1). By introducing peroxymonosulfate (PMS, 5 mM) as the chem. oxidant, over 2 mmol g^-1 CIP was synergistically adsorbed and oxidized within 30 min although PMS itself could not oxidize CIP efficiently, suggesting the formation of reactive oxidative species. Theor. calculations revealed that PMS anions preferentially adsorbed on the activated C atoms adjacent to the graphitic N dopant, where the carbon matrix served as the electron donor, instead of as an electron mediator. The adsorbed PMS possessed a smaller MO energy gap, indicating that it was much easier to be activated than free PMS anions. Surface-bound reactive species were elucidated to be the dominant contributor through chem. quenching experiments and electrochem. characterizations. The catalytic activity of PPBK700 could be greatly retained in repeated oxidations because of the stable N species, which serve as the active catalytic sites, while the CIP adsorption was greatly deteriorated because of the diminishing active adsorption sites (carbon matrix edge) caused by the partial oxidation of PMS. This work not only provides a facile and low-cost approach for the synthesis of functional biochar toward environmental remediation but also deepens the understanding of biochar-catalyzed PMS activation and nonradical oxidation

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem