Day: September 19, 2022

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. HPLC of Formula: 2403-88-5.

Ge, Jiali;Wang, Xinghao;Li, Chenguang;Wang, Siyuan;Wang, Lianhong;Qu, Ruijuan;Wang, Zunyao research published 《 Photodegradation of polychlorinated diphenyl sulfides mediated by reactive oxygen species on silica gel》, the research content is summarized as follows. Polychlorinated di-Ph sulfides (PCDPSs) are a group of dioxin-like compounds that have been widely used in agricultural and industrial productions. Here, we systematically investigated the photochem. behaviors of 2,2′,3′,4,5-pentachlorodiphenyl sulfide (2,2′,3′,4,5-PCDPS) on the surface of silica gel (SG) in an aqueous environment. Under the simulated sunlight irradiation, 2,2′,3′,4,5-PCDPS adsorbed on SG (0.11 mg/g) was found to be degraded with time, giving a removal rate of 68.5% within 16 h at pH 7.0. Environmental factors like pH and humic acid can also affect the removal rate. Results showed that the removal rate of 2,2′,3′,4,5-PCDPS in alk. conditions (75.6% at pH 11) was higher than that in acidic conditions (46.7% at pH 3). Moreover, the addition of (1-5 mg/L) humic acid can promote the degradation rate compared to control group. In our study, it was found that SG can act as photocatalyst to generate reactive oxygen species (ROS) for the degradation of PCDPSs, and UV light contributed much more than visible light (>420 nm). According to ESR (EPR) technol. and radicals quenching experiments, hydroxyl radical (·OH), single oxygen (¹O₂), and superoxide radical (·O^–₂) participated in the removal of the contaminant. Based on the identified intermediate products via LC-MS, two main pathways, i.e., the hydroxyl-substituted reaction of the benzene ring and the oxidation of the sulfur atom, were proposed for the photodegradation of 2,2′,3′,4,5-PCDPS. Then, the d. functional theory (DFT) was employed to confirm these reaction pathways. This study would enhance the understanding of the photochem. transformation and environmental fate of PCDPSs on the surface of solids in natural waters.

HPLC of Formula: 2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. SDS of cas: 84358-13-4.

Garbacz, Mateusz;Stecko, Sebastian research published 《 Synthesis of chiral branched allylamines through dual photoredox/nickel catalysis》, the research content is summarized as follows. This work describes a new approach for the preparation of allylamines, e.g., (S,E)-Et 7-((tert-butoxycarbonyl)amino)oct-5-enoate via cross-coupling of alkyl bromides, e.g., Et 4-bromobutanoate with simple 3-bromoallylamines, e.g., N-Boc (S,E)-4-bromobut-3-en-2-amine by merging the photoredox approach and Ni catalysis. The reaction proceeds under mild conditions, under blue light irradiation, and in the presence of an organic dye, 4CzIPN, as a photocatalyst. The scope of suitable reaction partners is broad, including alkyl bromides bearing reactive functionalities (e.g., esters, nitriles, aldehydes, ketones, epoxides) and N-protected allylamines, as well as N-allylated secondary and tertiary amines and heterocycles. The employment of non-racemic starting materials allows for rapid and easy construction of complex multifunctional allylamine derivatives without the loss of enantiomeric purity.

84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., SDS of cas: 84358-13-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 84358-13-4, formula is C11H19NO4, Name is 1-(tert-Butoxycarbonyl)piperidine-4-carboxylic acid. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Computed Properties of 84358-13-4.

Gao, Yuanyu;Liu, Yuanbai;Iqbal, Zafar;Sun, Jian;Ji, Jinbo;Zhai, Lijuan;Tang, Dong;Ji, Jingwen;He, Lili;Mu, Yangxiu;Yang, Haikang;Yang, Zhixiang research published 《 Amidine Derivatives of Avibactam: Synthesis and In Vitro β-Lactamase Inhibition Activity》, the research content is summarized as follows. Avibactam is a non-β-lactam based second generation β-lactamase inhibitor containing diazabicyclooctane (DBO) ring as β-lactam mimic. The C2 position of DBO scaffold was substituted by a number of amidine derivatives to form water soluble final compounds I [R¹ = CH₂NH₂, 4-thiazolyl, cyclohexylmethyl, 3-pyridylmethyl, etc.]. The synthesized compounds were evaluated for their antibacterial and synergistic activity in combination with an antibiotic in vitro. The compounds, were tested against ten bacterial strains alone and in combination with existing antibiotic, meropenem. All compounds didn’t showed antibacterial activity when alone (MIC, >128μM), however exhibited moderate to good synergistic activity in presence of meropenem by lowering its MIC values. Compound I [R¹ = (4-methylpiperazin-1-yl)methyl] proved most potent among other counterparts against all bacterial species with MIC from <0.29μM to 2.34μM, and showed comparable or improved activity to avibactam against eight bacterial strains. Compound I [R¹ = (4-methylpiperazin-1-yl)methyl] may prove a lead for next level in vivo and clin. studies.

Computed Properties of 84358-13-4, N-BOC-piperidine-4-carboxylic acid, also known asN-Boc-isonipecotic acid , is a useful research compound. Its molecular formula is C11H19NO4 and its molecular weight is 229,28 g/mole. The purity is usually 95%.

N-Boc-isonipecotic acid is a potent antitumor agent that has been clinically shown to be effective against leukemia and lymphoma. It has potent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. N-Boc-isonipecotic acid binds to the gyrase enzyme, which is used by these bacteria to maintain the integrity of their DNA, inhibiting protein synthesis and cell division. This drug also has anti-inflammatory properties. N-Boc-isonipecotic acid inhibits prostaglandin synthesis in cells, which may be due to its ability to inhibit the production of tumor necrosis factor α (TNFα) in macrophages., 84358-13-4.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Computed Properties of 2403-88-5.

Gao, Yaowen;Zhu, Yue;Li, Tong;Chen, Zhenhuan;Jiang, Qike;Zhao, Zhiyu;Liang, Xiaoying;Hu, Chun research published 《 Unraveling the high-activity origin of single-atom iron catalysts for organic pollutant oxidation via peroxymonosulfate activation》, the research content is summarized as follows. Single-atom catalysts (SACs) have emerged as efficient materials in the elimination of aqueous organic contaminants; however, the origin of high activity of SACs still remains elusive. Herein, we identify an 8.1-fold catalytic specific activity (reaction rate constant normalized to catalyst’s sp. surface area and dosage) enhancement that can be fulfilled with a single-atom iron catalyst (SA-Fe-NC) prepared via a cascade anchoring method compared to the iron nanoparticle-loaded catalyst, resulting in one of the most active currently known catalysts in peroxymonosulfate (PMS) conversion for organic pollutant oxidation Exptl. data and theor. results unraveled that the high-activity origin of the SA-Fe-NC stems from the Fe-pyridinic N₄ moiety, which dramatically increases active sites by not only creating the electron-rich Fe single atom as the catalytic site but also producing electron-poor carbon atoms neighboring pyridinic N as binding sites for PMS activation including synchronous PMS reduction and oxidation together with dissolved oxygen reduction Moreover, the SA-Fe-NC exhibits excellent stability and applicability to realistic industrial wastewater remediation. This work offers a novel yet reasonable interpretation for why a small amount of iron in the SA-Fe-NC can deliver extremely superior specific activity in PMS activation and develops a promising catalytic oxidation system toward actual environmental cleanup.

Computed Properties of 2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Recommanded Product: 2,2,6,6-Tetramethyl-4-piperidinol.

Gao, Yaowen;Zhu, Yue;Chen, Zhenhuan;Hu, Chun research published 《 Nitrogen-Coordinated Cobalt Embedded in a Hollow Carbon Polyhedron for Superior Catalytic Oxidation of Organic Contaminants with Peroxymonosulfate》, the research content is summarized as follows. The search for high-active and long-lasting materials is of paramount significance for elimination of aqueous organic contaminants. Herein, a nitrogen-coordinated cobalt embedded in hollow carbon polyhedron (marked as NCoHCP) has been synthesized by thermal transformation of core-shell-architectured ZIF-8@ZIF-67. XPS, X-ray absorption spectroscopy (XAS), and theor. calculations confirmed the coordination of a Co atom with one N atom in NCoHCP. The resultant NCoHCP catalyst delivers extremely superior catalytic performance in peroxymonosulfate (PMS) decomposition into active species toward complete oxidation of organic pollutants in less than 45 s. Exptl. data and theor. computations disclosed the formation of Co-pyridinic N moiety not only creates the Co species with higher electron d. as active sites but also increases the C atom neighboring pyridinic N with lower electron d. as binding sites for PMS conversion toward reactive oxygen species generation to oxidize organic pollutant. On the other hand, the donation of electron from organic contaminant toward the C atom adjacent to pyridinic N also induces organic contaminant oxidation The dual-pathway degradation contributes to superior catalytic oxidation of organics over NCoHCP. This study furnishes an effective strategy for developing high-performance and robust metal/carbon hybrid materials toward wide environmental applications.

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Recommanded Product: 2,2,6,6-Tetramethyl-4-piperidinol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. It is a colorless liquid with an odor described as objectionable, and typical of amines. Electric Literature of 5382-16-1.

Fischer, Oliver;Heinrich, Markus R. research published 《 2-Fluoro-5-nitrophenyldiazonium: A Novel Sanger-Type Reagent for the Versatile Functionalization of Alcohols》, the research content is summarized as follows. As a novel Sanger-type reagent, 2-fluoro-5-nitrophenyldiazonium tetrafluoroborate enabled the versatile functionalization of primary aliphatic alcs. e.g., β-citronellol and secondary aliphatic alcs. e.g., trans-1,2-cyclohexandiol. Based on a mild nucleophilic aromatic substitution of the fluorine atom under unprecedented, base-free conditions, the diazonium unit on the aromatic core of the resulting aryl-alkyl ether e.g., I could be employed for such diverse transformations as radical C-H activation and cyclization, as well as palladium catalyzed cross-coupling reactions.

5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., Electric Literature of 5382-16-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Recommanded Product: 4-Piperidinol.

Feng, Baicheng;Dong, Jingjing;Wang, Tielin;Lu, Jianqiang;Jin, Yan research published 《 Synthesis and characterization of N-(4-(piperidin-4-ylsulfonyl)phenyl)5-vinylpyrimidin-2-amine》, the research content is summarized as follows. Target product N-(4-(piperidin-4-ylsulfonyl)phenyl)5-vinylpyrimidin-2- amine was synthesized using 6-oxopyran-3-carbaldehyde and 4-hydroxypiperidine as starting materials by a series of nucleophilic substitution and oxidation Different acid-binding agents were discussed to explore the effect on the yield of tert-Bu 4-((4-((5-vinylpyrimidin-2-yl)amino)phenyl)sulfonyl)piperidine-1- carboxylate. The structures of products were characterized by ¹H NMR and mass spectra.

5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., Recommanded Product: 4-Piperidinol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Formula: C5H11NO.

Fang, Lincheng;Tian, Jiping;Zhang, Kaixuan;Zhang, Xiaoyi;Liu, Yingqiao;Cheng, Zhibo;Zhou, Jinpei;Zhang, Huibin research published 《 Discovery of 1,3,4-oxadiazole derivatives as potential antitumor agents inhibiting the programmed cell death-1/programmed cell death-ligand 1 interaction》, the research content is summarized as follows. Inhibition of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction by small-mol. inhibitors is emerging cancer immunotherapy. A series of novel 1,3,4-oxadiazole derivatives were designed, synthesized, and evaluated for their activities in vitro and vivo to find potent inhibitors of the PD-1/PD-L1 interaction. Among them, compound II-14 exhibited outstanding biochem. activity, with an IC₅₀ of 0.0380 μM. Importantly, compound II-14, with a TGI value of 35.74 %, had more potent efficacy in a mouse tumor model compared to that in the control group. Surprisingly, when compound II-14 combined with 5-FU in a mouse tumor model having a TGI value of 64.59 %, which showed potential anti-tumor synergistic effects. Furthermore, immunohistochem. anal. demonstrated that compound II-14 activated the immune microenvironment by promoting the infiltration of CD4+ T cells into tumor tissues. These results indicate that compound II-14 is a promising lead compound for further development of small-mol. PD-1/PD-L1 inhibitors for cancer therapy.

Formula: C5H11NO, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Piperidine the name comes from the genus name Piper, which is the Latin word for pepper. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Although piperidine is a common organic compound, it is best known as a representative structure element within many pharmaceuticals and alkaloids, such as natural-occurring solenopsins. Synthetic Route of 2403-88-5.

Fang, Cunxia;Gao, Xingmin;Zhang, Xiangcheng;Zhu, Jiahui;Sun, Sheng-Peng;Wang, Xiaoning;Wu, Winston Duo;Wu, Zhangxiong research published 《 Facile synthesis of alkaline-earth metal manganites for the efficient degradation of phenolic compounds via catalytic ozonation and evaluation of the reaction mechanism》, the research content is summarized as follows. In this paper, we demonstrate the facile and general synthesis of alk.-earth metal manganites, denoted as A(Mg, Ca, Ba)Mn_xO_y, for efficient degradation of high-concentration phenolic compounds via catalytic ozonation. The representative CaMn_xO_y oxides show a hierarchical spherical structure constructed by crystalline nanorods and numerous macropores. They possess mixed Mn⁴⁺/Mn³⁺ chem. valences and abundant surface hydroxyl (OH) groups. The ozone (O₃) decomposition rate on the CaMn_xO_y catalysts is greatly accelerated and follows the first-order law. These catalysts are promising for the degradation of phenolic compounds via catalytic ozonation, exhibiting rapid pseudofirst-order degradation kinetics, a high total organic carbon (TOC) removal efficiency and an excellent stability. Under optimized conditions (a low O₃ dosage of 1.5 mg/min and a catalyst dosage of 7.5 g/L), for the treatment of concentrated phenol (50-240 mg/L), the CaMn_xO_y catalysts show 100% degradation and 50-70% mineralization within 1.0 h. The Ca²⁺ ions are essential to create redox Mn⁴⁺/Mn³⁺ couples and to significantly reduce manganese leaching. High surface ratios of Mn⁴⁺/Mn³⁺ and OH/lattice oxygen (O_lat) are beneficial for enhancing the catalytic performance. Superoxide anion free radicals (^·O^–₂) and singlet oxygen (¹O₂) are the predominant reactive species for the oxidation degradation The ^·O^–₂ reaction pathway is proposed. Specifically, the surface OH sites activate O₃, displaying highly enhanced decomposition rates. The generated ^·O^–₂ and ¹O₂ play a role in oxidation The redox Mn⁴⁺/Mn³⁺ and the O_lat/oxygen vacancy (O_lat/O_vac) couples play important roles in electron transfer. The proposed mechanism is supported by active site probing, radical scavenging, spectroscopic studies, and the results in the degradation of substituted phenols.

2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., Synthetic Route of 2403-88-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: C5H5N + 3 H2 → C5H10NH. 2403-88-5, formula is C9H19NO, Name is 2,2,6,6-Tetramethyl-4-piperidinol. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol. HPLC of Formula: 2403-88-5.

Eysseric, Emmanuel;Gagnon, Christian;Segura, Pedro A. research published 《 Identifying congeners and transformation products of organic contaminants within complex chemical mixtures in impacted surface waters with a top-down non-targeted screening workflow》, the research content is summarized as follows. Over 350,000 compounds are registered for production and use including a high number of congeners found in complex chem. mixtures (CCMs). With such a high number of chems. being released in the environment and degraded into transformation products (TPs), the challenge of identifying contaminants by non-targeted screening (NTS) is massive. “Bottom-up” studies, where compounds are subjected to conditions simulating environmental degradation to identify new TPs, are time consuming and cannot be relied upon to study the TPs of hundreds of thousands of compounds Therefore, the development of “top-down” workflows, where the structural elucidation of unknown compounds is carried directly on the sample, is of interest. In this study, a top-down NTS workflow was developed using mol. networking and clustering (MNC). A total of 438 compounds were identified including 176 congeners of consumer product additives and 106 TPs. Reference standards were used to confirm the identification of 53 contaminants among them lesser-known pharmaceuticals (aliskiren, sitagliptin) and consumer product additives (lauramidopropyl betaine, 2,2,4-trimethyl-1,2-dihydroquinoline). The MNC tools allowed to group similar TPs and congeners together. As such, several previously unknown TPs of pesticides (metolachlor) and pharmaceuticals (gliclazide, irbesartan) were identified as tentative candidates or probable structures. Moreover, some congeners that had no entry on global repositories (PubChem, ChemSpider) were identified as probable structures. The workflow worked efficiently with oligomers containing ethylene oxide moieties, and with TPs structurally related to their parent compounds The top-down approach shown in this study addresses several issues with the identification of congeners of industrial compounds from CCMs. Furthermore, it allows elucidating the structure of TPs directly from samples without relying on bottom-up studies under conditions discussed herein. The top-down workflow and the MNC tools show great potential for data mining and retrospective anal. of previous NTS studies.

HPLC of Formula: 2403-88-5, 2,2,6,6-Tetramethyl-4-piperidinol(TEMPO) is a useful research compound. Its molecular formula is C9H19NO and its molecular weight is 157.25 g/mol. The purity is usually 95%.
TEMPO is an intermediate used in the preparation of Piperidinyloxy free radical derivatives.
TEMPO is an organic compound that acts as a radical scavenger. It is stable in the presence of water and air and can be used for the inhibition of bacterial growth. TEMPO reacts with reactive intermediates to form non-reactive substances and terminate chain reactions. This process is optimal at temperatures between 0°C and 40°C and pH values between 3.5 and 7.5. TEMPO has been shown to inhibit the growth of bacteria by reacting with reactive molecules such as amines, chlorides, or low energy radicals in aqueous solution. TEMPO also has genotoxic activity that inhibits DNA synthesis in bacterial cells through oxidation of guanine residues on DNA molecules., 2403-88-5.

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem