Month: April 2022

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Reaction of dihalopropionic acids and their nitriles with tertiary amines, published in 2004, which mentions a compound: 600-05-5, mainly applied to amine tertiary dehydrohalogenation dihalopropionic acid dihalopropionitrile; pyridine vinylation dihalopropionic acid; haloacrylic acid preparation; vinylpyridinium halide preparation, Recommanded Product: 600-05-5.

The reaction of 2,3-dichloro- and 2,3-dibromopropionic acid and the corresponding nitriles with tertiary aliphatic amines gave dehydrohalogenation products and amine hydrohalides. When pyridine was used, 1-vinylpyridinium halides were obtained.

As far as I know, this compound(600-05-5)Recommanded Product: 600-05-5 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Formula: C7H6ClNO. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(2-chloropyridine-4-yl)ethanone, is researched, Molecular C7H6ClNO, CAS is 23794-15-2, about Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3. Author is Ansideri, Francesco; Macedo, Joana T.; Eitel, Michael; El-Gokha, Ahmed; Zinad, Dhafer S.; Scarpellini, Camilla; Kudolo, Mark; Schollmeyer, Dieter; Boeckler, Frank M.; Blaum, Baerbel S.; Laufer, Stefan A.; Koch, Pierre.

Starting from known p38α mitogen-activated protein kinase (MAPK) inhibitors, a series of inhibitors of the c-Jun N-terminal kinase (JNK) 3 was obtained. Altering the substitution pattern of the pyridinylimidazole scaffold proved to be effective in shifting the inhibitory activity from the original target p38α MAPK to the closely related JNK3. In particular, a significant improvement for JNK3 selectivity could be achieved by addressing the hydrophobic region I with a small Me group. Furthermore, addnl. structural modifications permitted to explore structure-activity relationships. The most potent inhibitor 4-(4-methyl-2-(methylthio)-1H-imidazol-5-yl)-N-(4-morpholinophenyl)pyridin-2-amine showed an IC50 value for the JNK3 in the low triple digit nanomolar range and its binding mode was confirmed by x-ray crystallog.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Dissociation of halogen-substituted propionic acids in water-acetonitrile solvent mixtures. Substituent effects.Name: 2,3-Dibromopropionic acid.

The pK values of AcOH, EtCO2H and halogen-substituted EtCO2H in H2O/MeCN mixtures were determined at 25° by potentiometric titration The values for α-Cl-, β-Cl-, α-Br-, β-Br-, β-I-, α,α-di-Cl-, α,β-di-Cl-, α,β-di-Br-propionic acid, AcOH and EtCO2H in aqueous mixtures containing 0, 20, 40, 60 and 80 weight% MeCN are reported. The substituent effects on acidity are discussed.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis, anticonvulsant activity and QSAR studies of some new pyrazolyl pyridines, published in 2016-08-31, which mentions a compound: 23794-15-2, mainly applied to anticonvulsant epilepsy QSAR pyrazole pyridine, Safety of 1-(2-chloropyridine-4-yl)ethanone.

Twenty-one new 3,5-bipyridinyl-1H-pyrazole derivatives (pyrazolyl pyridines) have been synthesized and evaluated for their anticonvulsant activity in animal models of epilepsy. The pyrazolyl pyridines I [R1 = H, Cl, Ph, etc.; R2 = H, Cl, Ph, etc.] were obtained through a general one-pot synthesis, from ketones and acid chlorides via formation of 1,3-diketones in situ carried out in hydrocarbon solvent and LiHMDS base. The profile of anticonvulsant activity of final compounds was established in the maximal electroshock (MES) and s.c. pentylenetetrazole (s.c. PTZ) tests, after i.p. injection in rats and mice, resp., at doses of 30, 100, and 300 mg/kg. An observation was carried out at two different time intervals-0.5 and 4 h. Phenytoin was used as a standard antiepileptic against MES convulsions and valproic acid against s.c. PTZ convulsions. Furthermore, in addition to the primary anticonvulsant screening, the acute neurol. toxicity was determined in mice by the rotarod test and in rats by positional sense test. The compounds showed anticonvulsant activity exclusively against MES convulsions. The compounds were found especially active in 100 mg/kg dose at both the time points, i.e., 0.5 and 4 h, depending upon the lipophilicity of mols. as indicated by statistically significant reduction in the time spent in tonic extension phase (p < 0.001). Further, the newly synthesized compounds were subjected to two-dimensional quant. structure-activity relationship (2D QSAR) anal. through multiple linear regression, principal component regression, and partial least square regression anal., and three-dimensional quant. structure-activity relationship (3D QSAR) anal. by k-nearest neighbor mol. field anal. in conjunction with stepwise forward-backward, genetic algorithm, and simulated annealing variable selection methods using the software VLife MDS. The structure-activity relationship (SAR) as well as quant. structure-activity relationship (QSAR) studies for anticonvulsant activity confirmed the crucial role of 3,5-bipyridinyl-1H-pyrazole core fragment for anticonvulsant activity. As far as I know, this compound(23794-15-2)Safety of 1-(2-chloropyridine-4-yl)ethanone can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Esters of α, β-dibromopropionic acid, published in 1945, which mentions a compound: 600-05-5, Name is 2,3-Dibromopropionic acid, Molecular C3H4Br2O2, SDS of cas: 600-05-5.

The following esters of α, β-dibromopropionic acid were prepared in 60-5% yields by treating mixtures of the acid with the appropriate alc. and HCl with ice-cooling, followed by standing at room temperature, separation, and washing with water (b60-5, b., d420, nD20 given): Me 129-30°, 203-5°, 1.9333, 1.5127; Et 137-8°, 214-16°, 1.7966, 1.5007; Pr 149-50°, 221-4°, 1.6799, 1.4950; iso-Pr 143-6°, 210-14°, 1.6459, 1.4903; Bu 163-4°, 236-9°, 1.6107, 1.4890; iso-Bu 155-6°, 230-2°, 1.5783, 1.4882; iso-Am 165-9°, 240-4°, 1.5149, 1.4871; allyl 148-50°, 218-21°, 1.7412, 1.5126.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 600-05-5, is researched, Molecular C3H4Br2O2, about Reaction of α,β-dibromopropionic acid nitrile with sodium diethyl phosphite, the main research direction is bromopropionitrile addition sodium ethyl phosphite.Computed Properties of C3H4Br2O2.

BrCH2CHBrCN and (EtO)2PONa in Et2O gave (EtO)2PHO, O P(O)(OEt)2]2, and (EtO)2P(O)CH2CH2CN, which was hydrolyzed to the acid and converted to the anilide. (EtO)2P(O)CH:CHCN in Et2O added to (EtO)2PHO in (EtO)2PONa, after refluxing 18 hr and hydrolyzing the ester, gave (HO)2P(O)CH2CH2CO2H. BrCH2CHBrCO2Me and (EtO)2PONa in Et2O gave (EtO)2PHO, (EtO)2P(O)CH2CH2CO2Me, O[P(O)(OEt)2]2 and (EtO)3PO.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Faulkner, Adele; Scott, James S.; Bower, John F. published an article about the compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine( cas:175136-62-6,SMILESS:FC(C1=CC(C(F)(F)F)=CC(P(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=C1)(F)F ).Formula: C24H9F18P. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:175136-62-6) through the article.

The authors report efficient Pd-catalyzed cyclizations of oxime esters with 1,1-disubstituted alkenes as the basis of a general entry to α,α-disubstituted pyrrolidine derivatives, e.g. I [R1 = Ph, 2-naphthyl, 4-pyridinyl, etc.]. The authors also demonstrate that catalytic asym. variants of this chem. are feasible by employing a suitable chiral ligand.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4,4-Difluoropiperidine hydrochloride, is researched, Molecular C5H10ClF2N, CAS is 144230-52-4, about Observation of Vortex Domains in a Two-Dimensional Lead Iodide Perovskite Ferroelectric, the main research direction is lead iodide two dimensional perovskite ferroelec vortex domain.Application of 144230-52-4.

Topol. defects, such as vortices and skyrmions, provide a wealth of splendid possibilities for new nanoscale devices because of their marvelous electronic, magnetic, and mech. behaviors. Recently, great advances have been made in the study of the ferroelec. vortex in conventional perovskite oxides, such as BaTiO3 and BiFeO3. Despite extensive interest, however, no intriguing ferroelec. vortex structures have yet been found in organic-inorganic hybrid perovskites (OIHPs), which are desirable for their mech. flexibility, ease of fabrication, and low acoustical impedance. We observed the robust vortex-antivortex topol. configurations in a two-dimensional (2D) layered OIHP ferroelec. (4,4-DFPD)2PbI4 (4,4-DFPD is 4,4-difluoropiperidinium). This provides future directions for the study of perovskites and makes it a promising alternative for nanoscale ferroelec. devices in medical, micromech., and biomech. applications.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Electric Literature of C24H9F18P. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, is researched, Molecular C24H9F18P, CAS is 175136-62-6, about Palladium-catalysed C-H activation of aliphatic amines to give strained nitrogen heterocycles. Author is McNally, Andrew; Haffemayer, Benjamin; Collins, Beatrice S. L.; Gaunt, Matthew J..

The development of new chem. transformations based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the synthesis of complex mols. dramatically. Transition metal catalysis has emerged as a powerful tool with which to convert these unreactive bonds into carbon-carbon and carbon-heteroatom bonds, but the selective transformation of aliphatic C-H bonds is still a challenge. The most successful approaches involve a ‘directing group’, which positions the metal catalyst near a particular C-H bond, so that the C-H functionalization step occurs via cyclometallation. Most directed aliphatic C-H activation processes proceed through a five-membered-ring cyclometallated intermediate. Considering the number of new reactions that have arisen from such intermediates, it seems likely that identification of distinct cyclometallation pathways would lead to the development of other useful chem. transformations. Here we report a palladium-catalyzed C-H bond activation mode that proceeds through a four-membered-ring cyclopalladation pathway. The chem. described here leads to the selective transformation of a Me group that is adjacent to an unprotected secondary amine into a synthetically versatile nitrogen heterocycle. The scope of this previously unknown bond disconnection is highlighted through the development of C-H amination and carbonylation processes, leading to the synthesis of aziridines and β-lactams (resp.), and is suggestive of a generic C-H functionalization platform that could simplify the synthesis of aliphatic secondary amines, a class of small mols. that are particularly important features of many pharmaceutical agents. E.g., in presence of Pd(OAc)2, PhI(OAc)2, and Ac2O in toluene, aziridination of morpholine derivative (I) gave 74% fused aziridine (II).

This literature about this compound(175136-62-6)Electric Literature of C24H9F18Phas given us a lot of inspiration, and I hope that the research on this compound(Tris(3,5-bis(trifluoromethyl)phenyl)phosphine) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Category: piperidines. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4,4-Difluoropiperidine hydrochloride, is researched, Molecular C5H10ClF2N, CAS is 144230-52-4, about Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator. Author is Rennie, Glen R.; Barden, Timothy C.; Bernier, Sylvie G.; Carvalho, Andrew; Deming, Renee; Germano, Peter; Hudson, Colleen; Im, G-Yoon J.; Iyengar, Rajesh R.; Jia, Lei; Jung, Joon; Kim, Elise; Lee, Thomas W.-H.; Mermerian, Ara; Moore, Joel; Nakai, Takashi; Perl, Nicholas R.; Tobin, Jenny; Zimmer, Daniel P.; Renhowe, Paul A..

Soluble guanylate cyclase (sGC) is a clin. validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC have the potential to treat diseases that are affected by dysregulation of the NO-sGC-cGMP signal transduction pathway. This letter describes the SAR efforts that led to the discovery of CYR715, a novel carboxylic acid-containing sGC stimulator, with an improved metabolic profile relative to our previously described stimulator, IWP-051. CYR715 addressed potential idiosyncratic drug toxicity (IDT) liabilities associated with the formation of reactive, migrating acyl glucuronides (AG) found in related carboxylic acid-containing analogs and demonstrated high oral bioavailability in rat and dose-dependent hemodynamic pharmacol. in normotensive Sprague-Dawley rats.

This literature about this compound(144230-52-4)Category: piperidineshas given us a lot of inspiration, and I hope that the research on this compound(4,4-Difluoropiperidine hydrochloride) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem