Month: April 2022

Reference of Iron(III) trifluoromethanesulfonate. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Iron(III) trifluoromethanesulfonate, is researched, Molecular C3F9FeO9S3, CAS is 63295-48-7, about Synthesis of conductive elastomeric foams by an in situ polymerization of pyrrole using supercritical carbon dioxide and ethanol cosolvents. Author is Shenoy, S. L.; Kaya, I.; Erkey, C.; Weiss, R. A..

Elec. conductive polyurethane (PU) foams were prepared by first impregnating a PU foam with ferric trifluoromethane sulfonate (ferric triflate) using supercritical carbon dioxide (scCO2) containing 0.2 – 1.3 volume % ethanol as a cosolvent, and then exposing the foam to pyrrole vapor. Polypyrrole (PPy) was formed in situ by an chem. oxidative polymerization The conductivity of the composite foams ranged from 10-7 to 10-2 S/cm, depending on the amount of ethanol and impregnation time used. The amount of PPy produced depended on the amount of oxidant absorbed by the foam. For low ethanol concentrations and/or short impregnation time, the PPy produced was concentrated at or near the surfaces of the foam sample. The dispersion of the PPy in the foam was improved by increasing the amount of ethanol and the impregnation time. Ferric trifluoroacetate was more soluble in the scCO2/ethanol solutions, but produced foams with much lower conductivity than did ferric triflate.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: 4,4-Difluoropiperidine hydrochloride. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4,4-Difluoropiperidine hydrochloride, is researched, Molecular C5H10ClF2N, CAS is 144230-52-4, about Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity.

Targeting the menin-MLL protein-protein interaction is a new therapeutic strategy for the treatment of acute leukemia carrying MLL fusion (MLL leukemia). We describe herein the structure-based optimization of a class of covalent menin inhibitors, which led to the discovery of M-808 (16)(I) as a highly potent and efficacious covalent menin inhibitor. M-808 effectively inhibits leukemia cell growth at low nanomolar concentrations and is capable of achieving partial tumor regression in an MV4;11 xenograft tumor model in mice at a well-tolerated dose schedule. Determination of the co-crystal structure of M-808 in complex with menin provides a structural basis for their high-affinity, covalent interactions. M-808 represents a promising, covalent menin inhibitor for further optimization and evaluation toward developing a new therapy for the treatment of MLL leukemia.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A Protocol for Metal Triflate Catalyzed Direct Glycosylation with GalNAc 1-OPiv Donors, published in 2014-11-21, which mentions a compound: 63295-48-7, Name is Iron(III) trifluoromethanesulfonate, Molecular C3F9FeO9S3, Recommanded Product: Iron(III) trifluoromethanesulfonate.

Herein we report on the development of novel glycosylation methodol. for the concise synthesis of naturally occurring glycoconjugate motifs containing N-acetylgalactosamine (GalNAc) from the cheaper and com. available N-acetylglucosamine (GlcNAc). The stereoselective glycosylation proceed with catalytic amounts of a promoter and without the need for N-protection other than the biol. relevant N-acetyl group. Among the catalysts explored, both Bi(OTf)3 and Fe(OTf)3 were found to be highly active Lewis acids for this reaction. It was also found that other less reactive metal triflates such as those of Cu(II) and Yb(III) can be beneficial in glycosylation reactions on more demanding glycosyl acceptors. We have furthermore demonstrated that it is possible to control the anomeric stereoselectivity in the glycosylation via post-glycosylation in situ anomerization to obtain good yields of α-galactosides. The present protocol was used to prepare important naturally occurring carbohydrate motifs, including a trisaccharide fragment of the naturally occurring marine sponge clarhamnoside.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Computed Properties of C24H9F18P. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, is researched, Molecular C24H9F18P, CAS is 175136-62-6, about Development of highly efficient platinum catalysts for hydroalkoxylation and hydroamination of unactivated alkenes. Author is Zhou, Yali; Xu, Xingjun; Sun, Hongwei; Tao, Guanyu; Chang, Xiao-Yong; Xing, Xiangyou; Chen, Bo; Xu, Chen.

The design and discovery of “”donor-acceptor””-type platinum catalysts that were highly effective in both hydroalkoxylation and hydroamination of unactivated alkenes over a broad range of substrates under mild conditions were described. A number of alkene substitution patterns were accommodated, including tri-substituted, 1,1-disubstituted, (E)-disubstituted, (Z)-disubstituted and even mono-substituted double bonds. Detailed mechanistic investigations suggested a plausible pathway that included an unexpected dissociation/re-association of the electron-deficient ligand to form an alkene-bound “”donor-acceptor””-type intermediate. These mechanistic studies helped to understand the origins of the high reactivity exhibited by the catalytic system and provided a foundation for the rational design of chiral catalysts towards asym. hydrofunctionalization reactions.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

LaMattina, John L. published an article about the compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2,SMILESS:CC(=O)C1=CC(Cl)=NC=C1 ).Recommanded Product: 1-(2-chloropyridine-4-yl)ethanone. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:23794-15-2) through the article.

A general synthetic scheme for the preparation of 2-amino-4-(4-imidazolyl)pyridines I (R = NH2, NHEt, NMe2; R1 = H, Me; R2 = H, NH2, Me), potential histamine H2 antagonists, is based on the Neber rearrangement of 1-(4-pyridyl)-1-alkanone oxime O-tosylates to α-amino ketones or α-amino ketals, which are then converted to the imidazoles. The reaction of Grignard reagents with 2-chloroisonicotinonitrile, as well as nucleophilic displacement of Cl by amines on 2-chloroisonicotinonitrile and derivatives, are discussed in relation to the preparation of the ketone intermediates.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Expansion of the Ligand Knowledge Base for Monodentate P-Donor Ligands (LKB-P), published in 2010-12-13, which mentions a compound: 175136-62-6, Name is Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, Molecular C24H9F18P, COA of Formula: C24H9F18P.

Authors have expanded the ligand knowledge base for monodentate P-donor ligands (LKB-P, Chem. Eur. J.2006, 12, 291-302) by 287 ligands and added descriptors derived from computational results on a gold complex [AuClL]. This expansion to 348 ligands captures known ligand space for this class of monodentate two-electron donor ligands well, and we have used principal component anal. (PCA) of the descriptors to derive an improved map of ligand space. Potential applications of this map, including the visualization of ligand similarities/differences and trends in exptl. data, as well as the design of ligand test sets for high-throughput screening and the identification of ligands for reaction optimization, are discussed. Descriptors of ligand properties can also be used in regression models for the interpretation and prediction of available response data, and here we explore such models for both exptl. and calculated data, highlighting the advantages of large training sets that sample ligand space well.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Study of stereomeric peptoid chiral stationary phases containing different chiral side chains. Author is Wu, Haibo; Song, Guangjun; Wang, Dongqiang; Yu, Hui; Ke, Yanxiong; Liang, Xinmiao.

The authors studied six stereomeric peptoid chiral stationary phases (CSPs) successively combining N’-phenyl-proline amide, α-phenylethyl amine, 2-aminocyclohexyl phenylcarbamate and another α-phenylethyl amine under normal phase mode. CSPs 1-4, I, with R-S-(1R,2R)-S, R-S-(1S,2S)-S, R-R-(1R,2R)-R and R-R-(1S,2S)-R configuration exhibited much different enantiorecognition abilities. Overall, CSPs 1 and 2 performed better for the 55 analytes tested. CSP 5 (I, R-S-rac-S) with mixed selectors combined partial selectivities of CSPs 1 and 2. CSP 6 (I, S-R-(1R,2R)-R) as enantiomeric counterpart of CSP 2 exhibited similar enantioseparation ability and reversal elution orders for analytes resolved. For several biaryl type analytes, CSP 6 even outperformed com. Chiralpak AD-H and Chiralcel OD-H. Excellent resolution of 3,3′-diphenyl-2,2′-bi-1-naphthalol (VANOL) on CSP 6 illustrated its potential application in preparative enantioseparation Eluting orders of enantiomers on stereomeric CSPs also provided the authors further insight into enantiorecognition of some analytes.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Boc-4-(Aminomethyl)piperidine, is researched, Molecular C11H22N2O2, CAS is 144222-22-0, about Ni-catalyzed hydroalkylation of olefins with N-sulfonyl amines.Product Details of 144222-22-0.

Herein, a reliable method for accessing α-branched amines RNHCH(R1)(CH2)2R2 (R = (4-methylphenyl)sulfonyl, (2,4,6-trimethylphenyl)sulfonyl; R1 = Ph, 4-morpholinophenyl, furan-2-yl, etc.; R2 = Ph, 3-fluorophenyl, 9H-fluoren-2-yl, etc.) via nickel-catalyzed hydroalkylation reactions was reported. Specifically, by using bis(cyclooctadiene)nickel (Ni(cod)2) together with a phosphine ligand, a formal C(sp3)-H bond insertion reaction between olefins CH2=CHR2 and N-sulfonyl amines RNHCH2R1 without the need for an external hydride source was achieved. The amine not only provides the alkyl motif but also delivers hydride to the olefin by means of a nickel-engaged β-hydride elimination/reductive elimination process. This method provides a platform for constructing chiral α-branched amines (R/S)-RNHCH(R1)CH2CH2R2 by using a P-chiral ligand, demonstrating its potential utility in organic synthesis. Notably, a sulfonamidyl boronate complex formed in situ under basic conditions promotes ring-opening of the azanickellacycle reaction intermediate, leading to a significant improvement of the catalytic efficiency.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Electric Literature of C3F9FeO9S3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Iron(III) trifluoromethanesulfonate, is researched, Molecular C3F9FeO9S3, CAS is 63295-48-7, about Hidden Bronsted Acid Catalysis: Pathways of Accidental or Deliberate Generation of Triflic Acid from Metal Triflates. Author is Dang, Tuan Thanh; Boeck, Florian; Hintermann, Lukas.

The generation of a hidden Bronsted acid as a true catalytic species in hydroalkoxylation reactions from metal precatalysts has been clarified in case studies. The mechanism of triflic acid (CF3SO3H or HOTf) generation starting either from AgOTf in 1,2-dichloroethane (DCE) or from a Cp*RuCl2/AgOTf/phosphane combination in toluene has been elucidated. The deliberate and controlled generation of HOTf from AgOTf and cocatalytic amounts of tert-Bu chloride in the cold or from AgOTf in DCE at elevated temperatures results in a hidden Bronsted acid catalyst useful for mechanistic control experiments or for synthetic applications.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Application of 63295-48-7. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Iron(III) trifluoromethanesulfonate, is researched, Molecular C3F9FeO9S3, CAS is 63295-48-7, about Synthesis of conductive elastomeric foams using supercritical carbon dioxide: the effect of ethanol cosolvent on the impregnation of the foam with oxidant. Author is Shenoy, Suresh L.; Kaya, Ipek; Cohen, Daniel; Erkey, Can; Weiss, R. A..

Conductive elastomeric polypyrrole/polyurethane composite foams were prepared using supercritical CO2 in place of organic solvent to incorporate ferric triflate into a polyurethane foam for the chem. oxidative polymerization of pyrrole. A small amount of EtOH cosolvent greatly improved the solubility of ferric triflate in supercritical CO2.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem