Month: April 2022

Related Products of 175136-62-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine, is researched, Molecular C24H9F18P, CAS is 175136-62-6, about Cobalt-Catalyzed Intramolecular Alkyne/Benzocyclobutenone Coupling: C-C Bond Cleavage via a Tetrahedral Dicobalt Intermediate. Author is Zhu, Zixi; Li, Xinghan; Chen, Sicong; Chen, Peng-hao; Billett, Brent A.; Huang, Zhongxing; Dong, Guangbin.

A Co(0)-catalyzed intramol. alkyne/benzocyclobutenone coupling through C-C cleavage of benzocyclobutenones is described. Co2(CO)8/P[3,5-(CF3)2C6H3]3 was discovered to be an effective metal/ligand combination, which exhibits complementary catalytic activity to the previously established rhodium catalyst. In particular, the C8-substituted substrates failed in the Rh system, but succeeded with the Co catalysis. Exptl. and computational studies show that the initially formed tetrahedral dicobalt-alkyne complex undergoes C1-C2 activation via oxidative addition with Co(0), followed by migratory insertion and reductive elimination to give the β-naphthol products.

After consulting a lot of data, we found that this compound(175136-62-6)Related Products of 175136-62-6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Some reactions with derivatives of α-keto acids and α-keto esters》. Authors are Seifert, P.; Vogel, E.; Rossi, A.; Schinz, H..The article about the compound:2,3-Dibromopropionic acidcas:600-05-5,SMILESS:O=C(O)C(Br)CBr).Reference of 2,3-Dibromopropionic acid. Through the article, more information about this compound (cas:600-05-5) is conveyed.

A. Reaction of enolic derivatives of α-keto acids with SOCl2. α-Keto acids and their acetals cannot be converted to chlorides with SOCl2 (I) since they lose CO; however, enolic acetates and ethers of α-keto acids react normally with I. MeCOCO2H (10 g.) with 20 cc. Ac2O at 120° for 2 h. gave 30% of the enol acetate, b0.02 96-104°, which in Et2O with a large excess of I gave 62% of the chloride, b15 87-8°. To this in Et2O was added 2 mols. PhNH2 (II) in portions with cooling, giving CH2:C(OAc)CONHPh, m. 116-16.5°. In contrast to its higher homologs, the enol Me ether of MeCOCO2H could not be prepared by the method of Pfister, Robinson, and Tishler (C.A. 40, 1142.1), since BrCH2CHBrCO2H with KOH in MeOH gave not CH2:C(OMe)CO2H but 80% CH2:CBrCO2H, m. 68°. This, refluxed 10 h. with 2 mols. NaOMe in MeOH and the solvent evaporated gave a mixture of Na salts, from which was obtained a chloride, b13 53-4°, which with II gave α,β-dimethoxypropionanilide, m. 71°; in another experiment under slightly different conditions, another modification of the anilide, m. 56.5°, was obtained. EtCOCO2H with Ac2O at 140° for 2 h. or at 100° for 2 h. in the presence of 2 drops concentrated H2SO4 gave 65% of the enol acetate (III), m. 113-14° (from cyclohexane), b0.03 100-10°. III refluxed with EtOH containing some dry HCl gave a mixture of EtCOCO2H and its Et ester, which with 2,4-(O2N)2C6H3NHNH2.HCl, followed by washing with Na2CO3, gave the 2,4-dinitrophenylhydrazone of EtCOCO2Et, m. 141-2° (cf. Vogel, Schinz, C.A. 44, 5315c). III with I gave 71% of the chloride, b11 82°, from which was obtained the anilide, m. 86-8°; this with 10% aqueous NaOH gave oxanilic acid, m. 149°, while treatment with a dioxane-dilute HCl mixture yielded α-ketobutyranilide, m. 89-9.5°. Heating EtCOCO2Et (V. and S., loc. cit.) with Ac2O and 5 drops concentrated H2SO4 to 100° for 1 h. gave the enol acetate, b11 93-4°, nD21 1.4410. MeCH:CHCO2H, brominated by the method of P., R., and T., but at a lower temperature and under illumination, gave 90% MeCHBrCHBrCO2H, m. 82-4°, from which was obtained MeCH:C(OMe)CO2H, m. 60-2°, which with I gave the chloride, b22 58°, yielding the amide, m. 100-102° (Owen, C.A. 39, 4589.3), and, with 3 mols. II in Et2O, α-methoxycrotonanilide, m. 57-8°. This with dioxane-HCl gave EtCOCONHPh. PrCOCO2H with Ac2O at 140° gave the enol acetate, m. 78-9°, b0.1 120-6°, yielding 70% of the acid chloride (III), b11 90-1°, which with 3 mols. II in Et2O and washing of the solution with HCl and NaOH gave oxanilide and AcNHPh, a cleavage not observed with derivatives of enol Me ethers. However, III with 2 mols. II and without HCl and NaOH treatment gave the desired Me CH2CH:C(OAc)CONHPh, m. 88-9°. PrCH:CHCO2H, brominated in CCl4 under illumination, gave 41% α,β-dibromovaleric acid, m. 42.5°. b0.02 89-90°, nD17 1.5272, which with KOH in MeOH yielded 50% 2-methoxy-2-pentenoic acid, b0.05 74-6°, nD16 1.4559. This with I gave the chloride, b11 53-4°, from which the anilide, m. 64.5°, was prepared Me2C:CHCO2H on bromination in CCl4 under illumination gave 45% Me2CBrCHBrCO2H, m. 102-4°. This with KOH in MeOH yielded α-methoxy-β,β-dimethylacrylic acid, m. 67°, b11 106-7°, nD24 1.4492; S-benzylthiuronium salt, m. 170-1°. The acid chloride, b11 48°, gave a pasty anilide. B. Action of MeMgBr on α-keto esters, their ketals, and enolic ethers. EtCOCO2Et with 1 or 2 mols. MeMgI gave mixtures; with 3 mols., 30% EtMeC(OH)COMe was isolated as the allophanate, m. 120.5°. EtC(OEt)2CO2Et with 2 mols. MeMgI in Et2O gave 72.5% EtC(OEt)2COMe (IV), b11 68-70°. IV with 2 N HCl at 100° gave 6.5% EtCOCOMe, b45 77-82°. IV with 2,4-(O2N)2C6H3NHNH2.HCl gave 2,3-pentanedione bis(2,4-dinitrophenylhydrazone), m. 261-2° (from pyridine), also obtained directly from the diketone. MeCH:C(OMe)CO2Me with 1 or 2 mols. MeMgI gave mixtures; with 3 mols. was obtained 59% 3-methoxy-4-methyl-2-pentanone, b11 54.5°, d418 0.9443, nD18 1.4423, MRD 36.49; 2,4-dinitrophenylhydrazone, m. 137-8°. C. β-Brominated α-ketalic esters. PrCOCO2Et with Br in CHCl3 gave 53% Et β-bromo-α-ketovalerate, b11 94°, d416 1.3745, nD16 1.4623, MRD 44.04. Similarly were prepared, with 90% yields, Et α-keto-β-bromobutyrate, b12 80-81°, and Et α-keto-β-bromoisovalerate, b10 78-80°. Those compounds could not be converted to acetals. MeCH2C(OEt)2CO2Et in CCl4 with Br in the presence of red P and under illumination gave a product, b0.01 58°, d418 1.5305, nD18 1.4886, probably impure MeCHBrCBr(OEt),CO2Et, which on boiling with EtOH gave a product, b11 112-13°, d418 1.2590, nD18 1.4530, presumably very impure MeCHBrC(OEt)2CO2Et. MeCH:C(OMe)CO2H with Br in CCl4 in the prepuce of red P under illumination gave the dibromide (not isolated), which with MeOH for 2 days at room temperature gave 33% MeCHBrC(OMe)2CO2Me, b11 105°, d419 1.4295, nD19 1.4659, MRD 46.72. Me2C:C(OMe)CO2H with Br in CCl4 gave α-methoxy-α,β-dibromoisovaleric acid (not isolated); the reaction mixture with MeOH merely yielded the corresponding Me ester, b0.15 81-2°, d420 1.6824, nD20 1.5051, MRD 53.60, not changed by MeOH at 100°. Boiling this with Na in MeOH gave 50% CH2: CMeC(OMe)2CO2Me, b11 79-80°, d419 1.0667, nD19 1.4385, MRD 42.92; 2,4-dinitrophenylhydrazone, m. 136-7°. Attempts to add Br to enol acetates of α-keto acids were unsuccessful; enol ethers of α-keto esters reacted poorly.

After consulting a lot of data, we found that this compound(600-05-5)Reference of 2,3-Dibromopropionic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2,3-Dibromopropionic acid, is researched, Molecular C3H4Br2O2, CAS is 600-05-5, about Fourier transform double-resonance NMR on two- and three-spin systems, the main research direction is NMR Fourier transform strong coupling.Reference of 2,3-Dibromopropionic acid.

The flip angle dependence of the line intensities in gated double-resonance FT NMR experiments on the stongly coupled spin systems 2,3-dibromothiophene, 1,2,3-trichlorobenzene, vinyl acetate, and 2,3-dibromopropionic acid follow the theory of S. Shaublin, A. Hohener, and R. R. Ernest (1974). A general method for anal. of the flip-angle-dependent intensities in terms of spin level population differences is described, and it is demonstrated that the variation of line intensities with flip angle is sensitive to the relative signs of spin-spin couplings and to the mechanism of spin relaxation.

After consulting a lot of data, we found that this compound(600-05-5)Reference of 2,3-Dibromopropionic acid can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Tris(3,5-bis(trifluoromethyl)phenyl)phosphine( cas:175136-62-6 ) is researched.Safety of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine.Haji, Shaker; Erkey, Can published the article 《Investigation of rhodium catalyzed hydroformylation of ethylene in supercritical carbon dioxide by in situ FTIR spectroscopy》 about this compound( cas:175136-62-6 ) in Tetrahedron. Keywords: rhodium catalyzed hydroformylation ethylene supercritical carbon dioxide mechanism. Let’s learn more about this compound (cas:175136-62-6).

The reactions of RhH(CO)L3 [L=P(3,5-(CF3)2C6H3)3] with CO, H2, C2H4 and mixtures of these in supercritical carbon dioxide (scCO2) were investigated using high-pressure FTIR spectroscopy. The results were compared to the behavior of the conventional catalyst, RhH(CO)(PPh3)3, in organic solvents. RhH(CO)L3 does not dissociate in scCO2 and it is converted to RhH(CO)2L2 and to [Rh(CO)2L2]2 in the presence of CO and mainly to RhH(CO)L2 in the presence of an equimolar mixture of CO and H2. In the presence of CO and C2H4, the peaks observed in the acyl region and the terminal metal carbonyl region indicate the formation of three different acylrhodium complexes which are Rh(CO)L2(COEt), Rh(CO)2L2(COEt), and Rh(CO)3L(COEt). Similar species were also observed during the hydroformylation reaction. The first ever detection of the presence of Rh(CO)L2(COEt) under hydroformylation conditions provides direct evidence for the mechanism originally proposed by Wilkinson and co-workers. The carbonyl stretching frequencies of all of the rhodium-carbonyl species are shifted to higher wavenumbers due to a reduction of electron d. at the metal center by the CF3 groups.

After consulting a lot of data, we found that this compound(175136-62-6)Safety of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 23794-15-2, is researched, SMILESS is CC(=O)C1=CC(Cl)=NC=C1, Molecular C7H6ClNOPreprint, bioRxiv called Generation of strong casein kinase 1 inhibitor of Arabidopsis thaliana, Author is Saito, Ami N.; Matsuo, Hiromi; Kuwata, Keiko; Ono, Azusa; Kinoshita, Toshinori; Yamaguchi, Junichiro; Nakamichi, Norihito, the main research direction is Arabidopsis casein kinase inhibitor eukaryote.Computed Properties of C7H6ClNO.

Casein kinase 1 (CK1) is an evolutionarily conserved protein kinase among eukaryotes. Studies on yeast, fungi, and animals have revealed that CK1 plays roles in divergent biol. processes. By contrast, the collective knowledge regarding the biol. roles of plant CK1 lags was behind those of animal CK1. One of reasons for this is that plants have more multiple genes encoding CK1 than animals. To accelerate the research for plant CK1, a strong CK1 inhibitor that efficiently inhibits multiple members of CK1 proteins in vivo (in planta) is required. Here, we report a novel strong CK1 inhibitor of Arabidopsis (AMI-331). Using a circadian period-lengthening activity as estimation of the CK1 inhibitor effect in vivo, we performed a structure-activity relationship (SAR) study of PHA767491 (1,5,6,7-tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride), a potent CK1 inhibitor of Arabidopsis, and found that PHA767491 analogs bearing a propargyl group at the pyrrole nitrogen atom (AMI-212) or a bromine atom at the pyrrole C3 position (AMI-23) enhance the period-lengthening activity. The period lengthening activity of a hybrid mol. of AMI-212 and AMI-23 (AMI-331) is about 100-fold stronger than that of PHA767491. An in vitro assay indicated a strong inhibitory activity of CK1 kinase by AMI-331. Also, affinity proteomics using an AMI-331 probe showed that targets of AMI-331 are mostly CK1 proteins. As such, AMI-331 is a strong potent CK1 inhibitor that shows promise in the research of CK1 in plants.

After consulting a lot of data, we found that this compound(23794-15-2)Computed Properties of C7H6ClNO can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Xu, Jimin; Berastegui-Cabrera, Judith; Carretero-Ledesma, Marta; Chen, Haiying; Xue, Yu; Wold, Eric A.; Pachon, Jeronimo; Zhou, Jia; Sanchez-Cespedes, Javier researched the compound: 1-Boc-4-(Aminomethyl)piperidine( cas:144222-22-0 ).Category: piperidines.They published the article 《Discovery of a small molecule inhibitor of human adenovirus capable of preventing escape from the endosome》 about this compound( cas:144222-22-0 ) in International Journal of Molecular Sciences. Keywords: human adenovirus small mol inhibitor endosome; adenovirus; antiviral agent; entry inhibition; salicylamide derivatives. We’ll tell you more about this compound (cas:144222-22-0).

Human adenoviruses (HAdVs) display a wide range of tissue tropism and can cause an array of symptoms from mild respiratory illnesses to disseminated and life-threatening infections in immunocompromised individuals. However, no antiviral drug has been approved specifically for the treatment of HAdV infections. Herein, we report our continued efforts to optimize salicylamide derivatives and discover compound 16 (JMX0493) as a potent inhibitor of HAdV infection. Compound 16 displays submicromolar IC50 values, a higher selectivity index (SI > 100) and 2.5-fold virus yield reduction compared to our hit compound niclosamide. Moreover, unlike niclosamide, our mechanistic studies suggest that the antiviral activity of compound 16 against HAdV is achieved through the inhibition of viral particle escape from the endosome, which bars subsequent uncoating and the presentation of lytic protein VI.

After consulting a lot of data, we found that this compound(144222-22-0)Category: piperidines can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Statistical Modeling of a Ligand Knowledge Base, published in 2006-12-31, which mentions a compound: 175136-62-6, mainly applied to statistical analysis linear regression ligand phosphorus, Safety of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine.

A range of different statistical models has been fitted to exptl. data for the Tolman electronic parameter (TEP) based on a large set of calculated descriptors in a prototype ligand knowledge base (LKB) of phosphorus(III) donor ligands. The models have been fitted by ordinary least squares using subsets of descriptors, principal component regression, and partial least squares which use variables derived from the complete set of descriptors, least angle regression, and the least absolute shrinkage and selection operator. None of these methods is robust against outliers, so we also applied a robust estimation procedure to the linear regression model. Criteria for model evaluation and comparison have been discussed, highlighting the importance of resampling methods for assessing the robustness of models and the scope for making predictions in chem. intuitive models. For the ligands covered by this LKB, ordinary least squares models of descriptor subsets provide a good representation of the data, while partial least squares, principal component regression, and least angle regression models are less suitable for our dual aims of prediction and interpretation. A linear regression model with robustly fitted parameters achieves the best model performance over all classes of models fitted to TEP data, and the weightings assigned to ligands during the robust estimation procedure are chem. intuitive. The increased model complexity when compared to the ordinary least squares linear model is justified by the reduced influence of individual ligands on the model parameters and predictions of new ligands. Robust linear regression models therefore represent the best compromise for achieving statistical robustness in simple, chem. meaningful models.

After consulting a lot of data, we found that this compound(175136-62-6)Safety of Tris(3,5-bis(trifluoromethyl)phenyl)phosphine can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ganapathy, Hullathy Subban; Yuvaraj, Haldorai; Hwang, Ha Soo; Kim, Jong Su; Choi, Byung-Chun; Gal, Yeong-Soon; Lim, Kwon Taek published an article about the compound: Iron(III) trifluoromethanesulfonate( cas:63295-48-7,SMILESS:O=S(C(F)(F)F)([O-])=O.O=S(C(F)(F)F)([O-])=O.O=S(C(F)(F)F)([O-])=O.[Fe+3] ).Recommanded Product: 63295-48-7. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:63295-48-7) through the article.

Highly CO2-soluble, conjugated polythiophenes were prepared by oxidative polymerization of 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro-1-octyl 2-(3-thienyl)acetate (SFTE) and 2-(3-thienyl)ethyl perfluorobutyrate (FTE) with FeCl3 in supercritical carbon dioxide at 207 bar pressure and 40°. The properties of polymers, such as yield, mol. weight, elec. conductivity, and UV-vis absorption, were investigated and compared with those prepared in chloroform. The polymers showed a good solubility in CO2 at moderate pressure and temperature with higher solubility of PSFTE than PFTE.

After consulting a lot of data, we found that this compound(63295-48-7)Recommanded Product: 63295-48-7 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthetic Route of C3F9FeO9S3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Iron(III) trifluoromethanesulfonate, is researched, Molecular C3F9FeO9S3, CAS is 63295-48-7, about Fe(OTf)3- and γ-Cyclodextrin-Catalyzed Hydroamination of Alkenes with Carbazoles. Author is Xiao, En-Kai; Wu, Xian-Tao; Ma, Feng; Feng, Xiaohua; Chen, Peng; Jiang, Yi-Jun.

A Fe(OTf)3- and γ-cyclodextrin catalyzed hydroamination of alkenes with carbazoles is demonstrated. This biomimetic-catalyst-oriented sustainable and green method could deliver a wide scope of N-alkylated carbazoles and N-alkylated-carbazole-fused aromatics in up to 97% yield. The salient features of this transformation include simple and benign reaction conditions with no need for a strong base, additive, or the irradiation of light.

Although many compounds look similar to this compound(63295-48-7)Synthetic Route of C3F9FeO9S3, numerous studies have shown that this compound(SMILES:O=S(C(F)(F)F)([O-])=O.O=S(C(F)(F)F)([O-])=O.O=S(C(F)(F)F)([O-])=O.[Fe+3]), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A practical approach to three-dimensional NMR spectroscopy, published in 1987-07-31, which mentions a compound: 600-05-5, Name is 2,3-Dibromopropionic acid, Molecular C3H4Br2O2, Category: piperidines.

A technique is described for reducing the number of 3D experiments without sacrificing resolution by using selected pulse sequences. A method is described for reduction of the number of data matrixes. Applications of 3D spectrometry are described. Results are reported for 2,3-dibromopropionic acid.

Although many compounds look similar to this compound(600-05-5)Category: piperidines, numerous studies have shown that this compound(SMILES:O=C(O)C(Br)CBr), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem