Month: March 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19099-93-5,1-Cbz-Piperidin-4-one,as a common compound, the synthetic route is as follows.

To a -20 0C solution of N,N,N’,N’-tetramethylethylenediamine (0.335 g, 2.89 mmol) in TEtaF (1 mL) was added n-butyllithium (2.5M, 1.15 rnL, 2.89 mmol) over 10 min. After 30 min, the mixture was cooled to -78 0C and tert-butyl (6-chloropyridin-2-yl)carbamate (0.300 g, 1.31 mmol) in TEDF (0.8 mL) was added over 15 min. After Ih, the reaction was warmed to -50 0C, stirred for 2h and then N-benxyloxycarbonyl-4-piperidinone (0.459 g, 1.97 mmol) in TEtaF (1 mL) was added over 10 min. The reaction was allowed to warm to room temperature and then stirred for 24 h. A solution of saturated aqueous NaEtaCOs was added and the mixture extracted with EtOAc (3x). The combined organic layers were washed with H2O, brine, dried over MgStheta4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography, eluting with a gradient of 25 to 50% ethyl acetate: hexane to give the title compound (0.160 g). MS: m/z = 338.0 (M + 1)., 19099-93-5

19099-93-5 1-Cbz-Piperidin-4-one 643496, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; MERCK & CO., INC.; WO2007/16087; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72551-53-2,Ethyl 1-benzylpiperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

72551-53-2, General procedure: To a stirred solution of the carboxylate (1.50 g, 7.85 mmol, 1.0eq.) in toluene (25 ml), was added Red-Al (65 wt % in toluene,3.66 g, 3.54 ml, 11.8 mmol, 1.5 eq.) at 15-20 C. The contents were stirred overnight at rt. The reaction was quenched by the slowaddition of 10% sodium hydroxide (~1 ml) and then the addition ofwater. The contents were stirred for 30 min, and the toluene layerwas separated, washed with a saturated solution of sodium chloride.The organic layer was dried (anhydrous sodium sulfate), filtered and evaporated in vacuo to yield the alcohol which was used without any further purification

72551-53-2 Ethyl 1-benzylpiperidine-3-carboxylate 2736370, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; van Greunen, Divan G.; Cordier, Werner; Nell, Margo; van der Westhuyzen, Chris; Steenkamp, Vanessa; Panayides, Jenny-Lee; Riley, Darren L.; European Journal of Medicinal Chemistry; vol. 127; (2017); p. 671 – 690;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

72752-52-4, 2-Piperidinobenzonitrile is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 3-5; 4-methyl-2-(2-(1-piperidinyl)phenyl)pentanoic acid; This acid was synthesized in 3 steps from the intermediate 2-(1-piperidinyl)benzonitrile (see example 2-1). Step 1; 3-methyl-1-(2-(1-piperidinyl)phenyl)butan-1-ol; Under anhydrous atmosphere, 2-(1-piperidinyl)benzonitrile (10 g, 53.7 mmol) was solubilized in anhydrous THF (50 ml). Freshly prepared isobutylmagnesium bromide (83 ml at 3.9 mol/l in THF, 324 mmol) was added and the mixture was refluxed overnight. The mixture was hydrolyzed with water and acidified by a 1M HCl solution until pH 7. The resulting ketone was extracted by ethyl acetate, dried with magnesium sulfate (MgSO4), and evaporated. The residue was solubilized in methanol (100 ml) and the solution was cooled with an ice bath. Sodium borohydride (7.1 g, 188 mmol) was added portionwise at 0 C. and the reaction was slowly warmed to room temperature. Once the ketone was reduced, water was added and the alcohol was extracted by ethyl acetate, dried with magnesium sulfate (MgSO4) and evaporated. The expected product was purified by silica gel chromatography (cyclohexane/ethyl acetate 95/5). Yield: 60%, 72752-52-4

72752-52-4 2-Piperidinobenzonitrile 2774355, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; GENFIT; US2006/79696; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19099-93-5,1-Cbz-Piperidin-4-one,as a common compound, the synthetic route is as follows.

Step B. Benzyl T-chloro^’-oxo-l’^’-dihvdro-lH-spirorpiperidine^^’-pyridopj-difUloxazine]-.- carboxylate; To a -20 0C solution of N,N,N’,N’-tetramethylethylenediamine (0.335 g, 2.89 mmol) in TEtaF (1 mL) was added n-butyllithium (2.5M, 1.15 mL, 2.89 mmol) over 10 min. After 30 min, the mixture was cooled to -78 0C and fe/t-butyl (6-chloropyridin-2-yl)carbamate (0.300 g, 1.31 mmol) in TEtaF (0.8 mL) was added over 15 min. After Ih, the reaction was warmed to -50 0C, stirred for 2h and then N-benxyloxycarbonyl-4-piperidinone (0.459 g, 1.97 mmol) in TEtaF (1 mL) was added over 10 min. The reaction was allowed to warm to room temperature and then stirred for 24 h. A solution of saturated aqueous NaEtaCU3 was added and the mixture extracted with EtOAc (3x). The combined organic layers were washed with H2O, brine, dried over MgSC>4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography, eluting with a gradient of 25 to 50% ethyl acetate: hexane to give the title compound (0.160 g). MS: mlz = 338.0 (M + 1)., 19099-93-5

As the paragraph descriping shows that 19099-93-5 is playing an increasingly important role.

Reference：
Patent; MERCK & CO., INC.; WO2006/41830; (2006); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

914988-10-6, tert-Butyl 3-cyano-4-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0313] Step a: To a stirred suspension of 1-(2-methoxy-6-methylphenyl)hydrazine hydrochloride (3.77 g, 20.0 mmol) in EtOH (50 mL) and glacial acetic acid (10 mL, 208 mmol) was added tert-butyl 3-cyano-4-oxopiperidine-1-carboxylate (4.5 g, 22.0 mmol) at room temperature. The resulting mixture was stirred under reflux for 16 h. After removal of solvent under reduced pressure, the residue was dissolved in EtOAc and washed with aqueous NaOH (2 N), brine, and dried over MgSO4. The solvent was removed under reduced pressure and the residue was purified by silica gel flash chromatography (5 to 55% EtOAc in hexanes) to give tert-butyl 3-amino-2-(2-methoxy-6-methylphenyl)-6,7-dihydro-2H-pyrazolo[4,3-c]pyridine- 5(4H)-carboxylate . MS: (ES) m/z calculated for C19H27N4O3 [M + H]+ 359.2, found 359.2. Caution: Diazonium formation could be potentially dangerous, please handle with care and ware proper personal protection equipment.

914988-10-6, The synthetic route of 914988-10-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CHEMOCENTRYX, INC.; FAN, Pingchen; LANGE, Christopher W.; LUI, Rebecca M.; MALATHONG, Viengkham; MALI, Venkat Reddy; PUNNA, Sreenivas; SINGH, Rajinder; TANAKA, Hiroko; ZENG, Yibin; ZHANG, Penglie; (284 pag.)WO2018/222598; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

936130-82-4, Methyl 4-(piperidin-4-yl)benzoate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

936130-82-4, Synthesis of 4-[l-(4-formyl-phenyl)-piperidin-4-yl-|-benzoic acid methyl ester (1). A mixture of 4-(4-methoxycarboxyphenyl) piperidine HCl (256 mg, 1.0 mmol), 4-fluoro-benzaldehyde (105 mul, 1.0 mmol) and K2CO3 (250 mg, 1.8 mmol) in DMF (5 ml) was stirred at ambient temperature overnight. Reaction was diluted with water (30 ml). Formed precipitate was filtrated, washed with water (20 ml) and ether (20 ml), and dried in vacuum overnight to provide target compound (1) (203 mg, 63%) as white solid. LC-MS [M+H] 324.3 (C20H21NO3+H, requires 324.41).

936130-82-4 Methyl 4-(piperidin-4-yl)benzoate hydrochloride 42614593, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ACHAOGEN, INC.; WO2008/154642; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24666-55-5,Benzyl (2,6-dioxopiperidin-3-yl)carbamate,as a common compound, the synthetic route is as follows.

7.86 g of benzyl 2,6-dioxopiperidin-3-yl carbamate were dissolved in 30 mL of THF and 30 mL of methanol. 0.786 g of 10% Pd/C catalyst was added to the above solution. The mixture was allowed to react under a flow of hydrogen at room temperature for 2h, filtered to remove the catalyst, and evaporated to remove the solvent. A light blue solid (3.818 g) was obtained.

24666-55-5, 24666-55-5 Benzyl (2,6-dioxopiperidin-3-yl)carbamate 2735493, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Tianjin Hemey Bio-Tech Co., Ltd.; EP2093228; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen, 0.62 ml (3.7 mmol) 2,2,6,6-tetramethylpiperidine was added to 20 ml anhydrous THF (-78 C.). n-Buli 1.3 ml (2.5 M, 3.33 mmol) was added and the reaction mixture was stirred for 30 minutes. Compound 91 (0.83 g, 2.16 mmol), dissolved in 10 ml THF was added and the mixture was stirred for 30 minutes., 768-66-1

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

Reference：
Patent; STOIT, Axel; Coolen, Hein K.A.C.; Van Der Neut, Martina A. W.; Kruse, Cornelis G.; US2008/9514; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

71985-80-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71985-80-3,1-Methylpiperidine-4-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.

N-Methylisonipecotic acid hydrochloride (0.5 g) was dissolved in dry SOCl2 (1.5 mL) The mixture was then heated at 80 C. for 2 hours under argon. Cooling and evaporation to dryness afforded a yellow solid which was used without further purification.

71985-80-3 1-Methylpiperidine-4-carboxylic acid hydrochloride 2760043, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; LaVoie, Edmond J.; Parhi, Ajit; Pilch, Daniel S.; Zhang, Yongzheng; Kaul, Malvika; US2015/133465; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

161975-39-9, tert-Butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Raw material 15 (1.0 eq) was added to the reaction flask, and a sufficient amount of ACE was added as a solvent. The mixture was stirred at room temperature, and LiBr (3.0 eq) was slowly added thereto, and the temperature was gradually raised to reflux, overnight. The reaction solution was cooled to room temperature, and the reaction mixture was quenched with water. The reaction mixture was evaporated to dryness, and then the mixture was evaporated and evaporated with EtOAc and water, and the oil layer was collected, and the oil layer was washed three times with saturated brine, and the oil layer was dried over Na 2 SO 4 Product 16, no purification required.

161975-39-9, As the paragraph descriping shows that 161975-39-9 is playing an increasingly important role.

Reference：
Patent; Guangdong Zhongsheng Pharmaceutical Co., Ltd.; Chen Lijuan; Long Chaofeng; Chen Xiaoxin; Liu Zhuowei; Qian Zhiyong; Yang Jinliang; Xiang Mingli; (99 pag.)CN109970740; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem