Month: March 2022

109384-19-2, tert-Butyl 4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 82A tert-butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate The title compound was prepared as described in Example 41A substituting tert-butyl 4-hydroxypiperidine-1-carboxylate for 1-methylpiperidin-4-ol., 109384-19-2

The synthetic route of 109384-19-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Abbott Laboratories; US2010/317680; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the corresponding b-carboline-3-acid methyl ester(1 mmol), NaOH (4 mmol), C2H5OH (5 ml) and H2O (10 ml) was refluxed for 3 h, and the ethanol was removed on the rotary evaporator.The mixture was neutralized (pH = 5) with 5 N HCl and cooled. The precipitate was collected, washed well with H2O and dried in vacuum. The material was used without further purificationfor the following steps.

10315-06-7, 10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Wang, Jin; Wang, Zhi-Min; Li, Xue-Mei; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4324 – 4338;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,768-66-1

n-BuLi (2.5M in hexanes, 2.27 mL, 5.67mmol) was added to cold(-50 C) anhydrous THF (20 mL) under nitrogen. 2,2, 6, 6-Tetramethylpiperidine (0.957, 0.8 g, 5.67mmol) was then added and the mixture stirred at-78 C for 30 min. A solution of the title compound of Preparation 53 (0.5 g, 2.68mmol) in THF (5 mL) was added dropwise and the mixture was stirred at-78 C for 60 min. Then, iodine (1.51 g, 5.94mmol) was added and the mixture was stirred at that temperature for 90 min and then warmed to r. t. The mixture was quenched with methanol and the residual iodine destroyed with sat. sodiumthiosulphate (aq. ). The mixture was concentrated in vacuo, partitioned between ethyl acetate and water and the organic layer was washed with water, dried and evaporated to give an oil which was purified by column cromatography (n-Hex/EtOAc 4: 1) to afford the title compound (87% yield) as an oil which crystallised. 8 (CDCI3) : 4.22 (s, 3H), 7.47 (m, 3H), 7.96 (m, 2H), 8.29 (s,1 H).

768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ALMIRALL PRODESFARMA, S.A.; WO2005/49581; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2,7-diazaspiro[4.5]decan-1 -one hydrochloride (0.572 g, 3mmol) and triethylamine (0.836 mL, 6.00 mmol) in dichloromethane (DCM) (15ml_), cooled in an ice-water bath, was added 4-bromo-2-(trifluoromethyl)benzenesulfonyl chloride (0.971 g, 3.00 mmol). The reaction was allowed to warm to room temperature and stirred for 18 hours.The reaction was diluted with DCM (35 ml), washed with water (30ml_), passed through a hydrophobic frit and reduced in vacuo. The residue was purified by silica chromatography (Biotage SP4) eluting with 60% EtOAc in iso-hexanes (3 column volumes), a gradient from 60-100% EtOAc (over 9 column volumes) then EtOAc (3 column volumes) to yield 7-{[4-bromo-2-(trifluoromethyl)phenyl]sulfonyl}-2,7- diazaspiro[4.5]decan-1 -one as a white solid (0.826g, 62%)1H NMR (400 MHz, Chloroform-d) d ppm 1.61 – 1 .67 (m, 1 H) 1.69 – 1 .84 (m, 3 H) 2.05 (s, 1 H) 2.43 (s, 1 H) 2.59 – 2.67 (m, 1 H) 2.85 (d, J=12.7 Hz, 1 H) 3.32 – 3.45(m, 2 H) 3.67 (d, J=12.5 Hz, 1 H) 3.80 – 3.87 (m, 1 H) 5.72 (br. s., 1 H) 7.80 – 7.88 (m, 2 H) 8.01 (d, J=1.5 Hz, 1 H)

1187173-43-8, As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.

Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

138377-80-7, 3-Aminopiperidin-2-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 10 ; 3-[({4-[(3-chloro-2-fluorophenyl) amino]-7-methoxyquinazolin-6- yl} methyl) amino] piperidin-2-one; (Process (a)); 4- [ (3-Chloro-2-fluorophenyl) amino]-7-methoxyquinazoline-6-carbaldehyde was coupled with 3-amino-piperidin-2-one (prepared by converting 3-amino-piperidin-2-one hydrochloride to the free-base form) using an analogous method to that described for the equivalent step in Example 1 to give the title compound ; 1H NMR spectrum : (DMSO d6) 1. 5= (m, 1H), 1.68 (m, 1H), 1.84 (m, 1H), 2.16 (m, 1H), 2.73 (brs, 1H), 3.05 (dd, 1H), 3.13 (m, 2H), 3.84 (d, 1H), 3.93 (d, 1H), 3.98 (s, 3H), 7.21 (s, 1H), 7.28 (t, 1H), 7.48 (t, 1H), 7.53 (m, 2H), 8.35 (s, 1H), 8.44 (s, 1H), 9.80 (s, 1H); Mass Spectrum : (M+H) +430., 138377-80-7

The synthetic route of 138377-80-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/75439; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

321337-38-6, tert-Butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate (350 mg, 1.14 mmol) in DMF (5 mL) was added sodium hydride (0.14 g, 5.7 mmol) and iodomethane (0.81 g, 5.7 mmol). The reaction was stirred at ambient temperature for 1 h. Water (20 mL) was added to the reaction vessel and the resulting biphasic mixture was extracted with DCM (3 x 50 mL). The organic phase was washed with saturated aqueous NaCl (5 x 25 mL). The combined organics were dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The resulting oil was purified by flash column chromatography with a gradient elution of hexanes (100%) to hexanes (90%) and EtOAc (10%) to provide tert-butyl 4-(4-(methoxymethyl)phenoxy)piperidine-1-carboxylate (350 mg, 1.09 mmol) as a colorless oil.

321337-38-6, 321337-38-6 tert-Butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate 22632413, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; SUNOVION PHARMACEUTICALS INC.; HEFFERNAN, Michele L.R.; HARDY, Larry Wendell; BROWN, Scott P.; HERMAN, Lee W.; (180 pag.)WO2018/26371; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

220394-97-8, 1-Boc-4-(Cbz-amino)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of tert-butyl 4-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate obtained in Example 1a (13.1 g, 39.2 mmol), a 5 N aqueous hydrochloric acid solution (40 ml, 200 mmol) and methanol (40 ml) was stirred at mom temperature for 23 hours. A 5 N aqueous sodium hydroxide solution (40 ml) was added to the reaction mixture under ice-cooling. Water and the solvent were distilled off from the reaction mixture while the mixture was azeotropically distilled with ethanol. Ethanol was added to the residue, the insoluble matter was removed by filtration, and the filtrate was concentrated to give the title compound (9.10 g, yield 99.1%). 1H-NMR (400 MHz, CDCl3) delta ppm; 1.31-1.42 (2H, m), 1.92-2.04 (2H, br), 2.70 (2H, d, J=12 Hz), 3.10 (2H, d, J=12 Hz), 3.56-3.68 (1H, br), 4.72-4.81 (1H, br), 5.09 (2H, s), 7.26-7.40 (5H, m).

220394-97-8, 220394-97-8 1-Boc-4-(Cbz-amino)piperidine 1514305, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; EISAI R&D MANAGEMENT CO., LTD.; YOSHIDA, Ichiro; OKABE, Tadashi; MATSUMOTO, Yasunobu; WATANABE, Nobuhisa; ONIZAWA, Yuji; OHASHI, Yoshiaki; HARADA, Hitoshi; US2013/65925; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

23499-01-6, 1-(4-Nitrophenyl)piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6 1-(4-Nitrophenyl)-4-piperidone was reacted in a similar manner to Example 2 with N-benzyl-N-methylamine and then with fumaric acid. 4-(N-benzyl-N-methylamino)-1-(4-nitrophenyl)piperidine fumarate was obtained. Melting point 183 C.

23499-01-6, As the paragraph descriping shows that 23499-01-6 is playing an increasingly important role.

Reference：
Patent; BASF Aktiengesellschaft; US5260318; (1993); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

108612-54-0, tert-Butyl methyl(piperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of METHYL-PIPERIDIN-4-YL-CARBAMIC acid tert-butyl ester (3.57 g, 16.7 MMOL), NAHCO3 (6.7 g, 79 MMOL), Nal (1.5 g, 10 MMOL) and 1- (2-chloro-ethyl)-3- (2, 6-DIMETHYL-PYRIDIN-4-YL)-UREA (Example D1, 2.14 g 9.4 MMOL) in THF (30 mL) is stirred at 50°C for 14 days. The mixture is quenched with NA2CO3 (50 mL) and extracted with CH2CI2 (5 X 50 mL). The organic extracts are washed with sat. aq. NA2CO3 (30 mL), dried (NA2SO4), filtered and evaporated. The residue is purified by FC to provide the title compound., 108612-54-0

The synthetic route of 108612-54-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ACTELION PHARMACEUTICALS LTD; WO2005/30209; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.923009-50-1,tert-Butyl 1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate,as a common compound, the synthetic route is as follows.

923009-50-1, Preparation 45: tert-butyl 2-[bis(4-fluorophenyl)methyl]-1-oxo-2,7-diazaspiro[4,5]decane-7-carboxylate (P45)To a solution of ferf-butyl l-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate (p44, 150 mg, 0.589 mmol) in dry DM F (2 mL) was added NaH (60 % dispersion in mineral oil, 28.27 mg, 0.7 mmol) followed by addition of l-[chloro(4-fluorophenyl)methyl]-4-fluorobenzene (0.121 m L, 0.648 mmol). The mixture was heated at 100 C overnight, then cooled down to RT and the solvent was removed under vacuum. The residue was dissolved in ethyl acetate and washed with water. Organic phase was dried and concentrated under reduced pressure. Crude material was purified by FC on silica gel (eluent: Cy to Cy/EA to 70/30) affording ferf-butyl 2-[bis(4-fluorophenyl)methyl]-l-oxo-2,7-diazaspiro[4.5]decane-7- carboxylate (p45, 80 mg, y= 30%) as white solid.MS (ES) (m/z): 457.2 [M+H]+.

As the paragraph descriping shows that 923009-50-1 is playing an increasingly important role.

Reference：
Patent; SHIRE INTERNATIONAL GMBH; SEMERARO, Teresa; TARSI, Luca; MICHELI, Fabrizio; LUKER, Tim; CREMONESI, Susanna; (122 pag.)WO2016/42451; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem