Month: March 2022

495414-81-8, 1-tert-Butyl 4-ethyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of compound c (2.54 g, 8.6 mmol), cobalt chloride hexahydrate (1.02 g, 4.3 mmol) and methanol (50 mL) was added sodium borohydride (1.63 g, 43.1 mmol) under ice-cooling, and the mixture was stirred under ice-cooling for 2 h, and then at room temperature for 2 days, and then 60C for 2 h. Aqueous ammonia (28%, 5 mL) was added thereto, the precipitate was removed by filtration, and the filtration was extract with ethyl acetate(3×40 mL). The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography eluting with ethyl acetate to obtain the desired product d (0.83 g) as a white powder, yield: 39.3%, mp: 153.2-154.4C. 1H NMR (600 MHz, DMSO) delta 7.56 (s, 1H, CONH), 3.81 (d, J = 12.0 Hz, 2H, diazaspiro-CH2), 3.17 (t, J = 6.8 Hz, 2H, diazaspiro-CH2), 2.90 (s, 2H, diazaspiro-CH2), 1.95 (t, J = 6.8 Hz, 2H, diazaspiro-CH2), 1.54-1.48 (m, 2H, diazaspiro-CH2), 1.40 (s, 9H, C(CH3)3), 1.31 (d, J = 13.2 Hz, 2H, diazaspiro-CH2). 13C NMR (151 MHz, DMSO) delta 181.62, 154.68, 79.48, 41.97, 40.58, 38.72, 32.00, 31.82, 28.43. HRMS(ESI): calcd for C13H22N2O3 [M+Na]+, 277.1523, found, 277.1523.

495414-81-8, As the paragraph descriping shows that 495414-81-8 is playing an increasingly important role.

Reference：
Article; Li, Bing; Wang, Kaiyuan; Zhang, Rui; Li, Baihui; Shen, Yangli; Ji, Qinggang; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

768-66-1, 2,2,6,6-tetramethylpiperidine (7.20 kg, 51.1 mol, 3.0 eq., KF=0.30%) was added into a 100 L reactor equipped with a temperature probe and overhead stirrer and mixed at RT under nitrogen protection. THF (50 L) was added into the reactor and stirred. The vessel was purged with nitrogen three times and cooled to 0 C. n-BuLi (20.4 L, 3.0 eq.; 2.5 M hexane solution) was added to the mixture dropwise while keeping the temperature at about 0 C to about 5 C for over one hour. The color of the solution turned yellow. The mixture was stirred at about 0 C to about 5 C for 30 minutes. The mixture was cooled to about -78 C to about -70 C to form Solution A.

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

Reference：
Patent; HELSINN THERAPEUTICS (US) INC; HELSINN HEALTHCARE SA; HELSINN ADVANCED SYNTHESIS SA; RUBIO, Silvina Garcia; PERSEGHINI, Mauro; GUAINAZZI, Angelo; PIETRA, Claudio; GIULIANO, Claudio; (110 pag.)WO2019/118298; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3518-83-0, N-Ethyl-4-hydroxypiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2 6-Methoxy-2-(4-Methoxyphenyl)-3-(4-[1-Ethylpiperidin-4-oxy]benzoyl)benzo[b]thiophene 6-Methoxy-2-(4-methoxyphenyl)-3-(4-hydroxybenzoyl)benzo[b]thiophene (1.17 g, 3.00 mmol), 4-hydroxy-1-ethylpiperidine (775 mg, 6.00 mmol), triphenylphosphine (1.57 g, 6.00 mmol), and DEAD (6.00 mmol) were converted to product by the procedure of Example 1 to give 827 mg of the title compound. Yield: 55%. MS(FD) 501(M+). EA calculated for C30H31NO4S: C, 71.83; H, 6.23; N, 2.79. Found: C, 71.61; H, 5.94; N, 2.69.

3518-83-0, As the paragraph descriping shows that 3518-83-0 is playing an increasingly important role.

Reference：
Patent; ELI LILLY AND COMPANY; EP905132; (1999); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

683233-14-9, (R)-tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of(1S,3?R,6?R,7?R,8?E,11?S,12?R)-6-chloro-7?-methoxy- 11?, 1 2?-dimethyl-l 5? -oxo-3,4-dihydro-2H-spiro [naphthalene- 1,22? – [20joxa[13jthia[1,14jdiazatetracyclo[14.7.2.03,6.019,24jpentacosa[8,16,18,2 4jtetraenej-7?-carbaldehyde 13?,13?-dioxide (44 mg, 0.069 mmol) in 1,2-dichloroethane (1 mL) was added (R)-tert-butyl 2-(aminomethyl)piperidine-1- carboxylate (147 mg, 0.686 mmol). The resulting mixture was then stirred at room temperature for 1 h. Then, sodium triacetoxyborohydride (73 mg, 0.343 mmol) was added in portions. After addition, the mixture was then stirred at room temperature for 3 d. The mixture was purified by silica gel columnchromatography (0% to 20% MeOH/DCM) to provide 2-methyl-2-propanyl (2R)-2-(((((1S,3?R,6?R,7?R,8?E,1 1?S,12?R)-6-chloro-7?-methoxy-11?,12?-dimethyl-13?, 13? -dioxido- 15 ?-oxo-3,4-dihydro-2H-spiro[naphthalene- 1,22? -[20joxa[13jthia[1,14jdiazatetracyclo[14.7.2.03,6.019,24jpentacosa[8,16,18,24jtetraenj -7? -yl)methyl)amino)methyl)- 1 -piperidinecarboxylate (57.6 mg, 0.069mmol, 100 % yield) as a light yellow solid, which was used in the next step. MS (ESI, +ve ion) m/z 839.4 (M+H).

683233-14-9, As the paragraph descriping shows that 683233-14-9 is playing an increasingly important role.

Reference：
Patent; AMGEN INC.; HARRINGTON, Paul E.; ASHTON, Kate; BROWN, Sean P.; KALLER, Matthew R.; KOHN, Todd J.; LANMAN, Brian Alan; LI, Kexue; LI, Yunxiao; LOW, Jonathan D.; MINATTI, Ana Elena; PICKRELL, Alexander J.; STEC, Markian M.; TAYGERLY, Joshua; (991 pag.)WO2018/183418; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89895-06-7,1-(Piperidin-4-yl)ethanone hydrochloride,as a common compound, the synthetic route is as follows.

89895-06-7, EXAMPLE 65 5-chloro-2-(piperidin-4-yl)-1H-indole A mixture of 0.60 gm (3.4 mMol) 4-chlorophenylhydrazine hydrochloride and 0.54 mL (6.7 mMol) pyridine in 20 mL ethanol were stirred at 60 C. for 15 minutes. To this mixture was then added 4-acetylpiperidine hydrochloride and the reaction mixture was stirred for 2 hours at 70 C. The reaction mixture was concentrated under reduced pressure and the residue was treated with polyphosphoric acid. This mixture was heated at 90-100 C. for 48 hours. The reaction mixture was quenched with a slurry of ice in 5N sodium hydroxide. The aqueous mixture was extracted well with ethyl acetate. The organic phases were combined, washed with saturated aqueous sodium chloride, dried over sodium sulfate and concentrated under reduced pressure. The residue was subjected to silica gel chromatography, eluding with a dichloromethane gradient containing 4-20% methanol. Fractions containing product were combined and concentrated under reduced pressure to provide 0.26 gm (36%) of the title compound as a tan solid. MS(FD): m/e=234 (M+) EA: Calculated for: C13 H15 N2 Cl: Theory: C, 66.52; H, 6.44; N, 11.93. Found: C, 66.24; H, 6.34; N, 11.73.

The synthetic route of 89895-06-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Eli Lilly and Company; US5846982; (1998); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35856-62-3,Piperidine-1-sulfonyl chloride,as a common compound, the synthetic route is as follows.

To 0.350g (1. 62mmol) of 10001a in 1 OmL CH2CI2 was added 0.23 mL (1. 62mmol) of Et3N, then 0.446g (2. 42mmol) of 10004b in 5 mL CH2CI2 drop wise at rt. The reaction mixture was stirred at rt overnight. The reaction mixture was diluted with EtOAc, washed with a solution of aq. NH4CI and brine. The organic layers was dried over MgS04, filtered, concentrated in vacuo and purified by silica gel chromatography with 6 24% EtOAc in Hexane to yield 0.353g of product. Yield 60%.

35856-62-3, As the paragraph descriping shows that 35856-62-3 is playing an increasingly important role.

Reference：
Patent; SCHERING CORPORATION; WO2005/87721; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5773-58-0, 3-Methylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5773-58-0, 13.3: tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate; 6.8 g of 3-methylpiperidin-4-one, 16.7 ml of triethylamine, 19.6 g of di-t-butyl dicarbonate and 0.7 g of dimethylaminopyridine are placed in a mixture of 300 ml of THF and 30 ml of water. Stirring is maintained at ambient temperature for 18 h. After evaporation of the THF, the reaction medium is treated with a saturated aqueous potassium hydrogen sulphate solution to a pH of 1, and then extraction is carried out with ethyl acetate until the aqueous phase is completely depleted. The organic phase is then washed with a saturated aqueous potassium hydrogen sulphate solution, and then with a saturated aqueous sodium hydrogen carbonate solution and, finally, with a saturated aqueous sodium chloride solution. After drying over MgSO4 and concentration to dryness, the crude obtained is chromatographed on silica gel, elution being carried out with a 98/2 dichloromethane/methanol mixture. 10.3 g of tert-butyl 3-methyl-4-oxopiperidine-1-carboxylate are obtained.

As the paragraph descriping shows that 5773-58-0 is playing an increasingly important role.

Reference：
Patent; SANOFI-AVENTIS; US2007/191364; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.149554-03-0,tert-Butyl 2-(4-oxopiperidin-1-yl)acetate,as a common compound, the synthetic route is as follows.

149554-03-0, [000627] A solution of Example 1.2.7 (0.055 g,), fert-butyl 2-(4-oxopiperidin-l-yl)acetate (0.014 g) and sodium triacetoxyborohydride (0.019 g) was stirred in dichloromethane (0.5 mL) at room temperature. After stirring for 2 hours, trifluoroacetic acid (0.5 mL) was added to the reaction, and stirring was continued overnight. The reaction was concentrated, dissolved in N,N- dimethylformamide (1.5 mL) and water (0.5 mL) and purified by reverse phase HPLC using a Gilson system, eluting with 10-80% acetonitrile in water containing 0.1% v/v trifluoroacetic acid. The desired fractions were combined and freeze-dried to provide the title compound. NMR (501 MHz, dimethyl sulfoxide-^) delta ppm 12.85 (s, 1H), 8.80 (s, 2H), 8.03 (d, 1H), 7.80 (d, 1H), 7.62 (d, 1H), 7.55-7.41 (m, 3H), 7.36 (q, 2H), 7.29 (s, 1H), 6.96 (d, 1H), 4.96 (s, 2H), 4.07 (s, 2H), 3.89 (t, 2H), 3.83 (s, 2H), 3.66-3.55 (m, 4H), 3.30 (s, 1H), 3.08 (s, 4H), 3.02 (t, 2H), 2.22 (d, 2H), 2.10 (s, 3H), 1.97-1.78 (m, 2H), 1.44 (s, 2H), 1.31 (q, 4H), 1.20-0.96 (m, 6H), 0.87 (s, 6H). MS (ESI) m/e 887.3 (M+H)+.

149554-03-0 tert-Butyl 2-(4-oxopiperidin-1-yl)acetate 53407149, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ABBVIE INC.; TAO, Zhi-Fu; DOHERTY, George; WANG, Xilu; SULLIVAN, Gerard M.; SONG, Xiaohong; KUNZER, Aaron R.; WENDT, Michael D.; MARIN, Violeta L.; FREY, Robin R.; CULLEN, Steve C.; WELCH, Dennie S.; SHEN, Xiaoqiang; BENNETT, Nathan B.; HAIGHT, Anthony R.; ACKLER, Scott L.; BOGHAERT, Erwin R.; SOUERS, Andrew J.; JUDD, Andrew S.; (623 pag.)WO2016/94509; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

23499-01-6, 1-(4-Nitrophenyl)piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 26 4-Fluoronitrobenzene and piperidin-4-one hydrochloride were allowed to undergo the reaction in THF in the presence of potassium carbonate. The resulting compound was allowed to react with sodium hydride and ethyl diethylphosphonoacetate in THF. The resulting compound was subjected to catalytic hydrogenation in the same manner as shown in Reference Example 3 to obtain [1-(4-aminophenyl) piperidin-4-yl]acetic acid ethyl ester. NMR2: 1.27 (3 H, t, J = 7.2 Hz) , 2.33 (2 H, d, J = 7.2 Hz) , 6.66 – 6.89 (2H, m)., 23499-01-6

The synthetic route of 23499-01-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1518855; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.

Step 1. Preparation of the tetramethylpiperidide solution. 1.9 mL (11.7 mmol; 3 eq. ) of 2,2, 6,6-tetramethylpiperidine was dissolved in 4 mL of anhydrous THF; the solution was cooled TO-80C and then 3.9 mL (9.8 mmol; 2.5 eq) of a 2.5 M solution BuLi in Hexane were added. The mixture was stirred for 2h at 0C.Step 1. Preparation of the tetramethylpiperidide solution. 1.9 mL (11.7 mmol; 3 eq. ) of 2,2, 6,6-tetramethylpiperidine was dissolved in 3 mL of anhydrous THF; the solution was cooled TO-80C and then 3.9 mL (9.8 mmol; 2.5 eq) of a 2.5 M solution BuLi in Hexane were added. The mixture was stirred for 2h at 0C.

The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.; WO2005/7603; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem