Month: March 2022

122860-33-7, Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 25;. N-Benzyloxycarbonyl-4- (formyl)-piperidine (E-13).; A stirred suspension of N-(benzyloxycarbonyl)-4-hydroxymethyl)-piperidine (E-12,2 g, 8 mmol) and CeliteTM (4 g) in dry DCM (120 mL) at room temperature was treated with pyridinium chlorochromate (3.5 g, 16.0 mmol), stirred for 3 hours, and filtered on Celte. The filtrate was evaporated to a dark residue which was purified by column chromatography using a gradient of 25 to 50 % EtOAc in hexane as eluant to give 1.5 g (75 %) of aldehyde E-13 as a clear oil which was immediately used in the next step : 1H NMR (CDC13) 8 1.43 (dd, 2H, J=10), 1.78 (m, 2H), 2.31 (m, 1H), 2.91 (t, 2H, J=10. 6), 3.96 (m, 2H), 5.05 (s, 2H), 7.24 (m, 5H), 9.52 (s, 1H).

122860-33-7, 122860-33-7 Benzyl 4-(hydroxymethyl)piperidine-1-carboxylate 736490, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; BIOAXONE THERAPEUTIQUE INC.; WO2005/80394; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: An acetophenone derivative (1 equivalent), a benzaldehyde derivative (1 equivalent), and NaOH (1 equivalent) were added to an ethanol solvent and stirring was performed at room temperature. Water was added to the reaction mixture and extraction with ethyl acetate was performed. The organic solvent layer was collected and washed once again with water. Anhydrous MgSO4 was added thereto and dehydration was performed. Then, the solvent was distilled off under reduced pressure, and the remaining residue was purified by silica gel chromatography, to prepare the compound., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Industry-Academic Cooperation Foundation, Yonsei University; Ewha University-Industry Collaboration Foundation; Cha University Industry-Academic Cooperation Foundation; KIM, Eosu; NAMKOONG, Kee; JEONG, Jihyeon; JANG, Sooah; KWON, Young Joo; JUN, Kyu Yeon; JEON, Kyung Hwa; PARK, Minsun; KIM, Hyunjeong; NA, Younghwa; (44 pag.)EP3626703; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

936130-82-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.936130-82-4,Methyl 4-(piperidin-4-yl)benzoate hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of Compound 8BE (3 g, 11.73 mmol), CH2CI2 (30 ml_), triethyl amine (4.9 ml_, 35.19 mmol) and di-tert-butyl dicarbonate (3.83 g, 17.55 mmol) was stirred at room temperature for 3 hours. Diluted with CH2CI2 (100 ml_) and washed with water (100 ml_). The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified on silica gel eluting with 100% EtOAc to give the desired product 9BE (3.5 g, 93%).

As the paragraph descriping shows that 936130-82-4 is playing an increasingly important role.

Reference：
Patent; SCHERING CORPORATION; WO2008/156739; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

297172-16-8, (4-Methylpiperidin-4-yl)methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(4-methylpiperidin-4-yl)methanol (E4) (2.4 g, a mixture of the amino alcohol and NH4CO2H) was suspended in DCM (70 mL). Et3N (5 mL; 37.2 mmol) was then added followed by the drop-wise addition of ethyl chloroformate (1.05 mL, 13 mmol, 1.4 eq.). After 1 h at room temperature, 1N HCl (70 mL) was added and the layers were separated. The aqueous layer was extracted with DCM (70 mL) and the combined organic layers were dried over Na2SO4, filtered, and concentrated under high vacuum. The product (E5) (1.7 g) is obtained analytically pure as an oil and used without further purification. LC/MS m/z (M+1) 202.2, tR 1.89 minutes; (10-99% CH3CN-H2O gradient with 0.03% TFA, 5 min). 1H NMR (400 MHz, DMSO-d6) delta 4.05 (q, J=7.1 Hz, 2H), 3.66 (dt, J=13.6, 4.7 Hz, 2H), 3.32 (s, 2H), 3.11 (t, J=5.2 Hz, 1H), 3.11 (dd, J=23.9, 3.5 Hz, 1H), 1.44-1.37 (m, 3H), 1.26-1.22 (m, 2H), 1.19 (t, J=7.1 Hz, 3H), 0.93 (s, 3H).

297172-16-8, As the paragraph descriping shows that 297172-16-8 is playing an increasingly important role.

Reference：
Patent; Makings, Lewis R.; Blanco, Miguel Garcia-Guzman; Hurley, Dennis J.; Drutu, Ioana; Raffai, Gabriel; Bergeron, Daniele M.; Nakatani, Akiko; Termin, Andreas P.; Silina, Alina; US2008/15179; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,7-Diazaspiro[4.5]decan-1 -one hydrogen chloride (80 mg, 0.420 mmol) was dissolved in dichloromethane (4 mL) and triethylamine (0.1 17 mL, 0.839 mmol) before the addition of 3-(trifluoromethyl)benzenesulfonyl chloride (1 13 mg, 0.462 mmol). After stirring for 20 h the reaction mixture was concentrated in vacuo and the resulting residue was purified by MDAP to give 7-{[3-(trifluoromethyl)phenyl]sulfonyl}- 2,7-diazaspiro[4.5]decan-1 -one (60 mg, 0.162 mmol, 39% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .35 – 1.46 (m, 2 H) 1.51 – 1.64 (m, 1 H) 1.66 – 1 .74 (m, 1 H) 1.90 – 1.98 (m, 1 H) 2.00 – 2.09 (m, 1 H) 2.20 – 2.31 (m, 2 H) 3.12 – 3.24 (m, 2 H) 3.37 (d, J=1 1 .40 Hz, 1 H) 3.67 (d, J=1 1 .24 Hz, 1 H) 7.76 (s, 1 H) 7.92 (t, J=7.87 Hz, 1 H) 7.98 (s, 1 H) 8.08 (d, J=7.95 Hz, 1 H) 8.14 (d, J=7.84 Hz, 1 H). MS ES+ve m/z 363 (M+H)., 1187173-43-8

The synthetic route of 1187173-43-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

10338-57-5, General procedure: The 4-alkyl(aryl)aminobenzaldehyde (1 mmol) was added to(RMe2Si)3CLi, R=H,Me (1 mmol) in THF under argon. The mixturewas reacted according to Tables 1 and 2. The reaction was quenchedwith H2O, extracted with CH2Cl2 and dried over Na2SO4. The solventwas evaporated under reduced pressure and the residue was purifiedby preparative column chromatography (n-hexane/ethylacetate) andthe corresponding products were obtained.

As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Safa, Kazem Dindar; Nadimi, Sanaz; Alyari, Maryam; Journal of Chemical Research; vol. 38; 8; (2014); p. 498 – 501;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142851-03-4,Ethyl N-Boc-piperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (2.00 g, 7.77 mmol) in EtOH (26 mL) was added hydrazine hydrate (5.84 g, 117 mmol) at room temperature. The reaction mixture was refluxed overnight, cooled to room temperature and concentrated in vacuo. The residue was dissolved in DCM, washed with water 3 times and brine, dried over Na2SO4, filtered and concentrated in vacuo to afford tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate (985 mg, 52%) as a white solid. 1H-NMR (CDCl3, Varian, 400 MHz): delta 1.46 (9H, s), 1.58-1.70 (2H, m), 1.73-1.85 (2H, m), 2.19-2.26 (1H, m), 2.27 (2H, br. s), 3.90 (2H, s), 4.15 (2H, br. s), 6.99 (1H, s).

142851-03-4, As the paragraph descriping shows that 142851-03-4 is playing an increasingly important role.

Reference：
Patent; HANDOK INC.; CMG Pharmaceutical Co., Ltd.; Kim, Moonsoo; Lee, Chaewoon; Lee, Gilnam; Yoon, Cheolhwan; Seo, Jeongbeob; Kim, Jay Hak; Lee, Minwoo; Jeong, Hankyul; Choi, Hyang; Jung, Myung Eun; Lee, Ki Nam; Kim, Hyun Jung; Kim, Hye Kyoung; Lee, Jae Il; Lee, MinWoo; Kim, Misoon; Choi, Soongyu; (124 pag.)US2016/168156; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

20691-89-8, 1-Methyl-4-piperidinemethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 57 ; 3-methoxv-4-I(I -methvlDiDeridin-4-Vl)methoxvlbenzonitrile; 53.3 ml of 1 N sodium bis (trimethylsilyl)amide added to a stirred solution of 6.63 g (51.3 mmol) of (1-methyl-piperidin-4-yl)-methanol in 14 ml of THF. After 20 minutes, solid 4-fluoro-3-methoxy benzonitrile was added. The mixture was refluxed for 20 minutes, cooled to room temperature and poured into water. The mixture was extracted with ethyl acetate. The organic extracts were dried over magnesium sulfate. The solvent was removed and the residue was recrystallized from ethyl acetate-hexanes yielding 8.9 g of the title compound as a white solid: mass spectrum (electrospray, m/e): M+H 261.2.

20691-89-8, 20691-89-8 1-Methyl-4-piperidinemethanol 271971, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; WYETH; WO2005/115145; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.885279-92-5,1-Boc-1,8-diaza-spiro[4.5]decane,as a common compound, the synthetic route is as follows.

8-Benzyl 1-fetaut-butyl L8-diazaspiror4.5″|decane-l,8-dicarboxylate (C-I); To a solution of 5.0 g (20.8 mmol) A-S in 200 mL CH2Cl2 cooled to 00C was added 7.3 mL (41.6 mmol) DIPEA and 3.1 mL (21.8 mmol) benzyl chloroformate. After 30 minutes, the cooling bath was removed and the reaction was stirred at room temperature for 3 h before being dumped into 0.5 M HCl in a separatory funnel. The layers were separated, the aqueous layer was extracted once with CH2Cl2, the combined organic layers were washed again with 0.5M HCl, then with saturated aqueous NaHCO3, water, dried over Na2SO4, and concentrated by rotary evaporation. The residue was purified by column chromatography on silica gel (EtOAc/hexanes) to provide C-I as a white solid. Data for C-I: LC/MS: rt = 2. 73 min; m/z (M + H) = 375.1, found; 375.2 required., 885279-92-5

885279-92-5 1-Boc-1,8-diaza-spiro[4.5]decane 34178602, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; MERCK & CO., INC.; WO2007/25069; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

13096-31-6, 5-Hydroxypiperidine-2-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The upper step of the product (365.22g, 2 . 516 muM, 1 . 0eq.) dissolved in MeOH (3000 ml) in. under the ice-bath adds by dropsSOCl2(448.99g, 3.774mol, 1.5eq.)dropping process temperature can be raised to reflux, then completing, reflux 2h. LC – Ms detection reaction is complete; reducing pressure and solvent, a brown yellow liquid 489.81g, yield (theoretical): 100%. The crude product directly into the next step., 13096-31-6

13096-31-6 5-Hydroxypiperidine-2-carboxylic acid 151730, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Nanjing Furun Cade Biological Medicine Co., Ltd; Shi, Xiang; Liu, Guihua; Lian, Huawen; (18 pag.)CN106045999; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem