Month: March 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72551-53-2,Ethyl 1-benzylpiperidine-3-carboxylate,as a common compound, the synthetic route is as follows.,72551-53-2

Step 1: l-Benzylpiperidine-3-carbonyl chloride hydrochloride; [00273] Hydrochloric acid (20 % aq, 100 mL) was added to ethyl l-benzylpiperidine-3- carboxylate (14.2 g, 57.4 mmol) and the mixture heated at reflux for 4 h. The reaction was cooled and concentrated in vacuo to give l-benzylpiperidine-3-carboxylic acid as a pale yellow solid. This solid was dissolved in thionyl chloride and the resulting solution stirred at room temperature for 1 h. Thionyl chloride was removed in vacuo and the resulting solid was slurried in THF and azeotroped to afford the title compound as a pale yellow solid which was used without further purification (17.0 g, quant.).

As the paragraph descriping shows that 72551-53-2 is playing an increasingly important role.

Reference：
Patent; GALAPAGOS N.V.; WO2008/55959; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62718-31-4,1-Benzylpiperidine-4-carbonitrile,as a common compound, the synthetic route is as follows.

Step a: To solution of LHMDS (1 M in THF, 16.45 mL, 16.45 mmol) was added a solution of 1-benzylpiperidine-4-carbonitrile (1.50 g, 7.49 mmol) in THF (37.4 mL) at – 78 C. The resulting yellow solution was stirred for 1 h at -78 C. 1-Iodo-2-methylpropane (5.60mL, 48.7 mmol) was added and the reaction mixture was allowed to warm up to RT and stirring was continued for 3 days. Saturated aq. NH4C1 (-30 mL) was added at 0 C and the mixture was extracted with EtOAc. The organic phase was washed with water (50 mL) and brine (50 mL). Each aq. layer was extracted with EtOAc and the combined organic phases were dried over Na2SO4, filtered, and concentrated under reduced pressure to give crude 1 -benzyl-4- isobutylpiperidine-4-carbonitrile (2.54 g) as a yellow oil, which was directly used without further purification. MS m/z 257.3 (M+H)., 62718-31-4

The synthetic route of 62718-31-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

72551-53-2, Ethyl 1-benzylpiperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Acetic acid (20 mL) and hydrazine hydrate (136 mL (140 g, 2.8 mol) were added to a solution of (3RS)- ethyl l-(phenylmethyl)-3-piperidinecarboxylate (Description 72, 270 g, 1.092 mol) in ethanol (310 mL) and the mixture was heated under reflux for 3 days. The mixture was cooled and the solvent was partly evaporated under reduced pressure until a precipitation occurred. The solid was collected, aqueous KOH (50 g in 100 mL) was added and the mixture was extracted with CHCl3 (2 x 300 mL). The combined organic fractions were dried (Na2SO4) the solvent was partly evaporated under reduced pressure until a precipitation occurred. The solid was collected, the filtrate was diluted with Et2O (200 mL) and further solid was collected. The combined solids were washed with Et2O and dried in vacuo to give the title compound as a solid (217 g, 92%).

72551-53-2, 72551-53-2 Ethyl 1-benzylpiperidine-3-carboxylate 2736370, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Merck Sharp & Dohme Limited; DIRAT, Olivier; ELLIOTT, Jason, Matthew; WO2007/3965; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of various alpha,beta-unsaturated ketones 9 (0.28mmol) and different benzaldehydes (0.3mmol) in EtOH (5mL) at room temperature was added dropwise a solution of 20% NaOH. The reaction mixture was stirred at room temperature overnight and the resulting mixture was diluted with H2O (15mL) and extracted with EtOAc. The combined organic layers were washed with brine (15mL) and dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure. The residue was further purified by chromatography on silica gel to afford target Asymmetric MACs 10a-c., 10338-57-5

As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Liu, Zhiguo; Tang, Longguang; Zou, Peng; Zhang, Yali; Wang, Zhe; Fang, Qilu; Jiang, Lili; Chen, Gaozhi; Xu, Zheng; Zhang, Huajie; Liang, Guang; European Journal of Medicinal Chemistry; vol. 74; (2014); p. 671 – 682;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20691-89-8,1-Methyl-4-piperidinemethanol,as a common compound, the synthetic route is as follows.,20691-89-8

(1-Methyl-piperidin-4-yl)-methanol (2. 5USD g, 20 mmol) and hydroxy-diphenyl-acetic acid methyl ester (9. 69 g, 40 mmol) are suspended in toluene (65 ml). Molecular sieve 4A (1 g) is added and the mixture is stirred at room temperature for 10 minutes. Sodium (0.08 g) is added and the reaction mixture stirred at 80OC for 3 hours. Additional sodium (0.1 g) is then added and heating maintained at 80OC for 18 hours. The reaction mixture is cooled to room temperature, solid filtered off, and washed with ethylacetate. The filtrate is washed once with saturated aqueous NAHCO3 solution (50 ml) and twice with aqueous HCL 1M (25 ml each). The combined acidic aqueous layers are basified with saturated aqueous NAHCO3 solution and solid NAHCO3, the resulting precipitate is removed by filtration, drying under vacuum gives the title product as a white solid (M+H) + : 340.09.

20691-89-8 1-Methyl-4-piperidinemethanol 271971, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/815; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

23499-01-6, 1-(4-Nitrophenyl)piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 40 2.4 g (10.9 mmol) of 1-(4-nitrophenyl)-4-piperidone and 2.0 g (10.9 mmol) of N-methyl-N-(2-(4-nitrophenyl)ethyl)amine were reacted in a similar manner to Example 1. 2.2 g of 1-(4-nitrophenyl)-4-(N-methyl-N-(2-(4-nitrophenyl)ethyl)amino)piperidine were obtained. Melting point 97-98 C., 23499-01-6

23499-01-6 1-(4-Nitrophenyl)piperidin-4-one 3842562, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; BASF Aktiengesellschaft; US5260318; (1993); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

61869-08-7, (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.0 g of oily paroxetine free base and 1.24 g of cholic acid were completely dissolved in 10 mL of N,N-dimethylformamide with stirring for 10 minutes. The solution was slowly added dropwise to 100 mL of isopropyl acetate to precipitate a solid, stirred at 0 C. for 3 hours, and filtered. The filtered residue was washed with 30 mL of ethyl ether, and dried under vacuum to yield 1.84 g of solid paroxetine cholate as a light gray powder., 61869-08-7

As the paragraph descriping shows that 61869-08-7 is playing an increasingly important role.

Reference：
Patent; Lee, Sang Joon; Shin, Hee Jong; Ki, Min Hyo; Lee, Su Kyoung; Kim, Bok Young; Lee, Hong Woo; US2006/63747; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

61869-08-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61869-08-7,(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine,as a common compound, the synthetic route is as follows.

1.0 g of oily paroxetine free base and 1.24 g of cholic acid were completely dissolved in 20 mL of methanol while heating to 40 C. with shaking for 2 hours. The solvent was removed under reduced pressure, and then the residue was dried under vacuum, yielding 2.2 g of solid paroxetine cholate as a white powder. ; EXAMPLE 3 1.0 g of oily paroxetine free base and 1.24 g of cholic acid were completely dissolved in 10 mL of methanol while heating to 40 C. with shaking for one hour. The solution was slowly added dropwise to 100 mL of ethyl ether to precipitate a solid, stirred at 0 C. for 3 hours, and filtered. The filtered residue was washed with 30 mL of ethyl ether, and dried under vacuum to yield 1.89 g of solid paroxetine cholate as a light gray powder.

As the paragraph descriping shows that 61869-08-7 is playing an increasingly important role.

Reference：
Patent; Lee, Sang Joon; Shin, Hee Jong; Ki, Min Hyo; Lee, Su Kyoung; Kim, Bok Young; Lee, Hong Woo; US2006/63747; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of V-2 A solution of V-l (20 g, 85.72 mmol) in 80 mL of THF (dry) was added dropwise over lh to a solution of LDA (60 mL, 2.0 M, 120 mmol) in 80 mL of THF (dry) at 0C. The resultant mixture was stirred at 0C for 30 min, and then added to a pre-cooled (0C) solution of N- fluorobenzenesulfonimide (28.38 g, 90 mmol) in 120 mL of THF (dry). The resulting reaction mixture was stirred at 0C for 30 min, and then at 25C overnight. After dilution by 400 mL of EtOH, the mixture was washed with water (100 mL x3) and brine (100 mL), dried and concentrated. The crude was purified by silica gel chromatography (PE to PE/DCM=2/1 to DCM to DCM/MeOH=200/l) to afford V-2 (6 g, yield: 28%) as a colorless oil., 10315-06-7

The synthetic route of 10315-06-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SUZHOU SHANGZHI BIOTECH LIMITED; CHENG, Xueheng; WO2014/8629; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

61869-08-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61869-08-7,(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine,as a common compound, the synthetic route is as follows.

1.0 g of oily paroxetine free base and 1.24 g of cholic acid were completely dissolved in a mixed solvent of ethanol (20 mL) and isopropyl acetate (30 mL) while heating to 50 C. with shaking for 2 hours. The solution was allowed to stand at -20 C. for 48 hours, filtered, and dried under vacuum to yield 1.9 g of solid paroxetine cholate as a light gray powder.

The synthetic route of 61869-08-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Lee, Sang Joon; Shin, Hee Jong; Ki, Min Hyo; Lee, Su Kyoung; Kim, Bok Young; Lee, Hong Woo; US2006/63747; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem