Day: March 25, 2022

710972-40-0, tert-Butyl 4-((2-methoxyethyl)amino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

710972-40-0, 135 {l-r2-(lH-Indazol-4-yl)-4-mophiholin-4-yl-thienor3.2-dlpyrimidin-6-ylmethyl1- piperidin-4-yl|-isopropyl-(2-methoxy-ethyl)-amine.Via [l-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)- piperidin-4-yl]-isopropyl-(2-methoxy-ethyl)-amine, prepared from isopropyl-(2- methoxy-ethyl)-piperidin-4-yl-amine.Amine preparation: A mixture of 4-(2-methoxy-ethylamino)-piperidine-l- carboxylic acid tert-butyl ester (see preparation of 121) (300mg) and 2- bromopropane (1.2OmL) in MeCN (3mL) with potassium carbonate (192mg) were heated at 6O0C in a sealed tube for 7 days. The reaction mixture was cooled down, diluted with DCM, washed with brine, dried (MgSO4) and the solvent removed in vacuo. The residue was purified using flash chromatography to yield 4-[isopropyl-(2- methoxy-ethyl)-amino]-piperidine-l -carboxylic acid tert-butyl ester as an oil EPO (131mg). Treatment of this compound with HCl in DCM/MeOH and basic wash with aqueous sodium bicarbonate yielded the desired amine.1H NMR (400MHz, CDCl3) 1.03 (6H, d, J=6.6Hz), 1.62-1.72 (4H, m), 2.08-2.14 (2H, m), 2.52-2.60 (IH, m), 2.69 (2H, t, J=7.4Hz), 3.03-3.12 (4H, m), 3.33 (2H, t, J=7.3Hz), 3.35 (3H, s), 3.82 (2H, s), 3.92 (4H, t, J=4.5Hz), 4.05 (4H, t, J=4.5Hz), 7.35 (IH, s), 7.51 (IH, t, J=8.0Hz), 7.59 (IH, d, J=8.3Hz), 8.29 (IH, d, J=6.6Hz), 9.03 (IH, s), 10.10 (IH, br); MS (ESI+) 550 (MH+).

As the paragraph descriping shows that 710972-40-0 is playing an increasingly important role.

Reference：
Patent; PIRAMED LIMITED; WO2006/46031; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125224-43-3,((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol,as a common compound, the synthetic route is as follows.

Preparation of compound 13b was accomplished by dissolving ((3S,4R)-4-(4-fluorophenyl)piperidin-3- yl)methanol (0.765 mmol, 0.160 g) and sodium cyanoborohydride (2.30 mmol, 0.144 g) in THF (2.0 mL) and acetone (2.0 mL) at 0C. Acetic acid (3.06 mmol, 0.175 mL) was then added dropwise and the reaction was stirred overnight warming to room temperature. The reaction was neutralized with 2N NaOH and then extracted with ethyl acetate. The organic layer was washed 2x with NaCl, dried over MgSO4 and concentrated to give the desired product (0.15 g, 78% yield).

125224-43-3, As the paragraph descriping shows that 125224-43-3 is playing an increasingly important role.

Reference：
Article; Bouley, Renee; Waldschmidt, Helen V.; Cato, M. Claire; Cannavo, Alessandro; Song, Jianliang; Cheung, Joseph Y.; Yao, Xin-Qiu; Koch, Walter J.; Larsen, Scott D.; Tesmer, John J.G.; Molecular Pharmacology; vol. 92; 6; (2017); p. 707 – 717;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of the corresponding b-carboline-3-acid methyl ester(1 mmol), NaOH (4 mmol), C2H5OH (5 ml) and H2O (10 ml) was refluxed for 3 h, and the ethanol was removed on the rotary evaporator.The mixture was neutralized (pH = 5) with 5 N HCl and cooled. The precipitate was collected, washed well with H2O and dried in vacuum. The material was used without further purificationfor the following steps., 10315-06-7

10315-06-7 Methyl 1-benzylpiperidine-4-carboxylate 11436222, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Wang, Jin; Wang, Zhi-Min; Li, Xue-Mei; Li, Fan; Wu, Jia-Jia; Kong, Ling-Yi; Wang, Xiao-Bing; Bioorganic and Medicinal Chemistry; vol. 24; 18; (2016); p. 4324 – 4338;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

4801-58-5, Piperidin-1-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 16 (3R,S)-Hydroxy-1-(3-methoxyphenethyl)piperidine This was prepared as described in Preparation 15 from (3R,S)-hydroxypiperidine and 3-methoxyphenethyl bromide. The title compound was obtained as a pale yellow oil (1.63 g, 72%) which was characterised by its 1 H-n.m.r. spectrum; (CDCl3): delta=7.21 (1H, dd, J=8 and 7 Hz); 6.72-6.83 (3H, m); 3.78-3.88 (1H, m); 3.81 (3H, s); 2.30-2.84 (9H, m) and 1.47-1.90 (4H, m).

4801-58-5, As the paragraph descriping shows that 4801-58-5 is playing an increasingly important role.

Reference：
Patent; Pfizer Inc.; US5089505; (1992); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,768-66-1

In a 300 ml flask purged with nitrogen, 7.88 g (55.8 mmol) of 2,2,6,6-tetramethylpiperidine, 2.77 g of lithium chloride (65.3 mmol: 2,2,6,6-tetramethylpiperidine To 1.17 equivalents) THF was added, 24.2 g (58.2 mmol) of a 15% n-butyllithium hexane solution was dropped at -10 C. to obtain lithium 2,2,6,6-tetramethyl Piperidide solution was prepared. After cooling this solution to -50 C., 10.93 g (58.2 mmol) of triisopropoxyborane was added dropwise, followed by dropwise addition of 4.98 g (48.3 mmol) of benzonitrile, followed by aging at the same temperature for 3 hours did. Analysis of the reaction liquid by HPLC revealed that the area% of 2-cyanophenylboronic acid was 98.6%, the area% was 1.38%, 1-phenyl-1- (2,2,6,6-tetramethylpiperidine -1-yl) methyl imine as by-product was confirmed. This reaction solution was added to 38 ml of 3N HCl and hydrolyzed. 150 ml of ethyl acetate was added and stirred, The acid phase was separated. The organic phase was washed with 50 ml of 0.2 N HCl and the resultant organic phase solution was subjected to quantitative determination of 2-cyanophenylboronic acid using HPLC. As a result, 2-cyanophenylboronic acid was obtained in a yield of 95.0 % Confirmed that it was obtained. Further, it contained 0.45% of 1-phenyl- (2,2,6,6-tetramethylpiperidin-1-yl) methylimine in area%.

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

Reference：
Patent; TOSOH FINECHEM CORPORATION; HATTORI, YU; KANEKO, TOSHIYUKI; (13 pag.)JP2015/160823; (2015); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.,768-66-1

A solution of2,2,6,6-tetramethylpiperidine (1.6 mL, 9.6 mmol) in THF (10 mL) was treated withn-BuLi (6.0 mL, 1.60 M in hexane, 9.6 mmol) at 0 C. After stirring for 1 h at 0 C thesolution was added to a solution of compound 3 (1.81 g, 4.00 mmol) in THF (8 mL) at-78 C. After stirring for 30 min at -78 C and 3 h at -30 C the reaction mixture wastransferred to a suspension of ZnCl2 (1.09 g, 8.00 mmol) in THF (8 mL) at -78 C.Stirring was continued at -78 C for 30 min before the mixture was warmed to roomtemperature, where stirring was maintained for 30 min. To the resulting solution wasadded a solution of 1-bromo-3,5-di-t-butylbenzene (1.18 g, 4.40 mmol) and [Pd(PPh3)4](0.23 g, 0.20 mmol) in THF (8 mL). The reaction mixture was heated to 60 C for 10hours, before the reaction was quenched with a saturated aqueous ammonium chloride solution. The reaction mixture was extracted with hexane and the combined organicphases were washed with water and dried over MgSO4. After filtration, the filtrate wasevaporated to dryness under reduced pressure and the obtained residue was purified bycolumn chromatography on silica gel (hexane). Washing the resulting solid with smallamount of methanol to give compound 4 (1.99 g, 3.10 mmol, 78%). 4: orange solid, m.p.139-141 C. 1H NMR (300 MHz, CDCl3) delta 1.39 (s, 36H), 4.14 (s, 5H), 4.59 (s, 2H),7.35 (t, J = 1.8 Hz, 1H), 7.62 (d, J = 1.8 Hz, 2H); 13C NMR (75 MHz, CDCl3) delta 31.5 (q),34.9 (s), 67.0 (d), 73.5 (d), 79.7 (s), 88.6 (s), 120.9 (d), 124.4 (d), 135.5 (s), 149.8 (s).Anal. Calcd for C38H49BrFe: C, 71.14; H, 7.70%. Found: C, 71.30; H, 7.66%.

As the paragraph descriping shows that 768-66-1 is playing an increasingly important role.

Reference：
Article; Sasamori, Takahiro; Suzuki, Yuko; Sakagami, Michiyasu; Miyake, Hideaki; Tokitoh, Norihiro; Chemistry Letters; vol. 43; 9; (2014); p. 1464 – 1466;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1187173-43-8,2,7-Diazaspiro[4.5]decan-1-one hydrochloride,as a common compound, the synthetic route is as follows.,1187173-43-8

2,7-Diazaspiro[4.5]decan-1 -one hydrogen chloride (80 mg, 0.420 mmol) was dissolved in dichloromethane (4 mL) and triethylamine (0.1 17 ml_, 0.839 mmol) before the addition of 3,5-bis(trifluoromethyl)benzenesulfonyl chloride (144 mg, 0.462 mmol). After stirring for 20 h the reaction mixture was concentrated in vacuo and the resulting residue was purified by MDAP to give 7-{[3,5-bis(trifluoromethyl)phenyl]- sulfonyl}-2,7-diazaspiro[4.5]decan-1 -one (14 mg, 0.032 mmol, 8% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .32 – 1 .63 (m, 3 H) 1.66 – 1 .76 (m, 1 H) 1 .87 – 1 .97 (m, 1 H) 2.00 – 2.08 (m, 1 H) 2.35 – 2.47 (m, 2 H) 3.15 – 3.24 (m, 2 H) 3.47 (d, J=1 1 .45 Hz, 1 H) 3.71 (d, J=1 1 .67 Hz, 1 H) 7.75 (s, 1 H) 8.32 (s, 2 H) 8.55 (s, 1 H). MS ES+ve m/z 431 (M+H).

As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.

Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

690261-64-4, 2-(Piperidin-4-yl)pyrimidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

690261-64-4, The hydrochloride salt of the PYRIMIDYL PIPERIDINE (Intermediate 8) (67 mg, 0.34 mmol) was combined with Intermediate 4 (100 mg, 0.28 MMOL), triethylamine (46 P. L, 0.35 MMOL), and 4 A powdered molecular sieves (100 mg) in DCM. After 15 minutes at room temperature, sodium triacetoxyborohydride (240 mg, 1.13 mmol) was added and the resulting mixture was stirred for 3 days before being filtered through celite, diluted with DCM and washed with saturated sodium bicarbonate and brine. The organic layer was dried over MGS04, filtered and concentrated under reduced pressure to give a crude oil that was purified by preparative TLC (silica gel, 0.3 % NH40H/2. 7 % MeOH/97 % DCM) to give 110 mg of a colorless oil. Resolution of the individual diastereomers was accomplished by HPLC using a ChiralPak AD column eluting with 30 % isopropanol/hexanes to give 2 single diastereomers and a single mixture of the 2 other diastereomers. First peak 10 mg: ESI-MS calc. for C28H35F3N40: 500.28 ; found 504 (M+H). Second peak 11 mg: ESI-MS calc. for C28H35F3N40: 500.28 ; found 504 (M+H). Third peak 7.0 mg ESI-MS calc. for C28H35F3N40: 500.28 ; found 504 (M+H).

690261-64-4 2-(Piperidin-4-yl)pyrimidine hydrochloride 56965759, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; MERCK & CO., INC.; MERCK SHARP & DOHME LIMITED; WO2004/94371; (2004); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3612-20-2,1-Benzylpiperidin-4-one,as a common compound, the synthetic route is as follows.

Step 1 A mixture of 1-benzyl-4-piperidone (XXV, Chart G, 24.5 mL, 0.1295 mol), N-methylamine hydrochloride (44.75 g, 0.6628 mol) and methanol (50 ml) is stirred for 35 minutes at 20-25, at which time additional methanol (10 ml) is added. The mixture is then cooled in an ice bath and a solution of sodium cyanoborohydride (9.1749 g, 0.1460 mol) in methanol (68 ml) is added to the mixture. The mixture is stirred for 5 min and then is allowed to warm to 20-25. After 1.25 hr the mixture is concentrated under reduced pressure and saturated aqueous sodium bicarbonate is added. After stirring for 1 hr, the mixture is extracted with dichloromethane and the organic phases are combined, backwashed with saline, dried with magnesium sulfate and concentrated under reduced pressure to give (XXVII). The material is upgraded by forming the dihydrochloride salt and collecting the resulting solids. The dihydrochloride salt is further upgraded by trituration with dichloromethane. The free base (XXVII) is recovered by slurrying the dihydrochloride salt (7.5204 g, 0.02713 mol) in dichloromethane and adding enough saturated sodium bicarbonate to dissolve all the solids and then extracting the aqueous layer exhaustively with dichloromethane to obtain N-(1-benzylpiperidin-4-yl)-N-methylamine (XXVII), MS (m/z) 204; IR (neat) 2942, 2796, 2775, 743 and 2749 cm-1.

3612-20-2, 3612-20-2 1-Benzylpiperidin-4-one 19220, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Pharmacia & Upjohn Company; US5877317; (1999); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2,7-Diazaspiro[4.5]decan-1 -one (150 mg, 0.973 mmol) was dissolved in a mixture of triethylamine (0.542 mL, 3.89 mmol) and dichloromethane (10 mL), and 3-chloro-4- [(trifluoromethyl)oxy]benzenesulfonyl chloride (344 mg, 1.167 mmol) was added. After 16 h the reaction mixture was concentrated in vacuo and the resulting residue was purified by silica column chromatography on SP4 (gradient elution: 0 – 20% MeOH – DCM) to give 7-({3-chloro-4-[(trifluoromethyl)oxy]phenyl}sulfonyl)-2,7- diazaspiro[4.5]decan-1 -one (350 mg, 0.839 mmol, 86% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .37 – 1.49 (m, 2 H) 1.49 – 1.65 (m, 1 H) 1.65 – 1 .76 (m, 1 H) 1.88 – 2.08 (m, 2 H) 2.27 – 2.40 (m, 2 H) 3.19 (t, J=6.63 Hz, 2 H) 3.36 (d, J=1 1 .51 Hz, 1 H) 3.64 (d, J=1 1 .62 Hz, 1 H) 7.77 (s, 1 H) 7.80 – 7.87 (m, 2 H) 8.06 (dd, J=1.59, 0.82 Hz, 1 H). MS ES+ve m/z 413 (M+H)., 1187173-43-8

As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.

Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem