Day: March 25, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63845-28-3,2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid,as a common compound, the synthetic route is as follows.

(4-({ [(3-Chloro-pyrazin-2-yl)-(2-phenyl-quinolin-7-yl)-methyl]-carbamoyl}-methyl)- piperidine-1-carboxylic acid benzyl ester); [1123] (3-Chloropyrazin-2-yl)(2-phenylquinolin-7-yl)-methanamine (120.00 mg, 0.35 mmol), EDC (100.64 mg, 0.53 mmol) and HOBt (47.29 mg, 0.35 mmol) were suspended in CH2C12 (2 mL) and charge with DIEA (122.00 muL, 0.70 mmol) followed by the addition of 1- N-Cbz-4-piperidineacetic acid (127.56 mg, 0.46 mmol). The reaction mixture was stirred at rt for 16 h. The reaction mixture was diluted with CH2Cl2 (10 mL) and washed with saturated NaHC03 (2 x 20 mL) and brine (2 x 20 mL). The organic layer was dried over Na2S04 and concentrated in vacuo. The crude product was purified by a 10 g Jones silica gel (wetted with 50% EtOAc/ Hexane, dried loaded onto silica, and run with 60% EtOAc/ Hexanes – 70% EtOAc/ Hexanes) affording the desired product; ?H NMR (400 MHz, CHLOROFORM-d) 8 8.56 (1 H, d, J=2.47), 8.39 (1 H, d, J= 2.50), 8.23 (1 H, d, J= 4.77), 8.11 (2 H, d, J= 7.06), 7.85 (3 H, dd, J= 8.60, J= 8.38), 7.74 (1 H, s), 7.50 (3H, m), 7.32 (6H, m), 6.78 (1 H, d, J= 7.76), 5.10 (2 H, s), 4.11 (2 H, m), 2.75 (2 H, m), 2.21 (2 H, d, J= 7.00), 2.01 (1 H, m), 1.67 (2 H, m), 1.15 (2 H, d, J= 8.921) ; MS (ES+): m/z 605.96/606.98/608.93 (100/40/15) [MH(at)] ; HPLC: tR = 3.33 min. (OpenLynx, nonpolar_5min.).

63845-28-3, The synthetic route of 63845-28-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; OSI PHARMACEUTICALS, INC.; WO2005/97800; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13096-31-6,5-Hydroxypiperidine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,13096-31-6

To a mixture of 413 5-hydroxypiperidine-2-carboxylic acid (62 g, 427.13 mmol, 1 eq.) and Boc2O (102.54 g, 469.84 mmol, 107.94 mL, 1.1 eq.) in 46 dioxane (500 mL) was added 358 NaOH (34.17 g, 854.25 mmol, 2 eq.) and the mixture was stirred at 25 C. for 18 hrs. The mixture was then concentrated to remove dioxane and the pH was adjusted to 2-3 by addition of 1N HCl solution. The aqueous phase was extracted with 2-Me-THF (500 mL*3). The combined organic layers was dried over Na2SO4, filtered and concentrated to give 415 1-tert-butoxycarbonyl-5-hydroxy-piperidine-2-carboxylic acid (40 g, crude) as yellow oil. ESI [M+Na]=267.9

As the paragraph descriping shows that 13096-31-6 is playing an increasingly important role.

Reference：
Patent; Cyteir Therapeutics, Inc.; Castro, Alfredo C.; McComas, Casey Cameron; Vacca, Joseph; Maclay, Tyler; (132 pag.)US2019/77799; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

683233-14-9, (R)-tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of (1S,3?R,6?R,7?S,8?E,11?S,12?R)-6-chloro-7?-(2-methoxyethoxy)- 11?, 12? -dimethyl- 15? -oxo-3,4-dihydro-2H-spiro[naphthalene-1,22?-[20joxa[13jthia[1,14jdiazatetracyclo[14.7.2.03,6.&-49,24jpentacosa[8,16,18,24jtetraenej-7?-carbaldehyde 13?,13?-dioxide (55 mg, 0.080 mmol) and (R)-tertbutyl 2-(aminomethyl)piperidine-1-carboxylate (172 mg, 0.803 mmol) in 1,2-dichloroethane (0.8 mL) was stirred at room temperature for 14 h. Sodiumtriacetoxyborohydride (0.059 mL, 0.401 mmol) was added to the mixture and the mixture was then stirred at room temperature for 1 h. The mixture was dilutedwith MeOH (5 mL) and silica gel was added. The mixture was concentrated and dried in vacuo. The solid mixture was then purified by silica gel columnchromatography (solid loading, 0% to 100% EtOAc/heptane) provided 2-methyl-2-propanyl (2R)-2-(((((1S,3?R,6?R,7?S,8?E,1 1?S,12?R)-6-chloro-7?-(2-methoxyethoxy)- 11?, 12?-dimethyl- 13?, 13? -dioxido- 15 ?-oxo-3,4-dihydro-2H- spiro [naphthalene- 1,22? -[20joxa[13jthia[1,14jdiazatetracyclo[14.7.2.03,6.019,24jpentacosa[8,16,18,24jtetraenj -7? -yl)methyl)amino)methyl)- 1 -piperidinecarboxylate (64 mg, 0.072mmol, 90 % yield) as a light yellow solid. MS (ESI, -1-ye ion) m/z 883.5 (M+H)t, 683233-14-9

683233-14-9 (R)-tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate 1502021, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; AMGEN INC.; HARRINGTON, Paul E.; ASHTON, Kate; BROWN, Sean P.; KALLER, Matthew R.; KOHN, Todd J.; LANMAN, Brian Alan; LI, Kexue; LI, Yunxiao; LOW, Jonathan D.; MINATTI, Ana Elena; PICKRELL, Alexander J.; STEC, Markian M.; TAYGERLY, Joshua; (991 pag.)WO2018/183418; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Appropriate 2-((5-substitutedbenzothiazol-2-yl)thio) acetohydrazide (3a-3b) (0.002 mol), 4-substitutedbenzaldehyde (0.002 mol) and glacial acetic acid (0.1 mL) were refluxed in EtOH for 2 h. The mixture was cooled down in an ice-bath, precipitated product was filtered, dried and recrystallized from EtOH., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Osmaniye, Derya; Levent, Serkan; Karaduman, Abdullah Burak; Ilg?n, Sinem; Zkay, Yusuf; Kaplancikli, Zafer Asim; Molecules; vol. 23; 5; (2018);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39514-19-7,Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

Step A. 3-Oxo-piperidine-1 ,4-dicarboxylic acid 1 -tert-butyl ester 4-ethyl ester. A mixture of 1 -benzyl-3-oxo-piperidine-4-carboxylic acid ethyl ester (1 1 .31 g, 38 mmol), di-t-butyl dicarbonate (8.78 g, 40.2 mmol), Et3N (5.4 ml_, 38.7 mmol) and Pd(OH)2 on carbon (20percent on dry basis-Pearlman’s catalyst) (1 .3 g) were taken into EtOH (1 10 ml_). The mixture was hydrogenated at 60 psi for 24 h in a Parr bottle. The catalyst was removed by filtration and the filtrate was concentrated to dryness to tan solid. Crude residue was shaken well with hexane (100 ml_) and filtered. The filtrate was concentrated to yield the title compound (9.70 g, 94.25percent). MS (ESI) mass calcd. for Ci3H2i NO5, 271 .32; 1H NMR (400 MHz, CDCI3) 4.24 (q, J = 7.1 , 2H), 4.03 (s br, 2H), 3.49 (t, J = 5.6, 2H), 2.32 (m, 3H), 1 .47 (s, 9H), 1 .31 (t, J = 7.1 , 3H)., 39514-19-7

39514-19-7 Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate 419705, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; JANSSEN PHARMACEUTICA NV; BRANSTETTER, Bryan, James; LETAVIC, Michael, A.; LY, Kiev, S.; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T.; WO2011/50202; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24666-55-5, Benzyl (2,6-dioxopiperidin-3-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-(Benzyloxycarbonylamino)piperidine-2,6-dione (100 gm), methanol (1000 ml) and 10% palladium carbon (15 gm) were added and then applied hydrogen pressure at room temperature. The reaction mass was maintained for 2 hours and filtered over on celyte bed. The solvent was distilled off under vacuum from the filtrate thus obtained to obtain a crystalline solid. To the crystalline solid was added a mixture of dimethylformamide (400 ml), triethylamine (100 ml) and 2-(bromomethyl)-3-nirobenzoic acid methyl ester (100 gm) as obtained in example 1. The reaction mass was stirred for 6 hours at room temperature, filtered and then dried to obtain a solid. The solid obtained was dissolved in methanol (250 ml) and stirred for 1 hour at room temperature. The solid obtained was collected by filtration and dried to obtain 77 gm of 3-(4-nitro-l-oxo-l,3- dihydro-2H-isoindol-2-yl)piperidine-2,6-dione, 24666-55-5

24666-55-5 Benzyl (2,6-dioxopiperidin-3-yl)carbamate 2735493, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi; WO2013/5229; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

236406-22-7, 1-Boc-4-(Aminomethyl)-4-methylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Compound 26 (2.0 g, 8.8 mmol) and triethylamine (5.0 mL, 3.6 g, 36 mmol) in CH2Cl2 at 0 C. was added TFAA (1.5 mL, 2.2 g, 11 mmol). The reaction mixture was allowed to warm to rt, and was stirred for 18 h. The reaction mixture was diluted with CH2Cl2 and washed successively with 1 N HCl, water, 1 M aq NaHCO3, and brine. The organic layer was dried over Na2SO4 and filtered. Removal of the solvent gave 2.8 g (100%) of Compound 27., 236406-22-7

The synthetic route of 236406-22-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Schering Corporation; US2004/10013; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

876378-16-4,876378-16-4, (S)-Benzyl 3-aminopiperidine-1-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Oxalyl chloride (1.50 mL, 0.0177 mol) was added to 4-oxoadamantane-l-carboxylic acid (583 mg, 0.00300 mol) in methylene chloride (10 mL) at rt followed by 2 drops of DMF. The mixture was stirred at rt for 2 h. The volatiles were evaporated under reduced pressure and the residue was azeotropically evaported with toluene twice. The residue was dissolved in DCM (10 mL) and to the solution was added benzyl (3iS)-3-aminopiperidine-l-carboxylate hydrochloride (812.6 mg, 0.003001 mol) and A^Af-diisopropylethylamine (1.20 mL, 0.00689 mol). The mixture was stirred at rt for 1 h. The reaction mixture was diluted with DCM (100 mL) and washed with water, IN HC1 and brine. The organic phase was dried over NaiS04, filtered and concentrated to give the desired product.

876378-16-4 (S)-Benzyl 3-aminopiperidine-1-carboxylate hydrochloride 86605313, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; INCYTE CORPORATION; WO2006/20598; (2006); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10315-06-7,Methyl 1-benzylpiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

To A SOLUTION OF BULI (12. 4 ML OF A 1. 6 M SOLUTION IN HEXANE, 19. 8 MMOL) IN THF (25 mL) COOLED TO-78 C, ACETONITRILE (1 ML) WAS ADDED DROPWISE UNDER ARGON atmosphere. After stirring the resulting suspension for 5 min AT-78 C, A SOLUTION of methyl 1-BENZYLPIPERIDINE-4-CARBOXYLATE (2. 0 G, 8. 1 MMOL, OBTAINED IN THE previous section) IN THF (5 ML) WAS ADDED DROPWISE AND STIRRED FOR 30 min AT-78 C. It was allowed to reach room temperature and stirred at this temperature overnight. 1 N HCI WAS ADDED TO ADJUST THE PH TO 7 and the aqueous phase was extracted with CHCI3. The organic phase was dried over NA2S04 and concentrated to dryness, to afford 1. 92 G OF THE DESIRED COMPOUND IN A SOLID orange form (YIELD : 98%)., 10315-06-7

The synthetic route of 10315-06-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; J. URIACH Y COMPANIA S.A.; WO2004/76450; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

72551-53-2, Ethyl 1-benzylpiperidine-3-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,72551-53-2

A 4N-aqueous sodium hydroxide solution (15 ml) was added to a solution of ethyl 1-benzyl-3-piperidinecarboxylate (7.00 g, 28.3 mmol) in a mixture of tetrahydrofuran (30 ml) and 1,4-dioxane (30 ml), and the resulting mixture was stirred at room temperature for 4 hours. After a 4N-aqueous sodium hydroxide solution (15 ml) was added again, the resulting mixture was stirred overnight at room temperature. After completion of the reaction, the reaction solution was neutralized by the addition of 2N-hydrochloric acid (15 ml) under ice-cooling and the resulting mixture was subjected to azeotropic concentration with toluene. The residue was suspended in ethanol, followed by filtration, and the filtrate was concentrated to obtain 1-benzyl-3-piperidinecarboxylic acid (6.3 g, 100%).

The synthetic route of 72551-53-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1403255; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem