Day: March 25, 2022

118511-81-2, 1-(Piperidin-4-yl)-1H-indole is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 8 1-t-butoxycarbonyl-4-(1-indolyl)-piperidine To a 0 C. methylene chloride (20 mL) solution of tert-butoxycarbonate (5.44 mmol) containing triethylamine (0.76 mL, 5.44 mmol) was added 4-(1-indolyl)-piperidine (1.09 g, 5.44 mmol). The reaction was brought to room temperature. After 4 hours, the reaction was quenched with sat NaHCO3, water (2 *), dried, filtered and concentrated. The residue was purified by flash chromatography eluding with methylene chloride to give the title compound 1.25 g (76% yield) as an oil which crystallized on standing.

118511-81-2, The synthetic route of 118511-81-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Eli Lilly and Company; US5545636; (1996); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24686-78-0,1-Benzoylpiperidin-4-one,as a common compound, the synthetic route is as follows.

Step A Preparation of 1′-benzoyl-spiro[1,3-benzodithiole-2,4′-piperidine] 500 mgs (3.52 mmol) of 1,2-dimercaptobenzene and 610 mgs (3.00 mmol) of N-benzoyl-4-piperidone were stirred in CH2 Cl2 while anhydrous HCl gas was introduced Na2 SO4 (2 grams) was added and the mixture stirred 15 hours. The mixture was diluted with CH2 Cl2 filtered and washed with H2 O, and 10percent NaOH. The organics were dried (Na2 SO4) and concentrated to a solid (yield 740 mgs). ‘H NMR (CDCl3) delta:2.30 (bm, 4H); 3.5-4.0 (bd, 4H); 7.04 (m, 2H); 7.20 (m, 2H); 7.40 (m, 5H).

24686-78-0, As the paragraph descriping shows that 24686-78-0 is playing an increasingly important role.

Reference：
Patent; Merck & Co., Inc.; US5206240; (1993); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.92926-63-1,6-Chloro-1,2-dihydro-2-oxospiro[4H-3,1-benzoxazin-4,4′-piperidine],as a common compound, the synthetic route is as follows.

92926-63-1, Example 520 2-(5-{3-[6-chloro-1,2-dihydro-2-oxo-spiro[4H-3,1-benzoxazin-4,4′-piperidin]-1-yl]-propylidene}-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-7-yl)-propan-2-ol A solution of 6-chloro-1,2-dihydro-2-oxo-spiro[4H-3,1-benzoxazin-4,4′-piperidine] (Made by the procedure of Bock, et al. GB2,355,465, 0.25 g, 0.7 mmol) in isopropanol (5 mL) was treated with 2-[5-(3-Bromo-propylidene)-5,11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-7-yl]-propan-2-ol (0.19 g, 0.50 mmol) and catalytic potassium iodide. The solution was stirred at 80 C. for 5 hr, and evaporated in vacuo. The residue was purified by reverse-phase preparative HPLC to yield 0.029 g (10%) of the title compound, 1H-NMR (CD3OD) delta: 1.50 (3H, s), 2.18 (2H, brs), 2.95-3.2 (6H, m), 5.30 (2H, brs), 6.18 (1H, t), 6.79(1H, m), 6.92 (1H, m), 7.12 (1H, m), 7.38 (2H, m), 7.48 (2H, m), 7.81 (2H, m), 8.31 (1H, m), 8.55 (1H, d). ESI-MS m/z: 546 [M+1].

The synthetic route of 92926-63-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Luly, Jay R.; Nakasato, Yoshisuke; Ohshima, Etsuo; Harriman, Geraldine C.B.; Carson, Kenneth G.; Ghosh, Shomir; Elder, Amy M.; Mattia, Karen M.; US2005/70549; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2905-56-8,1-Benzylpiperidine,as a common compound, the synthetic route is as follows.

In the reaction tube is sequentially added 1n (0.5 mmol, 88 mg), 2a (0.6 mmol, 90 mg), acetonitrile (3 ml), copper bromide (0.05 mmol, 11 mg) and di-tert-butyl peroxide (1 mmol, 183 mul), in air (1 atm) atmosphere at 60 C stirring reaction 24 h. Then add 10 ml saturated salt water quenching reaction, extracted with ethyl acetate (10 ml × 3), combined with the organic phase, dried with anhydrous sodium sulfate. Filtering, turns on lathe does, too separating by silica gel column (petroleum ether/ethyl acetate=5/1) to get the yellow solid product 3n (71 mg, 51%)., 2905-56-8

The synthetic route of 2905-56-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Henan Normal University; Fan Xuesen; Shi Xiaonan; Zhang Xinying; Chen Qian; (19 pag.)CN108516952; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39514-19-7,Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate,as a common compound, the synthetic route is as follows.

Example 35(+/-)-cis-3-Butyl-4-(4-cyclohexyloxy-phenyl)-6-(3-methoxy-1-methyl-piperidin-4-ylmethoxy)-pyridazine dihydrochlorideTo a stirred suspension of 1 -benzyl -3-oxo-pi peri di n e-4-carboxyl i c acid ethyl ester hydrochloride salt (25 g) in EtOAc (500 mL) was added saturated sodium bicarbonate solution (200 mL) and continued stirring for 2 h. The organic layer was separated, dried over Na2S04, filtered and concentrated to provide ethyl 1 -benzyl-3-oxo-pi peri di ne-4-carboxyl ic acid ethyl ester (22.00 g). To a solution of ethyl 1-benzyl-3-oxo-piperidine-4-carboxylic acid ethyl ester (22 g, 84.18 mmol) in EtOAc (75 mL) was added (Boc)20 (20.21 g, 92.59 mmol) followed by 10percent Pd-C (2.4 g) and the resultant reaction mixture was subjected to hydrogenation at 50 psi of hydrogen for 14 h. The catalyst was filtered by passing through a pad of celite, washed the celite pad with EtOAc (200 mL) and the combined filtrate was concentrated. The residue was purified by flash silica gel column chromatography by eluting with 0.5percent ethyl acetate in hexanes to provide ethyl 3-oxo- pi peri di ne- 1 , 4-d i carboxyl i c acid 1-tert-butyl ester 4-ethyl ester (34 g)., 39514-19-7

The synthetic route of 39514-19-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; TRANSTECH PHARMA, INC.; GOHIMUKKULA, Devi, Reddy; JONES, David; QABAJA, Ghassan; ZHU, Jeff, Jiqun; COOPER, Jeremy, T.; BANNER, William, Kenneth; SUNDERMANN, Kurt; BONDLELA, Muralidhar; RAO, Mohan; WANG, Pingzhen; GOWDA, Raju, Bore; ANDREWS, Robert, C.; GUPTA, Suparna; HARI, Anitha; WO2011/103091; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.873779-30-7,tert-Butyl 5-bromo-2-oxospiro[indoline-3,4′-piperidine]-1′-carboxylate,as a common compound, the synthetic route is as follows.

To R8, purchased from ACTIVATE (200 mg, 0.53 mmol) in DMF (4 mL) is added sodium hydride (60% dispersion in mineral oil, 31.5 mg, 0.79 mmol) under cooling to 0 C. and reaction mixture is stirred for further 30 minutes at r.t. Methyl iodide (36 muL, 0.58 mmol) is added and the reaction mixture is stirred for 40 minutes at r.t. The reaction mixture is diluted with water and extracted with ethyl acetate. The organic layer is washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo to provide R9. Yield 98%., 873779-30-7

The synthetic route of 873779-30-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Boehringer Ingelheim International GmbH; VINTONYAK, Viktor; GRAUERT, Matthias; GRUNDL, Marc; PAUTSCH, Alexander; (64 pag.)US2016/75704; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

20691-89-8, 1-Methyl-4-piperidinemethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-[(2, 4-dichloro-5-methoxyphenyl) amino3-6-ethoxy-7-fluoro-3- quinolinecarbonitrile (200 mg, 0.49 mmol), 1-methylpiperidine-4-methanol (1888 mg, 0.98 mmol) (WO 20047212) and sodium hydride (196 mg, 4.6 mmol) in 5 mL of N, N-dimethylformamide was heated at 125C for 3 hours. The reaction mixture was poured into saturated sodium bicarbonate and stirred for 1 hour. The solid was collected by filtration, washed with water and dried in vacuo. The solid was purified by preparative thin layer chromatography, eluting with 15% methanol in dichloromethane. Trituation with diethyl ether provided 67 mg of 4-[(2,4-dichloro-5- methoxyphenyl) amino]-6-ethoxy-7- [ (1-methylpiperidin-4-yl) methoxy] quinoline-3- carbonitrile as a light brown solid, mp 182-186C. MS 513. 0 (M-H)- Analysis for C2gH28CI2N403-1. 4 H20 Calcd : C, 57.76 ; H, 5.74 ; N, 10.36. Found: C, 57.65 ; H, 5.43 ; N, 10.15., 20691-89-8

As the paragraph descriping shows that 20691-89-8 is playing an increasingly important role.

Reference：
Patent; WYETH; WO2005/47259; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

885279-92-5, 1-Boc-1,8-diaza-spiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of C2 and TEA (1.2 eq) in DMF (0.3 M) was added TBTU (1.3 eq). The mixture was and stirred for Ih and tert-butyl l,8-diazaspiro[4.5]decane-l-carboxylate together with TEA (4 eq) was added. The mixture was stirred for 2h and the product was purified by preparative RP-HPLC, using H2O/ACN (0.1% TFA) as eluents. The pooled fraction were concentrated under reduced pressure and the remaining oil was (C3) stirred for 30 min in a mixture of TFA/DCM (1:1). The solvents were removed under reduced pressure and the residue was lyophilized from H2O/ ACN. The title compound was obtained as a slightly orange foam.1U NMR (400 MHz, DMSO-d6) delta: 8.65 (2H, br. s), 8.17-8.10 (IH, m), 7.86 (s, IH), 7.84- 7.75 (m, 2H), 7.52-7.41 (m, 2H), 7.36-7.25 (m, 2H), 5.74 (s, 2H), 4.10-3.99 (m, IH), 3.31-3.07 (m, 5H), 2.00-1.72 (m, 6H), 1.69-1.60 (m, 2H). MS (ES) C24H25FN4O2 requires: 420, found: 421 (M+H)+., 885279-92-5

As the paragraph descriping shows that 885279-92-5 is playing an increasingly important role.

Reference：
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; WO2009/27730; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

10338-57-5, General procedure: o-amino thiophenol (1mmol), aromatic aldehyde (1.1mmol) andwater (10mL) were mixed in 25mL single neck round bottom flask, andto this Ammonium Nickel Sulphate (10 mol %) was added. The reactionmixture was sonicated at room temperature (250C) for the appropriate time(Table 2, entries 13-25), and the progress of reaction was monitored by TLC.After completion of reaction, the mixture was extracted with ethyl acetate(2×10mL). The combined organic layer was dried over anhydrous Na2SO4 andevaporated under reduced pressure; the crude material was purified by columnchromatography over silica gel to afford products 4a-4m with high purity.

As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Pardeshi, Sandeep D.; Sonar, Jayant P.; Pawar, Shivaji S.; Dekhane, Deepak; Gupta, Sunil; Zine, Ashok M.; Thore, Shivaji N.; Journal of the Chilean Chemical Society; vol. 59; 1; (2014); p. 2335 – 2340;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Chalcones analogs were synthesized by Claisen-Schmidt condensation reaction using appropriate equimolar amounts of substituted acetophenones and benzaldehydes in MeOH. NaOH was dissolved in the least amount of water and added dropwise (3mmol) (Scheme 1). Reactions were stirred overnight. All reactions were monitored by TLC using appropriate solvent or mixture of solvents. When the reaction was complete, the obtained precipitate was filtered, washed with cold methanol and dried under vacuum. The crude products were crystallized from different solvent systems based on their solubility or purified by column chromatography to give pure crystalline compounds., 10338-57-5

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Elkhalifa, Dana; Siddique, Abu Bakar; Qusa, Mohammed; Cyprian, Farhan S.; El Sayed, Khalid; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem