Day: March 24, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20691-89-8,1-Methyl-4-piperidinemethanol,as a common compound, the synthetic route is as follows.,20691-89-8

(1-Methyl-piperidin-4-yl)-methanol (2. 5USD g, 20 mmol) and hydroxy-diphenyl-acetic acid methyl ester (9. 69 g, 40 mmol) are suspended in toluene (65 ml). Molecular sieve 4A (1 g) is added and the mixture is stirred at room temperature for 10 minutes. Sodium (0.08 g) is added and the reaction mixture stirred at 80OC for 3 hours. Additional sodium (0.1 g) is then added and heating maintained at 80OC for 18 hours. The reaction mixture is cooled to room temperature, solid filtered off, and washed with ethylacetate. The filtrate is washed once with saturated aqueous NAHCO3 solution (50 ml) and twice with aqueous HCL 1M (25 ml each). The combined acidic aqueous layers are basified with saturated aqueous NAHCO3 solution and solid NAHCO3, the resulting precipitate is removed by filtration, drying under vacuum gives the title product as a white solid (M+H) + : 340.09.

20691-89-8 1-Methyl-4-piperidinemethanol 271971, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/815; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

23499-01-6, 1-(4-Nitrophenyl)piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 40 2.4 g (10.9 mmol) of 1-(4-nitrophenyl)-4-piperidone and 2.0 g (10.9 mmol) of N-methyl-N-(2-(4-nitrophenyl)ethyl)amine were reacted in a similar manner to Example 1. 2.2 g of 1-(4-nitrophenyl)-4-(N-methyl-N-(2-(4-nitrophenyl)ethyl)amino)piperidine were obtained. Melting point 97-98 C., 23499-01-6

23499-01-6 1-(4-Nitrophenyl)piperidin-4-one 3842562, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; BASF Aktiengesellschaft; US5260318; (1993); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

61869-08-7, (3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1.0 g of oily paroxetine free base and 1.24 g of cholic acid were completely dissolved in 10 mL of N,N-dimethylformamide with stirring for 10 minutes. The solution was slowly added dropwise to 100 mL of isopropyl acetate to precipitate a solid, stirred at 0 C. for 3 hours, and filtered. The filtered residue was washed with 30 mL of ethyl ether, and dried under vacuum to yield 1.84 g of solid paroxetine cholate as a light gray powder., 61869-08-7

As the paragraph descriping shows that 61869-08-7 is playing an increasingly important role.

Reference：
Patent; Lee, Sang Joon; Shin, Hee Jong; Ki, Min Hyo; Lee, Su Kyoung; Kim, Bok Young; Lee, Hong Woo; US2006/63747; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

61869-08-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61869-08-7,(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine,as a common compound, the synthetic route is as follows.

1.0 g of oily paroxetine free base and 1.24 g of cholic acid were completely dissolved in 20 mL of methanol while heating to 40 C. with shaking for 2 hours. The solvent was removed under reduced pressure, and then the residue was dried under vacuum, yielding 2.2 g of solid paroxetine cholate as a white powder. ; EXAMPLE 3 1.0 g of oily paroxetine free base and 1.24 g of cholic acid were completely dissolved in 10 mL of methanol while heating to 40 C. with shaking for one hour. The solution was slowly added dropwise to 100 mL of ethyl ether to precipitate a solid, stirred at 0 C. for 3 hours, and filtered. The filtered residue was washed with 30 mL of ethyl ether, and dried under vacuum to yield 1.89 g of solid paroxetine cholate as a light gray powder.

As the paragraph descriping shows that 61869-08-7 is playing an increasingly important role.

Reference：
Patent; Lee, Sang Joon; Shin, Hee Jong; Ki, Min Hyo; Lee, Su Kyoung; Kim, Bok Young; Lee, Hong Woo; US2006/63747; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10315-06-7, Methyl 1-benzylpiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of V-2 A solution of V-l (20 g, 85.72 mmol) in 80 mL of THF (dry) was added dropwise over lh to a solution of LDA (60 mL, 2.0 M, 120 mmol) in 80 mL of THF (dry) at 0C. The resultant mixture was stirred at 0C for 30 min, and then added to a pre-cooled (0C) solution of N- fluorobenzenesulfonimide (28.38 g, 90 mmol) in 120 mL of THF (dry). The resulting reaction mixture was stirred at 0C for 30 min, and then at 25C overnight. After dilution by 400 mL of EtOH, the mixture was washed with water (100 mL x3) and brine (100 mL), dried and concentrated. The crude was purified by silica gel chromatography (PE to PE/DCM=2/1 to DCM to DCM/MeOH=200/l) to afford V-2 (6 g, yield: 28%) as a colorless oil., 10315-06-7

The synthetic route of 10315-06-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SUZHOU SHANGZHI BIOTECH LIMITED; CHENG, Xueheng; WO2014/8629; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

61869-08-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61869-08-7,(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine,as a common compound, the synthetic route is as follows.

1.0 g of oily paroxetine free base and 1.24 g of cholic acid were completely dissolved in a mixed solvent of ethanol (20 mL) and isopropyl acetate (30 mL) while heating to 50 C. with shaking for 2 hours. The solution was allowed to stand at -20 C. for 48 hours, filtered, and dried under vacuum to yield 1.9 g of solid paroxetine cholate as a light gray powder.

The synthetic route of 61869-08-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Lee, Sang Joon; Shin, Hee Jong; Ki, Min Hyo; Lee, Su Kyoung; Kim, Bok Young; Lee, Hong Woo; US2006/63747; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78190-11-1,1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid,as a common compound, the synthetic route is as follows.,78190-11-1

[1247] A solution of Example A (18 g, 62 mmol). in THF (250 mL, 0.25 M) was treated with trichloroacetimidate (28 mL, 155 mmol) and BF3.Et2O (18 mL, 1 mL/g) at ambient temperature. After 18 h the reaction mixture was quenched with solid NaHCO3 followed by water and stirred vigorously. Then the solvent was removed, and partitioned with ethyl acetate (250 mL). The organic layer was separated and washed with brine (3×80 mL), dried (Na2SO4) and evaporated to dryness under reduced pressure to obtain the crude product. The title compound (19.2 g, 96%) was obtained by flash chromatography on silica gel eluting with 20% acetone:hexane. MS (ESI) m/e 320 (M+H)+.

78190-11-1 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid 234339, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Abbott Laboratories; US2004/116518; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20691-89-8,1-Methyl-4-piperidinemethanol,as a common compound, the synthetic route is as follows.

Example 24 1-Methyl-4-(4-nitrophenoxymethyl)piperidine (24): A mixture of 1-chloro-4-nitrobenzene (23) (2.37 g, 15.0 mmol), alcohol 22 (1.94 g, 15.0 mmol), and DMSO (25 mL) was treated portionwise with NaH (60% in mineral oil, 660 mg, 16.5 mmol) at 40 C. The mixture was stirred at 70 C. for 3 h, poured into water (150 mL), and extracted with Et2O (5*100 mL). The combined organic fractions were washed with water (250 mL) and brine (250 mL), dried (MgSO4), and the solvent was removed in vacuo. The resulting solid was recrystallized from Et2O to give 24 (3.12 g, 83%) as yellow needles. 1H NMR (300 MHz, CDCl3): delta=1.36-1.56 (m, 2H, 3-Hax, 5-Hax), 1.75-1.91 (m, 3H, 3-Heq, 4-H, 5-Heq), 1.98 (dt, J=11.9, 1.9 Hz, 2H, 2-Hax, 6-Hax), 2.30 (s, 3H, NMe), 2.85-2.98 (m, 2H, 2-Heq, 6-Heq), 3.90 (d, J=5.8 Hz, 2H, OCH2), 6.94 (mc, 2H, 2′-H, 6′-H), 8.19 (mc, 2H, 3′-H, 5′-H) ppm. -13C NMR (50.3 MHz, CDCl3): delta=28.9 (C-3, C-5), 35.1 (C-4), 46.4 (NMe), 55.3 (C-2, C-6), 73.3 (OCH2), 114.3 (C-2′, C-6′), 125.8 (C-3′, C-5′), 141.3 (C-4′), 164.1 (C-1′) ppm. -MS (70 eV, EI): m/z (%)=250 (79) [M]+, 249 (100) [M-H]+. -C13H18N2O3 (250.29): calcd. C, 62.38; H, 7.25; found C, 62.25; H, 7.40., 20691-89-8

As the paragraph descriping shows that 20691-89-8 is playing an increasingly important role.

Reference：
Patent; Beusker, Patrick Henry; De Groot, Franciscus Marinus Hendrikus; Tietze, Lutz F.; Major, Felix; Joosten, Johannes Albertus Frederikus; Spijker, Henri Johannes; US2009/318668; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

142851-03-4, Ethyl N-Boc-piperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 1-(tert-butyl) 4-ethyl piperidine-1,4-dicarboxylate (5g, 19.4mmol) in EtOH (5OmL) was added hydrazine hydrate (9.7g, 19.4mmol) dropwise. The mixture was refluxed for 16 h. The TLC showed reaction to be complete. The solvent was removed under reduced pressure. The residue was triturated with Et20 (lOOmI) to afford tert-butyl 4-(hydrazinecarbonyl) piperidine- 1 -carboxylate as off white solid. Yield: 4.lg (87%); 1H NMR (400 MHz, DMSO-d6): 8.99 (5, 1H), 3.91 (bs, 6H), 2.67 (bs, 2H), 2.17-2.25 (m, 1H), 1.56-1.61 (m, 2H), 1.44 (5, 9H); MS (ESl+) for CHNOS m/z 244.31 [M+H]., 142851-03-4

142851-03-4 Ethyl N-Boc-piperidine-4-carboxylate 2758812, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; DISCUVA LTD.; MEO, Dr Paul; KHAN, Dr. Nawaz; (284 pag.)WO2018/37223; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.,10338-57-5

A solution of the compound m2 (0.3323 g, 1 mmol) and 4-piperidin-1-yl-benzaldehyde (0.2081 g, 1.1 mmol) was added to a rear wall pressure vessel followed by 2 mL of DMSO, 10 mL of trimethylchlorosilane, C for 48 h. After TLC monitoring reaction, the crude product was purified by silica gel column chromatography (eluent: V (ethyl acetate): V (methanol): V (ammonia) = 10: 1: 0.1) To give a pale yellow solid, 0.4281 g, 85% yield.

The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Sun Yat-Sen University; HUANG, ZHISHU; TAN, JIAHENG; WANG, YUQING; (41 pag.)CN106220631; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem