Day: March 23, 2022

190906-92-4, tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 1-boc-2-methylpiperidin-4-one (0.55 g, 2.6 mmol, 1 eq) in dry DCM(7.5 mL) was cooled at 0C and DAST (0.68 mL, 5.2 mmol, 2 eq) was added dropwise.The reaction was stirred overnight at 10C, then diluted with DCM (10 mL), washed withNaHCO3 sat. solution (lOmL), 5% citric acid solution in water (10 mL) and finally withbrine (10 mL). The organic layer was dried over anh. Na2504, filtered and evaporated.The residue was purified by flash chromatography on silica gel (eluent 10/90 EtOAc/petroleum ether) affording 0.53 g of pure 1-N-boc-4,4-difluoromethylpiperidine as white solid., 190906-92-4

190906-92-4 tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate 12992764, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; AXXAM S.P.A.; PEVARELLO, Paolo; LOHMER, Stefan; LIBERATI, Chiara; SENECI, Pierfausto; PESENTI, Cristina; PRANDI, Adolfo; WO2015/118019; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

85908-96-9, N-Boc-2-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

85908-96-9, Diisopropylamine (1.7 mL, 12.1 mmol) of THF (10 mL)To the solution was added n-butyllithium (6.7 ml, 11.0 mmol) was added dropwise at -78 C., and the mixture was stirred for 30 minutes. Compound 34 (2 g, 10.0 mmol) in THF (10 mL) was added dropwise, and the mixture was stirred for 15 minutes. A solution of N-tert-butylbenzenesulfinimidoyl chloride (2.6 g, 12.1 mmol) in THF (5 mL) was added and the mixture was stirred for 30 minutes. Water was added to the reaction solution, the mixture was extracted with ethyl acetate, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (hexane / ethyl acetate) to give Compound 35 (750 mg, yield: 38%) as an orange solid.

The synthetic route of 85908-96-9 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; THE UNIVERSITY OF TOKYO; TOHOKU UNIVERSITY; SHIONOGI & COMPANY LIMITED; NAGANO, TETSUO; OKABE, TAKAYOSHI; KOJIMA, HIROTATSU; KAWAGUCHI, MITSUYASU; NUREKI, OSAMU; ISHITANI, RYUICHIRO; NISHIMASU, HIROSHI; AOKI, JUNKEN; TANAKA, NOBUYUKI; TATENO, YUSUKE; TAKAHASHI, YU; (85 pag.)JP2016/193887; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

768-66-1,768-66-1, 2,2,6,6-Tetramethylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 1L four-necked round bottom flask equipped with a mechanical stirrer, a reflux, a thermometer, a funnel and a septum are added 80 g of water, 20 g K2CO3 (99%; 1.44·10-1 mol), 20 g 2,2,6,6-tetramethylpiperidine (99%; 1.41·10-1 mol) and 150 g toluene. Then, a solution of 31.3 g of peracetic acid (35 wt %, Aldrich; 1.44·10-1 mol) in 300 g water is slowly added to the 1L flask while stirring vigorously (with a slightly exothermic reaction) and the flask is placed in a water bath at room temperature. After the addition, the reaction medium is stirred at room temperature overnight, and the organic phase becomes progressively red due to the formation of 2,2,6,6-tetramethylpiperidine-1-oxide (TEMPO). [0108] Then, the stirring is terminated and the water phase is removed from the reaction flask. The red organic phase is then degassed by bubbling argon for 10 minutes. 11.82 g azobisisobutyronitrile (AIBN, 7.2·10-2 mol) are then slowly added by small portions under an argon atmosphere and while stirring vigorously. Then, 100 g of degassed toluene is added rapidly to the reaction flask and the temperature is increased to 60 C. After 24 h at 60 C., the solution is cooled at room temperature. Finally, this organic solution is washed 3 times with water (pH=3) and then, dried with Na2SO4. After drying under vacuum at 50 C., 17.95 g of crude alkoxyamine 1 is collected.

The synthetic route of 768-66-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Detrembleur, Christophe; Grob, Thomas; Meyer, Rolf-Volker; US2004/2606; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141774-61-0,tert-Butyl (piperidin-2-ylmethyl)carbamate,as a common compound, the synthetic route is as follows.

A solution of 4-nitrophenyl(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)carbamate (2.08 g), tert-butyl (piperidin-2-ylmethyl)carbamate (1.19 g) and TEA (2.20 mL) in N,N-dimethylacetamide (25.0 mL) was stirred at room temperature for 2 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (2.17 g). 1H NMR (300 MHz, CDCl3) delta 1.36-1.54 (11H, m), 1.63-1.83 (4H, m), 2.70 (1H, t, J = 12.5 Hz), 3.12-3.28 (1H, m), 3.29-3.43 (1H, m), 4.03-4.22 (1H, m), 4.35 (1H, d, J = 12.5 Hz), 5.01 (1H, brs), 7.77 (2H, d, J = 8.7 Hz), 7.95-8.07 (2H, m), 8.56 (1H, brs) .

141774-61-0, The synthetic route of 141774-61-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Takeda Pharmaceutical Company Limited; KAIEDA, Akira; ISHII, Naoki; NARA, Hiroshi; YOSHIKAWA, Masato; DAINI, Masaki; (63 pag.)EP3342772; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.,768-66-1

2,3-Dichloro-4-iodo-pyridine (I-1) To a solution of n-BuLi (27.6 mL, 69 mmol, 2.5 M in hexanes) in dry Et2O (150 mL) cooled at -78 C., under a nitrogen atmosphere, was added 2,2,6,6-tetramethylpiperidine (11.64 mL, 69 mmol) dropwise. The resulting r.m. was stirred at -78 C. for 10 min, and then a solution of 2,3-dichloropyridine (10 g, 67.57 mmol) in dry THF (75 mL) was added dropwise. The mixture was stirred at -78 C. for 30 min and then a solution of iodine (25.38 g, 100 mmol) in dry THF (75 mL) was added. The mixture was allowed to warm to r.t. overnight, quenched with Na2S2O3 (aq sat. sol.) and extracted twice with EtOAc. The combined organic extracts were washed with NaHCO3 (aq. sat. sol.), dried (Na2SO4) and concentrated in vacuo. The crude residue was precipitated with heptane, filtered off and dried to yield intermediate I-1 (8.21 g, 44%) as a pale cream solid.

768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Janssen Pharmaceuticals, Inc.; Andres-Gil, Jose Ignacio; Alcazar-Vaca, Manuel Jesus; Cid-Nunez, Jose Maria; Trabanco-Suarez, Andres Avelino; Bormans, Guy Maurits R.; Celen, Sofie Jeanne Leopoldine; Koole, Michel; US2013/230459; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

236406-22-7, 1-Boc-4-(Aminomethyl)-4-methylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a homogeneous mixture of tert-butyl 4-(aminomethyl)-4-methylpiperidine- 1- carboxylate (53.0 mg, 0.23 mmol) in anhydrous DCM (2 mL), under nitrogenatmosphere, was added DIPEA (0.17 mL, 0.97 mmol) followed by 4-chlorobenzoyl chloride (0.05 mL, 0.390 mmol). The resulting mixture was stirred at ambient temperature for 4 hours, before being partitioned between DCM and water. The layers were separated and the aqueous layer was extracted twice more with DCM. These organic extracts were combined with the original organic layer and were concentrated invacuo to afford the title compound as an amber residue, which was used in the next step without purification. MS(ES): m/z = 367 [M+H]. tR = 1.00 mm (Method A)., 236406-22-7

236406-22-7 1-Boc-4-(Aminomethyl)-4-methylpiperidine 23282898, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; FLEXUS BIOSCIENCES, INC.; BECK, Hilary Plake; JAEN, Juan Carlos; OSIPOV, Maksim; POWERS, Jay Patrick; REILLY, Maureen Kay; SHUNATONA, Hunter Paul; WALKER, James Ross; ZIBINSKY, Mikhail; BALOG, James Aaron; WILLIAMS, David K.; MARKWALDER, Jay A.; SEITZ, Steven P.; CHERNEY, Emily Charlotte; ZHANG, Liping; SHAN, Weifang; GUO, Weiwei; HUANG, Audris; (231 pag.)WO2016/73774; (2016); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: To a stirred solution of [5] (2.0g, 10.47mmol), vinyl acetate (10.0ml, lOO.Ommol) was added at room temperature. After an additional stirring for 5 minutes at same temperature, PS-IM (0.20g, 10%) was added. The reaction temperature was allowed to increase up to 40C and stirring was continued for 16 h. Reaction mixture was passed through the bed of celite and evaporated to dryness which was further purified using silica gel column chromatography using 10% ethyl acetate/hexane as eluent to afford [6](0.9g, 45%)and [7] (0.8g, 40%) as transparent sticky material. Analytical Data: [6] ESIMS: 192 [M++1][7]ESIMS: 234 [M++l]., 14813-01-5

The synthetic route of 14813-01-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SPHAERA PHARMA PVT. LTD.; DRUG DISCOVERY RESEARCH CENTRE; DUGAR, Sundeep; MAHAJAN, Dinesh; RAI, Santosh Kumar; RAO, Kanury; SINGH, Varshneya; WO2015/181837; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

236406-22-7, 1-Boc-4-(Aminomethyl)-4-methylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Compound 26 (2.0 g, 8.8 mmol) and triethylamine (5.0 mL, 3.6 g, 36 mmol) in CH2Cl2 at 0 C. was added TFAA (1.5 mL, 2.2 g, 11 mmol). The reaction mixture was allowed to warm to rt, and was stirred for 18 h. The reaction mixture was diluted with CH2Cl2 and washed successively with 1 N HCl, water, 1 M aq NaHCO3, and brine. The organic layer was dried over Na2SO4 and filtered. Removal of the solvent gave 2.8 g (100%) of Compound 27.

236406-22-7, 236406-22-7 1-Boc-4-(Aminomethyl)-4-methylpiperidine 23282898, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Schering Corporation; US2004/10013; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Potassium hydroxide (3.6 g, 64 mmol) and sodium hydroxide (2.4 g, 60 mmol) weremixed and quickly crushed in a porcelain dish. Then the corresponding aldehyde(15 mmol) was added and the mixture was heated on a hot-plate under stirring until thealdehyde melted and additionally 5 minutes. When liquid aldehydes were used, heatingwas continued until temperature reached 140C. After cooling, the crude solid productmixture was added to water (100 mL) and ice (30 g) and acidified with hydrochloric acidto pH 4. The precipitate was collected, dried and recrystallized from ethanol.

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Pietrzak, Marek; J?drzejewska, Beata; M?drzejewska, Dorota; Bajorek, Agnieszka; Organic Preparations and Procedures International; vol. 49; 1; (2017); p. 45 – 52;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,14813-01-5

1000ml three necked flask, N-benzyl-3-hydroxypiperidine (95.6 g, 0.5 mol), 2-Butanone (478 ml) was added dropwise a solution of L-CSA (58 g, 0.25 mol) in 290 ml of 2-butanone at room temperature Stirring for 1 hour, precipitation of solid appeared, 0 heat 2 hours, filtration, 2-butanone 30ml washing,Dried to obtain 88 g of (S) -1-benzyl-3-hydroxypiperidine camphorsulfonate. (Ee: 93%) (theory: 105.9 g).

14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ABA Chemicals Corporation; Lin, ZhiGang; Xu, Jun; Liu, YanQin; Que, limin; Jiang, yueheng; CAI, Tong; (13 pag.)CN103864673; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem