Day: March 22, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189333-49-1,3-Benzyl-3,9-diazaspiro[5.5]undecane,as a common compound, the synthetic route is as follows.

Triethylamine (5.80 g, 57.29 mmol, 7.94 mL) and 4-dimethylaminopyridine (174.97 mg, 1.43 mmol) were slowly added into compound I2-A (3.50 g, 14.32 mmol) and Boc-anhydride (4.69 g, 21.48 mmol, 4.94 mL) in THF solution (40.00 mL) at r.t., the reaction mixture was stirred at 40C for 12 hours, then heated to 55C and stirred for 18 hours. The crude compound was concentrated up to dryness, purified by silica gel column (PE/EtOAc =6:1, 4:1) to give the compound I2-B. MS m/z: 345.5 [M+H]+

189333-49-1, The synthetic route of 189333-49-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Shijiazhuang Sagacity New Drug Development Co., Ltd.; QIAN, Wenyuan; YANG, Chundao; LI, Zhengwei; LI, Jie; LI, Jian; CHEN, Shuhui; (137 pag.)EP3572413; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118511-81-2,1-(Piperidin-4-yl)-1H-indole,as a common compound, the synthetic route is as follows.

PREPARATION 19 [t-Butoxycarbonylimino-(4-indol-1-yl-piperidin-1-yl)-methyl]-carbamic acid t-butyl ester This material was prepared by the known procedure. Tetrahedron Letters 1993, 34(48), 7677. To an ice cooled solution of 1-piperidin-4-yl-1H-indole (0.6 g, 3 mmol), N,N-bis-t-butoxycarbonylthiourea (0.83 g, 3 mmol) and triethylamine (1.38 g, 9.9 mmol) in dry DMF (5 mL was carefully added copper(II) chloride dihydrate (exothermic) (0.56 g, 3.3 mmol). After stirring for 30 minutes at ambient temperature, the mixture was diluted with ethyl acetate and filtered over Hyflo. The filtrate was washed twice each with brine and water, dried, evaporated. The residue was purified by column chromatography on silica gel eluding with toluene/acetone 95:5. 0.61 g of yellow crystals (46% of theory). H.Pt.: 115-118 C.

118511-81-2, As the paragraph descriping shows that 118511-81-2 is playing an increasingly important role.

Reference：
Patent; Eli Lilly and Company; US5545636; (1996); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

10338-57-5, 4-(Piperidin-1-yl)benzaldehyde is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: In a round bottom flask equipped with a magnetic stir bar, reflux condenser and a Soxhlet condenser filled with molecular sieves, DHA (4, 0.168 g, 1 mmol), 1 mmol of appropriate amino benzaldehyde 3a-e and catalytic amount of piperidine (8.5 mg, 0.1 mmol) were refluxed in dry toluene for 24 h. After complete reaction, toluene was removed under reduced pressure and residue was dissolved in CH2Cl2 and washed with water. Combined organic layer was dried over the anhydrous Na2SO4, and the solvent was removed in atmospheric pressure. Obtained crude solid was purified by recrystallization from EtOH.

10338-57-5, As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.

Reference：
Article; Teimuri-Mofrad, Reza; Rahimpour, Keshvar; Gholizadeh, Mohammad; Journal of the Iranian Chemical Society; vol. 17; 5; (2020); p. 1103 – 1109;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

63921-23-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63921-23-3,1-Phenylpiperidin-4-amine,as a common compound, the synthetic route is as follows.

Example 21 (397mg, lmmol), 1-phenylpiperidin-4-ylamine (176mg, Immol) and silver acetate (167mg, lmmol) in acetonitrile (20ml) were heated at reflux overnight. The reaction mixture was evaporated, purified by column chromatography on silica using 2-10% methanol in dichloromethane as the eluant, followed by mass triggered HPLC purification using an acid based eluant. The free base was liberated using a strong cation exchange cartridge to give the desired compound (40mg). 1H NMR 8 (ppm) 400MHz (CDC13), 1.45-1. 52 (2 H, m), 2.00-2. 13 (4 H, m), 2.32- 2.52 (5 H, m), 2.74-2. 80 (2 H, m), 3.25-3. 31 (2 H, m), 3.37-3. 46 (1 H, m), 3.55-3. 76 (4 H, m), 6.82-6. 93 (5 H, m), 7.14 (1 H, dd, J = 4.7, 7.4Hz), 7.23-7. 27 (2 H, m), 7.48 – 7. 52 (3 H, m), 8.37 (1 H, d, J = 4.3Hz). MSp m/z for MH+ =540.

63921-23-3 1-Phenylpiperidin-4-amine 21193347, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; MERCK SHARP & DOHME LIMITED; WO2005/51390; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.914988-10-6,tert-Butyl 3-cyano-4-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

914988-10-6, [0280] Step a: N,N-diisopropylethylamine (6 mL, 34.5 mmol) was added to a mixture of (2,6- dimethylphenyl)hydrazine hydrochloride (5 g, 28.9 mmol), tert-butyl 3-cyano-4-oxopiperidine- 1-carboxylate (5 g, 22.3 mmol) and EtOH (60 mL) in a 250 mL round bottom flask under magnetic stirring. The resulting mixture was stirred under reflux for 3 h. Glacial acetic acid (6 mL, 104 mmol) was added and the mixture was stirred under reflux for another 2 h. After removal of solvent under reduced pressure, the residue was dissolved in EtOAc and washed with aqueous NaOH (2N), brine and dried over MgSO4. The solvent was removed under reduced pressure and the residue was purified by silica gel flash chromatography (5 to 55% EtOAc in hexanes) to give tert-butyl 3-amino-2-(2,6-dimethylphenyl)-6,7-dihydro-2H-pyrazolo[4,3- c]pyridine-5(4H)-carboxylate . MS: (ES) m/z calculated for C19H27N4O2 [M + H]+ 343.2, found 343.2. Caution: Diazonium formation could be potentially dangerous, please handle with care and ware proper personal protection equipment.

As the paragraph descriping shows that 914988-10-6 is playing an increasingly important role.

Reference：
Patent; CHEMOCENTRYX, INC.; FAN, Pingchen; LANGE, Christopher W.; LUI, Rebecca M.; MALATHONG, Viengkham; MALI, Venkat Reddy; PUNNA, Sreenivas; SINGH, Rajinder; TANAKA, Hiroko; ZENG, Yibin; ZHANG, Penglie; (284 pag.)WO2018/222598; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

62718-31-4,62718-31-4, 1-Benzylpiperidine-4-carbonitrile is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step a: To a solution of N,N-diisopropylamine (14.0 mL, 97.5 mmol) in THF (100 mL) was added (at -78 C. and under N2) n-butyllithium (1.6 M in hexane; 59.0 mL, 94.25 mmol) dropwise. The resulting mixture was stirred for 30 min at RT. 1-benzyl piperidine-4-carbonitrile (6.5 g, 32.5 mmol) in THF (50 mL) was added at -78 C. After stirring for 30 min at this temperature, n-propyl iodide (20.5 mL, 211.3 mmol) was added. The resulting mixture was stirred at -78 C. for 1 h. The mixture was quenched by addition of saturated aqueous ammonium chloride solution and it was extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2SO4, filtered and concentrated to obtain 1-benzyl-4-propylpiperidine-4-carbonitrile (6.0 g, 24.8 mmol). This compound was used without further purification. MS m/z 243 (M+H)+.

As the paragraph descriping shows that 62718-31-4 is playing an increasingly important role.

Reference：
Patent; NOVARTIS AG; Chen, Christine Hiu-Tung; Chen, Zhuoliang; Fortanet, Jorge Garcia; Grunenfelder, Denise; Karki, Rajesh; Kato, Mitsunori; LaMarche, Matthew J.; Perez, Lawrence Blas; Stams, Travis Matthew; Williams, Sarah; (42 pag.)US2017/204080; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-benzyl-3-piperidinol (1.90 g, 9.93 mmol) was dissolved in THF: MeOH 1: 1, with 20% Pd/C (0.5 g) and subjected to 50 psi of hydrogen gas for 16 hours. The crude product was then filtered through celite and then concentrated in vacuo. The crude product was determined to be pure (0.985 g, 98%) BY LHNMR (400 MHz, CDC13) : 8 1.36 – 1. 56 (m, 2H), 1.68-1. 81 (m, 2H), 2.60-2. 76 (m, 3 H), 2.92 (dd, 1H, J=2.7, 11.9 Hz), 3.67 (sept, 1H, J=3.3 Hz)., 14813-01-5

As the paragraph descriping shows that 14813-01-5 is playing an increasingly important role.

Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/26145; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1169563-99-8, tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of tert-butyl 4-(5-amino-lH-pyrazol-3-yl)piperidine-l-carboxylate (300 mg, 1.126 ramol), 2-bromo-5-cyclopropylpyridine (234mg, 1.183mmol), copper(I) iodide (21.45mg, 0.1 13mmol), (lS,2S)-NN2-dime ylcyclohexane-l,2-diamine (16.02 mg, 0.113 mmol), and cesium carbonate (734mg, 2.253 mmol), DMSO (3 rnL), was purged with N2 for 30 min. The mixture was heated to 130 C in a sealed tube for 15 h. The mixture was cooled to rt. and water (30 mL) was added. The mixture was extracted with EtOAc (3 x 30 mL). The combined organic extracts were dried (MgS04) and concentrated in vacuo. The residue was purified by silica gel chromatography, eiuting with a solvent gradient of 0 to 40 % EtOAc in hexanes to give the product as a white solid. 1H NMR (400 MHz, CDC13) delta 8.03 (m, 1H), 7.74 (m, 1H), 7.32 (m, 1H), 5.88 (bs, 2H), 5.26 (s, 1H), 4.10 (m, 2H), 2.79 (m, 2H), 2.67 (m, 1H), 1.88-1.79 (ra, 3H), 1.61-1.54 (m, 2H), 1.42 (s, 9H), 1.20(t, J- 7.2 Hz, 1H), 0.94 (m, 2H), 0.63 (m, 2H)., 1169563-99-8

As the paragraph descriping shows that 1169563-99-8 is playing an increasingly important role.

Reference：
Patent; MERCK SHARP & DOHME CORP.; MCELROY, William, T.; LI, Guoqing; HO, Ginny Dai; TAN, Zheng; PALIWAL, Sunil; SEGANISH, William Michael; TULSHIAN, Deen; LAMPE, John; METHOT, Joey, L.; ZHOU, Hua; ALTMAN, Michael, D.; ZHU, Liang; WO2012/129258; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To solution of 4-((3-hydroxypiperidin-1-yl)methyl)benzohydrazide(9, 0.5 g, 2 mmol) in ethanol with catalytic amount of HClwas added the corresponding aldehyde (10, 2.4 mmol). The mixturewas stirred for 3 h at room temperature. Removal of the solventproduced a residue, which was purified using chromatographycolumn with the appropriate eluents systems.

10338-57-5, The synthetic route of 10338-57-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; Dias Viegas, Flavia Pereira; de Freitas Silva, Matheus; Divino da Rocha, Miguel; Castelli, Maisa Rosa; Riquiel, Mariana Maximo; Machado, Rafael Pereira; Vaz, Sarah Macedo; Simoes de Lima, Lais Medeiros; Mancini, Karla Cristine; Marques de Oliveira, Patricia Cruz; Morais, Elida Parreira; Gontijo, Vanessa Silva; da Silva, Fernanda Motta R.; D’Alincourt da Fonseca Pecanha, Dora; Castro, Newton Goncalves; Neves, Gilda A.; Giusti-Paiva, Alexandre; Vilela, Fabiana Cardoso; Orlandi, Lidiane; Camps, Ihosvany; Veloso, Marcia Paranho; Leomil Coelho, Luis Felipe; Ionta, Marisa; Ferreira-Silva, Guilherme Alvaro; Pereira, Rodrigo Machado; Dardenne, Laurent E.; Guedes, Isabella Alvim; de Oliveira Carneiro Junior, Wellerson; Quaglio Bellozi, Paula Maria; Pinheiro de Oliveira, Antonio Carlos; Ferreira, Fabio Furlan; Pruccoli, Letizia; Tarozzi, Andrea; Viegas, Claudio; European Journal of Medicinal Chemistry; vol. 147; (2018); p. 48 – 65;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

21168-72-9, 2-(4-(Aminomethyl)piperidin-1-yl)ethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 2-(4-Aminomethyl-piperidin-l-yl)-ethanol (0.5 mmol) in tetrahydrofuran (2 mL) at room temperature are added cyclohexylmethylaldehyde (0.6 mmol)) and anhydrous magnesium sulfate (60 mg). After stirring for 1.5h at room temperature, sodium borohydride (0.5 mmol) is added and the mixture is then stirred for a further 2h. Water (3 mL) is added to the mixture and stirring resumed for 10 min. Additional water is added (1 mL) and the mixture is extracted with dichloromethane (10 mL x 3). After being dried over anhydrous magnesium sulfate the solvent is removed under reduced pressure to give the crude product. This material is used in subsequent steps without requiring further purification. [00349] The amine obtained in the previous step (0.26mmol) is added to a solution of 5-chloro-l- methyl-3-tert-Butyl-l,6-dihydro-pyrazolo[4,3-d]pyrimidin-7-one (0.13mmol) in t- BuOH (0.5 mL). The reaction is heated in a sealed tube to 1000C for 24h. On complete reaction (monitored by LCMS), the mixture is allowed to cool to room temperature and the solvent is removed under reduced pressure. The final compound is then isolated by preparative HPLC.[00350] Preparative HPLC: Waters XBridge Prep C18 5mum ODB 19mm ID x 100mm L. The method uses MeCN/H2O 35-60% gradients. H2O contains 0.1% Trifluoroacetic acid (TFA).., 21168-72-9

As the paragraph descriping shows that 21168-72-9 is playing an increasingly important role.

Reference：
Patent; Galapagos NV; WO2009/71707; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem