Day: March 16, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.769944-79-8,4-(4-Bromophenyl)piperidine hydrochloride,as a common compound, the synthetic route is as follows.

The tert-butyl 4-[4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl]piperidine-l- carboxylate used as a reagent for this reaction was prepared as follows:Di-tert-butyl dicarbonate (0.914 ml) was added in one portion to 4-(4- bromophenyl)piperidine hydrochloride (1.00 g) and triethylamine (1.260 ml) in DCM (34 ml) at ambient temperature. The resulting solution was stirred for 70 minutes. The reaction mixture was evaporated and washed with isohexane. The filtrate was evaporated and there was thus obtained tert-butyl 4-(4-bromophenyl)piperidine-l-carboxylate (1.191 g); Mass Spectrum: (M-tBu)+H+ 281.28; RT 2.33 min; NMR Spectrum: (DMSOd6) 7.53 (2H, d), 7.27 (2H, d), 4.12 (2H, d), 2.75 – 2.96 (2H, m), 2.68 – 2.79 (IH, m), 1.79 (2H, d), 1.47 (9H, s), 1.44 – 1.58 (2H, m).

769944-79-8, The synthetic route of 769944-79-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASTRAZENECA AB; WO2009/7390; (2009); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

61995-20-8, Benzyl 3-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,61995-20-8

(3) To a solution of 83.7 g of 1-benzyloxycarbonyl-3-piperidone dissolved in 1.2 liters of methylene chloride was added 55.0 g of (R)-(+)-1-(1-naphthyl)ethylamine, and after the mixture was stirred at room temperature for 2 hours, 69 ml of acetic acid and 160 g of sodium triacetoxy borohydride were added to the mixture, and the mixture was stirred at room temperature for 15 hours. To the reaction mixture was added an aqueous sodium hydroxide to make the mixture basic, and then, chloroform was added to the mixture, the mixture was stirred and the liquids were separated. The organic layer was dried and concentrated, and the residue was purified by silica gel column chromatography (hexane: ethyl acetate=4:1?0:1) to obtain 98.7 g of benzyl 3-[(R)-1-(naphthalen-1-yl)ethylamino]-piperidine-1-carboxylate. MS·APCI (m/z): 389 [M+H]+

As the paragraph descriping shows that 61995-20-8 is playing an increasingly important role.

Reference：
Patent; TANABE SEIYAKU CO., LTD.; EP1757582; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

53617-36-0,53617-36-0, 1-Methyl-4-(piperidin-4-yl)piperazine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 72; 4-methoxy-N,2,6-trimethyl-N-[2-[2-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-2-oxoethoxy]ethyl]benzenesulphonamide; A suspension is prepared of 350 mg (1.06 mM) of acid obtained according to preparation III in 3 ml of DCM and 243 mg (1.27 mM) of EDCI (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and 173 mg (1.27 mM) of HOAT, are added. The mixture is agitated for 30 min at ambient temperature, and 232 mg (1.27 mM) of 1-methyl-4-(4-piperidinyl)piperazine are then added. The reaction mixture is agitated for 18 hours at ambient temperature and is then poured over 10 ml of water and extracted with DCM. The organic phase is washed with water, dried and concentrated under reduced pressure. The residue is purified by silica gel chromatography in eluting with the aid of a DCM/methanol mixture (90/10; v/v). 449 mg of the product sought after are thus obtained as a yellow oil (yield=86percent). 1H NMR (300 MHz, CD3CN) delta: 6.74 (s, 2H); 4.35 (d, 1H); 4.01 (q, 2H); 3.81 (s, 3H); 3.69 (d, 1H); 3.56 (t, 2H); 3.26 (t, 2H); 2.89 (t, 1H); 2.75 (s, 3H); 2.58 (s, 6H); 2.40 (m, 10H); 2.17 (s, 3H); 1.75 (m, 2H); 1.27 (m, 2H).

53617-36-0 1-Methyl-4-(piperidin-4-yl)piperazine 795707, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Laboratoires Fournier S.A.; US2006/178360; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

138022-04-5, tert-Butyl methyl(piperidin-4-ylmethyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of tert-butyl N-methyl-N-(4-piperidylmethyl)carbamate (3.00 g, 13.1 mmol, CAS138200-04-5) in a mixed solvent of CHCl3 (25 mL) and ACN (25 mL) was added K2CO3 (3.63 g, 26.2 mmol) and but-3-ynyl methanesulfonate (2.53 g, 17.0 mmol, Intermediate SG). The mixture was stirred at 70 C. for 16 hours. On completion, the reaction mixture was filtered and concentrated in vacuo to give a residue. The residue was purified by column chromatography (SiO2, PE/EA=6/1) to give the title compound (2.30 g, 62% yield) as light yellow oil. 1H NMR (400 MHz, CDCl3) delta 3.09 (d, J=6.8 Hz, 2H), 2.97-2.97 (m, 2H), 2.84 (s, 3H), 2.59 (t, J=8.0 Hz, 2H), 2.45-2.32 (m, 2H), 2.04-1.93 (m, 3H), 1.65-1.55 (m, 3H), 1.45 (s, 9H), 1.30-1.20 (m, 2H)., 138022-04-5

138022-04-5 tert-Butyl methyl(piperidin-4-ylmethyl)carbamate 23004743, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19099-93-5,1-Cbz-Piperidin-4-one,as a common compound, the synthetic route is as follows.

A mixtureof benzyl-4-oxopiperidine-1-carboxylate (11. 7 g, 50 mmol),potassium cyanide (4.87 g, 75 mmol) and ammonium carbonate (24 g, 250 mmol) in ethanol (100 ml), was placed in a stainless steel bomb and heated at 110C overnight. The reaction mixture was poured into ice-water(300 ml)and the resulting mixture was filtered. The pH of the mixturein water (100 ml)was adjusted to 2 by addition of anaqueous hydrochloric acid solution (6.0 M). The mixture was filtered and the filter cake was recrystallized15 from methanol: diethyl ether= 1:1 to afford benzyl-2,4-dioxo-1, 3,8-triazaspiro[4.5]decane-8-carboxylate as a white solid (10.0 g, 66%). LCMS (ESI): m/z = 304.1 [M+H(1 H-NMR (300 MHz, DMSO-d6):6 = 1.43-1.56 (m, 2H), 1.63-1.85(m, 2H), 2.45-2.60 (m, 2H), 3.33 (s, 2H), 3.88 (dd, J = 9.7, 4.0 Hz, 2H), 5.09 (s, 2H), 7.20-7.53 (m, 5H), 8.54 (s, 1H), 10.66 (s,1H). 20

19099-93-5, As the paragraph descriping shows that 19099-93-5 is playing an increasingly important role.

Reference：
Patent; X-RX DISCOVERY, INC.; BABISS, Lee; CLARK, Matthew; KEEFE, Anthony, D.; MULVIHILL, Mark, J.; NI, Haihong; RENZETTI, Louis; RUEBSAM, Frank; WANG, Ce; XIE, Zhifeng; ZHANG, Ying; WO2015/154023; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62718-31-4,1-Benzylpiperidine-4-carbonitrile,as a common compound, the synthetic route is as follows.,62718-31-4

Step a: To a solution of N^V-diisopropylamine (14.0 mL, 97.5 mmol) in THF (100 mL) was added (at -78 C and under N2) -butyllithium (1.6 M in hexane; 59.0 mL, 94.25 mmol) dropwise. The resulting mixture was stirred for 30 min at RT. 1-benzyl piperidine-4- carbonitrile (6.5 g, 32.5 mmol) in THF (50 mL) was added at -78 C. After stirring for 30 min at this temperature, -propyl iodide (20.5 mL, 211.3 mmol) was added. The resulting mixture was stirred at -78 C for 1 h. The mixture was quenched by addition of saturated aqueous ammonium chloride solution and it was extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2S04, filtered and concentrated to obtain 1 -benzyl -4-propylpiperidine-4- carbonitrile (6.0 g, 24.8 mmol). This compound was used without further purification. MS m/z 243 (M+H)+.

As the paragraph descriping shows that 62718-31-4 is playing an increasingly important role.

Reference：
Patent; NOVARTIS AG; CHEN, Zhuoliang; DORE, Michael; FORTANET, Jorge Garcia; KARKI, Rajesh; KATO, Mitsunori; LAMARCHE, Matthew J.; PEREZ, Lawrence Blas; WILLIAMS, Sarah; SENDZIK, Martin; WO2015/107494; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24686-78-0, 1-Benzoylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1′-Benzoyl-3,4-dihydro-6-methoxy-spiro[(2H)-1-benzopyran-2,4′-piperidine]-4-one Pyrrolidine (8.35 ml, 7.11 g, 0.1 mol) was added to a suspension of 2′-hydroxy-5′-methoxyacetophenone (16.62 g, 0.1 mol) in methanol (100 ml). The mixture was stirred for 10 minutes, then 1-benzoyl-4-piperidone (20.32 g, 0.1 mol) was added and the mixture was heated under reflux for 7 hr. The mixture was cooled and the solvent was evaporated under reduced pressure. Water (400 ml) was added and the mixture was extracted with ethyl acetate (3*400 ml). The combined organic fractions were evaporated under reduced pressure and the residue was recrystallized from methanol to give the ketone as a pale yellow solid (29.54 g, 84percent). 1 H NMR (CDCl3): delta7.41 (5H, s), 7.30 (1H, d, J=3.1 Hz), 7.12 (1H, dd, J=9.0, 3.1 Hz), 6.94 (1H, d, J=9.0 Hz), 4.5 (1H, br s), 3.8 (3H, s), 3.7-3.2 (3H, m), 2.73 (2H, s), 2.3-1.5 (4H, m)., 24686-78-0

As the paragraph descriping shows that 24686-78-0 is playing an increasingly important role.

Reference：
Patent; Merck & Co., Inc.; US5206240; (1993); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

180307-56-6, tert-Butyl 4-vinylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,180307-56-6

Step B: tert-Butyl 4-[(E)-2-(4-Fluoro-l-oxo-13-dihydro-2-benzofuran-5-yl)ethenyllpiperidine- 1-carboxylate To a flask added 5-bromo-4-fluoro-2-benzofuran-l (3H)-one (0.10 g, 0.43 mmol) palladium(II)acetate (0.097 g, 0.043 mmol), triethylamine (0.12 mL, 0.88 mmol) and tert-butyl 4-ethyenylpiperidine-l-carboxylate (0.27 g, 1.2 mmol); the resulting mixture was then dissolved in DMF (15 mL) and heated in an oil bath at 130 C for 2 h. The flask was cooled to room temperature, diluted with EtOAc and washed with saturated sodium bicarbonate and water, then dried (Na2SC>4), filtered and adsorbed into silica gel. MPLC (hexanes/EtOAc = 1/1) purification provided tert-butyl 4-[(E)-2-(4-fluoro- 1 -oxo- 1 ,3-dihydro-2-benzofuran-5-yl)ethenyl]piperidine- 1-carboxylate. LC/MS: [(M+2)]+ =233.

180307-56-6 tert-Butyl 4-vinylpiperidine-1-carboxylate 10910832, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; WO2013/39802; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

301225-58-1, tert-Butyl 4-(propylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A 4-(N-((4-Nitrobenzyl)oxycarbonyl)-N-(prop-1-yl)amino)-piperidine trifluoroacetate The title compound was prepared by the reaction of 4-(N-(prop-1-yl)amino)-1-tert-butoxycarbonylpiperidine (from Example 17, Step A) with (4-nitrobenzyl)chloroformate, followed by treatment of the product with 50% TFA in CH2Cl2 to remove the tert-butoxycarbonyl group, affording the title compound. ESI-MS: 322.2 (M+H).

301225-58-1, As the paragraph descriping shows that 301225-58-1 is playing an increasingly important role.

Reference：
Patent; Merck & Co., Inc.; US6399619; (2002); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23499-01-6,1-(4-Nitrophenyl)piperidin-4-one,as a common compound, the synthetic route is as follows.

EXAMPLE 224 1-(4-Amino-phenyl)-piperidin-4-one hydrochloride A mixture of 1-(4-nitro-phenyl)-piperidin-4-one (Synthesis 1981, 606) (4.0 g, 18 mmol) and 500 mg of 10% Pd/C in 75 mL of methylene chloride was hydrogenated under H2 (5~10 psi) for 1 hour. The catalyst was then removed by filtering through a short pad of silica gel. The filtrate was treated with hydrogen chloride gas and the precipitate was collected to give 2 g of the title compound as a tan solid; 1H NMR (300 MHz, DMSO-d6) delta 2.44 (t, J=6.0 Hz, 4H), 3.65 (t, J=6.0 Hz, 4H), 7.14 (d, J=9.0 Hz, 2H), 7.25 (d, J=9.0 Hz, 2H); MS (ES) m/z: 190.9 (MH+); HRMS Calcd. for C11H15N2O (MH+): 190.1106. Found: 190.1096., 23499-01-6

23499-01-6 1-(4-Nitrophenyl)piperidin-4-one 3842562, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Hu, Baihua; Sum, Fuk-Wah; Malamas, Michael S; US2002/28835; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem