Month: February 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78190-11-1,1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid,as a common compound, the synthetic route is as follows.,78190-11-1

A mixture of piperidine-1,3-dicarboxylic acid 1-benzyl ester (3.0 g, 11.4 mmol), triethylamine (4.62 g, 45.6 mmol), and 1-propanphosphonic acid anhydride (3.63 g, 11.4 mol, 6.80 mL of a 50% w/w solution in ethyl acetate) and 2 aminoacetophenone hydrochloride (1.96 g, 11.4 mmol) in THF (55 mL) was stirred at rt for 16 h. The mixture was then concentrated, and the residue was dissolved in CH2Cl2. The solution was washed with 1 M NaOH, dried through cotton, and concentrated. Silica gel chromatography eluding with 1:2 hexanes/ethyl acetate gave the title compound as a pale yellow solid.

As the paragraph descriping shows that 78190-11-1 is playing an increasingly important role.

Reference：
Patent; Pfizer Inc; US2006/19975; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1180112-41-7,tert-Butyl 1,7-diazaspiro[3.5]nonane-7-carboxylate,as a common compound, the synthetic route is as follows.

A suspension of tert-butyl 1,7-diazaspiro[3.5]nonane-7-carboxylate (0.5 g, 2.21 mmol) and 10% palladium on carbon (0.235 g, 0.221 mmol) in EtOH/MeCN (2:1, 5 mL) was prepared and stirred at RT under 2 atmospheres H2for 22 h. The reaction mixture was filtered through Celite, washing with MeOH (50 mL). The filtrate was concentrated in vacuo and the resulting residue was purified by chromatography on silica gel (12 g column, 0-15% (0.7 M Ammonia/MeOH)/DCM) to afford tert-butyl 1-ethyl-1,7- diazaspiro[3.5]nonane-7-carboxylate. This was dissolved in TFA/DCM (1:1, 10 mL) and stirred at RT for 90 min. The reaction was concentrated in vacuo and the resulting residue was loaded onto a column of SCX (10 g) in MeOH. The column was washed with MeOH and the product was eluted with 7 M ammonia in MeOH. The ammoniacal solution was concentrated in vacuo to afford the title compound (0.242 g, 70%) as a yellow oil.1H NMR (DMSO-d6) d 3.01 (t, J = 7.0 Hz, 2H), 2.85 – 2.75 (m, 2H), 2.42 – 2.32 (m, 4H), 1.76 (t, J = 7.0 Hz, 2H), 1.65 – 1.57 (m, 2H), 1.41 (td, J = 12.4, 4.4 Hz, 2H), 0.84 (t, J = 7.2 Hz, 3H). One exchangeable proton not observed.

1180112-41-7, The synthetic route of 1180112-41-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; INFLAZOME LIMITED; MILLER, David; MACLEOD, Angus; THOM, Stephen; MCPHERSON, Christopher G.; ALANINE, Thomas; CARRILLO ARREGUI, Jokin; CIANA, Claire-Lise; SHANNON, Jonathan; VAN WILTENBURG, Jimmy; DEN HARTOG, Jacobus Antonius Joseph; (603 pag.)WO2019/211463; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118511-81-2,1-(Piperidin-4-yl)-1H-indole,as a common compound, the synthetic route is as follows.

PREPARATION 3 1-(1-Ethyl-piperidin-4-yl)-1H-indole To a solution of 1-piperidin-4-yl-1H-indole (0.6 g, 3 mmol) in 5 mL of dry ethanol was added anhydrous potassium carbonate (680 mg, 4.9 mmol). After stirring for 15 minutes at ambient temperature, ethyl p-toluenesulfonate (0.48 mL,4.5 mmol) was added. The reaction was heated under reflux for 24 hours with stirring, quenched with water, extracted with methylene chloride (2*), dried and evaporated to give a residue. The residue was chromatographed on silica gel with toluene/acetone (50:50) to yield 360 mg straw colored material (53% of theory).

118511-81-2, The synthetic route of 118511-81-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Eli Lilly and Company; US5545636; (1996); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

24666-55-5, Benzyl (2,6-dioxopiperidin-3-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-N-benzyloxycarbonylamino-2,6-dioxopiperidine 40 g (0.153 mol) was sequentially added to the hydrogenation vessel.10percent Pd/C 4g, methanol 2L, 2mol/L hydrochloric acid 1.5L, a certain H2 pressure, kept at 25 ° C for 5 h, filtered after pressure relief, the filtrate was evaporated to dryness, and then 500 ml of methanol was added.After stirring for 0.5 h, it was filtered to give a white solid.The yield was 90.5percent., 24666-55-5

24666-55-5 Benzyl (2,6-dioxopiperidin-3-yl)carbamate 2735493, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Shijiazhuang Duen Pharmaceutical Technology Co., Ltd.; Fang Yu; Du Yumin; (8 pag.)CN109776493; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

534595-51-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.534595-51-2,1-Boc-4-(isopropylamino)piperidine,as a common compound, the synthetic route is as follows.

To a 0 C. solution of tert-butyl 4-(isopropylamino)piperidine-1-carboxylate (1.2 g, 5.19 mmol) in CH2Cl2 (18 mL) was added Et3N (1.44 mL, 10.38 mmol) followed by acetyl chloride (0.55 mL, 7.78 mmol). The resulting solution was stirred for 2.5 hours, then concentrated in vacuo. The material was purified by flash chromatography on silica gel, eluting with 0% to 5% of EtOAc/CH2Cl2, to afford tert-butyl 4-(N-isopropylacetamido)piperidine-1-carboxylate (0.88 g, 59%).

The synthetic route of 534595-51-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Resverlogix Corp.; Hansen, Henrik C.; (96 pag.)US9238640; (2016); B2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

109384-19-2, tert-Butyl 4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of ieri-butyl 4-hydroxypiperidine-1-carboxylate (10.9 g, 49.7 mmol, 1 .0 eq) in EtOAc (40 mL) was added a saturated solution of HCI in EtOAc (10 mL), and the resulting mixture was stirred at room temperature overnight. The mixture was concentrated to give the title compound (7.0 g) as a white solid

109384-19-2, As the paragraph descriping shows that 109384-19-2 is playing an increasingly important role.

Reference：
Patent; CTXT PTY LTD; BERGMAN, Ylva Elisabet; FOITZIK, Richard Charles; MORROW, Benjamin Joseph; CAMERINO, Michelle Ang; WALKER, Scott Raymond; LAGIAKOS, H. Rachel; FEUTRILL, John; STEVENSON, Graeme Irvine; STUPPLE, Paul Anthony; (222 pag.)WO2016/34673; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1062580-52-2, (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

100 gm of 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine and 205 gm of (3R,4R)-l-benzyl-N-4- dim ethyl piperidin-3-amine dihydrochloride, 216 gm of Potassium carbonate was dissolved in water and raise the temperature of about 90.0C. After the end of the reaction, extract the product into Toluene and filter off. Distill off the solvent completely under vacuum and isolated the product in Isopropyl alcohol. Filtered the material and dried to get 145 gm of N-((3R,4R)-l-benzyl-4-methylpiperidin-3-yl)-N- methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine., 1062580-52-2

The synthetic route of 1062580-52-2 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; PHALANX LABS PRIVATE LIMITED; AVIRNENI, Sri Ramakrishna; (26 pag.)WO2018/172821; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.851956-01-9,(S)-Piperidine-3-carboxylic acid hydrochloride,as a common compound, the synthetic route is as follows.

851956-01-9, A suspension of sodium borohydride (7.6 g; 200 mmol) and (S)-NPA hydrochloride(16.6 g; 100 mmol, from EXAMPLE 2) in THF (100 mL) was heated for 2 h at 700C, tillthe gas evolution ceased. The temperature was lowered to 50C and a solution of concentrated sulfuric acid (10.0 g; 100 mmol) in 40 mL of THFwas added during 30 mm. The suspension was heated to 70C for 1 h, then cooled to room temperature and carefully poured onto 20 g of cracked ice and 20 g of concentrated hydrochloric acid.The mixture was stirred overnight, basified with sodium hydroxide (40% solution in water) to pH >12, filtered and extracted three times with iso-butanol/toluene (9:11; 50 mL). Concentration under reduced pressured yielded (S)-PPM as a solid (47% yield), which had a chemical purity of 96% and an optical purity of 99.64 : 0.36.

As the paragraph descriping shows that 851956-01-9 is playing an increasingly important role.

Reference：
Patent; REUTER CHEMISCHE APPARATEBAU KG; REUTER, Karl; WEDEL, Tobias; ANDRUSHKO, Vasyl; WIEGAND, Christian; STOLZ, Florian; WO2014/173855; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3612-20-2, 1-Benzylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of 1 -benzyl-N-phenylpiperidin-4-amine (Compound 7-2) [00238j To a solution of aniline (Compound 7-1, 3.72 g, 40 mmol) indichloromethane (50 mL), was added 1-benzylpiperidin-4-one (7.94 g, 42 mmol) and acetic acid (240 mg, 4 mmol). After stirred at room temperature for 2 h, sodium triacetoxyborohydride (12.72 g, 60 mmol) was added. The reaction mixture was stirred for another 1 h, then diluted with water (50 mL), neutralized to pH 7 with sodium bicarbonate, extracted with dichloromethane (100 ml x 2). The combined organic layer was washed with brine (100 ml x 2), dried over anhydrous sodium sulfate and concentrated to give 1-benzyl-N-phenylpiperidin-4-amine (Compound 7-2, 9.49 g, yield: 89%) as a white solid. MS (ES): mlz: 267[M+H]., 3612-20-2

As the paragraph descriping shows that 3612-20-2 is playing an increasingly important role.

Reference：
Patent; FANG, Qun, Kevin; SPEAR, Kerry, L.; CAMPBELL, Una; WO2014/106238; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1104083-27-3,tert-Butyl 3-hydroxy-3-methylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of tert-butyl 3-hydroxy-3-methylpiperidine-1-carboxylate (0.3 g, 1.39 mmol) in MeOH (5 mL) was added 4.0 M HC1 in Dioxane (1.73 mL) at 0 C. The reaction mixture was stirred at room temperature for 4 h. After completion, volatiles were removed under reduced pressure to afford 0.15 g of 3 -methylpiperidin-3 -ol hydrochloride (Yield = 71%)., 1104083-27-3

The synthetic route of 1104083-27-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; DORDEVIC, Luka; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (425 pag.)WO2016/100940; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem