Month: February 2022

Recommanded Product: 177-11-7. Zhang, YJ; Su, JY; Niu, WJ; Li, YJ in [Zhang, YongJian; Su, Junyi; Niu, Wenjie; Li, Yujin] Zhejiang Univ Technol, Dept Chem & Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310032, Zhejiang, Peoples R China published Iodine-promoted Intermolecular Dehydrogenation Diamination: Synthesis of Unsymmetrical ,-Diamido Ketones in 2019, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Iodine-promoted direct diamination of ,-unsaturated ketone to form two C-N bonds has been developed starting from chalcone and secondary amine. This reaction was performed in THF at 50 degrees C in the presence of I-2 and K2CO3. The protocol is metal-free, operationally simple and carried out under mild conditions, providing an effective new way for directing diamination reactions.

Recommanded Product: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Zhang, YJ; Su, JY; Niu, WJ; Li, YJ or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive WOS:000565355500001 published article about COUPLING REACTIONS; ARYL CHLORIDES; PHOTOREDOX; AMINES; PRECATALYST; AMMONIA in [Han, Dongyang; Li, Sasa; Jin, Jian] Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Synthet Chem Nat Subst, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Xia, Siqi; Su, Mincong] Shanghai Univ, Ctr Supramol Chem & Catalysis, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China in 2020, Cited 65. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple Ni(II)salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the correspondingN-arylation product in an excellent yield.

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Han, DY; Li, SS; Xia, SQ; Su, MC; Jin, J or send Email.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Amide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility WOS:000651790900005 published article about BIOLOGICAL EVALUATION; MMPL3; INHIBITION in [Tan, Yu Jia; Gunawan, Gregory Adrian; Lam, Yulin] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore; [Li, Ming; Nyantakyi, Samuel Agyei; Go, Mei-Lin] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore; [Dick, Thomas] Hackensack Meridian Hlth, Ctr Discovery & Innovat, Hackensack Meridian Sch Med, Nutley, NJ 07110 USA; [Dick, Thomas] Georgetown Univ, Dept Microbiol & Immunol, Washington, DC 20057 USA in 2021, Cited 19. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. SDS of cas: 177-11-7

Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility. Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (33, MIC90Mtb , 0.13 mu M, MBC99.9Mtb, 0.63 mu M), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent. It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.

SDS of cas: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Tan, YJ; Li, M; Gunawan, GA; Nyantakyi, SA; Dick, T; Go, ML; Lam, YL or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Product Details of 177-11-7. Recently I am researching about COUPLING REACTIONS; ACTIVATED ALKENES; N-ARYLACRYLAMIDES; PHOTOREDOX; RADICALS; NITROGEN; OLEFINS; BOND; AMINATION; FUNCTIONALIZATION, Saw an article supported by the National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [NSF 21871115]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Wang, YZ; Lin, WJ; Zou, JY; Yu, W; Liu, XY. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The cascade amination/cyclization ofN-arylacrylamides with alkyl amines under visible-light photoredox catalysis is realized via intermediacy of aminium radicals. The aminium radicals are generated by a two-step sequence which involves N-chlorination of alkyl amines and subsequent reductive N-Cl cleavage. This method provides a convenient access to aminated oxindoles.

Product Details of 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Wang, YZ; Lin, WJ; Zou, JY; Yu, W; Liu, XY or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Decarboxylative ipso Amination of Activated Benzoic Acids WOS:000455033700042 published article about TRANSITION-METAL-FREE; C-H AMINATION; NUCLEOPHILIC-SUBSTITUTION; REDUCTIVE ELIMINATION; CATALYZED AMINATION; COUPLING REACTIONS; CARBOXYLIC-ACIDS; CROSS-COUPLINGS; DIRECTING-GROUP; ARYL CHLORIDES in [Drapeau, Martin Pichette; Bahri, Janet; Lichte, Dominik; Goossen, Lukas J.] Ruhr Univ Bochum, Fak Chem & Biochem, ZEMOS, Univ Str 150, D-44801 Bochum, Germany in 2019, Cited 80. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C-C, C-Cl, and C-N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.

Welcome to talk about 177-11-7, If you have any questions, you can contact Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ or send Email.. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recommanded Product: 177-11-7. Zhang, YJ; Su, JY; Niu, WJ; Li, YJ in [Zhang, YongJian; Su, Junyi; Niu, Wenjie; Li, Yujin] Zhejiang Univ Technol, Dept Chem & Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310032, Zhejiang, Peoples R China published Iodine-promoted Intermolecular Dehydrogenation Diamination: Synthesis of Unsymmetrical ,-Diamido Ketones in 2019, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Iodine-promoted direct diamination of ,-unsaturated ketone to form two C-N bonds has been developed starting from chalcone and secondary amine. This reaction was performed in THF at 50 degrees C in the presence of I-2 and K2CO3. The protocol is metal-free, operationally simple and carried out under mild conditions, providing an effective new way for directing diamination reactions.

Recommanded Product: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Zhang, YJ; Su, JY; Niu, WJ; Li, YJ or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2020 ORG LETT published article about C-H FUNCTIONALIZATION; PHOTOCATALYTIC OXIDATION; REGIOSELECTIVE AMINATION; IMIDYL RADICALS; IODINE; ELECTROSYNTHESIS; GENERATION; AMIDATION; CHEMISTRY; ARENES in [Lei, Ning; Shen, Yanling; Li, Yujun; Tao, Pan; Yang, Liquan; Su, Zhishan; Zheng, Ke] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China in 2020, Cited 72. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

An environmentally friendly electrochemical approach for iodoamination of various indole derivatives with a series of unactivated amines, amino acid derivatives, and benzotriazoles (more than 80 examples) has been developed. This strategy was further applied in late-stage functionalization of natural products and pharmaceuticals and gram-scale synthesis and radiosynthesis of I-13(1)-labeled compounds. Fundamental insights into the mechanism of the reaction based on control experiments, density functional theory calculation, and cyclic voltammetry are provided.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Lei, N; Shen, YL; Li, YJ; Tao, P; Yang, LQ; Su, ZS; Zheng, K or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about TRANSFORMATIONS; PHOTOCONVERSION; PHOTOCHEMISTRY; REACTIVITY; PHOTOLYSIS, Saw an article supported by the . Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Ma, XS; Han, YX; Bennett, DJ. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Compared to the abundance of methodologies accessing 1-substituted and 1,3-disubstuted bicyclo[1.1.1] pentanes (BCPs), the synthetic accessibility of BCPs with substitutions at the methylene position has been limited. Herein, we report a selective synthesis of 1-dialkylamino-2-alkylbicyclo[1.1.1]pentanes from prefunctionalized starting materials. We also achieved further functionalizations of these 1,2-disubstituted BCPs and developed a synthesis of these compounds with minimum necessity of chromatographic purifications starting from 1,3-dichloroacetone. Finally, we also detailed the synthesis of a 1,2,3-trisubstituted BCP analogue.

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Ma, XS; Han, YX; Bennett, DJ or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Authors De Angelis, L; Crawford, AM; Su, YL; Wherritt, D; Arman, H; Doyle, MP in AMER CHEMICAL SOC published article about in [De Angelis, Luca; Crawford, Alexandra M.; Su, Yong-Liang; Wherritt, Daniel; Arman, Hadi; Doyle, Michael P.] Univ Texas San Antonio, Dept Chem, San Antonio, TX 78249 USA in 2021, Cited 23. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The formation of nitrile oxides with diazocarbonyl compounds by nitrosyl transfer from tert-butyl nitrite under mild conditions and without the use of a catalyst or an additive is reported. This transformation is broadly applicable to the synthesis of furoxans by dimerization and isoxazoles and isoxazolines by cycloaddition. This methodology is also applied for the millimole-scale synthesis of two biologically active compounds. The formation of the nitrile oxide from a diazoacetamide is stable and confirmed experimentally.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 J ORG CHEM published article about C-H FUNCTIONALIZATION; ELECTROPHILIC AMINATION; MULTICOMPONENT REACTIONS; INSERTION REACTION; FACILE ACCESS; OXIMES; CYCLOADDITION; ISONITRILES; CYCLIZATION; ARYL in [Yang, Zhen; Jiang, Kun; Chen, Ying-Chun; Wei, Ye] Army Med Univ, Coll Pharm, Chongqing 400038, Peoples R China; [Wei, Ye] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China in 2019, Cited 57. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A copper-catalyzed protocol has been realized for the rapid assembly of dihydroquinolinones from readily accessible isocyanides and O-benzoyl hydroxylamines. The reactions (10 mol % of CuOAc, 10 mol % of dppe, 3 equiv of PhONa, 30 degrees C) deliver various structurally interesting dihydroquinolinones in moderate to good yields (up to 76%). The reactions may proceed in a cascade manner involving isocyanide insertion into the N-O bond, Mumm-type rearrangement, and intramolecular nucleophilic substitution.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem