Day: February 10, 2022

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about AGONIST SALVINORIN; PROLACTIN; DYNORPHIN; LY2456302; DOPAMINE; STRESS; 2-METHYL-N-((2′-(PYRROLIDIN-1-YLSULFONYL)BIPHENYL-4-YL)METHYL)PROPAN-1-AMINE; EXPRESSION; DISCOVERY; BINDING, Saw an article supported by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Neurological Disorders & Stroke (NINDS); BlackThorn Therapeutics; Blueprint Neurotherapeutics Network (BPN) of the NIH Blueprint for Neuroscience Research [1UH2 NS093030-01]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Guerrero, M; Urbano, M; Kim, EK; Gamo, AM; Riley, S; Abgaryan, L; Leaf, N; Van Orden, LJ; Brown, SJ; Xie, JY; Porreca, F; Cameron, MD; Rosen, H; Roberts, E. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

kappa opioid receptor (KOR) antagonists are potential pharmacotherapies for the treatment of migraine and stress-related mood disorders including depression, anxiety, and drug abuse, thus the development of novel KOR antagonists with an improved potency/selectivity profile and medication-like duration of action has attracted the interest of the medicinal chemistry community. In this paper, we describe the discovery of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2 H-pyran-4-yl)piperidin-4 amine (CYM-53093, BTRX-335140) as a potent and selective KOR antagonist, endowed with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments. Orally administered CYM-53093 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice. CYM-53093 exhibited a broad selectivity over a panel of off-target proteins. This compound is in phase 1 clinical trials for the treatment of neuropsychiatric disorders wherein dynorphin is thought to contribute to the underlying pathophysiology.

Welcome to talk about 177-11-7, If you have any questions, you can contact Guerrero, M; Urbano, M; Kim, EK; Gamo, AM; Riley, S; Abgaryan, L; Leaf, N; Van Orden, LJ; Brown, SJ; Xie, JY; Porreca, F; Cameron, MD; Rosen, H; Roberts, E or send Email.. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Product Details of 177-11-7. I found the field of Chemistry very interesting. Saw the article Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines published in 2019, Reprint Addresses Hull, KL (corresponding author), Univ Illinois, Dept Chem, 600 S Mathews, Urbana, IL 61801 USA.; Schultz, DM (corresponding author), Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA.; Hull, KL (corresponding author), Univ Texas Austin, 105 E 24th St, Austin, TX 78712 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T in [Alvarez, Eva Maria; Plutschack, Matthew B.; Berger, Florian; Ritter, Tobias] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany published Site-Selective C-H Functionalization-Sulfination Sequence to Access Aryl Sulfonamides in 2020, Cited 33. Computed Properties of C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C-H sulfination sequence via aryl sulfonium salts to access aryl sulfonamides. Combined with site-selective aromatic thianthrenation, an operationally simple one-pot palladium-catalyzed protocol introduces the sulfonyl group using sodium hydroxymethylsulfinate (Rongalite) as a source of SO22-. The hydroxymethyl sulfone intermediate generated from the catalytic process can be employed as a synthetic handle to deliver a variety of sulfonyl-containing compounds.

Computed Properties of C7H13NO2. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Direct Catalytic Reductive N-Alkylation of Amines with Carboxylic Acids: Chemoselective Enannine Formation and further Functionalizations WOS:000480503700099 published article about TERTIARY AMIDES; HYDROGENATION; DERIVATIVES; AMINATION; NITRILES; HYDROSILANES; METHYLATION; AMIDATION; CHEMISTRY; MECHANISM in [Trillo, Paz; Adolfsson, Hans] Umea Univ, Dept Chem, KBC3,Linnaeus Vag 10, SE-90187 Umea, Sweden in 2019, Cited 66. COA of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Direct reductive N-alkylation of secondary amines with carboxylic acids using molybdenum hexacarbonyl (5 mol %) as catalyst and diethoxymethylsilane as reducing agent generate enamines in a straightforward fashion in high yields. The formed enamines are without the need for isolation or purification further reacted with trimethylsilyl cyanide in the same reaction flask to yield alpha-amino nitriles in good yields. In the optimized reaction conditions equimolar amounts of carboxylic acid and amine are reacted under neat conditions, and a catalytic amount of trifluoroethanol (0.1 mol %) is added along with TMSCN for the cyanation step. The reductive N-alkylation reaction is demonstrated to be highly chemoselective, tolerating a multitude of different functional groups present in the starting carboxylic acids and amines. The reaction is scalable and the generated alpha-amino nitriles are converted to other useful compounds, e.g., alpha-amino acids or amino-tetrazoles. In addition, the intermediate enamines are further transformed into triazolines, sulfonylformamidines, pyrimidinediones, and TMS-propargylamines, respectively, in high yields under mild reaction conditions. Benzoic acids react with secondary amines under similar conditions to give tertiary amines in high yields, and using this methodology, the biologically active compound Piribedil was isolated in 80% yield in a direct one-pot reaction setup.

COA of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Trillo, P; Adolfsson, H or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Asmafiliz, N; Berberoglu, I; Ozgur, M; Kilic, Z; Kayalak, H; Acik, L; Turk, M; Hokelek, T in [Asmafiliz, Nuran; Berberoglu, Ipek; Ozgur, Mehtap; Kilic, Zeynel] Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey; [Kayalak, Hande; Acik, Leyla] Gazi Univ, Dept Biol, TR-06500 Ankara, Turkey; [Turk, Mustafa] Kirikkale Univ, Dept Bioengn, TR-71450 Kirikkale, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, TR-06800 Ankara, Turkey published Phosphorus-nitrogen compounds: Part 46. The reactions of N3P3Cl6 with bidentate and monodentate ligands: The syntheses, structural characterizations, antimicrobial and cytotoxic activities, and DNA interactions of (N/N)spirocyclotriphosphazenes with 4-chlorobenzyl pendant arm in 2019, Cited 59. Recommanded Product: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

In the present study, the partly and fully-substituted monospiro (4-6, 4a-6d), cis-dispiro (7-9), trans-dispiro (10-15) cyclotriphosphazenes were synthesized for the investigations of their chemical, stereogenic and biological properties. The cis/trans phosphazenes (7-12) have two stereogenic P centers. They are expected to be in meso and racemic forms. In addition, the structures of four compounds were evaluated using X-ray crystal-lographic data. Compound 13 was found to be a single enantiomer (RR) in the solid state, as also proved with its CD spectrum. The antibacterial and antifungal activities of the phosphazenes were elucidated for against Gram-positive (G+) and Gram-negative (G-) bacteria, and yeast strains, respectively. Of the compounds, 14 exhibits strong antimicrobial activity against most of the tested organisms, especially B. cereus and E. hirae. MBC and MFC values of compounds on different bacterial and fungal species ranged from < 9.8 mu M to 2500 mu M. Furthermore, the cytotoxic activities of 6, 4c, 10 and 14 were investigated against L929 fibroblast and DLD-1 cells, and 14 was the most cytotoxic compound against DLD-1. Welcome to talk about 177-11-7, If you have any questions, you can contact Asmafiliz, N; Berberoglu, I; Ozgur, M; Kilic, Z; Kayalak, H; Acik, L; Turk, M; Hokelek, T or send Email.. Recommanded Product: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem