Month: January 2022

An article Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia WOS:000481437100010 published article about NF-KAPPA-B; WATER-SOLUBLE PARTHENOLIDE; SESQUITERPENE LACTONE; IN-VITRO; AMINO-DERIVATIVES; BIOLOGICAL EVALUATION; ANTICANCER AGENTS; CRYSTAL-STRUCTURE; CANCER CELLS; FEVERFEW in [Li, Xingjian; Payne, Daniel T.; Dutton, Mark J.; Quy, Alex S.; Fossey, John S.] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England; [Ampolu, Badarinath; Bland, Nicholas; Brown, Jane T.; Hamza, Daniel; Jones, Geraint; Lane, Rebecca; Merisor, Elena G.; Schulz-Utermoehl, Timothy; Stevenson, Brett] BioCity, Sygnat Discovery, Discovery Bldg,Pennyfoot St, Nottingham NG1 1GR, England; [Fitton, Catherine A.; Scarll, Rosanna; Stankovic, Tatjana; Agathanggelou, Angelo] Univ Birmingham, Inst Canc & Genom Sci, Birmingham B15 2TT, W Midlands, England; [Gulliver, Abigail; Hale, Lee] Univ Birmingham, Winterbourne Bot Garden, 58 Edgbaston Pk Rd, Birmingham B15 2RT, W Midlands, England; [Leach, Andrew G.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Byrom St, Liverpool L3 3AF, Merseyside, England; [Male, Louise] Univ Birmingham, Sch Chem, Xray Crystallog Facil, Birmingham B15 2TT, W Midlands, England; [Morton, Michael J.; Roberts, Ruth] ApconiX Ltd, Alderly Pk, Nether Alderly SK10 4TG, Cheshire, England; [Roberts, Ruth] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England in 2019, Cited 143. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 177-11-7

Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good bioavailability and pharmacological properties was identified through a screening cascade based on in vitro anti-leukaemic activity and calculated drug-likeness properties, in vitro and in vivo pharmacokinetics studies and hERG liability testing. In vitro studies showed the most promising derivative to have comparable anti-leukaemic activity to DMAPT, a previously described parthenolide derivative. The newly identified compound was shown to have pro-oxidant activity and in silico molecular docking studies indicate a prodrug mode of action. A synthesis scheme is presented for the production of amine 7 used in the generation of 5f.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Li, Y; Ali, A; Dong, JC; Zhang, Y; Shi, LL; Liu, Q; Fu, JK in [Li, Yang; Ali, Arshad; Dong, Junchao; Zhang, Yu; Liu, Qun; Fu, Junkai] Northeast Normal Univ, Dept Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Peoples R China; [Shi, Lili; Fu, Junkai] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China; [Shi, Lili; Fu, Junkai] Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, Shenzhen 518055, Peoples R China published Copper-Catalyzed Diamination of Unactivated Alkenes With Electron-Rich Amino Sources in 2021, Cited 65. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The catalytic intermolecular diamination of unactivated alkenes with electron-rich amino sources is a challenge. Herein, by employing a directing-group strategy, a copper-catalyzed diamination of unactivated alkenes was realized. Symmetrical diamines were efficiently produced in a highly diastereoselective manner with readily available dialkylamines as amino sources, while a one-pot and two-step operation was necessary to produce the unsymmetrical diamines. These reactions were proposed to proceed through aziridinium intermediates.

Welcome to talk about 177-11-7, If you have any questions, you can contact Li, Y; Ali, A; Dong, JC; Zhang, Y; Shi, LL; Liu, Q; Fu, JK or send Email.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Computed Properties of C7H13NO2. In 2020 J ORG CHEM published article about SUBSTITUTED ARYL IODIDES; ARYLATIVE DEAROMATIZATION; FLUORESCENT-PROBE; ACCESS; LEVOFLOXACIN; BOND; PD; CYCLIZATION; AMINATION; AGENTS in [Zhang, Zhe; Zhang, Bo-Sheng; An, Yang; Liu, Ce; Gou, Xue-Ya; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Li, Kai-Li] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Peoples R China in 2020, Cited 103. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

This report describes a palladium-catalyzed dearomatization and amination tandem reaction of 2,3-disubstituted indoles and benzofurans via the Catellani strategy. This reaction provides a new method for the construction of amino-substituted indoline-fused cyclic and benzofuran spiro compounds in good yields. The reaction has broad functional group compatibility and substrate scope.

Computed Properties of C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Zhang, Z; Zhang, BS; Li, KL; An, Y; Liu, C; Gou, XY; Liang, YM or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

COA of Formula: C7H13NO2. In 2020 ORG LETT published article about PALLADIUM-CATALYZED SYNTHESIS; SULFUR-DIOXIDE SURROGATE; ONE-POT; SULFONYL FLUORIDES; BORONIC ACIDS; DABSO; BORYLATION; RONGALITE; REAGENTS; HALIDES in [Alvarez, Eva Maria; Plutschack, Matthew B.; Berger, Florian; Ritter, Tobias] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany in 2020, Cited 33. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C-H sulfination sequence via aryl sulfonium salts to access aryl sulfonamides. Combined with site-selective aromatic thianthrenation, an operationally simple one-pot palladium-catalyzed protocol introduces the sulfonyl group using sodium hydroxymethylsulfinate (Rongalite) as a source of SO22-. The hydroxymethyl sulfone intermediate generated from the catalytic process can be employed as a synthetic handle to deliver a variety of sulfonyl-containing compounds.

Welcome to talk about 177-11-7, If you have any questions, you can contact Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T or send Email.. COA of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Nosova, EV; Batanova, OA; Lipunova, GN; Kotovskaya, SK; Slepukhin, PA; Kravchenko, MA; Charushin, VN in ELSEVIER SCIENCE SA published article about BENZOTHIAZINONE DERIVATIVES; TUBERCULOSIS; IDENTIFICATION in [Nosova, Emiliya V.; Batanova, Olga A.; Kotovskaya, Svetlana K.; Slepukhin, Pavel A.; Charushin, Valery N.] Ural Fed Univ, Dept Organ & Biomol Chem, 19 Mira st, Ekaterinburg 620002, Russia; [Nosova, Emiliya V.; Lipunova, Galina N.; Kotovskaya, Svetlana K.; Slepukhin, Pavel A.; Charushin, Valery N.] Russian Acad Sci, Postovsky Inst Organ Synth, Ural Branch, 22 S Kovalevskaya St,20 Akad Skaya St, Ekaterinburg 620137, Russia; [Kravchenko, Marionella A.] Ural Res Inst Phthisiopulmonol, 50 22 Partsezda St, Ekaterinburg 620039, Russia in 2019, Cited 22. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Novel fluorinated 2-substituted 1,3-benzothiazin-4-ones were obtained through the addition of N-nucleophiles to ortho-fluorobenzoylisothiocyanates, followed by cyclization of fluorobenzoyl-thioureas. Synthetic approaches to original 2-cycloalkylimino- and 2-carbonylpiperazino- substituted benzothiazinones, bearing different number of fluorine atoms in the benzene ring have been found. 2-Ethoxycarbonylpiperazino-5-fluoro-1,3-benzothiazin-4-one proved to exhibit a high tuberculostatic activity in vitro (MIC 0.7 microgram/mL), thus indicating that a search of biologically active compounds in this family of heterocycles appears to be a reasonable approach.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive WOS:000565355500001 published article about COUPLING REACTIONS; ARYL CHLORIDES; PHOTOREDOX; AMINES; PRECATALYST; AMMONIA in [Han, Dongyang; Li, Sasa; Jin, Jian] Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Synthet Chem Nat Subst, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Xia, Siqi; Su, Mincong] Shanghai Univ, Ctr Supramol Chem & Catalysis, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China in 2020, Cited 65. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple Ni(II)salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the correspondingN-arylation product in an excellent yield.

Welcome to talk about 177-11-7, If you have any questions, you can contact Han, DY; Li, SS; Xia, SQ; Su, MC; Jin, J or send Email.. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Vanable, EP; Kennemur, JL; Joyce, LA; Ruck, RT; Schultz, DM; Hull, KL in [Vanable, Evan P.; Kennemur, Jennifer L.; Hull, Kami L.] Univ Illinois, Dept Chem, 600 S Mathews, Urbana, IL 61801 USA; [Joyce, Leo A.; Ruck, Rebecca T.; Schultz, Danielle M.] Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA; [Kennemur, Jennifer L.] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany; [Hull, Kami L.] Univ Texas Austin, 105 E 24th St, Austin, TX 78712 USA published Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines in 2019, Cited 36. Category: piperidines. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.

Category: piperidines. Welcome to talk about 177-11-7, If you have any questions, you can contact Vanable, EP; Kennemur, JL; Joyce, LA; Ruck, RT; Schultz, DM; Hull, KL or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Flood, DT; Asai, S; Zhang, XJ; Wang, J; Yoon, L; Adams, ZC; Dillingham, BC; Sanchez, BB; Vantourout, JC; Flanagan, ME; Piotrowsld, DW; Richardson, P; Green, SA; Shenvi, RA; Chen, JS; Baran, PS; Dawson, PE in [Flood, Dillon T.; Asai, Shota; Zhang, Xuejing; Wang, Jie; Yoon, Leonard; Adams, Zoe C.; Dillingham, Blythe C.; Vantourout, Julien C.; Green, Samantha A.; Shenvi, Ryan A.; Baran, Phil S.; Dawson, Philip E.] Scripps Res, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [Zhang, Xuejing] Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Drug Synth & Pharmaceut Proc, Guangzhou 510006, Guangdong, Peoples R China; [Flanagan, Mark E.; Piotrowsld, David W.] Pfizer Med Chem, Eastern Point Rd, Groton, CT 06340 USA; [Richardson, Paul] Pfizer Med Chem, 10578 Sci Ctr Dr, San Diego, CA 92121 USA; [Sanchez, Brittany B.; Chen, Jason S.] Scripps Res, Automated Synth Facil, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA published Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support in 2019, Cited 46. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although DEL provides access to libraries of unprecedented size and diversity, the idiosyncratic and hydrophilic nature of the DNA tag severely limits the scope of applicable chemistries. It is known that biomacromolecules can be reversibly, noncovalently adsorbed and eluted from solid supports, and this phenomenon has been utilized to perform synthetic modification of biomolecules in a strategy we have described as reversible adsorption to solid support (RASS). Herein, we present the adaptation of RASS for a DEL setting, which allows reactions to be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities to DEL. The RASS approach enabled the rapid development of C(sp(2))-C(sp(3)) decarboxylative cross couplings with broad substrate scope, an electrochemical amination (the first electrochemical synthetic transformation performed in a DEL context), and improved reductive amination conditions. The utility of these reactions was demonstrated through a DEL-rehearsal in which all newly developed chemistries were orchestrated to afford a compound rich in diverse skeletal linkages. We believe that RASS will offer expedient access to new DEL reactivities, expanded chemical space, and ultimately more drug-like libraries.

Welcome to talk about 177-11-7, If you have any questions, you can contact Flood, DT; Asai, S; Zhang, XJ; Wang, J; Yoon, L; Adams, ZC; Dillingham, BC; Sanchez, BB; Vantourout, JC; Flanagan, ME; Piotrowsld, DW; Richardson, P; Green, SA; Shenvi, RA; Chen, JS; Baran, PS; Dawson, PE or send Email.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about POT FACILE SYNTHESIS; PEPTIDE-SYNTHESIS; HIGHLY EFFICIENT; AMIDE SYNTHESIS; CHEMISTRY; THIOACIDS; FUNCTIONALIZATION; PHOTOCATALYSIS; ALCOHOLS; ESTERS, Saw an article supported by the [ESS01/2018]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Srivastava, V; Singh, PK; Singh, PP. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Recommanded Product: 177-11-7

A visible-light promoted photoredox catalysed, green one-pot approach for the amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. The proposed strategy is extendable also to biologically active amides and could represent a low-cost alternative to the common synthetic pathways. The developed strategy may hold great potential for a comprehensive display of biologically interesting peptide synthesis and amino acid modification. (C) 2018 Elsevier Ltd. All rights reserved.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ in WILEY-V C H VERLAG GMBH published article about TRANSITION-METAL-FREE; C-H AMINATION; NUCLEOPHILIC-SUBSTITUTION; REDUCTIVE ELIMINATION; CATALYZED AMINATION; COUPLING REACTIONS; CARBOXYLIC-ACIDS; CROSS-COUPLINGS; DIRECTING-GROUP; ARYL CHLORIDES in [Drapeau, Martin Pichette; Bahri, Janet; Lichte, Dominik; Goossen, Lukas J.] Ruhr Univ Bochum, Fak Chem & Biochem, ZEMOS, Univ Str 150, D-44801 Bochum, Germany in 2019, Cited 80. COA of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C-C, C-Cl, and C-N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.

COA of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem