Recently I am researching about C-H FUNCTIONALIZATION; PHOTOCATALYTIC OXIDATION; REGIOSELECTIVE AMINATION; IMIDYL RADICALS; IODINE; ELECTROSYNTHESIS; GENERATION; AMIDATION; CHEMISTRY; ARENES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21602142]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities. Product Details of 177-11-7. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Lei, N; Shen, YL; Li, YJ; Tao, P; Yang, LQ; Su, ZS; Zheng, K. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane
An environmentally friendly electrochemical approach for iodoamination of various indole derivatives with a series of unactivated amines, amino acid derivatives, and benzotriazoles (more than 80 examples) has been developed. This strategy was further applied in late-stage functionalization of natural products and pharmaceuticals and gram-scale synthesis and radiosynthesis of I-13(1)-labeled compounds. Fundamental insights into the mechanism of the reaction based on control experiments, density functional theory calculation, and cyclic voltammetry are provided.
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem