Day: December 31, 2021

HPLC of Formula: C7H13NO2. In 2020 CRIT CARE published article about PROPORTIONAL ASSIST VENTILATION; MECHANICAL VENTILATION; INSPIRATORY PRESSURE; ELECTRICAL-ACTIVITY; ESOPHAGEAL; IMPACT; INJURY; VOLUME; SLEEP; EVOLUTION in [Di Mussi, Rosa; Pisani, Luigi; Iannuzziello, Rachele; Dalfino, Lidia; Murgolo, Francesco; Grasso, Salvatore] Univ Bari Aldo Moro, Osped Policlin, Dipartimento Emergenza & Trapianti Organo DETO, Sez Anestesiol & Rianimaz, Piazza Giulio Cesare 11, Bari, Italy; [Spadaro, Savino; Volta, Carlo Alberto] Univ Ferrara, Dipartimento Morfol Chirurg & Med Sperimentale, Sez Anestesiol & Terapia Intens Univ, Ferrara, Italy; [Bartolomeo, Nicola; Trerotoli, Paolo] Univ Aldo Moro, Dipartimento Sci Biomed & Oncol Umana, Cattedra Stat Med, Bari, Italy; [Staffieri, Francesco] Univ Bari Aldo Moro, Dipartimento Emergenza & Trapianti Organo DETO, Sez Chirurg Vet, Bari, Italy in 2020, Cited 67. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Introduction Pressure support ventilation (PSV) should allow spontaneous breathing with a normal neuro-ventilatory drive. Low neuro-ventilatory drive puts the patient at risk of diaphragmatic atrophy while high neuro-ventilatory drive may causes dyspnea and patient self-inflicted lung injury. We continuously assessed for 12 h the electrical activity of the diaphragm (EAdi), a close surrogate of neuro-ventilatory drive, during PSV. Our aim was to document the EAdi trend and the occurrence of periods of Low and/or High neuro-ventilatory drive during clinical application of PSV. Method In 16 critically ill patients ventilated in the PSV mode for clinical reasons, inspiratory peak EAdi peak (EAdi(PEAK)), pressure time product of the trans-diaphragmatic pressure per breath and per minute (PTPDI/b and PTPDI/min, respectively), breathing pattern and major asynchronies were continuously monitored for 12 h (from 8 a.m. to 8 p.m.). We identified breaths with Normal (EAdi(PEAK) 5-15 mu V), Low (EAdi(PEAK) < 5 mu V) and High (EAdi(PEAK) > 15 mu V) neuro-ventilatory drive. Results Within all the analyzed breaths (177.117), the neuro-ventilatory drive, as expressed by the EAdi(PEAK), was Low in 50.116 breath (28%), Normal in 88.419 breaths (50%) and High in 38.582 breaths (22%). The average times spent in Low, Normal and High class were 1.37, 3.67 and 0.55 h, respectively (p < 0.0001), with wide variations among patients. Eleven patients remained in the Low neuro-ventilatory drive class for more than 1 h, median 6.1 [3.9-8.5] h and 6 in the High neuro-ventilatory drive class, median 3.4 [2.2-7.8] h. The asynchrony index was significantly higher in the Low neuro-ventilatory class, mainly because of a higher number of missed efforts. Conclusions We observed wide variations in EAdi amplitude and unevenly distributed Low and High neuro ventilatory drive periods during 12 h of PSV in critically ill patients. Further studies are needed to assess the possible clinical implications of our physiological findings. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2019 ORG LETT published article about NUCLEOPHILIC TRIFLUOROMETHYLATION; ELECTROPHILIC AMINATION; TRANSFER HYDROGENATION; DIORGANOZINC REAGENTS; IMINES; AMINES; FLUORINE; ALKENES; ACCESS; ARYL in [Takata, Tatsuaki; Hirano, Koji; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan in 2019, Cited 81. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

A copper-catalyzed regioselective net hydroamination of 1-trifluoromethylalkenes with hydrosilanes and hydroxylamines has been developed. The judicious choice of ligand and additive suppresses the conceivable but undesired beta-F elimination of an alpha-CF3-substituted organocopper intermediate, leading to targeted alpha-trifluoromethylamines in good yields with excellent regioselectivity. Additionally, with an appropriate chiral bisphosphine ligand, the enantioselective reaction is also possible to deliver optically active alpha-trifluoromethylamines of high potential in medicinal and pharmaceutical chemistry.

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Takata, T; Hirano, K; Miura, M or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about NUCLEOPHILIC TRIFLUOROMETHYLATION; ELECTROPHILIC AMINATION; TRANSFER HYDROGENATION; DIORGANOZINC REAGENTS; IMINES; AMINES; FLUORINE; ALKENES; ACCESS; ARYL, Saw an article supported by the JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP 15H05485, 18K19078, JP 17H06092]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Takata, T; Hirano, K; Miura, M. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A copper-catalyzed regioselective net hydroamination of 1-trifluoromethylalkenes with hydrosilanes and hydroxylamines has been developed. The judicious choice of ligand and additive suppresses the conceivable but undesired beta-F elimination of an alpha-CF3-substituted organocopper intermediate, leading to targeted alpha-trifluoromethylamines in good yields with excellent regioselectivity. Additionally, with an appropriate chiral bisphosphine ligand, the enantioselective reaction is also possible to deliver optically active alpha-trifluoromethylamines of high potential in medicinal and pharmaceutical chemistry.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Takata, T; Hirano, K; Miura, M or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Okumus, A; Elmas, G; Kilic, Z; Binici, A; Ramazanoglu, N; Acik, L; Cosut, B; Hokelek, T; Guzel, R; Tunali, BC; Turk, M; Simsek, H in WILEY published article about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; INTERMOLECULAR INTERACTIONS; BIOLOGICAL-ACTIVITIES; CRYSTAL-STRUCTURES; CHIRAL CONFIGURATIONS; QUANTITATIVE-ANALYSIS; HIRSHFELD SURFACES; CYCLOTRIPHOSPHAZENE; ANTITUBERCULOSIS in [Okumus, Aytug; Elmas, Gamze; Kilic, Zeynel] Ankara Univ, Dept Chem, Ankara, Turkey; [Binici, Arzu] Republ Turkey Minist Hlth, Ankara, Turkey; [Ramazanoglu, Nagehan] Sci & Technol Res Council Turkey, Ankara, Turkey; [Acik, Leyla] Gazi Univ, Dept Biol, Ankara, Turkey; [cosut, Bunyemin] Gebze Tech Univ, Dept Chem, Gebze, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, Ankara, Turkey; [Guzel, Remziye] Dicle Univ, Dept Chem, Diyarbakir, Turkey; [Tunali, Beste cagdas; Turk, Mustafa] Kirikkale Univ, Dept Bioengn, Kirikkale, Turkey; [Simsek, Hulya] Bozok Univ, Dept Microbiol, Yozgat, Turkey in 2021, Cited 106. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

In this study, two kinds of compounds, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes, were obtained by the Cl replacement reaction of N4P4Cl8 (1) with an equimolar amount of sodium 3-(N-ferrocenylmethylamino)-1-propanoxide (2). The reactions of 2,4-ansa (3) with excess diamines and dialkoxides resulted in the formation of ansa-cyclotetraphosphazenes (3a-3e). Spiro (4) was reacted with excess diamines and dialkoxides to give the mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d). Although 2,4-ansa (3) produced the dispiro (3a) with N-(4-fluorobenzyl)-N ‘-methylethane-1,2-diamine, it afforded both monospiro (3b) and dispiro (3c) with N-(4-fluorobenzyl)-N ‘-methylpropane-1,3-diamine. However, spiro (4) yielded a trispiro (4a) with N-(4-fluorobenzyl)-N ‘-methylethane-1,2-diamine and 2,6-dispiro (4b) with N-(4-fluorobenzyl)-N ‘-methylpropane-1,3-diamine. The structures of the phosphazenes were elucidated by FTIR, ESI-MS and/or HRMS, spectroscopic and crystallographic (for 3f and 4b) data. Furthermore, the electrochemical findings of cyclotetraphosphazenes exhibited electrochemically reversible one-electron oxidation of Fe-redox centre. As an example, the chirality of 3c was investigated by P-31 NMR spectroscopy on the addition of (R)-(+)-2,2,2-trifluoro-1-(9 ‘-anthryl)-ethanol, chiral solvating agent (CSA). The circular dichroism (CD) (for 3d and 3e), HPLC (for 3d, 3e and 3f) and X-ray (for 3f) display that these compounds have chirality (RS ‘ or SR ‘) in the solution and solid state. This paper also focuses on the antimicrobial activities, the interactions with pBR322 DNA, in vitro anticancer activity against L929 fibroblast and MCF7 breast cells, and antituberculosis activity against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Okumus, A; Elmas, G; Kilic, Z; Binici, A; Ramazanoglu, N; Acik, L; Cosut, B; Hokelek, T; Guzel, R; Tunali, BC; Turk, M; Simsek, H or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Formula: C7H13NO2. I found the field of Chemistry very interesting. Saw the article Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines published in 2020, Reprint Addresses Dai, HX (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China.; Dai, HX (corresponding author), Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.; Dai, HX (corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.

Welcome to talk about 177-11-7, If you have any questions, you can contact Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX or send Email.. Formula: C7H13NO2

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about RAPID COLORIMETRIC ASSAY; ANTIPROLIFERATIVE EVALUATION; MOLECULAR HYBRIDIZATION; ANALOGS; CANCER; CAMPTOTHECIN; ALKALOIDS; MECHANISM; DISCOVERY; APOPTOSIS, Saw an article supported by the Ministry of Science and Technology, TaiwanMinistry of Science and Technology, Taiwan [MOST104-2113-M-038-001]; Taipei Medical University [TMUTOP103003-1]; National Defense Medical Center [TMU-NDMC-104-02]; NIH-NCIUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI). Published in ELSEVIER in AMSTERDAM ,Authors: Chen, TC; Yu, DS; Chen, SJ; Chen, CL; Lee, CC; Hsieh, YY; Chang, LC; Guh, JH; Lin, JJ; Huang, HS. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Several 9-chloro-11H-indeno[1,2-c]quinolin-11-one derivatives have been designed which is replacing side chains with different groups containing oxygen, nitrogen or sulfur atoms. Substitution of C-6 on the starting structure, 6,9-dichloro-11H-indeno[1,2-c]quinolin-11-one, using apposite nucleophilic group with a suitable base or acid could be obtained 28 novel tetracyclic azafluorenone derivatives. The cytotoxic activity of these analogues was examined in cancer cell lines by MTT assay and compounds 4, 5, 13, and 26 were selected to evaluate in topoisomerase I drug screening assay, respectively. At the same time, 17 compounds were selected for NCI-60 anticancer drug screen to prevent the narrower concept of an in vitro screening model. Its worth to find that 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (12) showed greater cytotoxicity than another azafluorenone derivatives with an average GI(50) of 10.498 mu M over 60 cell lines. We also found that another analogue, 9-chloro-6-(2-methylpiperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (13), exhibited preferential growth inhibition effect toward cancer cell lines and showed a significant inhibitory effect on topoisomerase I. (C) 2016 Production and hosting by Elsevier B.V. on behalf of King Saud University.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140) WOS:000460365600004 published article about AGONIST SALVINORIN; PROLACTIN; DYNORPHIN; LY2456302; DOPAMINE; STRESS; 2-METHYL-N-((2′-(PYRROLIDIN-1-YLSULFONYL)BIPHENYL-4-YL)METHYL)PROPAN-1-AMINE; EXPRESSION; DISCOVERY; BINDING in [Guerrero, Miguel; Urbano, Mariangela; Kim, Eun-Kyong; Gamo, Ana M.; Riley, Sean; Abgaryan, Lusine; Leaf, Nora; Brown, Steven J.; Rosen, Hugh; Roberts, Edward] Scripps Res Inst, Dept Mol Med, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [Van Orden, Lori Jean] BlackThorn Therapeut Inc, 780 Brannan St, San Francisco, CA 94103 USA; [Xie, Jennifer Y.; Porreca, Frank] Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA; [Cameron, Michael D.] Scripps Res Inst, Dept Mol Med, Jupiter, FL 33458 USA; [Xie, Jennifer Y.] Arkansas State Univ, Coll Osteopath Med, New York Inst Technol, Dept Basic Sci, Jonesboro, AR 72446 USA in 2019, Cited 47. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. COA of Formula: C7H13NO2

kappa opioid receptor (KOR) antagonists are potential pharmacotherapies for the treatment of migraine and stress-related mood disorders including depression, anxiety, and drug abuse, thus the development of novel KOR antagonists with an improved potency/selectivity profile and medication-like duration of action has attracted the interest of the medicinal chemistry community. In this paper, we describe the discovery of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2 H-pyran-4-yl)piperidin-4 amine (CYM-53093, BTRX-335140) as a potent and selective KOR antagonist, endowed with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments. Orally administered CYM-53093 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice. CYM-53093 exhibited a broad selectivity over a panel of off-target proteins. This compound is in phase 1 clinical trials for the treatment of neuropsychiatric disorders wherein dynorphin is thought to contribute to the underlying pathophysiology.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Baska, F; Sipos, A; Orfi, Z; Nemes, Z; Dobos, J; Szantai-Kis, C; Szabo, E; Szenasi, G; Dezsi, L; Hamar, P; Cserepes, MT; Tovari, J; Garamvolgyi, R; Kreko, M; Orfi, L in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about ACUTE MYELOID-LEUKEMIA; RISK MYELODYSPLASTIC SYNDROME; ACUTE MYELOGENOUS LEUKEMIA; TYROSINE KINASE; ACTIVATING MUTATION; TANDEM DUPLICATION; WILD-TYPE; IN-VITRO; PHASE-I; RECEPTOR in [Baska, Ferenc; Sipos, Anna; Nemes, Zoltan; Dobos, Judit; Szantai-Kis, Csaba; Garamvolgyi, Rita; Orfi, Laszlo] Vichem Chem Res Ltd, H-1022 Budapest, Hungary; [Orfi, Zoltan] Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany; [Szabo, Eszter] Semmelweis Univ, Dept Paediat 1, H-1083 Budapest, Hungary; [Szenasi, Gabor; Dezsi, Laszlo; Hamar, Peter] Semmelweis Univ, Inst Pathophysiol, H-1089 Budapest, Hungary; [Dezsi, Laszlo] Semmelweis Univ, Nanomed Res & Educ Ctr, H-1089 Budapest, Hungary; [Cserepes, Mihaly T.; Tovari, Jozsef] Natl Inst Oncol, Dept Expt Pharmacol, H-1122 Budapest, Hungary; [Kreko, Marcell; Orfi, Laszlo] Semmelweis Univ, Dept Pharmaceut Chem, Hogyes Endre U 9, H-1085 Budapest, Hungary; [Orfi, Laszlo] Drug Res Co, Batthyany U 92, H-1161 Budapest, Hungary in 2019, Cited 62. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Aberrant activation of FMS-like tyrosine receptor kinase 3 (FLT3) is implicated in the pathogenesis of acute myeloid leukemia (AML) in 20-30% of patients. In this study we identified a highly selective (phenylethenyl)quinazoline compound family as novel potent inhibitors of the FLT3-ITD and FLT3-D835Y kinases. Their prominent effects were confirmed by biochemical and cellular proliferation assays followed by mice xenograft studies. Our modelling experiments and the chemical structures of the compounds predict the possibility of covalent inhibition. The most effective compounds triggered apoptosis in FLT3-ITD AML cells but had either weak or no effect in FLT3-independent leukemic and non-leukemic cell lines. Our results strongly suggest that our compounds may become therapeutics in relapsing and refractory AML disease harboring various ITD and tyrosine kinase domain mutations, by their ability to overcome drug resistance. (C) 2019 Elsevier Masson SAS. All rights reserved.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 MEDCHEMCOMM published article about NF-KAPPA-B; WATER-SOLUBLE PARTHENOLIDE; SESQUITERPENE LACTONE; IN-VITRO; AMINO-DERIVATIVES; BIOLOGICAL EVALUATION; ANTICANCER AGENTS; CRYSTAL-STRUCTURE; CANCER CELLS; FEVERFEW in [Li, Xingjian; Payne, Daniel T.; Dutton, Mark J.; Quy, Alex S.; Fossey, John S.] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England; [Ampolu, Badarinath; Bland, Nicholas; Brown, Jane T.; Hamza, Daniel; Jones, Geraint; Lane, Rebecca; Merisor, Elena G.; Schulz-Utermoehl, Timothy; Stevenson, Brett] BioCity, Sygnat Discovery, Discovery Bldg,Pennyfoot St, Nottingham NG1 1GR, England; [Fitton, Catherine A.; Scarll, Rosanna; Stankovic, Tatjana; Agathanggelou, Angelo] Univ Birmingham, Inst Canc & Genom Sci, Birmingham B15 2TT, W Midlands, England; [Gulliver, Abigail; Hale, Lee] Univ Birmingham, Winterbourne Bot Garden, 58 Edgbaston Pk Rd, Birmingham B15 2RT, W Midlands, England; [Leach, Andrew G.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Byrom St, Liverpool L3 3AF, Merseyside, England; [Male, Louise] Univ Birmingham, Sch Chem, Xray Crystallog Facil, Birmingham B15 2TT, W Midlands, England; [Morton, Michael J.; Roberts, Ruth] ApconiX Ltd, Alderly Pk, Nether Alderly SK10 4TG, Cheshire, England; [Roberts, Ruth] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England in 2019, Cited 143. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good bioavailability and pharmacological properties was identified through a screening cascade based on in vitro anti-leukaemic activity and calculated drug-likeness properties, in vitro and in vivo pharmacokinetics studies and hERG liability testing. In vitro studies showed the most promising derivative to have comparable anti-leukaemic activity to DMAPT, a previously described parthenolide derivative. The newly identified compound was shown to have pro-oxidant activity and in silico molecular docking studies indicate a prodrug mode of action. A synthesis scheme is presented for the production of amine 7 used in the generation of 5f.

Welcome to talk about 177-11-7, If you have any questions, you can contact Li, XJ; Payne, DT; Ampolu, B; Bland, N; Brown, JT; Dutton, MJ; Fitton, CA; Gulliver, A; Hale, L; Hamza, D; Jones, G; Lane, R; Leach, AG; Male, L; Merisor, EG; Morton, MJ; Quy, AS; Roberts, R; Scarll, R; Schulz-Utermoehl, T; Stankovic, T; Stevenson, B; Fossey, JS; Agathanggelou, A or send Email.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article SuFEx Activation with Ca(NTf2)(2) : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides WOS:000538848600065 published article about SULFONYL FLUORIDES; CLICK CHEMISTRY; TOSYLATES; CHLORIDES; REAGENT in [Woroch, Cristian P.; Carneiro, Sabrina N.; Kwan, Sabrina C.; Khasnavis, Samuel R.; Gu, Junha; Ball, Nicholas D.] Pomona Coll, Dept Chem, Claremont, CA 91711 USA; [Mahapatra, Subham; Butler, Todd W.; Dutra, Jason K.; Vetelino, Beth C.; Bellenger, Justin; Ende, Christopher W. am] Pfizer Worldwide Res & Dev, Groton, CT 06340 USA in 2020, Cited 35. HPLC of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.

HPLC of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Mahapatra, S; Woroch, CP; Butler, TW; Carneiro, SN; Kwan, SC; Khasnavis, SR; Gu, J; Dutra, JK; Vetelino, BC; Bellenger, J; Ende, CWA; Ball, ND or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem