Day: December 20, 2021

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140) published in 2019. Formula: C7H13NO2, Reprint Addresses Roberts, E (corresponding author), Scripps Res Inst, Dept Mol Med, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

kappa opioid receptor (KOR) antagonists are potential pharmacotherapies for the treatment of migraine and stress-related mood disorders including depression, anxiety, and drug abuse, thus the development of novel KOR antagonists with an improved potency/selectivity profile and medication-like duration of action has attracted the interest of the medicinal chemistry community. In this paper, we describe the discovery of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2 H-pyran-4-yl)piperidin-4 amine (CYM-53093, BTRX-335140) as a potent and selective KOR antagonist, endowed with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments. Orally administered CYM-53093 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice. CYM-53093 exhibited a broad selectivity over a panel of off-target proteins. This compound is in phase 1 clinical trials for the treatment of neuropsychiatric disorders wherein dynorphin is thought to contribute to the underlying pathophysiology.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. In 2021 ORG LETT published article about NITROSO-COMPOUNDS; PHOTOCHEMISTRY; NITROSAMINES; NITROSODIALKYLAMINES; GENERATION; RADICALS in [Patil, Dilip, V; Si, Tengda; Oh, Kyungsoo] Chung Ang Univ, Ctr Metareceptome Res, Grad Sch Pharmaceut Sci, Seoul 06974, South Korea; [Kim, Hun Young] Chung Ang Univ, Dept Global Innovat Drugs, Seoul 06974, South Korea in 2021, Cited 46. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The generation of aminium radical cation species from N-nitrosoamines is disclosed for the first time through visible-light excitation at 453 nm. The developed visible-light-promoted photoaddition reaction of N-nitrosoamines to alkenes was combined with the o-NQ-catalyzed aerobic oxidation protocol of amines to telescope the direct handling of harmful N-nitroso compounds, where the desired aamino oxime derivatives were obtained in a one-pot tandem Nnitrosation and photoaddition sequence.

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 ACS CATAL published article about H BOND FUNCTIONALIZATION; ASYMMETRIC DEAROMATIZATION; OXIDATIVE DEAROMATIZATION; AEROBIC FUNCTIONALIZATION; UNIFIED SYNTHESIS; ALPHA-AMINATION; NAPHTHOLS; HYDROAMINATION; REARRANGEMENT; AMINOBORATION in [Yao, Zhi-Li; Shao, Nan-Qi; Wang, Dong-Hui] Chinese Acad Sci, Shanghai Inst Organ Chem, CAS Key Lab Synthet & Self Assembly Chem Organ Fu, Univ Chinese Acad Sci,Ctr Excellence Mol Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Wang, Lei; Guo, Yin-Long] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Univ Chinese Acad Sci,Ctr Excellence Mol Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019, Cited 82. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A Cu-catalyzed dearomative amination of simple phenols with O-benzoylhydroxylamines (R’RN-OBz) to synthesize alpha-aminocyclohexa-2,4-dienones is reported. This intermolecular transformation occurs exclusively at the position ortho to the hydroxyl group, providing a convenient method to synthesize the desired products in high yields. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. Mechanistic studies indicate that this transformation proceeds via either (1) a single-electron transfer process involving attack of an N-centered radical onto the phenol or (2) a two-electron pathway involving addition of phenol to an electrophilic Cu-III-amino complex via an inner-sphere process.

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Yao, ZL; Wang, L; Shao, NQ; Guo, YL; Wang, DH or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination WOS:000477787400017 published article about ALLYLATION; LIGANDS; HYDROGENATION; REDUCTION; COMPLEXES; ENANTIO in [Ghorai, Samir; Chirke, Sahadev Shrihari; Xu, Wen-Bin; Chen, Jia-Feng; Li, Changkun] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Li, Changkun] Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China in 2019, Cited 45. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. SDS of cas: 177-11-7

The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic carbonates bearing alkyl groups with both aromatic and aliphatic amines has been developed. The process allows rapid access of allylic amines in high yields with exclusively branched selectivity and excellent enantioselectivities (normally 99% ee) under mild reaction conditions.

Welcome to talk about 177-11-7, If you have any questions, you can contact Ghorai, S; Chirke, SS; Xu, WB; Chen, JF; Li, CK or send Email.. SDS of cas: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ in WILEY-V C H VERLAG GMBH published article about TRANSITION-METAL-FREE; C-H AMINATION; NUCLEOPHILIC-SUBSTITUTION; REDUCTIVE ELIMINATION; CATALYZED AMINATION; COUPLING REACTIONS; CARBOXYLIC-ACIDS; CROSS-COUPLINGS; DIRECTING-GROUP; ARYL CHLORIDES in [Drapeau, Martin Pichette; Bahri, Janet; Lichte, Dominik; Goossen, Lukas J.] Ruhr Univ Bochum, Fak Chem & Biochem, ZEMOS, Univ Str 150, D-44801 Bochum, Germany in 2019, Cited 80. Recommanded Product: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C-C, C-Cl, and C-N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Product Details of 177-11-7. In 2019 CHEM-ASIAN J published article about ALKENE DIAMINATION; ASYMMETRIC DIAMINATION; CATALYZED DIAMINATION; VICINAL DIAMINES; SECONDARY-AMINES; CHIRAL DIAMINES; REAGENTS; 1,2-DIAMINATION; PALLADIUM; DERIVATIVES in [Zhang, YongJian; Su, Junyi; Niu, Wenjie; Li, Yujin] Zhejiang Univ Technol, Dept Chem & Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310032, Zhejiang, Peoples R China in 2019, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Iodine-promoted direct diamination of ,-unsaturated ketone to form two C-N bonds has been developed starting from chalcone and secondary amine. This reaction was performed in THF at 50 degrees C in the presence of I-2 and K2CO3. The protocol is metal-free, operationally simple and carried out under mild conditions, providing an effective new way for directing diamination reactions.

Product Details of 177-11-7. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Voller, J; Zahajska, L; Plihalova, L; Jerabkova, J; Burget, D; Pataki, AC; Krystof, V; Zatloukal, M; Brabek, J; Rosel, D; Mik, V; Tkac, M; Pospisil, T; Gucky, T; Dolezal, K; Strnad, M in [Voller, Jiri; Plihalova, Lucie; Jerabkova, Jana; Burget, David; Krystof, Vladimir; Tkac, Martin; Dolezal, Karel; Strnad, Miroslav] Czech Acad Sci, Inst Expt Bot, Lab Growth Regulators, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic; [Voller, Jiri; Plihalova, Lucie; Jerabkova, Jana; Burget, David; Krystof, Vladimir; Tkac, Martin; Dolezal, Karel; Strnad, Miroslav] Palacky Univ, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic; [Voller, Jiri] Palacky Univ, Fac Med & Dent, Inst Mol & Translat Med, Dept Clin & Mol Pathol, Hnevotinska 3, Olomouc 77515, Czech Republic; [Zahajska, Lenka] Czech Acad Sci, Inst Expt Bot, Isotope Lab, Videnska 1083, Prague 14200 4, Czech Republic; [Plihalova, Lucie; Zatloukal, Marek; Mik, Vaclav; Pospisil, Tomas; Gucky, Tomas; Dolezal, Karel] Palacky Univ, Ctr Reg Hana Biotechnol & Agr Res, Dept Chem Biol & Genet, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic; [Pataki, Andreea Csilla; Brabek, Jan; Rosel, Daniel] Charles Univ Prague, Fac Sci, Dept Cell Biol, Vinicna 7, Prague 12843 2, Czech Republic published 6-Substituted purines as ROCK inhibitors with anti-metastatic activity in 2019, Cited 50. COA of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Rho-associated serine/threonine kinases (ROCKs) are principal regulators of the actin cytoskeleton that regulate the contractility, shape, motility, and invasion of cells. We explored the relationships between structure and anti-ROCK2 activity in a group of purine derivatives substituted at the C6 atom by piperidin-1-yl or azepan-1-yl groups. Structure-activity relationship (SAR) analyses suggested that anti-ROCK activity is retained, and may be further increased, by substitution of the parent compounds at the C2 atom or by expansion of the C6 side chain. These inhibitors of ROCK can reach effective concentrations within cells, as demonstrated by a decrease in phosphorylation of the ROCK target MLC, and by inhibition of the ROCK-dependent invasion of melanoma cells in the collagen matrix. Our study may be useful for further optimization of C6-substituted purine inhibitors of ROCKs and of other sensitive kinases identified by the screening of a broad panel of protein kinases.

COA of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Voller, J; Zahajska, L; Plihalova, L; Jerabkova, J; Burget, D; Pataki, AC; Krystof, V; Zatloukal, M; Brabek, J; Rosel, D; Mik, V; Tkac, M; Pospisil, T; Gucky, T; Dolezal, K; Strnad, M or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines for direct access to sulfinamides WOS:000498291800009 published article about ASYMMETRIC-SYNTHESIS; COMPLEXES in [Li, Gang-Jian; Pan, You-Lu; Liu, Yan-Ling; Xu, Hai-Feng; Chen, Jian-Zhong] Zhejiang Univ, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou, Zhejiang, Peoples R China in 2019, Cited 40. HPLC of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

It was reported to develop a simple and convenient method for the Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines without an acid/base to afford secondary or tertiary sulfinamides in moderate to good yields. The method can provide the desired products with broad substrate scope, good chemoselectivity and good functional group compatibility. The presented approach may enrich the Nil NHC catalyst system and promote the applications of methyl sulfinates in the organic sulfur chemistry. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 177-11-7, If you have any questions, you can contact Li, GJ; Pan, YL; Liu, YL; Xu, HF; Chen, JZ or send Email.. HPLC of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about ALLYLATION; LIGANDS; HYDROGENATION; REDUCTION; COMPLEXES; ENANTIO, Saw an article supported by the National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21602130]; Shanghai Jiao Tong University. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Ghorai, S; Chirke, SS; Xu, WB; Chen, JF; Li, CK. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

The first earth-abundant cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic carbonates bearing alkyl groups with both aromatic and aliphatic amines has been developed. The process allows rapid access of allylic amines in high yields with exclusively branched selectivity and excellent enantioselectivities (normally 99% ee) under mild reaction conditions.

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

SDS of cas: 177-11-7. Recently I am researching about C-H FUNCTIONALIZATION; ALLYLIC ALKYLATIONS; ARYLATION; PD/NORBORNENE; TERMINATION; BOND, Saw an article supported by the NSF of ChinaNational Natural Science Foundation of China (NSFC) [22071068, 21672075]; Instrumental Analysis Center of Huaqiao University. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Chen, YH; Lv, WW; Ba, D; Wen, S; Cheng, GL. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

We report a highly chemoselective palladium-catalyzed Catellani-type amination of aryl iodides terminated by the Heck reaction using allylic esters as terminating reagents. 2-Aminocinnamyl esters were formed exclusively via beta-H elimination rather than beta-OAc elimination without the assistance of a silver salt. This protocol represents a useful extension of Catellani-type transformations.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem