Day: December 1, 2021

Today I’d like to introduce a new chemical compound, CAS is 1159408-72-6, Computed Properties of 1159408-72-6, Name is (2S,4R)-2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-N-[2-[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]-1,1-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]ethyl]-1-pyrrolidinedodecanamide, Formula is C117H175N11O42, Molecular Weight is 2407.69g/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.

The general reactant of this compound is (3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-pyrrolidinol, 12,19,25-Trioxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacosanoic acid, Reagents is Diisopropylethylamine, 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide, Catalyst(), Solvent is Dichloromethane, Products (2S,4R)-2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-N-[2-[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]-1,1-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]ethyl]-1-pyrrolidinedodecanamide, Yield: 73%, Synthetic Methods procedure :1. Add HBTU ( 2.10 g, 5.55 mmol ) and DIEA ( 3 mL, 17 mmol ) to a solution of the acid ( 10.13 g, 5.05 mmol ) and amine ( 2.32 g, 5.55 mmol ) in DCM ( 100 mL ) ., 2. Stir the mixture for 2 hours at room temperature., 3. Dilute the reaction mixture with DCM and wash with water., 4. Purify the crude product by silica gel chromatography ( eluent: 3-15 % MeOH in DCM containing 0.1% Et3N ) ., Acylation of Nitrogen Nucleophiles by Carboxylic Acids, Transfornation (Acylation of Nitrogen Nucleophiles by Carboxylic Acids. Characterization Data include ‘s Proton NMR Spectrum : ( 400 MHz, DMSO-d 6, mixture of rotamers: ~0.7 ( major ) , ~0.3 ( minor ) ) : δ7.87-7.79 ( m, 6H, NH ) , 7.73 ( t, J = 5.6 Hz, 3H, NH ) ; 7.34-7.24 ( m, 4H ) ; 7.24-7.14 ( m, 5H ) ; 6.97 ( s, 1H, NH ) ; 6.90-6.82 ( m, 4H ) ; 5.20 ( d, J = 3.4, 3H, sugar H4 ) ; 4.99-4.93 ( m, 3.7H ) ; 4.88 ( d, J = 4.2, 0.3H, OH ) ; 4.48 ( d, J = 8.4, 3H, sugar H1 ) ; 4.42-4.34 ( m, 0.7H ) ; 4.32-4.24 ( m, 0.3H ) ; 4.17-4.07 ( m, 1H ) ; 4.05-3.97 ( m, 9H, sugar H5, H6, H6′ ) ; 3.86 ( dt, J = 8.8, 10.9 Hz, 3H, sugar H2 ) ; 3.72 ( s, 6H ) ; 3.69 ( dt, J = 5.4, 9.8 Hz, 3H ) ; 3.62-3.44 ( m, 13H ) ; 3.39 ( dt, J = 6.4, 9.9 Hz, 3H ) ; 3.35-3.28 ( m, 0.7H ) ; 3.27-3.21 ( m, 0.3H ) ; 3.18-3.12 ( m, 1H ) ; 3.11-2.93 ( m, 13H ) ; 2.27 ( t, J = 6.2, 6H ) ; 2.19 ( t, J = 7.5, 1.7H ) ; 2.09 ( s, 9H ) ; 2.03 ( t, J = 7.3, 8.3H ) ; 1.98 ( s, 9H ) ; 1.96-1.80 ( m, 2H ) ; 1.89 ( s, 9H ) ; 1.76 ( s, 9H ) ; 1.55-1.37 ( m, 22H ) ; 1.12-1.30 ( m, 12H ) ., Carbon-13 NMR : ( 101 MHz, DMSO-d 6 ) : δ 172.5, 172.0, 171.6, 171.2, 171.1, 171.0, 170.1, 170.00; 169.9; 169.6, 169.4, 158.1, 158.0, 157.8, 148.4, 145.1, 144.8, 140.2, 135.9, 135.8, 135.5, 135.4, 129.6, 128.9, 127.9, 127.8, 127.7, 127.6, 127.4, 126.6, 126.4, 113.2, 113.1, 112.7, 101.0, 85.8, 85.1, 79.9, 70.5, 69.8, 68.7, 68.3, 67.3, 66.7, 63.4, 62.1, 61.4, 59.5, 57.6, 55.2, 55.1, 55.0, 55.0, 54.9, 49.4, 36.4, 36.3, 36.0, 35.9, 35.1, 34.3, 29.3, 29.0, 28.6, 28.6, 25.3, 24.5, 24.5, 22.8, 21.9, 20.5, 20.4., Mass Spectrum: Mass calc. for C117H175N11O42 2406.19; found 2429.18 ( M+Na+, MALDI-TOF, matrix: HABA ) ., State is white solid

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Reference:
CAS Method Number 3-355-CAS-9994399,
,CAS Method Number 3-010-CAS-8275923

An article Step-wise and one-pot synthesis of highly substituted conjugated trienes from 2-oxobenzo [h]chromenes/2H-pyran-2-ones WOS:000639414200001 published article about STEREOSELECTIVE-SYNTHESIS in [Elagamy, Amr; Pratap, Ramendra] Univ Delhi, Dept Chem, North Campus, Delhi 110007, India; [Althagafi, Ismail] Umm Al Qura Univ, Fac Sci, Chem Dept, Mecca 21955, Saudi Arabia in 2021, Cited 36. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

A mild and efficient route for the synthesis of conjugated trienes via nitroethane-mediated ring contraction of 2-oxobenzo[h]chromenes/2H-pyran-2-ones followed by decarboxylative rearrangement of the obtained spirobutenolides and butenolides is described. The (E)-isomer of trienes was obtained by step-wise and one-pot approaches from 2-oxobenzo[h]chromenes. Butenolides 4a-l as new substrates have been developed for the construction of trienes. The mixture of the (E)- and (Z)-isomers of spirobutenolides undergoes decarboxylative rearrangement in the presence of sodium ethoxide as a base to yield the (E)-isomer of trienes, while the (E)-isomer of butenolides reacts to give a mixture of (2E,4E)- and (2E,4Z)-isomers of trienes in an almost steady ratio of 45 : 55 or 1 : 1.2. The structure and geometry of the obtained butenolides and trienes were confirmed by single-crystal X-ray analysis.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Elagamy, A; Althagafi, I; Pratap, R or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about FEBRIFUGINE; INHIBITORS; CHEMISTRY; UPDATE, Saw an article supported by the National Research Foundation (NRF) [IFRR 11534, UID 98937]. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Published in WILEY in HOBOKEN ,Authors: Prinsloo, IF; Zuma, NH; Aucamp, J; N’Da, DD. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically used drugs. As a result, there is a dire need for the development of new antileishmanial drugs that are safe, affordable, and efficient. In this study, two new series of synthesized quinazolinone derivatives were investigated as potential future antileishmanial agents, by assessing their activities against theLeishmania(L.)donovaniandL. majorspecies. The cytotoxicity profiles of these derivatives were assessed in vitro on Vero cells. The compounds were found to be safer and without any toxic activities against mammalian cells, compared to the reference drug, halofuginone, a clinical derivative of febrifugine. However, they had demonstrated poor antileishmanial growth inhibition efficacies. The two compounds that had been found the most active were the mono quinazolinone2dand the bisquinazolinone5bwith growth inhibitory efficacies of 35% and 29% for theL. majorandL. donovani9515 promastigotes, respectively. These outcomes had suggested structural redesign,inter aliathe inclusion of polar groups on the quinazolinone ring, to potentially generate novel quinazolinone derivatives, endowed with effective antileishmanial potential.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Prinsloo, IF; Zuma, NH; Aucamp, J; N’Da, DD or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article PIFA-Promoted, Solvent-Controlled Selective Functionalization of C(sp(2))-H or C(sp(3))-H: Nitration via C-N Bond Cleavage of CH3NO2, Cyanation, or Oxygenation in Water WOS:000467320000028 published article about HYPERVALENT IODINE REAGENTS; AROMATIC NITRATION; TERTIARY-AMINES; H FUNCTIONALIZATION; CONJUGATE ADDITION; SODIUM-NITRITE; UREA NITRATE; NITROMETHANE; OXIDATION; ATOM in [Kim, Mi-hyun] Gachon Univ, Coll Pharm, Gachon Inst Pharmaceut Sci, 191 Hambakmoeiro, Incheon 21936, South Korea; Gachon Univ, Coll Pharm, Dept Pharm, 191 Hambakmoeiro, Incheon 21936, South Korea in 2019, Cited 71. HPLC of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A novel nitration (via C(sp(3))-N breaking/C(sp(2))-N formation with CH3NO2) mediated by [bis-(trifluoroacetoxy)iodo]benzene (PIFA) is described. The NO2 transfer from CH3NO2 to the aromatic group of the substrate is possible with careful selection of the solvent, NaX, and oxidant. In addition, the solvent-controlled C(sp(2))-H functionalization can shift to an alpha-C(sp(3))-H functionalization (cyanation or oxygenation) of the alpha-C(sp(3))-H of cyclic amines.

Welcome to talk about 177-11-7, If you have any questions, you can contact Mudithanapelli, C; Dhorma, LP; Kim, MH or send Email.. HPLC of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Sahoo, T; Sarkar, S; Ghosh, SC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sahoo, Tapan; Sarkar, Souvik; Ghosh, Subhash Chandra] Cent Salt & Marine Chem Res Inst CSIR CSMCRI, Nat Prod & Green Chem Div, GB Marg, Bhavnagar 364002, Gujarat, India; [Sahoo, Tapan; Ghosh, Subhash Chandra] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2021, Cited 50. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A simple and facile copper(II) mediated protocol for C-8 amination of 1-naphthylamide derivatives is reported here. Picolinamide and its derivatives were used as a bidentate directing group for the C-8 amination reaction. Various substituted naphthylamide derivatives with numerous cyclic and acyclic amines proceed in good yields under mild conditions. Air was used solely as an oxidant. (C) 2021 Elsevier Ltd. All rights reserved.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; STEREOGENIC PROPERTIES; BIOLOGICAL-ACTIVITIES; CYTOTOXIC ACTIVITIES; ELECTROCHEMICAL INVESTIGATIONS; ANTIMICROBIAL ACTIVITIES; CRYSTAL-STRUCTURES; ANTITUBERCULOSIS; MONO, Saw an article supported by the . Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Elmas, G. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The Cl exchange reaction of hexachlorocyclotriphosphazene, N3P3Cl6 (1), with one equimolar amount of sodium salt of N/O donor type bidentate ligand containing a 2-pyridyl pendant arm (2) afforded, regioselectively, the partly substituted 2-pyridyl(N/O)spirocyclotriphosphazene (3; with a yield of 65%) in THF. The reactions of 3 with excess pyrrolidine, morpholine and 1,4-dioxa-8-azaspiro[4,5]decane (DASD) led to the formation of the tetraamino-2-pyridyl(N/O)spirocyclotriphosphazenes (3a-3c) in high yields. Compound 3 also gave both tetrapiperidino (3d) and gem-bispiperidino (3e) products with excess piperidine. The structures of all the compounds were determined by elemental analyses, ESI-MS, FTIR, HSQC, HMBC and H-1, C-13, and P-31 NMR techniques. The crystal structure of 3c was identified by single crystal X-ray crystallography. Besides, the compound 3e had one stereogenic P atom, and its chirality was verified by P-31 NMR spectroscopy in the presence of (S)-(+)-2,2,2-trifluoro-1-(9′-anthryl)-ethanol (CSA).

Welcome to talk about 177-11-7, If you have any questions, you can contact Elmas, G or send Email.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Flood, DT; Asai, S; Zhang, XJ; Wang, J; Yoon, L; Adams, ZC; Dillingham, BC; Sanchez, BB; Vantourout, JC; Flanagan, ME; Piotrowsld, DW; Richardson, P; Green, SA; Shenvi, RA; Chen, JS; Baran, PS; Dawson, PE in AMER CHEMICAL SOC published article about GREEN-I; SELECTION; MUTATION; DAMAGE in [Flood, Dillon T.; Asai, Shota; Zhang, Xuejing; Wang, Jie; Yoon, Leonard; Adams, Zoe C.; Dillingham, Blythe C.; Vantourout, Julien C.; Green, Samantha A.; Shenvi, Ryan A.; Baran, Phil S.; Dawson, Philip E.] Scripps Res, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [Zhang, Xuejing] Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Drug Synth & Pharmaceut Proc, Guangzhou 510006, Guangdong, Peoples R China; [Flanagan, Mark E.; Piotrowsld, David W.] Pfizer Med Chem, Eastern Point Rd, Groton, CT 06340 USA; [Richardson, Paul] Pfizer Med Chem, 10578 Sci Ctr Dr, San Diego, CA 92121 USA; [Sanchez, Brittany B.; Chen, Jason S.] Scripps Res, Automated Synth Facil, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA in 2019, Cited 46. Category: piperidines. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although DEL provides access to libraries of unprecedented size and diversity, the idiosyncratic and hydrophilic nature of the DNA tag severely limits the scope of applicable chemistries. It is known that biomacromolecules can be reversibly, noncovalently adsorbed and eluted from solid supports, and this phenomenon has been utilized to perform synthetic modification of biomolecules in a strategy we have described as reversible adsorption to solid support (RASS). Herein, we present the adaptation of RASS for a DEL setting, which allows reactions to be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities to DEL. The RASS approach enabled the rapid development of C(sp(2))-C(sp(3)) decarboxylative cross couplings with broad substrate scope, an electrochemical amination (the first electrochemical synthetic transformation performed in a DEL context), and improved reductive amination conditions. The utility of these reactions was demonstrated through a DEL-rehearsal in which all newly developed chemistries were orchestrated to afford a compound rich in diverse skeletal linkages. We believe that RASS will offer expedient access to new DEL reactivities, expanded chemical space, and ultimately more drug-like libraries.

Category: piperidines. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. I found the field of Chemistry very interesting. Saw the article Modular Continuous Flow Synthesis of Imatinib and Analogues published in 2019, Reprint Addresses Jamison, TF (corresponding author), MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

A modular continuous flow synthesis of imatinib and analogues is reported. Structural y diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.

Welcome to talk about 177-11-7, If you have any questions, you can contact Fu, WC; Jamison, TF or send Email.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about C-H FUNCTIONALIZATION; PHOTOCATALYTIC OXIDATION; REGIOSELECTIVE AMINATION; IMIDYL RADICALS; IODINE; ELECTROSYNTHESIS; GENERATION; AMIDATION; CHEMISTRY; ARENES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21602142]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities. Product Details of 177-11-7. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Lei, N; Shen, YL; Li, YJ; Tao, P; Yang, LQ; Su, ZS; Zheng, K. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

An environmentally friendly electrochemical approach for iodoamination of various indole derivatives with a series of unactivated amines, amino acid derivatives, and benzotriazoles (more than 80 examples) has been developed. This strategy was further applied in late-stage functionalization of natural products and pharmaceuticals and gram-scale synthesis and radiosynthesis of I-13(1)-labeled compounds. Fundamental insights into the mechanism of the reaction based on control experiments, density functional theory calculation, and cyclic voltammetry are provided.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article A General Catalytic Route to Enantioenriched Isoindolinones and Phthalides: Application in the Synthesis of (S)-PD 172938 WOS:000456633000015 published article about ASYMMETRIC MANNICH REACTION; ALDOL-TYPE REACTION; ENANTIOSELECTIVE SYNTHESIS; BRONSTED ACID; ETHYL DIAZOACETATE; ALPHA-DIAZOMETHYLPHOSPHONATES; 3-SUBSTITUTED ISOINDOLINONES; ARYLATION; ALDEHYDES; CASCADE in [Ray, Sumit K.; Sadhu, Milon M.; Biswas, Rayhan G.; Unhale, Rajshekhar A.] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal 462066, MP, India; [Singh, Vinod K.] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India in 2019, Cited 93. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Chiral Bronsted acid catalyzed enantioselective syntheses of isoindolinones and phthalides have been accomplished via tandem Mannich-lactamization and aldol-lactonization reactions, respectively. A variety of enantioenriched isoindolinones (up to 99% ee) and phthalides (up to 85% ee) containing alpha-diazoesters were afforded in excellent yields. Furthermore, a concise synthesis of (S)-PD 172938 has been demonstrated by using this protocol.

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Ray, SK; Sadhu, MM; Biswas, RG; Unhale, RA; Singh, VK or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem