Month: November 2021

An article Visible-Light-Induced Photoaddition of N-Nitrosoalkylamines to Alkenes: One-Pot Tandem Approach to 1,2-Diamination of Alkenes from Secondary Amines WOS:000641296000049 published article about NITROSO-COMPOUNDS; PHOTOCHEMISTRY; NITROSAMINES; NITROSODIALKYLAMINES; GENERATION; RADICALS in [Patil, Dilip, V; Si, Tengda; Oh, Kyungsoo] Chung Ang Univ, Ctr Metareceptome Res, Grad Sch Pharmaceut Sci, Seoul 06974, South Korea; [Kim, Hun Young] Chung Ang Univ, Dept Global Innovat Drugs, Seoul 06974, South Korea in 2021, Cited 46. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The generation of aminium radical cation species from N-nitrosoamines is disclosed for the first time through visible-light excitation at 453 nm. The developed visible-light-promoted photoaddition reaction of N-nitrosoamines to alkenes was combined with the o-NQ-catalyzed aerobic oxidation protocol of amines to telescope the direct handling of harmful N-nitroso compounds, where the desired aamino oxime derivatives were obtained in a one-pot tandem Nnitrosation and photoaddition sequence.

Welcome to talk about 177-11-7, If you have any questions, you can contact Patil, DV; Si, T; Kim, HY; Oh, K or send Email.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article 6-Substituted purines as ROCK inhibitors with anti-metastatic activity published in 2019. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane, Reprint Addresses Voller, J (corresponding author), Czech Acad Sci, Inst Expt Bot, Lab Growth Regulators, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic.; Voller, J (corresponding author), Palacky Univ, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Rho-associated serine/threonine kinases (ROCKs) are principal regulators of the actin cytoskeleton that regulate the contractility, shape, motility, and invasion of cells. We explored the relationships between structure and anti-ROCK2 activity in a group of purine derivatives substituted at the C6 atom by piperidin-1-yl or azepan-1-yl groups. Structure-activity relationship (SAR) analyses suggested that anti-ROCK activity is retained, and may be further increased, by substitution of the parent compounds at the C2 atom or by expansion of the C6 side chain. These inhibitors of ROCK can reach effective concentrations within cells, as demonstrated by a decrease in phosphorylation of the ROCK target MLC, and by inhibition of the ROCK-dependent invasion of melanoma cells in the collagen matrix. Our study may be useful for further optimization of C6-substituted purine inhibitors of ROCKs and of other sensitive kinases identified by the screening of a broad panel of protein kinases.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Category: piperidines. Takata, T; Hirano, K; Miura, M in [Takata, Tatsuaki; Hirano, Koji; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan published Synthesis of alpha-Trifluoromethylamines by Cu-Catalyzed Regio- and Enantioselective Hydroamination of 1-Trifluoromethylaikenes in 2019, Cited 81. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A copper-catalyzed regioselective net hydroamination of 1-trifluoromethylalkenes with hydrosilanes and hydroxylamines has been developed. The judicious choice of ligand and additive suppresses the conceivable but undesired beta-F elimination of an alpha-CF3-substituted organocopper intermediate, leading to targeted alpha-trifluoromethylamines in good yields with excellent regioselectivity. Additionally, with an appropriate chiral bisphosphine ligand, the enantioselective reaction is also possible to deliver optically active alpha-trifluoromethylamines of high potential in medicinal and pharmaceutical chemistry.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. Category: piperidines

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

COA of Formula: C7H13NO2. In 2020 ORG BIOMOL CHEM published article about TRANSFER RADICAL-ADDITION; HECK-TYPE ALKENYLATION; TERTIARY-ALKYLATIONS; COPPER; QUINONES; ANNULATION; STRATEGY; HETEROCYCLES; REDUCTASE; COUPLINGS in [Li, Dengke] Qujing Normal Univ, Coll Chem & Environm Sci, Qujing 655011, Yunnan, Peoples R China; [Shen, Xianfu] Qujing Normal Univ, Ctr Yunnan Guizhou Plateau Chem Funct Mat & Pollu, Qujing 655011, Yunnan, Peoples R China in 2020, Cited 86. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A simple and efficient Fe-catalyzed regioselective alkylation of 1,4-quinones and coumarins, using functionalized alkyl bromides as alkylating reagents, has been developed. The reaction proceeds under mild conditions with the addition of alkyl bromides to a wide range of 1,4-quinone and coumarin derivatives with a broad substrate scope and wide functional group tolerance to provide the products in good yields. Further application of these strategies could be extended to important biologically active antimalarial lead drugs, such as plasmodione on a gram scale in a single step for medicinal purposes.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2020 CHEM-EUR J published article about COUPLING REACTIONS; ARYL CHLORIDES; PHOTOREDOX; AMINES; PRECATALYST; AMMONIA in [Han, Dongyang; Li, Sasa; Jin, Jian] Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Synthet Chem Nat Subst, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Xia, Siqi; Su, Mincong] Shanghai Univ, Ctr Supramol Chem & Catalysis, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China in 2020, Cited 65. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple Ni(II)salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the correspondingN-arylation product in an excellent yield.

Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Anti-Markovnikov Hydroamination of Racemic Allylic Alcohols to Access Chiral gamma-Amino Alcohols WOS:000573540200001 published article about CATALYZED ASYMMETRIC HYDROGENATION; METHODOLOGY COOPERATIVE CATALYSIS; COMPLEX RUPHOX-RU; C-H AMINATION; BORROWING HYDROGEN; ENANTIOSELECTIVE SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; SECONDARY ALCOHOLS; N-ALKYLATION; KETONES in [Xu, Ruirui; Wang, Kun; Liu, Haoying; Tang, Weijun; Sun, Huaming; Xue, Dong; Wang, Chao] Shaanxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Appl Surface & Colloid Chem, Xian 710062, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England in 2020, Cited 129. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. SDS of cas: 177-11-7

A ruthenium-catalyzed formal anti-Markovnikov hydroamination of allylic alcohols for the synthesis of chiral gamma-amino alcohols is presented. Proceeding via an asymmetric hydrogen-borrowing process, the catalysis allows racemic secondary allylic alcohols to react with various amines, affording enantiomerically enriched chiral gamma-amino alcohols with broad substrate scope and excellent enantioselectivities (68 examples, up to >99 %ee).

SDS of cas: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Xu, RR; Wang, K; Liu, HY; Tang, WJ; Sun, HM; Xue, D; Xiao, JL; Wang, C or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Synthesis of C4-Aminated Indoles via a Catellani and Retro-Diels-Alder Strategy WOS:000471835600045 published article about C-H ARYLATION; TETRASUBSTITUTED HELICAL ALKENES; PALLADIUM-CATALYZED ANNULATION; REGIOSELECTIVE SYNTHESIS; FUNCTIONALIZATION; ACTIVATION; ROUTE; PD/NORBORNENE; AMIDATION in [Zhang, Bo-Sheng; Zhang, Zhe; An, Yang; Wen, Yu-Hua; Gou, Xue-Ya; Quan, Si-Qi; Wang, Xin-Gang; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Ctr Sci Modeling & Computat, Shatin, Hong Kong, Peoples R China in 2019, Cited 83. SDS of cas: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Highly functionalized 4-aminoindoles were synthesized via the three-component cross-coupling of o-iodoaniline, N-benzoyloxyamines, and norbornadiene. The Catellani and retro-Diels-Alder strategy was used in this domino process. o-Iodoaniline, with electron-donating and sterically hindered protecting groups, made the reaction selective toward o-C-H amination. On the basis of density functional theory calculations, the intramolecular Buchwald coupling of this reaction underwent a dearomatization and a 1,3-palladium migration process. The reasons for the control of the chemical selectivity by the protecting groups are given. Moreover, synthetic applications toward 4-piperazinylindole and a GOT1 inhibitor were realized.

SDS of cas: 177-11-7. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Hu, R; Chen, FJ; Zhang, XF; Zhang, M; Su, WP in [Hu, Rong; Su, Weiping] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China; [Hu, Rong; Chen, Fa-Jie; Zhang, Xiaofeng; Zhang, Min; Su, Weiping] Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China published Copper-catalyzed dehydrogenative gamma-C(sp(3))-H amination of saturated ketones for synthesis of polysubstituted anilines in 2019, Cited 70. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Metal-catalyzed beta-C-H functionalization of saturated carbonyls via dehydrogenative desaturation proved to be a powerful tool for simplifying synthesis of valuable beta-substituted carbonyls. Here, we report a copper-catalyzed dehydrogenative gamma-C(sp(3))-H amination of saturated ketones that initiates the three-component coupling of saturated ketones, amines and N-substituted maleimides to construct polysubstituted anilines. The protocol presented herein enables both linear and alpha-branched butanones to couple a wide spectrum of amines and various N-substituted maleimides to produce diverse tetra- or penta-substituted anilines in fair-to-excellent yields with good functional group tolerance. The mechanism studies support that this ketone dehydrogenative gamma-C(sp(3))-H amination was triggered by the ketone alpha,beta-dehydrogenation desaturation that activates the adjacent gamma-C(sp(3))-H bond towards functionalization. This alpha,beta-dehydrogenation desaturation-triggered cascade sequence opens up a new avenue to the remote C(sp(3))-H functionalization of saturated ketones and has the potential to enable the rapid syntheses of complex compounds from simple starting materials.

Welcome to talk about 177-11-7, If you have any questions, you can contact Hu, R; Chen, FJ; Zhang, XF; Zhang, M; Su, WP or send Email.. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about PALLADIUM-CATALYZED AMINATION; CARBON-SULFUR; COOPERATIVE CATALYSIS; EFFICIENT SYNTHESIS; METAL-COMPLEXES; ACTIVATION; FUNCTIONALIZATION; COBALT; BENZOXAZOLES; CYCLIZATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21520102003]; Hubei Province Natural Science Foundation of ChinaNatural Science Foundation of Hubei Province [2017CFA010]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Lv, ZC; Wang, HM; Quan, ZC; Gao, Y; Lei, AW. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. HPLC of Formula: C7H13NO2

Research on the cleavage of C-C bonds has been well developed. By comparison with this, the activation of C-S bonds remains challenging. Herein, dioxygen-triggered oxidative cleavage of C-S bonds has been achieved, delivering a series of N-containing heterocyclic compounds that are frequently found in pesticides and pharmaceuticals. Additionally, the potential utility of this protocol was further demonstrated by a gram-scale experiment. Mechanistically, dioxygen plays a key role in the cleavage of C-S bonds towards C-N bond formation.

HPLC of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Lv, ZC; Wang, HM; Quan, ZC; Gao, Y; Lei, AW or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Computed Properties of C7H13NO2. In 2019 ORG LETT published article about ORGANIC ELECTROSYNTHESIS; AMIDATION; HALIDES; ARENES; FUNCTIONALIZATION; COMPATIBILITY; OXYGENATION; ALKYLAMINES; ACTIVATION; BENZAMIDES in [Kathiravan, Subban; Nicholls, Ian A.] Linnaeus Univ, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden; Linnaeus Univ, Ctr Biomat Chem, SE-39182 Kalmar, Sweden in 2019, Cited 69. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C-H activation for sp(2) C-N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergistic combination of copper catalysis and electrocatalysis for aryl C-H amination under mild reaction conditions in an atom-and step-economical manner with the liberation of H-2 as the sole and benign byproduct.

Welcome to talk about 177-11-7, If you have any questions, you can contact Kathiravan, S; Suriyanarayanan, S; Nicholls, IA or send Email.. Computed Properties of C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem