Day: November 5, 2021

In 2019 J ORG CHEM published article about BUCHWALD-HARTWIG AMINATION; C-N; ARYL CHLORIDES; REDUCTIVE AMINATION; ROOM-TEMPERATURE; AROMATIC AMINATION; ARYLATION; EFFICIENT; AMINES; MONOARYLATION in [Chen, Zicong; Chen, Xiangmeng; So, Chau Ming] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, Hong Kong, Peoples R China; [So, Chau Ming] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China in 2019, Cited 81. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(pi-cinnamyl)Cl](2) enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Chen, ZC; Chen, XM; So, CM or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Copper-Catalyzed Diamination of Unactivated Alkenes With Electron-Rich Amino Sources WOS:000656057300052 published article about N-BROMOMORPHOLINE; AMINATION; PALLADIUM; CHEMISTRY; BONDS in [Li, Yang; Ali, Arshad; Dong, Junchao; Zhang, Yu; Liu, Qun; Fu, Junkai] Northeast Normal Univ, Dept Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Peoples R China; [Shi, Lili; Fu, Junkai] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China; [Shi, Lili; Fu, Junkai] Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, Shenzhen 518055, Peoples R China in 2021, Cited 65. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Formula: C7H13NO2

The catalytic intermolecular diamination of unactivated alkenes with electron-rich amino sources is a challenge. Herein, by employing a directing-group strategy, a copper-catalyzed diamination of unactivated alkenes was realized. Symmetrical diamines were efficiently produced in a highly diastereoselective manner with readily available dialkylamines as amino sources, while a one-pot and two-step operation was necessary to produce the unsymmetrical diamines. These reactions were proposed to proceed through aziridinium intermediates.

Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Li, Y; Ali, A; Dong, JC; Zhang, Y; Shi, LL; Liu, Q; Fu, JK or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2019 ANGEW CHEM INT EDIT published article about TRANSITION-METAL-FREE; C-H AMINATION; NUCLEOPHILIC-SUBSTITUTION; REDUCTIVE ELIMINATION; CATALYZED AMINATION; COUPLING REACTIONS; CARBOXYLIC-ACIDS; CROSS-COUPLINGS; DIRECTING-GROUP; ARYL CHLORIDES in [Drapeau, Martin Pichette; Bahri, Janet; Lichte, Dominik; Goossen, Lukas J.] Ruhr Univ Bochum, Fak Chem & Biochem, ZEMOS, Univ Str 150, D-44801 Bochum, Germany in 2019, Cited 80. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C-C, C-Cl, and C-N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Nosova, EV; Batanova, OA; Lipunova, GN; Kotovskaya, SK; Slepukhin, PA; Kravchenko, MA; Charushin, VN in [Nosova, Emiliya V.; Batanova, Olga A.; Kotovskaya, Svetlana K.; Slepukhin, Pavel A.; Charushin, Valery N.] Ural Fed Univ, Dept Organ & Biomol Chem, 19 Mira st, Ekaterinburg 620002, Russia; [Nosova, Emiliya V.; Lipunova, Galina N.; Kotovskaya, Svetlana K.; Slepukhin, Pavel A.; Charushin, Valery N.] Russian Acad Sci, Postovsky Inst Organ Synth, Ural Branch, 22 S Kovalevskaya St,20 Akad Skaya St, Ekaterinburg 620137, Russia; [Kravchenko, Marionella A.] Ural Res Inst Phthisiopulmonol, 50 22 Partsezda St, Ekaterinburg 620039, Russia published SYNTHESIS AND ANTITUBERCULAR EVALUATION OF FLUORINATED 2-CYCLOALKYLIMINO SUBSTITUTED 1,3-BENZOTHIAZIN-4-ONES in 2019, Cited 22. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Novel fluorinated 2-substituted 1,3-benzothiazin-4-ones were obtained through the addition of N-nucleophiles to ortho-fluorobenzoylisothiocyanates, followed by cyclization of fluorobenzoyl-thioureas. Synthetic approaches to original 2-cycloalkylimino- and 2-carbonylpiperazino- substituted benzothiazinones, bearing different number of fluorine atoms in the benzene ring have been found. 2-Ethoxycarbonylpiperazino-5-fluoro-1,3-benzothiazin-4-one proved to exhibit a high tuberculostatic activity in vitro (MIC 0.7 microgram/mL), thus indicating that a search of biologically active compounds in this family of heterocycles appears to be a reasonable approach.

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Computed Properties of C7H13NO2. In 2019 TETRAHEDRON LETT published article about ASYMMETRIC-SYNTHESIS; COMPLEXES in [Li, Gang-Jian; Pan, You-Lu; Liu, Yan-Ling; Xu, Hai-Feng; Chen, Jian-Zhong] Zhejiang Univ, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou, Zhejiang, Peoples R China in 2019, Cited 40. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

It was reported to develop a simple and convenient method for the Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines without an acid/base to afford secondary or tertiary sulfinamides in moderate to good yields. The method can provide the desired products with broad substrate scope, good chemoselectivity and good functional group compatibility. The presented approach may enrich the Nil NHC catalyst system and promote the applications of methyl sulfinates in the organic sulfur chemistry. (C) 2019 Elsevier Ltd. All rights reserved.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

SDS of cas: 177-11-7. In 2019 INORG CHIM ACTA published article about CHIRAL CONFIGURATIONS; BIOLOGICAL-ACTIVITIES; MOLECULAR DOCKING; PHOSPHAZENES; BINDING; ASSAY in [Asmafiliz, Nuran; Berberoglu, Ipek; Ozgur, Mehtap; Kilic, Zeynel] Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey; [Kayalak, Hande; Acik, Leyla] Gazi Univ, Dept Biol, TR-06500 Ankara, Turkey; [Turk, Mustafa] Kirikkale Univ, Dept Bioengn, TR-71450 Kirikkale, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, TR-06800 Ankara, Turkey in 2019, Cited 59. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

In the present study, the partly and fully-substituted monospiro (4-6, 4a-6d), cis-dispiro (7-9), trans-dispiro (10-15) cyclotriphosphazenes were synthesized for the investigations of their chemical, stereogenic and biological properties. The cis/trans phosphazenes (7-12) have two stereogenic P centers. They are expected to be in meso and racemic forms. In addition, the structures of four compounds were evaluated using X-ray crystal-lographic data. Compound 13 was found to be a single enantiomer (RR) in the solid state, as also proved with its CD spectrum. The antibacterial and antifungal activities of the phosphazenes were elucidated for against Gram-positive (G+) and Gram-negative (G-) bacteria, and yeast strains, respectively. Of the compounds, 14 exhibits strong antimicrobial activity against most of the tested organisms, especially B. cereus and E. hirae. MBC and MFC values of compounds on different bacterial and fungal species ranged from < 9.8 mu M to 2500 mu M. Furthermore, the cytotoxic activities of 6, 4c, 10 and 14 were investigated against L929 fibroblast and DLD-1 cells, and 14 was the most cytotoxic compound against DLD-1. SDS of cas: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Asmafiliz, N; Berberoglu, I; Ozgur, M; Kilic, Z; Kayalak, H; Acik, L; Turk, M; Hokelek, T or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about BENZOTHIAZINONE DERIVATIVES; TUBERCULOSIS; IDENTIFICATION, Saw an article supported by the Russian Scientific FoundationRussian Science Foundation (RSF) [15-13-00077-P]; Ministry of Education of Russian Federation [4.6351.2017/8.9]; Russian Science FoundationRussian Science Foundation (RSF) [18-13-16012] Funding Source: Russian Science Foundation. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Nosova, EV; Batanova, OA; Lipunova, GN; Kotovskaya, SK; Slepukhin, PA; Kravchenko, MA; Charushin, VN. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Novel fluorinated 2-substituted 1,3-benzothiazin-4-ones were obtained through the addition of N-nucleophiles to ortho-fluorobenzoylisothiocyanates, followed by cyclization of fluorobenzoyl-thioureas. Synthetic approaches to original 2-cycloalkylimino- and 2-carbonylpiperazino- substituted benzothiazinones, bearing different number of fluorine atoms in the benzene ring have been found. 2-Ethoxycarbonylpiperazino-5-fluoro-1,3-benzothiazin-4-one proved to exhibit a high tuberculostatic activity in vitro (MIC 0.7 microgram/mL), thus indicating that a search of biologically active compounds in this family of heterocycles appears to be a reasonable approach.

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Nosova, EV; Batanova, OA; Lipunova, GN; Kotovskaya, SK; Slepukhin, PA; Kravchenko, MA; Charushin, VN or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Copper-Catalyzed Diamination of Unactivated Alkenes With Electron-Rich Amino Sources WOS:000656057300052 published article about N-BROMOMORPHOLINE; AMINATION; PALLADIUM; CHEMISTRY; BONDS in [Li, Yang; Ali, Arshad; Dong, Junchao; Zhang, Yu; Liu, Qun; Fu, Junkai] Northeast Normal Univ, Dept Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Peoples R China; [Shi, Lili; Fu, Junkai] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China; [Shi, Lili; Fu, Junkai] Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, Shenzhen 518055, Peoples R China in 2021, Cited 65. Product Details of 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The catalytic intermolecular diamination of unactivated alkenes with electron-rich amino sources is a challenge. Herein, by employing a directing-group strategy, a copper-catalyzed diamination of unactivated alkenes was realized. Symmetrical diamines were efficiently produced in a highly diastereoselective manner with readily available dialkylamines as amino sources, while a one-pot and two-step operation was necessary to produce the unsymmetrical diamines. These reactions were proposed to proceed through aziridinium intermediates.

Product Details of 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Li, Y; Ali, A; Dong, JC; Zhang, Y; Shi, LL; Liu, Q; Fu, JK or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Chemistry very interesting. Saw the article Step-wise and one-pot synthesis of highly substituted conjugated trienes from 2-oxobenzo [h]chromenes/2H-pyran-2-ones published in 2021. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane, Reprint Addresses Pratap, R (corresponding author), Univ Delhi, Dept Chem, North Campus, Delhi 110007, India.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A mild and efficient route for the synthesis of conjugated trienes via nitroethane-mediated ring contraction of 2-oxobenzo[h]chromenes/2H-pyran-2-ones followed by decarboxylative rearrangement of the obtained spirobutenolides and butenolides is described. The (E)-isomer of trienes was obtained by step-wise and one-pot approaches from 2-oxobenzo[h]chromenes. Butenolides 4a-l as new substrates have been developed for the construction of trienes. The mixture of the (E)- and (Z)-isomers of spirobutenolides undergoes decarboxylative rearrangement in the presence of sodium ethoxide as a base to yield the (E)-isomer of trienes, while the (E)-isomer of butenolides reacts to give a mixture of (2E,4E)- and (2E,4Z)-isomers of trienes in an almost steady ratio of 45 : 55 or 1 : 1.2. The structure and geometry of the obtained butenolides and trienes were confirmed by single-crystal X-ray analysis.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2020 J ORG CHEM published article about SUBSTITUTED ARYL IODIDES; ARYLATIVE DEAROMATIZATION; FLUORESCENT-PROBE; ACCESS; LEVOFLOXACIN; BOND; PD; CYCLIZATION; AMINATION; AGENTS in [Zhang, Zhe; Zhang, Bo-Sheng; An, Yang; Liu, Ce; Gou, Xue-Ya; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Li, Kai-Li] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Peoples R China in 2020, Cited 103. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Product Details of 177-11-7

This report describes a palladium-catalyzed dearomatization and amination tandem reaction of 2,3-disubstituted indoles and benzofurans via the Catellani strategy. This reaction provides a new method for the construction of amino-substituted indoline-fused cyclic and benzofuran spiro compounds in good yields. The reaction has broad functional group compatibility and substrate scope.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem