Day: November 3, 2021

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Authors Wu, J; Zheng, CM; Li, BY; Hawkins, JM; Scott, SL in ROYAL SOC CHEMISTRY published article about in [Wu, Jing; Zheng, Chunming; Scott, Susannah L.] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA; [Li, Bryan] Pfizer Global Res & Dev, Chem R&D La Jolla Lab, San Diego, CA 92121 USA; [Hawkins, Joel M.] Pfizer Global Res & Dev, Groton, CT 06371 USA; [Scott, Susannah L.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA in 2021, Cited 64. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

N-Boc deprotection (deBoc) is a common reaction in pharmaceutical research and development, as well as pharma manufacturing. Use of a catalyst lowers the required reaction temperature, and heterogeneous catalysts allow the reaction to be conducted in a continuous flow reactor with a low-boiling solvent, facilitating product separation and enhancing efficiency and productivity relative to a batch process. In this study, we explore the use of simple solid Bronsted acid catalysts to achieve continuous N-Boc deprotection of amines, without additional workup steps. Using THF as the solvent, H-BEA zeolite affords high yields of a variety of aromatic and aliphatic amines, often in residence times of less than a minute at 140 degrees C. The same catalyst/solvent combination is ineffective in batch conditions, due to the much lower temperature of refluxing THF. Boc-protected p-chloroaniline was deprotected with a throughput of 18 mmol p-chloroaniline per h per g(cat), sustained over 9 h. The active sites of the zeolite do not appear to be directly associated with the Al framework substitution in the micropores, since partially ion-exchanged Na/H-BEA shows activity similar to H-BEA. The strong Bronsted acid sites (framework [Si(OH)Al]), are likely poisoned by the amine product. Moderate Bronsted acid sites associated with silanol defects near Al on or near the external surface (and not susceptible to Na+-exchange) are presumably the active sites, since they are not poisoned even by more basic aliphatic amines.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wu, J; Zheng, CM; Li, BY; Hawkins, JM; Scott, SL or concate me.. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Category: piperidines. I found the field of Chemistry very interesting. Saw the article Visible light photoredox catalysed amidation of carboxylic acids with amines published in 2019, Reprint Addresses Singh, PP (corresponding author), United Coll Engn & Res, Dept Chem, Allahabad 211010, Uttar Pradesh, India.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

A visible-light promoted photoredox catalysed, green one-pot approach for the amidation of carboxylic acids with amines has been developed for the synthesis of diverse aliphatic and aromatic amides. The proposed strategy is extendable also to biologically active amides and could represent a low-cost alternative to the common synthetic pathways. The developed strategy may hold great potential for a comprehensive display of biologically interesting peptide synthesis and amino acid modification. (C) 2018 Elsevier Ltd. All rights reserved.

Category: piperidines. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Srivastava, V; Singh, PK; Singh, PP or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Yang, Z; Jiang, K; Chen, YC; Wei, Y in AMER CHEMICAL SOC published article about C-H FUNCTIONALIZATION; ELECTROPHILIC AMINATION; MULTICOMPONENT REACTIONS; INSERTION REACTION; FACILE ACCESS; OXIMES; CYCLOADDITION; ISONITRILES; CYCLIZATION; ARYL in [Yang, Zhen; Jiang, Kun; Chen, Ying-Chun; Wei, Ye] Army Med Univ, Coll Pharm, Chongqing 400038, Peoples R China; [Wei, Ye] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China in 2019, Cited 57. Category: piperidines. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A copper-catalyzed protocol has been realized for the rapid assembly of dihydroquinolinones from readily accessible isocyanides and O-benzoyl hydroxylamines. The reactions (10 mol % of CuOAc, 10 mol % of dppe, 3 equiv of PhONa, 30 degrees C) deliver various structurally interesting dihydroquinolinones in moderate to good yields (up to 76%). The reactions may proceed in a cascade manner involving isocyanide insertion into the N-O bond, Mumm-type rearrangement, and intramolecular nucleophilic substitution.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Yang, Z; Jiang, K; Chen, YC; Wei, Y or concate me.. Category: piperidines

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Cao, Q; Nicholson, WI; Jones, AC; Browne, DL in ROYAL SOC CHEMISTRY published article about N-HETEROCYCLIC CARBENES; ARYL CHLORIDES; MECHANOCHEMISTRY; COMPLEXES; PRECATALYST; CATALYSTS; LIGANDS; NHC in [Cao, Qun; Nicholson, William I.; Jones, Andrew C.; Browne, Duncan L.] Cardiff Univ, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3EQ, S Glam, Wales in 2019, Cited 35. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

An operationally simple mechanochemical method for the Pd catalysed Buchwald-Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. The system is demonstrated on 30 substrates and applied in the context of a target synthesis. Furthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution and mechanochemical conditions, the observations are discussed herein.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Cao, Q; Nicholson, WI; Jones, AC; Browne, DL or concate me.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Iodine-promoted Intermolecular Dehydrogenation Diamination: Synthesis of Unsymmetrical ,-Diamido Ketones WOS:000470179400020 published article about ALKENE DIAMINATION; ASYMMETRIC DIAMINATION; CATALYZED DIAMINATION; VICINAL DIAMINES; SECONDARY-AMINES; CHIRAL DIAMINES; REAGENTS; 1,2-DIAMINATION; PALLADIUM; DERIVATIVES in [Zhang, YongJian; Su, Junyi; Niu, Wenjie; Li, Yujin] Zhejiang Univ Technol, Dept Chem & Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310032, Zhejiang, Peoples R China in 2019, Cited 56. HPLC of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Iodine-promoted direct diamination of ,-unsaturated ketone to form two C-N bonds has been developed starting from chalcone and secondary amine. This reaction was performed in THF at 50 degrees C in the presence of I-2 and K2CO3. The protocol is metal-free, operationally simple and carried out under mild conditions, providing an effective new way for directing diamination reactions.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhang, YJ; Su, JY; Niu, WJ; Li, YJ or concate me.. HPLC of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Iodine-promoted Intermolecular Dehydrogenation Diamination: Synthesis of Unsymmetrical ,-Diamido Ketones WOS:000470179400020 published article about ALKENE DIAMINATION; ASYMMETRIC DIAMINATION; CATALYZED DIAMINATION; VICINAL DIAMINES; SECONDARY-AMINES; CHIRAL DIAMINES; REAGENTS; 1,2-DIAMINATION; PALLADIUM; DERIVATIVES in [Zhang, YongJian; Su, Junyi; Niu, Wenjie; Li, Yujin] Zhejiang Univ Technol, Dept Chem & Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310032, Zhejiang, Peoples R China in 2019, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Iodine-promoted direct diamination of ,-unsaturated ketone to form two C-N bonds has been developed starting from chalcone and secondary amine. This reaction was performed in THF at 50 degrees C in the presence of I-2 and K2CO3. The protocol is metal-free, operationally simple and carried out under mild conditions, providing an effective new way for directing diamination reactions.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhang, YJ; Su, JY; Niu, WJ; Li, YJ or concate me.. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Chemistry very interesting. Saw the article Phosphorus-nitrogen compounds. Part 42. The comparative syntheses of 2-cis-4-ansa(N/O) and spiro(N/O) cyclotetraphosphazene derivatives: spectroscopic and crystallographic characterization, antituberculosis and cytotoxic activity studies published in 2019. Formula: C7H13NO2, Reprint Addresses Elmas, G; Kilic, Z (corresponding author), Ankara Univ, Dept Chem, TR-06100 Tandogan, Turkey.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The reaction of N4P4Cl8 (1) with one equimolar amount of the sodium salt of an N/O donor-type bidentate ligand (2) afforded two kinds of derivatives, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes. The reaction yield (35%) of 4 was significantly larger than that of 3 (14%). The 2,4-ansa compound (3) was reacted with excess secondary amines to produce 2-cis-4-dichloro-ansa-cyclotetraphosphazenes (3a-3d). On the other hand, the spiro compound (4) gave fully substituted mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d) with excess monoamines as well. The tetrameric phosphazene derivatives were characterized by ESI-MS and/or HRMS, FTIR, HSQC, HMBC, H-1, C-13, and P-31 NMR spectroscopy and X-ray crystallography (for 4). It is observed that the 2,4-ansa and spiro-cyclotetraphosphazenes have different thermal stabilities. Additionally, the CVs of the new mono-ferrocenyl pendant-armed cyclotetraphosphazenes revealed electrochemically reversible one-electron oxidation of the Fe-redox centre. The 2,4-ansa phosphazenes (3 and 3a-3d) have two different stereogenic P centers indicating that they are expected to be in racemic mixtures (RR’/SS’). The chiralities of 3a and 3c were investigated by chiral HPLC. The manuscript also deals with the antimicrobial activities against G(+)/G(-) bacteria and fungi, the interactions with plasmid DNA, the in vitro cytotoxic activities against L929 fibroblast and MCF7 breast cells, and the antituberculosis activities against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Binici, A; Okumus, A; Elmas, G; Kilic, Z; Ramazanoglu, N; Acik, L; Simsek, H; Tunali, BC; Turk, M; Guzel, R; Hokelek, T or concate me.. Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Visible-Light-Induced Photoaddition of N-Nitrosoalkylamines to Alkenes: One-Pot Tandem Approach to 1,2-Diamination of Alkenes from Secondary Amines WOS:000641296000049 published article about NITROSO-COMPOUNDS; PHOTOCHEMISTRY; NITROSAMINES; NITROSODIALKYLAMINES; GENERATION; RADICALS in [Patil, Dilip, V; Si, Tengda; Oh, Kyungsoo] Chung Ang Univ, Ctr Metareceptome Res, Grad Sch Pharmaceut Sci, Seoul 06974, South Korea; [Kim, Hun Young] Chung Ang Univ, Dept Global Innovat Drugs, Seoul 06974, South Korea in 2021, Cited 46. SDS of cas: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The generation of aminium radical cation species from N-nitrosoamines is disclosed for the first time through visible-light excitation at 453 nm. The developed visible-light-promoted photoaddition reaction of N-nitrosoamines to alkenes was combined with the o-NQ-catalyzed aerobic oxidation protocol of amines to telescope the direct handling of harmful N-nitroso compounds, where the desired aamino oxime derivatives were obtained in a one-pot tandem Nnitrosation and photoaddition sequence.

SDS of cas: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Patil, DV; Si, T; Kim, HY; Oh, K or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Adamson, NJ; Jeddi, H; Malcolmson, SJ in [Adamson, Nathan J.; Jeddi, Haleh; Malcolmson, Steven J.] Duke Univ, Dept Chem, Durham, NC 27708 USA published Preparation of Chiral Allenes through Pd-Catalyzed Intermolecular Hydroamination of Conjugated Enynes: Enantioselective Synthesis Enabled by Catalyst Design in 2019, Cited 68. HPLC of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

In this study, we establish that conjugated enynes undergo selective 1,4-hydroamination under Pd catalysis to deliver chiral allenes with pendant allylic amines. Several primary and secondary aliphatic and aryl-substituted amines couple with a wide range of mono- and disubstituted enynes in a nonenantioselective reaction where DPEphos serves as the ligand for Pd. Benzophenone imine acts as an ammonia surrogate to afford primary amines in a two-step/one-pot process. Examination of chiral catalysts revealed a high degree of reversibility in the C-N bond formation that negatively impacted enantioselectivity. Consequently, an electron-poor ferrocenyl-PHOX ligand was developed to enable efficient and enantioselective enyne hydroamination.

HPLC of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Adamson, NJ; Jeddi, H; Malcolmson, SJ or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Decarboxylative ipso Amination of Activated Benzoic Acids WOS:000455033700042 published article about TRANSITION-METAL-FREE; C-H AMINATION; NUCLEOPHILIC-SUBSTITUTION; REDUCTIVE ELIMINATION; CATALYZED AMINATION; COUPLING REACTIONS; CARBOXYLIC-ACIDS; CROSS-COUPLINGS; DIRECTING-GROUP; ARYL CHLORIDES in [Drapeau, Martin Pichette; Bahri, Janet; Lichte, Dominik; Goossen, Lukas J.] Ruhr Univ Bochum, Fak Chem & Biochem, ZEMOS, Univ Str 150, D-44801 Bochum, Germany in 2019, Cited 80. Category: piperidines. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C-C, C-Cl, and C-N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.

Category: piperidines. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem