Day: November 2, 2021

An article Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines for direct access to sulfinamides WOS:000498291800009 published article about ASYMMETRIC-SYNTHESIS; COMPLEXES in [Li, Gang-Jian; Pan, You-Lu; Liu, Yan-Ling; Xu, Hai-Feng; Chen, Jian-Zhong] Zhejiang Univ, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou, Zhejiang, Peoples R China in 2019, Cited 40. COA of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

It was reported to develop a simple and convenient method for the Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines without an acid/base to afford secondary or tertiary sulfinamides in moderate to good yields. The method can provide the desired products with broad substrate scope, good chemoselectivity and good functional group compatibility. The presented approach may enrich the Nil NHC catalyst system and promote the applications of methyl sulfinates in the organic sulfur chemistry. (C) 2019 Elsevier Ltd. All rights reserved.

COA of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Li, GJ; Pan, YL; Liu, YL; Xu, HF; Chen, JZ or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about PALLADIUM-CATALYZED SYNTHESIS; SULFUR-DIOXIDE SURROGATE; ONE-POT; SULFONYL FLUORIDES; BORONIC ACIDS; DABSO; BORYLATION; RONGALITE; REAGENTS; HALIDES, Saw an article supported by the MPI fur Kohlenforschung. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C-H sulfination sequence via aryl sulfonium salts to access aryl sulfonamides. Combined with site-selective aromatic thianthrenation, an operationally simple one-pot palladium-catalyzed protocol introduces the sulfonyl group using sodium hydroxymethylsulfinate (Rongalite) as a source of SO22-. The hydroxymethyl sulfone intermediate generated from the catalytic process can be employed as a synthetic handle to deliver a variety of sulfonyl-containing compounds.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T or concate me.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2021 ORG LETT published article about NITROSO-COMPOUNDS; PHOTOCHEMISTRY; NITROSAMINES; NITROSODIALKYLAMINES; GENERATION; RADICALS in [Patil, Dilip, V; Si, Tengda; Oh, Kyungsoo] Chung Ang Univ, Ctr Metareceptome Res, Grad Sch Pharmaceut Sci, Seoul 06974, South Korea; [Kim, Hun Young] Chung Ang Univ, Dept Global Innovat Drugs, Seoul 06974, South Korea in 2021, Cited 46. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 177-11-7

The generation of aminium radical cation species from N-nitrosoamines is disclosed for the first time through visible-light excitation at 453 nm. The developed visible-light-promoted photoaddition reaction of N-nitrosoamines to alkenes was combined with the o-NQ-catalyzed aerobic oxidation protocol of amines to telescope the direct handling of harmful N-nitroso compounds, where the desired aamino oxime derivatives were obtained in a one-pot tandem Nnitrosation and photoaddition sequence.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Patil, DV; Si, T; Kim, HY; Oh, K or concate me.. Recommanded Product: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Zhang, BS; Li, YK; Zhang, Z; An, Y; Wen, YH; Gou, XY; Quan, SQ; Wang, XG; Liang, YM in AMER CHEMICAL SOC published article about C-H ARYLATION; TETRASUBSTITUTED HELICAL ALKENES; PALLADIUM-CATALYZED ANNULATION; REGIOSELECTIVE SYNTHESIS; FUNCTIONALIZATION; ACTIVATION; ROUTE; PD/NORBORNENE; AMIDATION in [Zhang, Bo-Sheng; Zhang, Zhe; An, Yang; Wen, Yu-Hua; Gou, Xue-Ya; Quan, Si-Qi; Wang, Xin-Gang; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Ctr Sci Modeling & Computat, Shatin, Hong Kong, Peoples R China in 2019, Cited 83. Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Highly functionalized 4-aminoindoles were synthesized via the three-component cross-coupling of o-iodoaniline, N-benzoyloxyamines, and norbornadiene. The Catellani and retro-Diels-Alder strategy was used in this domino process. o-Iodoaniline, with electron-donating and sterically hindered protecting groups, made the reaction selective toward o-C-H amination. On the basis of density functional theory calculations, the intramolecular Buchwald coupling of this reaction underwent a dearomatization and a 1,3-palladium migration process. The reasons for the control of the chemical selectivity by the protecting groups are given. Moreover, synthetic applications toward 4-piperazinylindole and a GOT1 inhibitor were realized.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhang, BS; Li, YK; Zhang, Z; An, Y; Wen, YH; Gou, XY; Quan, SQ; Wang, XG; Liang, YM or concate me.. Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Chen, TC; Yu, DS; Chen, SJ; Chen, CL; Lee, CC; Hsieh, YY; Chang, LC; Guh, JH; Lin, JJ; Huang, HS in ELSEVIER published article about RAPID COLORIMETRIC ASSAY; ANTIPROLIFERATIVE EVALUATION; MOLECULAR HYBRIDIZATION; ANALOGS; CANCER; CAMPTOTHECIN; ALKALOIDS; MECHANISM; DISCOVERY; APOPTOSIS in [Chen, Tsung-Chih; Chen, Chun-Liang; Lee, Chia-Chung; Huang, Hsu-Shan] Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery, Taipei 110, Taiwan; [Chen, Tsung-Chih; Yu, Dah-Shyong; Chen, Chun-Liang; Lee, Chia-Chung; Huang, Hsu-Shan] Natl Def Med Ctr, Grad Inst Life Sci, Taipei 114, Taiwan; [Chen, Tsung-Chih; Chen, Shiag-Jiun; Hsieh, Ying-Yu; Huang, Hsu-Shan] Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan; [Yu, Dah-Shyong] Triserv Gen Hosp, Dept Surg, Div Urol, Urooncol Lab, Taipei 114, Taiwan; [Yu, Dah-Shyong] Natl Def Med Ctr, Inst Prevent Med, Taipei 114, Taiwan; [Chang, Lien-Cheng; Lin, Jing-Jer] Natl Taiwan Univ, Coll Med, Inst Biochem & Mol Biol, Taipei 100, Taiwan; [Chang, Lien-Cheng] Minist Hlth & Welf, Food & Drug Adm, Taipei 115, Taiwan; [Guh, Jih-Hwa] Natl Taiwan Univ, Sch Pharm, Taipei 100, Taiwan in 2019, Cited 40. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Several 9-chloro-11H-indeno[1,2-c]quinolin-11-one derivatives have been designed which is replacing side chains with different groups containing oxygen, nitrogen or sulfur atoms. Substitution of C-6 on the starting structure, 6,9-dichloro-11H-indeno[1,2-c]quinolin-11-one, using apposite nucleophilic group with a suitable base or acid could be obtained 28 novel tetracyclic azafluorenone derivatives. The cytotoxic activity of these analogues was examined in cancer cell lines by MTT assay and compounds 4, 5, 13, and 26 were selected to evaluate in topoisomerase I drug screening assay, respectively. At the same time, 17 compounds were selected for NCI-60 anticancer drug screen to prevent the narrower concept of an in vitro screening model. Its worth to find that 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (12) showed greater cytotoxicity than another azafluorenone derivatives with an average GI(50) of 10.498 mu M over 60 cell lines. We also found that another analogue, 9-chloro-6-(2-methylpiperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (13), exhibited preferential growth inhibition effect toward cancer cell lines and showed a significant inhibitory effect on topoisomerase I. (C) 2016 Production and hosting by Elsevier B.V. on behalf of King Saud University.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Chen, TC; Yu, DS; Chen, SJ; Chen, CL; Lee, CC; Hsieh, YY; Chang, LC; Guh, JH; Lin, JJ; Huang, HS or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Product Details of 177-11-7. In 2021 ORG LETT published article about N-BROMOMORPHOLINE; AMINATION; PALLADIUM; CHEMISTRY; BONDS in [Li, Yang; Ali, Arshad; Dong, Junchao; Zhang, Yu; Liu, Qun; Fu, Junkai] Northeast Normal Univ, Dept Chem, Jilin Prov Key Lab Organ Funct Mol Design & Synth, Changchun 130024, Peoples R China; [Shi, Lili; Fu, Junkai] Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China; [Shi, Lili; Fu, Junkai] Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, Shenzhen 518055, Peoples R China in 2021, Cited 65. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The catalytic intermolecular diamination of unactivated alkenes with electron-rich amino sources is a challenge. Herein, by employing a directing-group strategy, a copper-catalyzed diamination of unactivated alkenes was realized. Symmetrical diamines were efficiently produced in a highly diastereoselective manner with readily available dialkylamines as amino sources, while a one-pot and two-step operation was necessary to produce the unsymmetrical diamines. These reactions were proposed to proceed through aziridinium intermediates.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Li, Y; Ali, A; Dong, JC; Zhang, Y; Shi, LL; Liu, Q; Fu, JK or concate me.. Product Details of 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Diastereoselective synthesis of chiral 3-substituted isoindolinones via rhodium(iii)-catalyzed oxidative C-H olefination/annulation WOS:000661230200001 published article about N-ACYL KETIMINES; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; 1,3-DISUBSTITUTED ISOINDOLINES; STEREOSELECTIVE-SYNTHESIS; CATALYZED ARYLATION; MICHAEL REACTIONS; DIRECTING GROUP; 3+2 ANNULATION; ACTIVATION in [Li, Xue-Hong; Gong, Jun-Fang; Song, Mao-Ping] Zhengzhou Univ, Green Catalysis Ctr, Coll Chem, Zhengzhou 450001, Peoples R China in 2021, Cited 104. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(iii)-catalyzed chiral N-sulfinyl amide directed asymmetric [4 + 1] annulation of benzamides with acrylic esters has been developed. The reaction proceeded through an oxidative C-H olefination and a subsequent cyclization by intramolecular aza-Michael addition, producing a series of diastereoisomeric chiral isoindolinones (20 examples) in generally good yields with a dr value up to 5.5 : 1. The absolute configurations of the newly formed C-stereocenters in the major and minor diastereomers of the catalysis product have been determined by X-ray crystal diffraction analysis to be S and R, respectively. The separation of the major diastereoisomers from the catalysis products and subsequent removal of the N-sulfinyl chiral auxiliary afforded enantiomerically pure (S)-isoindolinones. The application of the obtained (S)-isoindolinones in the synthesis of several biologically active isoindolinones such as (S)-PD172938, (S)-pazinaclone and (S)-pagoclone is presented.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Li, XH; Gong, JF; Song, MP or concate me.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Xu, RR; Wang, K; Liu, HY; Tang, WJ; Sun, HM; Xue, D; Xiao, JL; Wang, C in WILEY-V C H VERLAG GMBH published article about CATALYZED ASYMMETRIC HYDROGENATION; METHODOLOGY COOPERATIVE CATALYSIS; COMPLEX RUPHOX-RU; C-H AMINATION; BORROWING HYDROGEN; ENANTIOSELECTIVE SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; SECONDARY ALCOHOLS; N-ALKYLATION; KETONES in [Xu, Ruirui; Wang, Kun; Liu, Haoying; Tang, Weijun; Sun, Huaming; Xue, Dong; Wang, Chao] Shaanxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Appl Surface & Colloid Chem, Xian 710062, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England in 2020, Cited 129. Recommanded Product: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A ruthenium-catalyzed formal anti-Markovnikov hydroamination of allylic alcohols for the synthesis of chiral gamma-amino alcohols is presented. Proceeding via an asymmetric hydrogen-borrowing process, the catalysis allows racemic secondary allylic alcohols to react with various amines, affording enantiomerically enriched chiral gamma-amino alcohols with broad substrate scope and excellent enantioselectivities (68 examples, up to >99 %ee).

Recommanded Product: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Xu, RR; Wang, K; Liu, HY; Tang, WJ; Sun, HM; Xue, D; Xiao, JL; Wang, C or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2020 J AM CHEM SOC published article about IN-VITRO; BENZENESULFINYL AZIDE; NH-SULFOXIMINES; CHEMISTRY; SUFEX; SULFUR; INHIBITOR; DISCOVERY; SULFIDES; SOF4 in [Davies, Thomas Q.; Tilby, Michael J.; Ren, Jack; Parker, Nicholas A.; Duarte, Fernanda; Willis, Michael C.] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England; [Skolc, David; Hall, Adrian] UCB Biopharma SPRL, B-1420 Braine Lalleud, Belgium in 2020, Cited 68. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Sulfoximines and sulfonimidamides are promising compounds for medicinal and agrochemistry. As monoaza analogues of sulfones and sulfonamides, respectively, they combine good physicochemical properties, high stability, and the ability to build complexity from a three-dimensional core. However, a lack of quick and efficient methods to prepare these compounds has hindered their uptake in molecule discovery programmes. Herein, we describe a unified, one-pot approach to both sulfoximines and sulfonimidamides, which exploits the high electrophilicity of sulfinyl nitrenes. We generate these rare reactive intermediates from a novel sulfinylhydroxylamine (R-O-N=S=O) reagent through an N-O bond fragmentation process. Combining sulfinyl nitrenes with carbon and nitrogen nucleophiles enables the synthesis of sulfoximines and sulfonimidamides in a reaction time of just 15 min. Alkyl, (hetero)aryl, and alkenyl organometallic reagents can all be used as the first or second component in the reaction, while primary and secondary amines, and anilines, all react with high efficiency as the second nucleophile. The tolerance of the reaction to steric and electronic factors has allowed for the synthesis of the most diverse set of sulfoximines and sulfonimidamides yet described. Experimental and computational investigations support the intermediacy of sulfinyl nitrenes, with nitrene formation proceeding via a transient triplet intermediate before reaching a planar singlet species.

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Davies, TQ; Tilby, MJ; Ren, J; Parker, NA; Skolc, D; Hall, A; Duarte, F; Willis, MC or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Schuppe, AW; Knippel, JL; Borrajo-Calleja, GM; Buchwald, SL in AMER CHEMICAL SOC published article about in [Schuppe, Alexander W.; Knippel, James Levi; Borrajo-Calleja, Gustavo M.; Buchwald, Stephen L.] MIT, Dept Chem, Cambridge, MA 02139 USA in 2021, Cited 56. Name: 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The catalytic enantioselective synthesis of a-chiral olefins represents a valuable strategy for rapid generation of structural diversity in divergent syntheses of complex targets. Herein, we report a protocol for the dual CuH- and Pd-catalyzed asymmetric Markovnikov hydroalkenylation of vinyl arenes and the anti-Markovnikov hydroalkenylation of unactivated olefins, in which readily available enol triflates can be utilized as alkenyl coupling partners. This method allowed for the synthesis of diverse alpha-chiral olefins, including tri- and tetrasubstituted olefin products, which are challenging to prepare by existing approaches.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Schuppe, AW; Knippel, JL; Borrajo-Calleja, GM; Buchwald, SL or concate me.. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem