Month: October 2021

Recently I am researching about DNA INTERACTIONS; STEREOGENIC PROPERTIES; STRUCTURAL CHARACTERIZATIONS; ANTIMICROBIAL ACTIVITIES; ELECTROCHEMICAL INVESTIGATIONS; CYCLOTRIPHOSPHAZENE CORE; CHIRAL CONFIGURATIONS; DENDRIMERS; CYCLOPHOSPHAZENES; CHEMISTRY, Saw an article supported by the Scientific and Technical Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215Z496]; Hacettepe University Scientific Research Project UnitHacettepe University [013 D04 602 004]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Binici, A; Okumus, A; Elmas, G; Kilic, Z; Ramazanoglu, N; Acik, L; Simsek, H; Tunali, BC; Turk, M; Guzel, R; Hokelek, T. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

The reaction of N4P4Cl8 (1) with one equimolar amount of the sodium salt of an N/O donor-type bidentate ligand (2) afforded two kinds of derivatives, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes. The reaction yield (35%) of 4 was significantly larger than that of 3 (14%). The 2,4-ansa compound (3) was reacted with excess secondary amines to produce 2-cis-4-dichloro-ansa-cyclotetraphosphazenes (3a-3d). On the other hand, the spiro compound (4) gave fully substituted mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d) with excess monoamines as well. The tetrameric phosphazene derivatives were characterized by ESI-MS and/or HRMS, FTIR, HSQC, HMBC, H-1, C-13, and P-31 NMR spectroscopy and X-ray crystallography (for 4). It is observed that the 2,4-ansa and spiro-cyclotetraphosphazenes have different thermal stabilities. Additionally, the CVs of the new mono-ferrocenyl pendant-armed cyclotetraphosphazenes revealed electrochemically reversible one-electron oxidation of the Fe-redox centre. The 2,4-ansa phosphazenes (3 and 3a-3d) have two different stereogenic P centers indicating that they are expected to be in racemic mixtures (RR’/SS’). The chiralities of 3a and 3c were investigated by chiral HPLC. The manuscript also deals with the antimicrobial activities against G(+)/G(-) bacteria and fungi, the interactions with plasmid DNA, the in vitro cytotoxic activities against L929 fibroblast and MCF7 breast cells, and the antituberculosis activities against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Binici, A; Okumus, A; Elmas, G; Kilic, Z; Ramazanoglu, N; Acik, L; Simsek, H; Tunali, BC; Turk, M; Guzel, R; Hokelek, T or concate me.. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 J AM CHEM SOC published article about C-H ARYLATION; TETRASUBSTITUTED HELICAL ALKENES; PALLADIUM-CATALYZED ANNULATION; REGIOSELECTIVE SYNTHESIS; FUNCTIONALIZATION; ACTIVATION; ROUTE; PD/NORBORNENE; AMIDATION in [Zhang, Bo-Sheng; Zhang, Zhe; An, Yang; Wen, Yu-Hua; Gou, Xue-Ya; Quan, Si-Qi; Wang, Xin-Gang; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Ctr Sci Modeling & Computat, Shatin, Hong Kong, Peoples R China in 2019, Cited 83. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Highly functionalized 4-aminoindoles were synthesized via the three-component cross-coupling of o-iodoaniline, N-benzoyloxyamines, and norbornadiene. The Catellani and retro-Diels-Alder strategy was used in this domino process. o-Iodoaniline, with electron-donating and sterically hindered protecting groups, made the reaction selective toward o-C-H amination. On the basis of density functional theory calculations, the intramolecular Buchwald coupling of this reaction underwent a dearomatization and a 1,3-palladium migration process. The reasons for the control of the chemical selectivity by the protecting groups are given. Moreover, synthetic applications toward 4-piperazinylindole and a GOT1 inhibitor were realized.

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhang, BS; Li, YK; Zhang, Z; An, Y; Wen, YH; Gou, XY; Quan, SQ; Wang, XG; Liang, YM or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Product Details of 177-11-7. In 2019 J AM CHEM SOC published article about ANTI-MARKOVNIKOV HYDROAMINATION; INTERMOLECULAR HYDROAMINATION; ALKENES; DISCOVERY; ALDEHYDES in [Vanable, Evan P.; Kennemur, Jennifer L.; Hull, Kami L.] Univ Illinois, Dept Chem, 600 S Mathews, Urbana, IL 61801 USA; [Joyce, Leo A.; Ruck, Rebecca T.; Schultz, Danielle M.] Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA; [Kennemur, Jennifer L.] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany; [Hull, Kami L.] Univ Texas Austin, 105 E 24th St, Austin, TX 78712 USA in 2019, Cited 36. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Vanable, EP; Kennemur, JL; Joyce, LA; Ruck, RT; Schultz, DM; Hull, KL or concate me.. Product Details of 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

COA of Formula: C7H13NO2. Authors De Angelis, L; Crawford, AM; Su, YL; Wherritt, D; Arman, H; Doyle, MP in AMER CHEMICAL SOC published article about in [De Angelis, Luca; Crawford, Alexandra M.; Su, Yong-Liang; Wherritt, Daniel; Arman, Hadi; Doyle, Michael P.] Univ Texas San Antonio, Dept Chem, San Antonio, TX 78249 USA in 2021, Cited 23. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The formation of nitrile oxides with diazocarbonyl compounds by nitrosyl transfer from tert-butyl nitrite under mild conditions and without the use of a catalyst or an additive is reported. This transformation is broadly applicable to the synthesis of furoxans by dimerization and isoxazoles and isoxazolines by cycloaddition. This methodology is also applied for the millimole-scale synthesis of two biologically active compounds. The formation of the nitrile oxide from a diazoacetamide is stable and confirmed experimentally.

COA of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact De Angelis, L; Crawford, AM; Su, YL; Wherritt, D; Arman, H; Doyle, MP or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Chen, TC; Yu, DS; Chen, SJ; Chen, CL; Lee, CC; Hsieh, YY; Chang, LC; Guh, JH; Lin, JJ; Huang, HS in [Chen, Tsung-Chih; Chen, Chun-Liang; Lee, Chia-Chung; Huang, Hsu-Shan] Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery, Taipei 110, Taiwan; [Chen, Tsung-Chih; Yu, Dah-Shyong; Chen, Chun-Liang; Lee, Chia-Chung; Huang, Hsu-Shan] Natl Def Med Ctr, Grad Inst Life Sci, Taipei 114, Taiwan; [Chen, Tsung-Chih; Chen, Shiag-Jiun; Hsieh, Ying-Yu; Huang, Hsu-Shan] Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan; [Yu, Dah-Shyong] Triserv Gen Hosp, Dept Surg, Div Urol, Urooncol Lab, Taipei 114, Taiwan; [Yu, Dah-Shyong] Natl Def Med Ctr, Inst Prevent Med, Taipei 114, Taiwan; [Chang, Lien-Cheng; Lin, Jing-Jer] Natl Taiwan Univ, Coll Med, Inst Biochem & Mol Biol, Taipei 100, Taiwan; [Chang, Lien-Cheng] Minist Hlth & Welf, Food & Drug Adm, Taipei 115, Taiwan; [Guh, Jih-Hwa] Natl Taiwan Univ, Sch Pharm, Taipei 100, Taiwan published Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents in 2019, Cited 40. Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Several 9-chloro-11H-indeno[1,2-c]quinolin-11-one derivatives have been designed which is replacing side chains with different groups containing oxygen, nitrogen or sulfur atoms. Substitution of C-6 on the starting structure, 6,9-dichloro-11H-indeno[1,2-c]quinolin-11-one, using apposite nucleophilic group with a suitable base or acid could be obtained 28 novel tetracyclic azafluorenone derivatives. The cytotoxic activity of these analogues was examined in cancer cell lines by MTT assay and compounds 4, 5, 13, and 26 were selected to evaluate in topoisomerase I drug screening assay, respectively. At the same time, 17 compounds were selected for NCI-60 anticancer drug screen to prevent the narrower concept of an in vitro screening model. Its worth to find that 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (12) showed greater cytotoxicity than another azafluorenone derivatives with an average GI(50) of 10.498 mu M over 60 cell lines. We also found that another analogue, 9-chloro-6-(2-methylpiperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (13), exhibited preferential growth inhibition effect toward cancer cell lines and showed a significant inhibitory effect on topoisomerase I. (C) 2016 Production and hosting by Elsevier B.V. on behalf of King Saud University.

Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Chen, TC; Yu, DS; Chen, SJ; Chen, CL; Lee, CC; Hsieh, YY; Chang, LC; Guh, JH; Lin, JJ; Huang, HS or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ in [Drapeau, Martin Pichette; Bahri, Janet; Lichte, Dominik; Goossen, Lukas J.] Ruhr Univ Bochum, Fak Chem & Biochem, ZEMOS, Univ Str 150, D-44801 Bochum, Germany published Decarboxylative ipso Amination of Activated Benzoic Acids in 2019, Cited 80. Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C-C, C-Cl, and C-N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ or concate me.. Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Biochemistry & Molecular Biology; Biophysics very interesting. Saw the article Optimization of norbornyl-based carbocyclic nucleoside analogs as cyclin-dependent kinase 2 inhibitors published in 2020. Formula: C7H13NO2, Reprint Addresses Lepsik, M; Nencka, R (corresponding author), Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Nam 2, Prague 16610 6, Czech Republic.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

We report on the discovery of norbornyl moiety as a novel structural motif for cyclin-dependent kinase 2 (CDK2) inhibitors which was identified by screening a carbocyclic nucleoside analogue library. Three micromolar hits were expanded by the use of medicinal chemistry methods into a series of 16 novel compounds. They had prevailingly micromolar activities against CDK2 and the best compound of the series attained IC(50)of 190 nM. The binding modes were explored in molecular details by modeling and docking. Quantum mechanics-based scoring was used to rationalize the affinities. In conclusion, the discovered 9-hydroxymethylnorbornyl moiety was shown by joint experimental-theoretical efforts to be able to serve as a novel substituent for CDK2 inhibitors. This finding opens door to the exploration of chemical space towards more effective derivatives targeting this important class of protein kinases.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Kopruluoglu, C; Dejmek, M; Sala, M; Ajani, H; Hrebabecky, H; Fanfrlik, J; Jorda, R; Dracinsky, M; Prochazkova, E; Sacha, P; Krystof, V; Hobza, P; Lepsik, M; Nencka, R or concate me.. Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Li, DK; Shen, XF in ROYAL SOC CHEMISTRY published article about TRANSFER RADICAL-ADDITION; HECK-TYPE ALKENYLATION; TERTIARY-ALKYLATIONS; COPPER; QUINONES; ANNULATION; STRATEGY; HETEROCYCLES; REDUCTASE; COUPLINGS in [Li, Dengke] Qujing Normal Univ, Coll Chem & Environm Sci, Qujing 655011, Yunnan, Peoples R China; [Shen, Xianfu] Qujing Normal Univ, Ctr Yunnan Guizhou Plateau Chem Funct Mat & Pollu, Qujing 655011, Yunnan, Peoples R China in 2020, Cited 86. SDS of cas: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A simple and efficient Fe-catalyzed regioselective alkylation of 1,4-quinones and coumarins, using functionalized alkyl bromides as alkylating reagents, has been developed. The reaction proceeds under mild conditions with the addition of alkyl bromides to a wide range of 1,4-quinone and coumarin derivatives with a broad substrate scope and wide functional group tolerance to provide the products in good yields. Further application of these strategies could be extended to important biologically active antimalarial lead drugs, such as plasmodione on a gram scale in a single step for medicinal purposes.

SDS of cas: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Li, DK; Shen, XF or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; INTERMOLECULAR INTERACTIONS; BIOLOGICAL-ACTIVITIES; CRYSTAL-STRUCTURES; CHIRAL CONFIGURATIONS; QUANTITATIVE-ANALYSIS; HIRSHFELD SURFACES; CYCLOTRIPHOSPHAZENE; ANTITUBERCULOSIS, Saw an article supported by the Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences; Hacettepe University Scientific Research Project UnitHacettepe University [013 D04 602 004]; Scientific and Technical Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215Z496]. Published in WILEY in HOBOKEN ,Authors: Okumus, A; Elmas, G; Kilic, Z; Binici, A; Ramazanoglu, N; Acik, L; Cosut, B; Hokelek, T; Guzel, R; Tunali, BC; Turk, M; Simsek, H. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

In this study, two kinds of compounds, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes, were obtained by the Cl replacement reaction of N4P4Cl8 (1) with an equimolar amount of sodium 3-(N-ferrocenylmethylamino)-1-propanoxide (2). The reactions of 2,4-ansa (3) with excess diamines and dialkoxides resulted in the formation of ansa-cyclotetraphosphazenes (3a-3e). Spiro (4) was reacted with excess diamines and dialkoxides to give the mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d). Although 2,4-ansa (3) produced the dispiro (3a) with N-(4-fluorobenzyl)-N ‘-methylethane-1,2-diamine, it afforded both monospiro (3b) and dispiro (3c) with N-(4-fluorobenzyl)-N ‘-methylpropane-1,3-diamine. However, spiro (4) yielded a trispiro (4a) with N-(4-fluorobenzyl)-N ‘-methylethane-1,2-diamine and 2,6-dispiro (4b) with N-(4-fluorobenzyl)-N ‘-methylpropane-1,3-diamine. The structures of the phosphazenes were elucidated by FTIR, ESI-MS and/or HRMS, spectroscopic and crystallographic (for 3f and 4b) data. Furthermore, the electrochemical findings of cyclotetraphosphazenes exhibited electrochemically reversible one-electron oxidation of Fe-redox centre. As an example, the chirality of 3c was investigated by P-31 NMR spectroscopy on the addition of (R)-(+)-2,2,2-trifluoro-1-(9 ‘-anthryl)-ethanol, chiral solvating agent (CSA). The circular dichroism (CD) (for 3d and 3e), HPLC (for 3d, 3e and 3f) and X-ray (for 3f) display that these compounds have chirality (RS ‘ or SR ‘) in the solution and solid state. This paper also focuses on the antimicrobial activities, the interactions with pBR322 DNA, in vitro anticancer activity against L929 fibroblast and MCF7 breast cells, and antituberculosis activity against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes.

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Okumus, A; Elmas, G; Kilic, Z; Binici, A; Ramazanoglu, N; Acik, L; Cosut, B; Hokelek, T; Guzel, R; Tunali, BC; Turk, M; Simsek, H or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about TRANSITION-METAL-FREE; C-H AMINATION; NUCLEOPHILIC-SUBSTITUTION; REDUCTIVE ELIMINATION; CATALYZED AMINATION; COUPLING REACTIONS; CARBOXYLIC-ACIDS; CROSS-COUPLINGS; DIRECTING-GROUP; ARYL CHLORIDES, Saw an article supported by the DFGGerman Research Foundation (DFG)European Commission [EXC/1069, SFB/TRR 88]; Alexander von Humboldt FoundationAlexander von Humboldt Foundation; Fonds de Recherche du Quebec-Nature et Technologies (FRQNT). Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C-C, C-Cl, and C-N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ or concate me.. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem