Day: October 27, 2021

I found the field of Chemistry very interesting. Saw the article Phosphorus-nitrogen compounds. Part 42. The comparative syntheses of 2-cis-4-ansa(N/O) and spiro(N/O) cyclotetraphosphazene derivatives: spectroscopic and crystallographic characterization, antituberculosis and cytotoxic activity studies published in 2019. COA of Formula: C7H13NO2, Reprint Addresses Elmas, G; Kilic, Z (corresponding author), Ankara Univ, Dept Chem, TR-06100 Tandogan, Turkey.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The reaction of N4P4Cl8 (1) with one equimolar amount of the sodium salt of an N/O donor-type bidentate ligand (2) afforded two kinds of derivatives, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes. The reaction yield (35%) of 4 was significantly larger than that of 3 (14%). The 2,4-ansa compound (3) was reacted with excess secondary amines to produce 2-cis-4-dichloro-ansa-cyclotetraphosphazenes (3a-3d). On the other hand, the spiro compound (4) gave fully substituted mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d) with excess monoamines as well. The tetrameric phosphazene derivatives were characterized by ESI-MS and/or HRMS, FTIR, HSQC, HMBC, H-1, C-13, and P-31 NMR spectroscopy and X-ray crystallography (for 4). It is observed that the 2,4-ansa and spiro-cyclotetraphosphazenes have different thermal stabilities. Additionally, the CVs of the new mono-ferrocenyl pendant-armed cyclotetraphosphazenes revealed electrochemically reversible one-electron oxidation of the Fe-redox centre. The 2,4-ansa phosphazenes (3 and 3a-3d) have two different stereogenic P centers indicating that they are expected to be in racemic mixtures (RR’/SS’). The chiralities of 3a and 3c were investigated by chiral HPLC. The manuscript also deals with the antimicrobial activities against G(+)/G(-) bacteria and fungi, the interactions with plasmid DNA, the in vitro cytotoxic activities against L929 fibroblast and MCF7 breast cells, and the antituberculosis activities against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes.

COA of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Binici, A; Okumus, A; Elmas, G; Kilic, Z; Ramazanoglu, N; Acik, L; Simsek, H; Tunali, BC; Turk, M; Guzel, R; Hokelek, T or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of General & Internal Medicine very interesting. Saw the article Continuous assessment of neuro-ventilatory drive during 12 h of pressure support ventilation in critically ill patients published in 2020. Recommanded Product: 177-11-7, Reprint Addresses Grasso, S (corresponding author), Univ Bari Aldo Moro, Osped Policlin, Dipartimento Emergenza & Trapianti Organo DETO, Sez Anestesiol & Rianimaz, Piazza Giulio Cesare 11, Bari, Italy.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Introduction Pressure support ventilation (PSV) should allow spontaneous breathing with a normal neuro-ventilatory drive. Low neuro-ventilatory drive puts the patient at risk of diaphragmatic atrophy while high neuro-ventilatory drive may causes dyspnea and patient self-inflicted lung injury. We continuously assessed for 12 h the electrical activity of the diaphragm (EAdi), a close surrogate of neuro-ventilatory drive, during PSV. Our aim was to document the EAdi trend and the occurrence of periods of Low and/or High neuro-ventilatory drive during clinical application of PSV. Method In 16 critically ill patients ventilated in the PSV mode for clinical reasons, inspiratory peak EAdi peak (EAdi(PEAK)), pressure time product of the trans-diaphragmatic pressure per breath and per minute (PTPDI/b and PTPDI/min, respectively), breathing pattern and major asynchronies were continuously monitored for 12 h (from 8 a.m. to 8 p.m.). We identified breaths with Normal (EAdi(PEAK) 5-15 mu V), Low (EAdi(PEAK) < 5 mu V) and High (EAdi(PEAK) > 15 mu V) neuro-ventilatory drive. Results Within all the analyzed breaths (177.117), the neuro-ventilatory drive, as expressed by the EAdi(PEAK), was Low in 50.116 breath (28%), Normal in 88.419 breaths (50%) and High in 38.582 breaths (22%). The average times spent in Low, Normal and High class were 1.37, 3.67 and 0.55 h, respectively (p < 0.0001), with wide variations among patients. Eleven patients remained in the Low neuro-ventilatory drive class for more than 1 h, median 6.1 [3.9-8.5] h and 6 in the High neuro-ventilatory drive class, median 3.4 [2.2-7.8] h. The asynchrony index was significantly higher in the Low neuro-ventilatory class, mainly because of a higher number of missed efforts. Conclusions We observed wide variations in EAdi amplitude and unevenly distributed Low and High neuro ventilatory drive periods during 12 h of PSV in critically ill patients. Further studies are needed to assess the possible clinical implications of our physiological findings. Recommanded Product: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Di Mussi, R; Spadaro, S; Volta, CA; Bartolomeo, N; Trerotoli, P; Staffieri, F; Pisani, L; Iannuzziello, R; Dalfino, L; Murgolo, F; Grasso, S or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

SDS of cas: 177-11-7. Authors Schuppe, AW; Knippel, JL; Borrajo-Calleja, GM; Buchwald, SL in AMER CHEMICAL SOC published article about in [Schuppe, Alexander W.; Knippel, James Levi; Borrajo-Calleja, Gustavo M.; Buchwald, Stephen L.] MIT, Dept Chem, Cambridge, MA 02139 USA in 2021, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The catalytic enantioselective synthesis of a-chiral olefins represents a valuable strategy for rapid generation of structural diversity in divergent syntheses of complex targets. Herein, we report a protocol for the dual CuH- and Pd-catalyzed asymmetric Markovnikov hydroalkenylation of vinyl arenes and the anti-Markovnikov hydroalkenylation of unactivated olefins, in which readily available enol triflates can be utilized as alkenyl coupling partners. This method allowed for the synthesis of diverse alpha-chiral olefins, including tri- and tetrasubstituted olefin products, which are challenging to prepare by existing approaches.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Schuppe, AW; Knippel, JL; Borrajo-Calleja, GM; Buchwald, SL or concate me.. SDS of cas: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140) published in 2019, Reprint Addresses Roberts, E (corresponding author), Scripps Res Inst, Dept Mol Med, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

kappa opioid receptor (KOR) antagonists are potential pharmacotherapies for the treatment of migraine and stress-related mood disorders including depression, anxiety, and drug abuse, thus the development of novel KOR antagonists with an improved potency/selectivity profile and medication-like duration of action has attracted the interest of the medicinal chemistry community. In this paper, we describe the discovery of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2 H-pyran-4-yl)piperidin-4 amine (CYM-53093, BTRX-335140) as a potent and selective KOR antagonist, endowed with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments. Orally administered CYM-53093 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice. CYM-53093 exhibited a broad selectivity over a panel of off-target proteins. This compound is in phase 1 clinical trials for the treatment of neuropsychiatric disorders wherein dynorphin is thought to contribute to the underlying pathophysiology.

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Guerrero, M; Urbano, M; Kim, EK; Gamo, AM; Riley, S; Abgaryan, L; Leaf, N; Van Orden, LJ; Brown, SJ; Xie, JY; Porreca, F; Cameron, MD; Rosen, H; Roberts, E or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 ORG LETT published article about HYPERVALENT IODINE REAGENTS; AROMATIC NITRATION; TERTIARY-AMINES; H FUNCTIONALIZATION; CONJUGATE ADDITION; SODIUM-NITRITE; UREA NITRATE; NITROMETHANE; OXIDATION; ATOM in [Kim, Mi-hyun] Gachon Univ, Coll Pharm, Gachon Inst Pharmaceut Sci, 191 Hambakmoeiro, Incheon 21936, South Korea; Gachon Univ, Coll Pharm, Dept Pharm, 191 Hambakmoeiro, Incheon 21936, South Korea in 2019, Cited 71. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A novel nitration (via C(sp(3))-N breaking/C(sp(2))-N formation with CH3NO2) mediated by [bis-(trifluoroacetoxy)iodo]benzene (PIFA) is described. The NO2 transfer from CH3NO2 to the aromatic group of the substrate is possible with careful selection of the solvent, NaX, and oxidant. In addition, the solvent-controlled C(sp(2))-H functionalization can shift to an alpha-C(sp(3))-H functionalization (cyanation or oxygenation) of the alpha-C(sp(3))-H of cyclic amines.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Mudithanapelli, C; Dhorma, LP; Kim, MH or concate me.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. Authors Schuppe, AW; Knippel, JL; Borrajo-Calleja, GM; Buchwald, SL in AMER CHEMICAL SOC published article about in [Schuppe, Alexander W.; Knippel, James Levi; Borrajo-Calleja, Gustavo M.; Buchwald, Stephen L.] MIT, Dept Chem, Cambridge, MA 02139 USA in 2021, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The catalytic enantioselective synthesis of a-chiral olefins represents a valuable strategy for rapid generation of structural diversity in divergent syntheses of complex targets. Herein, we report a protocol for the dual CuH- and Pd-catalyzed asymmetric Markovnikov hydroalkenylation of vinyl arenes and the anti-Markovnikov hydroalkenylation of unactivated olefins, in which readily available enol triflates can be utilized as alkenyl coupling partners. This method allowed for the synthesis of diverse alpha-chiral olefins, including tri- and tetrasubstituted olefin products, which are challenging to prepare by existing approaches.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Schuppe, AW; Knippel, JL; Borrajo-Calleja, GM; Buchwald, SL or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Metal-Free Cyclocarboamination of ortho-Formyl Phenylacetylenes with Secondary Amines: Access to 1,3-Diamino-1H-Indenes and 3-Amino-1-Indanones WOS:000457795500026 published article about CATALYZED HYDROAMINATION; INTERNAL ALKYNES; H BONDS; CARBOAMINATION; ALKENES; GENERATION; ACID; HETEROCYCLES; CYCLIZATION; INSERTION in [Cui, Jian-Fang; Tang, Rishi; Yang, Bin; Lai, Nathanael Chun-Him; Jiang, Jia-Jun; Deng, Jie-Ren; Wong, Man-Kin] Hong Kong Polytech Univ, State Key Lab Chem Biol & Drug Discovery, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China; [Cui, Jian-Fang] Southern Univ Sci & Technol, Dept Chem, Shenzhen, Peoples R China in 2019, Cited 62. Computed Properties of C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

This work first discloses a new strategy for amine activation to give reactive amine anion by in situ generated iminium cation-amine anion pair through decomposition of sterically hindered aminals. Utilizing this strategy, a highly regio- and chemoselective cyclocarboamination of ortho-formyl phenylacetylenes with secondary amines has been realized under metal-free mild reaction conditions. The cyclocarboamination with notably tunable product profiles depends on the separation and purification procedure, a diverse range of 1, 3-diamino-1H-indenes (essentially reactive enamines) and 3-amino-1-indanones were obtained, respectively. Moreover, using iodine as an electrophile to couple with various ortho-formyl phenylacetylenes and secondary amines, a series of 3-amino-2-iodo-1-indanones were efficiently achieved with four bonds (C=O, C-C, C-N and C-I) formation in an one-pot three-component reaction. These results demonstrated an unprecedented methodology for the construction of highly functionalized 1H-indene and 1-indanone compounds.

Computed Properties of C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Cui, JF; Tang, RS; Yang, B; Lai, NCH; Jiang, JJ; Deng, JR; Wong, MK or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Computed Properties of C7H13NO2. Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T in [Alvarez, Eva Maria; Plutschack, Matthew B.; Berger, Florian; Ritter, Tobias] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany published Site-Selective C-H Functionalization-Sulfination Sequence to Access Aryl Sulfonamides in 2020, Cited 33. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C-H sulfination sequence via aryl sulfonium salts to access aryl sulfonamides. Combined with site-selective aromatic thianthrenation, an operationally simple one-pot palladium-catalyzed protocol introduces the sulfonyl group using sodium hydroxymethylsulfinate (Rongalite) as a source of SO22-. The hydroxymethyl sulfone intermediate generated from the catalytic process can be employed as a synthetic handle to deliver a variety of sulfonyl-containing compounds.

Computed Properties of C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Dioxygen-triggered oxidative cleavage of the C-S bond towards C-N bond formation WOS:000491549100009 published article about PALLADIUM-CATALYZED AMINATION; CARBON-SULFUR; COOPERATIVE CATALYSIS; EFFICIENT SYNTHESIS; METAL-COMPLEXES; ACTIVATION; FUNCTIONALIZATION; COBALT; BENZOXAZOLES; CYCLIZATION in [Lv, Zongchao; Wang, Huamin; Quan, Zhicong; Gao, Yuan; Lei, Aiwen] Wuhan Univ, Coll Chem & Mol Sci, Inst Adv Studies, Wuhan 430072, Hubei, Peoples R China; [Lei, Aiwen] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China in 2019, Cited 68. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Computed Properties of C7H13NO2

Research on the cleavage of C-C bonds has been well developed. By comparison with this, the activation of C-S bonds remains challenging. Herein, dioxygen-triggered oxidative cleavage of C-S bonds has been achieved, delivering a series of N-containing heterocyclic compounds that are frequently found in pesticides and pharmaceuticals. Additionally, the potential utility of this protocol was further demonstrated by a gram-scale experiment. Mechanistically, dioxygen plays a key role in the cleavage of C-S bonds towards C-N bond formation.

Computed Properties of C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Lv, ZC; Wang, HM; Quan, ZC; Gao, Y; Lei, AW or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Fedoseev, SV; Belikov, MY; Ievlev, MY; Ershov, OV in ROYAL SOC CHEMISTRY published article about MALONONITRILE; FLUOROPHORES; FLUORESCENCE; DYES; RED in [Fedoseev, Sergey V.; Belikov, Mikhail Yu.; Ievlev, Mikhail Yu.; Ershov, Oleg V.] Ulyanov Chuvash State Univ, Moskovsky Pr 15, Cheboksary, Russia in 2019, Cited 46. Product Details of 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The first representatives of D-pi-A chromophores containing a hydroxytricyanopyrrole (HTCP) acceptor and N,N-disubstituted aminophenyl donor were synthesized. The obtained molecules include reactive NH- and OH-fragments allowing the photophysical properties of the chromophores to be tuned, which is not possible for the well-known chromophores of the tricyanofuran (TCF) and tricyanopyrrole (TCP) series. The absorption properties of the synthesized HTCP-chromophores with a p-aminophenyl electron donor substituent were thoroughly studied.

Product Details of 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Fedoseev, SV; Belikov, MY; Ievlev, MY; Ershov, OV or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem