Day: October 25, 2021

Formula: C7H13NO2. I found the field of Chemistry very interesting. Saw the article Preparation of Chiral Allenes through Pd-Catalyzed Intermolecular Hydroamination of Conjugated Enynes: Enantioselective Synthesis Enabled by Catalyst Design published in 2019, Reprint Addresses Malcolmson, SJ (corresponding author), Duke Univ, Dept Chem, Durham, NC 27708 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

In this study, we establish that conjugated enynes undergo selective 1,4-hydroamination under Pd catalysis to deliver chiral allenes with pendant allylic amines. Several primary and secondary aliphatic and aryl-substituted amines couple with a wide range of mono- and disubstituted enynes in a nonenantioselective reaction where DPEphos serves as the ligand for Pd. Benzophenone imine acts as an ammonia surrogate to afford primary amines in a two-step/one-pot process. Examination of chiral catalysts revealed a high degree of reversibility in the C-N bond formation that negatively impacted enantioselectivity. Consequently, an electron-poor ferrocenyl-PHOX ligand was developed to enable efficient and enantioselective enyne hydroamination.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Adamson, NJ; Jeddi, H; Malcolmson, SJ or concate me.. Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. I found the field of Chemistry very interesting. Saw the article Robust Buchwald-Hartwig amination enabled by ball-milling published in 2019, Reprint Addresses Browne, DL (corresponding author), Cardiff Univ, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3EQ, S Glam, Wales.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

An operationally simple mechanochemical method for the Pd catalysed Buchwald-Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. The system is demonstrated on 30 substrates and applied in the context of a target synthesis. Furthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution and mechanochemical conditions, the observations are discussed herein.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Cao, Q; Nicholson, WI; Jones, AC; Browne, DL or concate me.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. Wang, YZ; Lin, WJ; Zou, JY; Yu, W; Liu, XY in [Wang, Yu-Zhao; Lin, Wu-Jie; Zou, Jian-Yu; Yu, Wei; Liu, Xue-Yuan] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China published Preparation of Oxindoles via Visible-Light-Induced Amination/Cyclization of Arylacrylamides with Alkyl Amines in 2020, Cited 68. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The cascade amination/cyclization ofN-arylacrylamides with alkyl amines under visible-light photoredox catalysis is realized via intermediacy of aminium radicals. The aminium radicals are generated by a two-step sequence which involves N-chlorination of alkyl amines and subsequent reductive N-Cl cleavage. This method provides a convenient access to aminated oxindoles.

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wang, YZ; Lin, WJ; Zou, JY; Yu, W; Liu, XY or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recommanded Product: 177-11-7. Voller, J; Zahajska, L; Plihalova, L; Jerabkova, J; Burget, D; Pataki, AC; Krystof, V; Zatloukal, M; Brabek, J; Rosel, D; Mik, V; Tkac, M; Pospisil, T; Gucky, T; Dolezal, K; Strnad, M in [Voller, Jiri; Plihalova, Lucie; Jerabkova, Jana; Burget, David; Krystof, Vladimir; Tkac, Martin; Dolezal, Karel; Strnad, Miroslav] Czech Acad Sci, Inst Expt Bot, Lab Growth Regulators, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic; [Voller, Jiri; Plihalova, Lucie; Jerabkova, Jana; Burget, David; Krystof, Vladimir; Tkac, Martin; Dolezal, Karel; Strnad, Miroslav] Palacky Univ, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic; [Voller, Jiri] Palacky Univ, Fac Med & Dent, Inst Mol & Translat Med, Dept Clin & Mol Pathol, Hnevotinska 3, Olomouc 77515, Czech Republic; [Zahajska, Lenka] Czech Acad Sci, Inst Expt Bot, Isotope Lab, Videnska 1083, Prague 14200 4, Czech Republic; [Plihalova, Lucie; Zatloukal, Marek; Mik, Vaclav; Pospisil, Tomas; Gucky, Tomas; Dolezal, Karel] Palacky Univ, Ctr Reg Hana Biotechnol & Agr Res, Dept Chem Biol & Genet, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic; [Pataki, Andreea Csilla; Brabek, Jan; Rosel, Daniel] Charles Univ Prague, Fac Sci, Dept Cell Biol, Vinicna 7, Prague 12843 2, Czech Republic published 6-Substituted purines as ROCK inhibitors with anti-metastatic activity in 2019, Cited 50. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Rho-associated serine/threonine kinases (ROCKs) are principal regulators of the actin cytoskeleton that regulate the contractility, shape, motility, and invasion of cells. We explored the relationships between structure and anti-ROCK2 activity in a group of purine derivatives substituted at the C6 atom by piperidin-1-yl or azepan-1-yl groups. Structure-activity relationship (SAR) analyses suggested that anti-ROCK activity is retained, and may be further increased, by substitution of the parent compounds at the C2 atom or by expansion of the C6 side chain. These inhibitors of ROCK can reach effective concentrations within cells, as demonstrated by a decrease in phosphorylation of the ROCK target MLC, and by inhibition of the ROCK-dependent invasion of melanoma cells in the collagen matrix. Our study may be useful for further optimization of C6-substituted purine inhibitors of ROCKs and of other sensitive kinases identified by the screening of a broad panel of protein kinases.

Recommanded Product: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Voller, J; Zahajska, L; Plihalova, L; Jerabkova, J; Burget, D; Pataki, AC; Krystof, V; Zatloukal, M; Brabek, J; Rosel, D; Mik, V; Tkac, M; Pospisil, T; Gucky, T; Dolezal, K; Strnad, M or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Di Mussi, R; Spadaro, S; Volta, CA; Bartolomeo, N; Trerotoli, P; Staffieri, F; Pisani, L; Iannuzziello, R; Dalfino, L; Murgolo, F; Grasso, S in BMC published article about PROPORTIONAL ASSIST VENTILATION; MECHANICAL VENTILATION; INSPIRATORY PRESSURE; ELECTRICAL-ACTIVITY; ESOPHAGEAL; IMPACT; INJURY; VOLUME; SLEEP; EVOLUTION in [Di Mussi, Rosa; Pisani, Luigi; Iannuzziello, Rachele; Dalfino, Lidia; Murgolo, Francesco; Grasso, Salvatore] Univ Bari Aldo Moro, Osped Policlin, Dipartimento Emergenza & Trapianti Organo DETO, Sez Anestesiol & Rianimaz, Piazza Giulio Cesare 11, Bari, Italy; [Spadaro, Savino; Volta, Carlo Alberto] Univ Ferrara, Dipartimento Morfol Chirurg & Med Sperimentale, Sez Anestesiol & Terapia Intens Univ, Ferrara, Italy; [Bartolomeo, Nicola; Trerotoli, Paolo] Univ Aldo Moro, Dipartimento Sci Biomed & Oncol Umana, Cattedra Stat Med, Bari, Italy; [Staffieri, Francesco] Univ Bari Aldo Moro, Dipartimento Emergenza & Trapianti Organo DETO, Sez Chirurg Vet, Bari, Italy in 2020, Cited 67. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Introduction Pressure support ventilation (PSV) should allow spontaneous breathing with a normal neuro-ventilatory drive. Low neuro-ventilatory drive puts the patient at risk of diaphragmatic atrophy while high neuro-ventilatory drive may causes dyspnea and patient self-inflicted lung injury. We continuously assessed for 12 h the electrical activity of the diaphragm (EAdi), a close surrogate of neuro-ventilatory drive, during PSV. Our aim was to document the EAdi trend and the occurrence of periods of Low and/or High neuro-ventilatory drive during clinical application of PSV. Method In 16 critically ill patients ventilated in the PSV mode for clinical reasons, inspiratory peak EAdi peak (EAdi(PEAK)), pressure time product of the trans-diaphragmatic pressure per breath and per minute (PTPDI/b and PTPDI/min, respectively), breathing pattern and major asynchronies were continuously monitored for 12 h (from 8 a.m. to 8 p.m.). We identified breaths with Normal (EAdi(PEAK) 5-15 mu V), Low (EAdi(PEAK) < 5 mu V) and High (EAdi(PEAK) > 15 mu V) neuro-ventilatory drive. Results Within all the analyzed breaths (177.117), the neuro-ventilatory drive, as expressed by the EAdi(PEAK), was Low in 50.116 breath (28%), Normal in 88.419 breaths (50%) and High in 38.582 breaths (22%). The average times spent in Low, Normal and High class were 1.37, 3.67 and 0.55 h, respectively (p < 0.0001), with wide variations among patients. Eleven patients remained in the Low neuro-ventilatory drive class for more than 1 h, median 6.1 [3.9-8.5] h and 6 in the High neuro-ventilatory drive class, median 3.4 [2.2-7.8] h. The asynchrony index was significantly higher in the Low neuro-ventilatory class, mainly because of a higher number of missed efforts. Conclusions We observed wide variations in EAdi amplitude and unevenly distributed Low and High neuro ventilatory drive periods during 12 h of PSV in critically ill patients. Further studies are needed to assess the possible clinical implications of our physiological findings. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Di Mussi, R; Spadaro, S; Volta, CA; Bartolomeo, N; Trerotoli, P; Staffieri, F; Pisani, L; Iannuzziello, R; Dalfino, L; Murgolo, F; Grasso, S or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. I found the field of Science & Technology – Other Topics very interesting. Saw the article Copper-catalyzed dehydrogenative gamma-C(sp(3))-H amination of saturated ketones for synthesis of polysubstituted anilines published in 2019, Reprint Addresses Su, WP (corresponding author), ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China.; Su, WP (corresponding author), Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

Metal-catalyzed beta-C-H functionalization of saturated carbonyls via dehydrogenative desaturation proved to be a powerful tool for simplifying synthesis of valuable beta-substituted carbonyls. Here, we report a copper-catalyzed dehydrogenative gamma-C(sp(3))-H amination of saturated ketones that initiates the three-component coupling of saturated ketones, amines and N-substituted maleimides to construct polysubstituted anilines. The protocol presented herein enables both linear and alpha-branched butanones to couple a wide spectrum of amines and various N-substituted maleimides to produce diverse tetra- or penta-substituted anilines in fair-to-excellent yields with good functional group tolerance. The mechanism studies support that this ketone dehydrogenative gamma-C(sp(3))-H amination was triggered by the ketone alpha,beta-dehydrogenation desaturation that activates the adjacent gamma-C(sp(3))-H bond towards functionalization. This alpha,beta-dehydrogenation desaturation-triggered cascade sequence opens up a new avenue to the remote C(sp(3))-H functionalization of saturated ketones and has the potential to enable the rapid syntheses of complex compounds from simple starting materials.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Hu, R; Chen, FJ; Zhang, XF; Zhang, M; Su, WP or concate me.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Palladium-Catalyzed Chemoselective Synthesis of 2-Aminocinnamyl Esters via Sequential Amination and Olefination of Aryl Iodides WOS:000582579900039 published article about C-H FUNCTIONALIZATION; ALLYLIC ALKYLATIONS; ARYLATION; PD/NORBORNENE; TERMINATION; BOND in [Chen, Yanhui; Lv, Weiwei; Ba, Dan; Wen, Si; Cheng, Guolin] Huaqiao Univ, Coll Mat Sci & Engn, Xiamen 361021, Peoples R China in 2020, Cited 48. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

We report a highly chemoselective palladium-catalyzed Catellani-type amination of aryl iodides terminated by the Heck reaction using allylic esters as terminating reagents. 2-Aminocinnamyl esters were formed exclusively via beta-H elimination rather than beta-OAc elimination without the assistance of a silver salt. This protocol represents a useful extension of Catellani-type transformations.

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Chen, YH; Lv, WW; Ba, D; Wen, S; Cheng, GL or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Copper-catalyzed dehydrogenative gamma-C(sp(3))-H amination of saturated ketones for synthesis of polysubstituted anilines WOS:000480684400008 published article about C-H BONDS; ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS; DIRECT BETA-ARYLATION; INTRAMOLECULAR AMINATION; AEROBIC DEHYDROGENATION; C(SP(3))-H BONDS; GAMMA-AMINATION; ARYL KETONES; PALLADIUM; FUNCTIONALIZATION in [Hu, Rong; Su, Weiping] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China; [Hu, Rong; Chen, Fa-Jie; Zhang, Xiaofeng; Zhang, Min; Su, Weiping] Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China in 2019, Cited 70. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Metal-catalyzed beta-C-H functionalization of saturated carbonyls via dehydrogenative desaturation proved to be a powerful tool for simplifying synthesis of valuable beta-substituted carbonyls. Here, we report a copper-catalyzed dehydrogenative gamma-C(sp(3))-H amination of saturated ketones that initiates the three-component coupling of saturated ketones, amines and N-substituted maleimides to construct polysubstituted anilines. The protocol presented herein enables both linear and alpha-branched butanones to couple a wide spectrum of amines and various N-substituted maleimides to produce diverse tetra- or penta-substituted anilines in fair-to-excellent yields with good functional group tolerance. The mechanism studies support that this ketone dehydrogenative gamma-C(sp(3))-H amination was triggered by the ketone alpha,beta-dehydrogenation desaturation that activates the adjacent gamma-C(sp(3))-H bond towards functionalization. This alpha,beta-dehydrogenation desaturation-triggered cascade sequence opens up a new avenue to the remote C(sp(3))-H functionalization of saturated ketones and has the potential to enable the rapid syntheses of complex compounds from simple starting materials.

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Hu, R; Chen, FJ; Zhang, XF; Zhang, M; Su, WP or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 J MED CHEM published article about AGONIST SALVINORIN; PROLACTIN; DYNORPHIN; LY2456302; DOPAMINE; STRESS; 2-METHYL-N-((2′-(PYRROLIDIN-1-YLSULFONYL)BIPHENYL-4-YL)METHYL)PROPAN-1-AMINE; EXPRESSION; DISCOVERY; BINDING in [Guerrero, Miguel; Urbano, Mariangela; Kim, Eun-Kyong; Gamo, Ana M.; Riley, Sean; Abgaryan, Lusine; Leaf, Nora; Brown, Steven J.; Rosen, Hugh; Roberts, Edward] Scripps Res Inst, Dept Mol Med, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [Van Orden, Lori Jean] BlackThorn Therapeut Inc, 780 Brannan St, San Francisco, CA 94103 USA; [Xie, Jennifer Y.; Porreca, Frank] Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA; [Cameron, Michael D.] Scripps Res Inst, Dept Mol Med, Jupiter, FL 33458 USA; [Xie, Jennifer Y.] Arkansas State Univ, Coll Osteopath Med, New York Inst Technol, Dept Basic Sci, Jonesboro, AR 72446 USA in 2019, Cited 47. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

kappa opioid receptor (KOR) antagonists are potential pharmacotherapies for the treatment of migraine and stress-related mood disorders including depression, anxiety, and drug abuse, thus the development of novel KOR antagonists with an improved potency/selectivity profile and medication-like duration of action has attracted the interest of the medicinal chemistry community. In this paper, we describe the discovery of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2 H-pyran-4-yl)piperidin-4 amine (CYM-53093, BTRX-335140) as a potent and selective KOR antagonist, endowed with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments. Orally administered CYM-53093 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice. CYM-53093 exhibited a broad selectivity over a panel of off-target proteins. This compound is in phase 1 clinical trials for the treatment of neuropsychiatric disorders wherein dynorphin is thought to contribute to the underlying pathophysiology.

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Guerrero, M; Urbano, M; Kim, EK; Gamo, AM; Riley, S; Abgaryan, L; Leaf, N; Van Orden, LJ; Brown, SJ; Xie, JY; Porreca, F; Cameron, MD; Rosen, H; Roberts, E or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; STRUCTURAL INVESTIGATIONS; CYTOTOXIC ACTIVITIES; PHOSPHAZENES; DERIVATIVES; SPIRO, Saw an article supported by the Ankara University, Scientific Research Unit (Turkey) [16H0430017]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences. Published in ELSEVIER in AMSTERDAM ,Authors: Kuzey, NG; Ozgur, M; Cemaloglu, R; Asmafiliz, N; Kilic, Z; Acik, L; Aydin, B; Hokelek, T. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

The N/N donor-type bromobenzyldiamines (1-3) were successively prepared by reduction of Schiff bases formed as a result of condensation reactions of 4-bromobenzaldehyde with aliphatic diamines. The Cl exchange reactions of hexachlorocyclotriphosphazene (HCCP; trimer; N3P3Cl6; 4) with the bidentate ligands (1-3) produced the new monospiro- (5-7) and dispirocyclotriphosphazenes (8-13) containing 4-bromo-benzyl pendant arm(s). The tetrachloro phosphazenes (5-7) were reacted with pyrrolidine, tetra-1,4-dioxa-8-azaspiro [4.5]decane (DASD) and piperidine to give the tetraamino substituted mono-spirophosphazenes (5a-7c). The spectral analyses of all the phosphazenes were made using appropriate spectroscopic methods; such as FTIR, H-1, C-13, P-31 NMR and ESI-MS. The molecular and crystal structures of 5, 6, 7 and 12 were also determined by X-ray crystallography. On the other hand, the antimicrobial activities of the phosphazenes were evaluated against G (-) and G (+) bacteria and fungi. Some of the tetraaminophosphazenes were found to be very active against several bacteria and fungi. Besides, the interactions of the cyclotriphosphazenes with plasmid DNA were investigated using agarose gel electrophoresis. (C) 2020 Elsevier B.V. All rights reserved.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Kuzey, NG; Ozgur, M; Cemaloglu, R; Asmafiliz, N; Kilic, Z; Acik, L; Aydin, B; Hokelek, T or concate me.. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem