Day: October 25, 2021

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Voller, J; Zahajska, L; Plihalova, L; Jerabkova, J; Burget, D; Pataki, AC; Krystof, V; Zatloukal, M; Brabek, J; Rosel, D; Mik, V; Tkac, M; Pospisil, T; Gucky, T; Dolezal, K; Strnad, M in [Voller, Jiri; Plihalova, Lucie; Jerabkova, Jana; Burget, David; Krystof, Vladimir; Tkac, Martin; Dolezal, Karel; Strnad, Miroslav] Czech Acad Sci, Inst Expt Bot, Lab Growth Regulators, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic; [Voller, Jiri; Plihalova, Lucie; Jerabkova, Jana; Burget, David; Krystof, Vladimir; Tkac, Martin; Dolezal, Karel; Strnad, Miroslav] Palacky Univ, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic; [Voller, Jiri] Palacky Univ, Fac Med & Dent, Inst Mol & Translat Med, Dept Clin & Mol Pathol, Hnevotinska 3, Olomouc 77515, Czech Republic; [Zahajska, Lenka] Czech Acad Sci, Inst Expt Bot, Isotope Lab, Videnska 1083, Prague 14200 4, Czech Republic; [Plihalova, Lucie; Zatloukal, Marek; Mik, Vaclav; Pospisil, Tomas; Gucky, Tomas; Dolezal, Karel] Palacky Univ, Ctr Reg Hana Biotechnol & Agr Res, Dept Chem Biol & Genet, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic; [Pataki, Andreea Csilla; Brabek, Jan; Rosel, Daniel] Charles Univ Prague, Fac Sci, Dept Cell Biol, Vinicna 7, Prague 12843 2, Czech Republic published 6-Substituted purines as ROCK inhibitors with anti-metastatic activity in 2019, Cited 50. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Rho-associated serine/threonine kinases (ROCKs) are principal regulators of the actin cytoskeleton that regulate the contractility, shape, motility, and invasion of cells. We explored the relationships between structure and anti-ROCK2 activity in a group of purine derivatives substituted at the C6 atom by piperidin-1-yl or azepan-1-yl groups. Structure-activity relationship (SAR) analyses suggested that anti-ROCK activity is retained, and may be further increased, by substitution of the parent compounds at the C2 atom or by expansion of the C6 side chain. These inhibitors of ROCK can reach effective concentrations within cells, as demonstrated by a decrease in phosphorylation of the ROCK target MLC, and by inhibition of the ROCK-dependent invasion of melanoma cells in the collagen matrix. Our study may be useful for further optimization of C6-substituted purine inhibitors of ROCKs and of other sensitive kinases identified by the screening of a broad panel of protein kinases.

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Voller, J; Zahajska, L; Plihalova, L; Jerabkova, J; Burget, D; Pataki, AC; Krystof, V; Zatloukal, M; Brabek, J; Rosel, D; Mik, V; Tkac, M; Pospisil, T; Gucky, T; Dolezal, K; Strnad, M or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Gou, Q; Liu, ZN; Cao, TW; Tan, XP; Shi, WB; Ran, M; Cheng, FX; Qn, J in [Gou, Quan; Cao, Tuanwu; Tan, Xiaoping; Shi, Wenbing; Ran, Man] Yangtze Normal Univ, Chongqing, Peoples R China; [Liu, Zining; Cheng, Feixiang] Qujing Normal Univ, Qujing, Peoples R China; [Qn, Jun] Yunnan Univ, Kunming, Yunnan, Peoples R China published Copper-Catalyzed Coupling of Sulfonamides with Alkylamines: Synthesis of (E)-N-Sulfonylformamidines in 2020, Cited 43. SDS of cas: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize (E)-N-sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerates a broad scope of substrates and generates the products with exclusive (E)-stereoselectivity.

SDS of cas: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Gou, Q; Liu, ZN; Cao, TW; Tan, XP; Shi, WB; Ran, M; Cheng, FX; Qn, J or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Electrochemical Nonacidic N-Nitrosation/N-Nitration of Secondary Amines through a Biradical Coupling Reaction WOS:000546649400001 published article about METAL; NITROSAMINES; AMINATION; NITRO in [Zhao, Ji-Ping; Ding, Lu-jia; Wang, Peng-Cheng; Liu, Ying; Huang, Min-Jun; Zhou, Xin-Li; Lu, Ming] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China in 2020, Cited 54. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

An acid-free N-nitrosation/nitration of the N-H bonds in secondary amines with Fe(NO3)(3)center dot 9H(2)O as the nitroso/nitro source through an electrocatalyzed radical coupling reaction was developed. Cyclic aliphatic amines and N-heteroaromatic compounds were N-nitrosated and N-nitrated, respectively, under mild conditions. Control and competition experiments, as well as kinetic studies, demonstrate that N-nitrosation and N-nitration involve two different radical reaction pathways involving N+ and N-center dot radicals. Moreover, the electrocatalysis method enables the preferential activation of the N-H bond over the electrode and thus provides high selectivity for specific N atoms. Finally, this strategy exhibits a broad scope and provides a green and straightforward approach to generate useful N-nitroso/nitro compounds in good yields.

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhao, JP; Ding, LJ; Wang, PC; Liu, Y; Huang, MJ; Zhou, XL; Lu, M or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Formula: C7H13NO2. Authors Sahoo, T; Sarkar, S; Ghosh, SC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sahoo, Tapan; Sarkar, Souvik; Ghosh, Subhash Chandra] Cent Salt & Marine Chem Res Inst CSIR CSMCRI, Nat Prod & Green Chem Div, GB Marg, Bhavnagar 364002, Gujarat, India; [Sahoo, Tapan; Ghosh, Subhash Chandra] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2021, Cited 50. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A simple and facile copper(II) mediated protocol for C-8 amination of 1-naphthylamide derivatives is reported here. Picolinamide and its derivatives were used as a bidentate directing group for the C-8 amination reaction. Various substituted naphthylamide derivatives with numerous cyclic and acyclic amines proceed in good yields under mild conditions. Air was used solely as an oxidant. (C) 2021 Elsevier Ltd. All rights reserved.

Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Sahoo, T; Sarkar, S; Ghosh, SC or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Li, DK; Shen, XF in ROYAL SOC CHEMISTRY published article about TRANSFER RADICAL-ADDITION; HECK-TYPE ALKENYLATION; TERTIARY-ALKYLATIONS; COPPER; QUINONES; ANNULATION; STRATEGY; HETEROCYCLES; REDUCTASE; COUPLINGS in [Li, Dengke] Qujing Normal Univ, Coll Chem & Environm Sci, Qujing 655011, Yunnan, Peoples R China; [Shen, Xianfu] Qujing Normal Univ, Ctr Yunnan Guizhou Plateau Chem Funct Mat & Pollu, Qujing 655011, Yunnan, Peoples R China in 2020, Cited 86. SDS of cas: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A simple and efficient Fe-catalyzed regioselective alkylation of 1,4-quinones and coumarins, using functionalized alkyl bromides as alkylating reagents, has been developed. The reaction proceeds under mild conditions with the addition of alkyl bromides to a wide range of 1,4-quinone and coumarin derivatives with a broad substrate scope and wide functional group tolerance to provide the products in good yields. Further application of these strategies could be extended to important biologically active antimalarial lead drugs, such as plasmodione on a gram scale in a single step for medicinal purposes.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Li, DK; Shen, XF or concate me.. SDS of cas: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Synthesis of alpha-Trifluoromethylamines by Cu-Catalyzed Regio- and Enantioselective Hydroamination of 1-Trifluoromethylaikenes WOS:000471212100087 published article about NUCLEOPHILIC TRIFLUOROMETHYLATION; ELECTROPHILIC AMINATION; TRANSFER HYDROGENATION; DIORGANOZINC REAGENTS; IMINES; AMINES; FLUORINE; ALKENES; ACCESS; ARYL in [Takata, Tatsuaki; Hirano, Koji; Miura, Masahiro] Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan in 2019, Cited 81. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A copper-catalyzed regioselective net hydroamination of 1-trifluoromethylalkenes with hydrosilanes and hydroxylamines has been developed. The judicious choice of ligand and additive suppresses the conceivable but undesired beta-F elimination of an alpha-CF3-substituted organocopper intermediate, leading to targeted alpha-trifluoromethylamines in good yields with excellent regioselectivity. Additionally, with an appropriate chiral bisphosphine ligand, the enantioselective reaction is also possible to deliver optically active alpha-trifluoromethylamines of high potential in medicinal and pharmaceutical chemistry.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Takata, T; Hirano, K; Miura, M or concate me.. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive WOS:000565355500001 published article about COUPLING REACTIONS; ARYL CHLORIDES; PHOTOREDOX; AMINES; PRECATALYST; AMMONIA in [Han, Dongyang; Li, Sasa; Jin, Jian] Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Synthet Chem Nat Subst, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Xia, Siqi; Su, Mincong] Shanghai Univ, Ctr Supramol Chem & Catalysis, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China in 2020, Cited 65. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. SDS of cas: 177-11-7

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple Ni(II)salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the correspondingN-arylation product in an excellent yield.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Han, DY; Li, SS; Xia, SQ; Su, MC; Jin, J or concate me.. SDS of cas: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article First representatives of functionalized D-pi-A chromophores containing a tunable hydroxytricyanopyrrole (HTCP) acceptor and N,N-disubstituted aminophenyl donor WOS:000499476200001 published article about MALONONITRILE; FLUOROPHORES; FLUORESCENCE; DYES; RED in [Fedoseev, Sergey V.; Belikov, Mikhail Yu.; Ievlev, Mikhail Yu.; Ershov, Oleg V.] Ulyanov Chuvash State Univ, Moskovsky Pr 15, Cheboksary, Russia in 2019, Cited 46. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. HPLC of Formula: C7H13NO2

The first representatives of D-pi-A chromophores containing a hydroxytricyanopyrrole (HTCP) acceptor and N,N-disubstituted aminophenyl donor were synthesized. The obtained molecules include reactive NH- and OH-fragments allowing the photophysical properties of the chromophores to be tuned, which is not possible for the well-known chromophores of the tricyanofuran (TCF) and tricyanopyrrole (TCP) series. The absorption properties of the synthesized HTCP-chromophores with a p-aminophenyl electron donor substituent were thoroughly studied.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Fedoseev, SV; Belikov, MY; Ievlev, MY; Ershov, OV or concate me.. HPLC of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. I found the field of Chemistry very interesting. Saw the article Site-Selective C-H Functionalization-Sulfination Sequence to Access Aryl Sulfonamides published in 2020, Reprint Addresses Ritter, T (corresponding author), Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C-H sulfination sequence via aryl sulfonium salts to access aryl sulfonamides. Combined with site-selective aromatic thianthrenation, an operationally simple one-pot palladium-catalyzed protocol introduces the sulfonyl group using sodium hydroxymethylsulfinate (Rongalite) as a source of SO22-. The hydroxymethyl sulfone intermediate generated from the catalytic process can be employed as a synthetic handle to deliver a variety of sulfonyl-containing compounds.

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2020 ADV SYNTH CATAL published article about METAL; NITROSAMINES; AMINATION; NITRO in [Zhao, Ji-Ping; Ding, Lu-jia; Wang, Peng-Cheng; Liu, Ying; Huang, Min-Jun; Zhou, Xin-Li; Lu, Ming] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China in 2020, Cited 54. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. COA of Formula: C7H13NO2

An acid-free N-nitrosation/nitration of the N-H bonds in secondary amines with Fe(NO3)(3)center dot 9H(2)O as the nitroso/nitro source through an electrocatalyzed radical coupling reaction was developed. Cyclic aliphatic amines and N-heteroaromatic compounds were N-nitrosated and N-nitrated, respectively, under mild conditions. Control and competition experiments, as well as kinetic studies, demonstrate that N-nitrosation and N-nitration involve two different radical reaction pathways involving N+ and N-center dot radicals. Moreover, the electrocatalysis method enables the preferential activation of the N-H bond over the electrode and thus provides high selectivity for specific N atoms. Finally, this strategy exhibits a broad scope and provides a green and straightforward approach to generate useful N-nitroso/nitro compounds in good yields.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhao, JP; Ding, LJ; Wang, PC; Liu, Y; Huang, MJ; Zhou, XL; Lu, M or concate me.. COA of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem