Day: October 9, 2021

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about C-H FUNCTIONALIZATION; ALLYLIC ALKYLATIONS; ARYLATION; PD/NORBORNENE; TERMINATION; BOND, Saw an article supported by the NSF of ChinaNational Natural Science Foundation of China (NSFC) [22071068, 21672075]; Instrumental Analysis Center of Huaqiao University. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Chen, YH; Lv, WW; Ba, D; Wen, S; Cheng, GL. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

We report a highly chemoselective palladium-catalyzed Catellani-type amination of aryl iodides terminated by the Heck reaction using allylic esters as terminating reagents. 2-Aminocinnamyl esters were formed exclusively via beta-H elimination rather than beta-OAc elimination without the assistance of a silver salt. This protocol represents a useful extension of Catellani-type transformations.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Chen, YH; Lv, WW; Ba, D; Wen, S; Cheng, GL or concate me.. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about PALLADIUM-CATALYZED SYNTHESIS; SULFUR-DIOXIDE SURROGATE; ONE-POT; SULFONYL FLUORIDES; BORONIC ACIDS; DABSO; BORYLATION; RONGALITE; REAGENTS; HALIDES, Saw an article supported by the MPI fur Kohlenforschung. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Recommanded Product: 177-11-7

Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C-H sulfination sequence via aryl sulfonium salts to access aryl sulfonamides. Combined with site-selective aromatic thianthrenation, an operationally simple one-pot palladium-catalyzed protocol introduces the sulfonyl group using sodium hydroxymethylsulfinate (Rongalite) as a source of SO22-. The hydroxymethyl sulfone intermediate generated from the catalytic process can be employed as a synthetic handle to deliver a variety of sulfonyl-containing compounds.

Recommanded Product: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Chemistry very interesting. Saw the article RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis published in 2020. Recommanded Product: 177-11-7, Reprint Addresses Baran, PS; Dawson, PE (corresponding author), Scripps Res, Dept Chem, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

DNA encoded libraries (DEL) have shown promise as a valuable technology for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to libraries of unprecedented size, their production has been hampered by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible chemistry to dilute aqueous environments. Recently reversible adsorption to solid support (RASS) has been demonstrated as a promising method to expand DEL reactivity using standard organic synthesis protocols. Here we demonstrate a suite of on-DNA chemistries to incorporate medicinally relevant and C-S, C-P and N-S linkages into DELs, which are underrepresented in the canonical methods.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents WOS:000504900300246 published article about RAPID COLORIMETRIC ASSAY; ANTIPROLIFERATIVE EVALUATION; MOLECULAR HYBRIDIZATION; ANALOGS; CANCER; CAMPTOTHECIN; ALKALOIDS; MECHANISM; DISCOVERY; APOPTOSIS in [Chen, Tsung-Chih; Chen, Chun-Liang; Lee, Chia-Chung; Huang, Hsu-Shan] Taipei Med Univ, Coll Med Sci & Technol, Grad Inst Canc Biol & Drug Discovery, Taipei 110, Taiwan; [Chen, Tsung-Chih; Yu, Dah-Shyong; Chen, Chun-Liang; Lee, Chia-Chung; Huang, Hsu-Shan] Natl Def Med Ctr, Grad Inst Life Sci, Taipei 114, Taiwan; [Chen, Tsung-Chih; Chen, Shiag-Jiun; Hsieh, Ying-Yu; Huang, Hsu-Shan] Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan; [Yu, Dah-Shyong] Triserv Gen Hosp, Dept Surg, Div Urol, Urooncol Lab, Taipei 114, Taiwan; [Yu, Dah-Shyong] Natl Def Med Ctr, Inst Prevent Med, Taipei 114, Taiwan; [Chang, Lien-Cheng; Lin, Jing-Jer] Natl Taiwan Univ, Coll Med, Inst Biochem & Mol Biol, Taipei 100, Taiwan; [Chang, Lien-Cheng] Minist Hlth & Welf, Food & Drug Adm, Taipei 115, Taiwan; [Guh, Jih-Hwa] Natl Taiwan Univ, Sch Pharm, Taipei 100, Taiwan in 2019, Cited 40. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Several 9-chloro-11H-indeno[1,2-c]quinolin-11-one derivatives have been designed which is replacing side chains with different groups containing oxygen, nitrogen or sulfur atoms. Substitution of C-6 on the starting structure, 6,9-dichloro-11H-indeno[1,2-c]quinolin-11-one, using apposite nucleophilic group with a suitable base or acid could be obtained 28 novel tetracyclic azafluorenone derivatives. The cytotoxic activity of these analogues was examined in cancer cell lines by MTT assay and compounds 4, 5, 13, and 26 were selected to evaluate in topoisomerase I drug screening assay, respectively. At the same time, 17 compounds were selected for NCI-60 anticancer drug screen to prevent the narrower concept of an in vitro screening model. Its worth to find that 9-chloro-6-(piperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (12) showed greater cytotoxicity than another azafluorenone derivatives with an average GI(50) of 10.498 mu M over 60 cell lines. We also found that another analogue, 9-chloro-6-(2-methylpiperazin-1-yl)-11H-indeno[1,2-c]quinolin-11-one (13), exhibited preferential growth inhibition effect toward cancer cell lines and showed a significant inhibitory effect on topoisomerase I. (C) 2016 Production and hosting by Elsevier B.V. on behalf of King Saud University.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Chen, TC; Yu, DS; Chen, SJ; Chen, CL; Lee, CC; Hsieh, YY; Chang, LC; Guh, JH; Lin, JJ; Huang, HS or concate me.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. Zhang, Z; Zhang, BS; Li, KL; An, Y; Liu, C; Gou, XY; Liang, YM in [Zhang, Zhe; Zhang, Bo-Sheng; An, Yang; Liu, Ce; Gou, Xue-Ya; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Li, Kai-Li] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Peoples R China published Palladium-Catalyzed Amination/Dearomatization Reaction of Indoles and Benzofurans in 2020, Cited 103. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

This report describes a palladium-catalyzed dearomatization and amination tandem reaction of 2,3-disubstituted indoles and benzofurans via the Catellani strategy. This reaction provides a new method for the construction of amino-substituted indoline-fused cyclic and benzofuran spiro compounds in good yields. The reaction has broad functional group compatibility and substrate scope.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhang, Z; Zhang, BS; Li, KL; An, Y; Liu, C; Gou, XY; Liang, YM or concate me.. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

SDS of cas: 177-11-7. Cao, Q; Nicholson, WI; Jones, AC; Browne, DL in [Cao, Qun; Nicholson, William I.; Jones, Andrew C.; Browne, Duncan L.] Cardiff Univ, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3EQ, S Glam, Wales published Robust Buchwald-Hartwig amination enabled by ball-milling in 2019, Cited 35. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

An operationally simple mechanochemical method for the Pd catalysed Buchwald-Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. The system is demonstrated on 30 substrates and applied in the context of a target synthesis. Furthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution and mechanochemical conditions, the observations are discussed herein.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Cao, Q; Nicholson, WI; Jones, AC; Browne, DL or concate me.. SDS of cas: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Schuppe, AW; Knippel, JL; Borrajo-Calleja, GM; Buchwald, SL in AMER CHEMICAL SOC published article about in [Schuppe, Alexander W.; Knippel, James Levi; Borrajo-Calleja, Gustavo M.; Buchwald, Stephen L.] MIT, Dept Chem, Cambridge, MA 02139 USA in 2021, Cited 56. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The catalytic enantioselective synthesis of a-chiral olefins represents a valuable strategy for rapid generation of structural diversity in divergent syntheses of complex targets. Herein, we report a protocol for the dual CuH- and Pd-catalyzed asymmetric Markovnikov hydroalkenylation of vinyl arenes and the anti-Markovnikov hydroalkenylation of unactivated olefins, in which readily available enol triflates can be utilized as alkenyl coupling partners. This method allowed for the synthesis of diverse alpha-chiral olefins, including tri- and tetrasubstituted olefin products, which are challenging to prepare by existing approaches.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Schuppe, AW; Knippel, JL; Borrajo-Calleja, GM; Buchwald, SL or concate me.. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2019 ORG BIOMOL CHEM published article about C-H; OXIDATION; SULFENAMIDES; THIOLS; WATER; STRATEGIES; AMINES; ALKYL; BOND in [Tang, Shanyu; Li, Longjia; Ren, Xuanhe; Li, Jiao; Yang, Guanyu; Li, Heng; Yuan, Bingxin] Zhengzhou Univ, Dept Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China; [Liu, Yan] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 44. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Product Details of 177-11-7

A practical and scalable electrochemical oxidation of S-H and N-H was developed. This oxidant-and catalyst-free electrochemical process enables S-N bond formation with inexpensive nickel electrodes in an undivided cell. This procedure exhibits broad substrate scopes and good functional-group compatibility. A 50 g scale oxidative coupling augurs well for industrial applications.

Product Details of 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Tang, SY; Liu, Y; Li, LJ; Ren, XH; Li, J; Yang, GY; Li, H; Yuan, BX or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2019 NEW J CHEM published article about DNA INTERACTIONS; STEREOGENIC PROPERTIES; STRUCTURAL CHARACTERIZATIONS; ANTIMICROBIAL ACTIVITIES; ELECTROCHEMICAL INVESTIGATIONS; CYCLOTRIPHOSPHAZENE CORE; CHIRAL CONFIGURATIONS; DENDRIMERS; CYCLOPHOSPHAZENES; CHEMISTRY in [Binici, Arzu] Turkeys Hlth Minist, Gen Directorate Publ Hlth, TR-06100 Ankara, Turkey; [Okumus, Aytug; Elmas, Gamze; Kilic, Zeynel] Ankara Univ, Dept Chem, TR-06100 Tandogan, Turkey; [Ramazanoglu, Nagehan; Acik, Leyla] Gazi Univ, Dept Biol, TR-06500 Ankara, Turkey; [Simsek, Hulya] Bozok Univ, Fac Med, TR-66900 Yozgat, Turkey; [Tunali, Beste Cagdas; Turk, Mustafa] Kirikkale Univ, Dept Bioengn, TR-71450 Kirikkale, Turkey; [Guzel, Remziye] Dicle Univ, Dept Chem, TR-21280 Diyarbakir, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, TR-06800 Ankara, Turkey in 2019, Cited 67. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Category: piperidines

The reaction of N4P4Cl8 (1) with one equimolar amount of the sodium salt of an N/O donor-type bidentate ligand (2) afforded two kinds of derivatives, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes. The reaction yield (35%) of 4 was significantly larger than that of 3 (14%). The 2,4-ansa compound (3) was reacted with excess secondary amines to produce 2-cis-4-dichloro-ansa-cyclotetraphosphazenes (3a-3d). On the other hand, the spiro compound (4) gave fully substituted mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d) with excess monoamines as well. The tetrameric phosphazene derivatives were characterized by ESI-MS and/or HRMS, FTIR, HSQC, HMBC, H-1, C-13, and P-31 NMR spectroscopy and X-ray crystallography (for 4). It is observed that the 2,4-ansa and spiro-cyclotetraphosphazenes have different thermal stabilities. Additionally, the CVs of the new mono-ferrocenyl pendant-armed cyclotetraphosphazenes revealed electrochemically reversible one-electron oxidation of the Fe-redox centre. The 2,4-ansa phosphazenes (3 and 3a-3d) have two different stereogenic P centers indicating that they are expected to be in racemic mixtures (RR’/SS’). The chiralities of 3a and 3c were investigated by chiral HPLC. The manuscript also deals with the antimicrobial activities against G(+)/G(-) bacteria and fungi, the interactions with plasmid DNA, the in vitro cytotoxic activities against L929 fibroblast and MCF7 breast cells, and the antituberculosis activities against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes.

Category: piperidines. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Binici, A; Okumus, A; Elmas, G; Kilic, Z; Ramazanoglu, N; Acik, L; Simsek, H; Tunali, BC; Turk, M; Guzel, R; Hokelek, T or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Step-wise and one-pot synthesis of highly substituted conjugated trienes from 2-oxobenzo [h]chromenes/2H-pyran-2-ones WOS:000639414200001 published article about STEREOSELECTIVE-SYNTHESIS in [Elagamy, Amr; Pratap, Ramendra] Univ Delhi, Dept Chem, North Campus, Delhi 110007, India; [Althagafi, Ismail] Umm Al Qura Univ, Fac Sci, Chem Dept, Mecca 21955, Saudi Arabia in 2021, Cited 36. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 177-11-7

A mild and efficient route for the synthesis of conjugated trienes via nitroethane-mediated ring contraction of 2-oxobenzo[h]chromenes/2H-pyran-2-ones followed by decarboxylative rearrangement of the obtained spirobutenolides and butenolides is described. The (E)-isomer of trienes was obtained by step-wise and one-pot approaches from 2-oxobenzo[h]chromenes. Butenolides 4a-l as new substrates have been developed for the construction of trienes. The mixture of the (E)- and (Z)-isomers of spirobutenolides undergoes decarboxylative rearrangement in the presence of sodium ethoxide as a base to yield the (E)-isomer of trienes, while the (E)-isomer of butenolides reacts to give a mixture of (2E,4E)- and (2E,4Z)-isomers of trienes in an almost steady ratio of 45 : 55 or 1 : 1.2. The structure and geometry of the obtained butenolides and trienes were confirmed by single-crystal X-ray analysis.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Elagamy, A; Althagafi, I; Pratap, R or concate me.. Recommanded Product: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem