Day: October 8, 2021

Computed Properties of C7H13NO2. In 2019 J ORG CHEM published article about BUCHWALD-HARTWIG AMINATION; C-N; ARYL CHLORIDES; REDUCTIVE AMINATION; ROOM-TEMPERATURE; AROMATIC AMINATION; ARYLATION; EFFICIENT; AMINES; MONOARYLATION in [Chen, Zicong; Chen, Xiangmeng; So, Chau Ming] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, Hong Kong, Peoples R China; [So, Chau Ming] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China in 2019, Cited 81. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(pi-cinnamyl)Cl](2) enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.

Computed Properties of C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Chen, ZC; Chen, XM; So, CM or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines WOS:000547468700027 published article about BINAPHTHOL DERIVATIVES; C(SP(3))-H BONDS; ARENES; HYDROXYLATION; C(SP(2))-H; FUNCTIONALIZATION; MECHANISM; MILD in [Cheng, Tai-Jin; Xu, Hui; Dai, Hui-Xiong] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; [Dai, Hui-Xiong] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Cheng, Tai-Jin; Dai, Hui-Xiong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wu, Peng; Lin, Hai-Xia] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China; [Huang, Wei] Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China in 2020, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Kathiravan, S; Suriyanarayanan, S; Nicholls, IA in [Kathiravan, Subban; Nicholls, Ian A.] Linnaeus Univ, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden; Linnaeus Univ, Ctr Biomat Chem, SE-39182 Kalmar, Sweden published Electrooxidative Amination of sp(2) C-H Bonds: Coupling of Amines with Aryl Amides via Copper Catalysis in 2019, Cited 69. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C-H activation for sp(2) C-N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergistic combination of copper catalysis and electrocatalysis for aryl C-H amination under mild reaction conditions in an atom-and step-economical manner with the liberation of H-2 as the sole and benign byproduct.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Kathiravan, S; Suriyanarayanan, S; Nicholls, IA or concate me.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Computed Properties of C7H13NO2. Recently I am researching about BINAPHTHOL DERIVATIVES; C(SP(3))-H BONDS; ARENES; HYDROXYLATION; C(SP(2))-H; FUNCTIONALIZATION; MECHANISM; MILD, Saw an article supported by the Shanghai Institute of Materia Medica, Chinese Academy of SciencesChinese Academy of Sciences; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772211]; Youth Innovation Promotion Association CAS [2014229, 2018293]; Institutes for Drug Discovery and Development, Chinese Academy of Sciences [CASIMM0120163006]; Science and Technology Commission of Shanghai MunicipalityScience & Technology Commission of Shanghai Municipality (STCSM) [17JC1405000]; Program of Shanghai Academic Research Leader [19XD1424600]; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China [2018ZX09711002-006]; State Key Laboratory of Natural and Biomimetic Drugs. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.

Computed Properties of C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Patil, DV; Si, T; Kim, HY; Oh, K in [Patil, Dilip, V; Si, Tengda; Oh, Kyungsoo] Chung Ang Univ, Ctr Metareceptome Res, Grad Sch Pharmaceut Sci, Seoul 06974, South Korea; [Kim, Hun Young] Chung Ang Univ, Dept Global Innovat Drugs, Seoul 06974, South Korea published Visible-Light-Induced Photoaddition of N-Nitrosoalkylamines to Alkenes: One-Pot Tandem Approach to 1,2-Diamination of Alkenes from Secondary Amines in 2021, Cited 46. Category: piperidines. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

The generation of aminium radical cation species from N-nitrosoamines is disclosed for the first time through visible-light excitation at 453 nm. The developed visible-light-promoted photoaddition reaction of N-nitrosoamines to alkenes was combined with the o-NQ-catalyzed aerobic oxidation protocol of amines to telescope the direct handling of harmful N-nitroso compounds, where the desired aamino oxime derivatives were obtained in a one-pot tandem Nnitrosation and photoaddition sequence.

Category: piperidines. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Patil, DV; Si, T; Kim, HY; Oh, K or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Kopruluoglu, C; Dejmek, M; Sala, M; Ajani, H; Hrebabecky, H; Fanfrlik, J; Jorda, R; Dracinsky, M; Prochazkova, E; Sacha, P; Krystof, V; Hobza, P; Lepsik, M; Nencka, R in WILEY published article about SCORING FUNCTION; SMALL MOLECULES; ROSCOVITINE; POTENT; IDENTIFICATION; SITE in [Kopruluoglu, Cemal; Dejmek, Milan; Sala, Michal; Ajani, Haresh; Hrebabecky, Hubert; Fanfrlik, Jindrich; Dracinsky, Martin; Prochazkova, Eliska; Sacha, Pavel; Hobza, Pavel; Lepsik, Martin; Nencka, Radim] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo Nam 2, Prague 16610 6, Czech Republic; [Kopruluoglu, Cemal; Ajani, Haresh; Hobza, Pavel] Palacky Univ, Reg Ctr Adv Technol & Mat, Dept Phys Chem, Olomouc, Czech Republic; [Jorda, Radek; Krystof, Vladimir] Palacky Univ, Fac Sci, Lab Growth Regulators, Olomouc, Czech Republic; [Jorda, Radek; Krystof, Vladimir] Czech Acad Sci, Inst Expt Bot, Olomouc, Czech Republic in 2020, Cited 45. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

We report on the discovery of norbornyl moiety as a novel structural motif for cyclin-dependent kinase 2 (CDK2) inhibitors which was identified by screening a carbocyclic nucleoside analogue library. Three micromolar hits were expanded by the use of medicinal chemistry methods into a series of 16 novel compounds. They had prevailingly micromolar activities against CDK2 and the best compound of the series attained IC(50)of 190 nM. The binding modes were explored in molecular details by modeling and docking. Quantum mechanics-based scoring was used to rationalize the affinities. In conclusion, the discovered 9-hydroxymethylnorbornyl moiety was shown by joint experimental-theoretical efforts to be able to serve as a novel substituent for CDK2 inhibitors. This finding opens door to the exploration of chemical space towards more effective derivatives targeting this important class of protein kinases.

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Kopruluoglu, C; Dejmek, M; Sala, M; Ajani, H; Hrebabecky, H; Fanfrlik, J; Jorda, R; Dracinsky, M; Prochazkova, E; Sacha, P; Krystof, V; Hobza, P; Lepsik, M; Nencka, R or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2019 PHOSPHORUS SULFUR published article about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; STEREOGENIC PROPERTIES; BIOLOGICAL-ACTIVITIES; CYTOTOXIC ACTIVITIES; ELECTROCHEMICAL INVESTIGATIONS; ANTIMICROBIAL ACTIVITIES; CRYSTAL-STRUCTURES; ANTITUBERCULOSIS; MONO in [Elmas, Gamze] Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey in 2019, Cited 41. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Formula: C7H13NO2

The Cl exchange reaction of hexachlorocyclotriphosphazene, N3P3Cl6 (1), with one equimolar amount of sodium salt of N/O donor type bidentate ligand containing a 2-pyridyl pendant arm (2) afforded, regioselectively, the partly substituted 2-pyridyl(N/O)spirocyclotriphosphazene (3; with a yield of 65%) in THF. The reactions of 3 with excess pyrrolidine, morpholine and 1,4-dioxa-8-azaspiro[4,5]decane (DASD) led to the formation of the tetraamino-2-pyridyl(N/O)spirocyclotriphosphazenes (3a-3c) in high yields. Compound 3 also gave both tetrapiperidino (3d) and gem-bispiperidino (3e) products with excess piperidine. The structures of all the compounds were determined by elemental analyses, ESI-MS, FTIR, HSQC, HMBC and H-1, C-13, and P-31 NMR techniques. The crystal structure of 3c was identified by single crystal X-ray crystallography. Besides, the compound 3e had one stereogenic P atom, and its chirality was verified by P-31 NMR spectroscopy in the presence of (S)-(+)-2,2,2-trifluoro-1-(9′-anthryl)-ethanol (CSA).

Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Elmas, G or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

HPLC of Formula: C7H13NO2. Authors Sahoo, T; Sarkar, S; Ghosh, SC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sahoo, Tapan; Sarkar, Souvik; Ghosh, Subhash Chandra] Cent Salt & Marine Chem Res Inst CSIR CSMCRI, Nat Prod & Green Chem Div, GB Marg, Bhavnagar 364002, Gujarat, India; [Sahoo, Tapan; Ghosh, Subhash Chandra] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2021, Cited 50. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A simple and facile copper(II) mediated protocol for C-8 amination of 1-naphthylamide derivatives is reported here. Picolinamide and its derivatives were used as a bidentate directing group for the C-8 amination reaction. Various substituted naphthylamide derivatives with numerous cyclic and acyclic amines proceed in good yields under mild conditions. Air was used solely as an oxidant. (C) 2021 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Sahoo, T; Sarkar, S; Ghosh, SC or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about BIOLOGICAL EVALUATION; MMPL3; INHIBITION, Saw an article supported by the Ministry of Education (MoE) Academic Research FundMinistry of Education, Singapore [R148000234114, R148000286114]; Ministry of Health National Medical Research Council (Singapore)Ministry of Health-SingaporeNational Medical Research Council, Singapore [NMRC/TCR/011-NUHS/2014]; National Institute of Allergy and Infectious Diseases of the National Institutes of Health (USA)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R01AI132374]; MoE SingaporeMinistry of Education, Singapore. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Tan, YJ; Li, M; Gunawan, GA; Nyantakyi, SA; Dick, T; Go, ML; Lam, YL. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. HPLC of Formula: C7H13NO2

Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility. Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (33, MIC90Mtb , 0.13 mu M, MBC99.9Mtb, 0.63 mu M), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent. It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.

HPLC of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Tan, YJ; Li, M; Gunawan, GA; Nyantakyi, SA; Dick, T; Go, ML; Lam, YL or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article First representatives of functionalized D-pi-A chromophores containing a tunable hydroxytricyanopyrrole (HTCP) acceptor and N,N-disubstituted aminophenyl donor WOS:000499476200001 published article about MALONONITRILE; FLUOROPHORES; FLUORESCENCE; DYES; RED in [Fedoseev, Sergey V.; Belikov, Mikhail Yu.; Ievlev, Mikhail Yu.; Ershov, Oleg V.] Ulyanov Chuvash State Univ, Moskovsky Pr 15, Cheboksary, Russia in 2019, Cited 46. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Product Details of 177-11-7

The first representatives of D-pi-A chromophores containing a hydroxytricyanopyrrole (HTCP) acceptor and N,N-disubstituted aminophenyl donor were synthesized. The obtained molecules include reactive NH- and OH-fragments allowing the photophysical properties of the chromophores to be tuned, which is not possible for the well-known chromophores of the tricyanofuran (TCF) and tricyanopyrrole (TCP) series. The absorption properties of the synthesized HTCP-chromophores with a p-aminophenyl electron donor substituent were thoroughly studied.

Product Details of 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Fedoseev, SV; Belikov, MY; Ievlev, MY; Ershov, OV or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem