Day: August 17, 2021

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Product Details of 287192-97-6, Which mentioned a new discovery about 287192-97-6

The present invention relates to compounds of formula I, wherein the groups R1, LP, LQ, X1, X2, X3, Ar and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H15610N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Product Details of 6574-15-8, Which mentioned a new discovery about 6574-15-8

N-(1-Oxy-pyridin-2-ylmethyl)oxalamic acid was identified as efficient ligand for CuI-catalyzed amination of aryl halides at room temperature. In our catalytic system, N-arylation of cyclic secondary amines, primary amines, amino acids, and ammonia proceeded with moderate to excellent yields and high functional group tolerance.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H15317N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C14H17NO4, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10314-98-4, Name is N-Cbz-4-Piperidinecarboxylic acid, molecular formula is C14H17NO4. In a Article, authors is Boxus, Thierry，once mentioned of 10314-98-4

Several RGD peptidomimetics have been prepared, in a convergent way, from the common ortho-amino-tyrosine template (O-substituted with an anchorage-arm or a methyl group, and alphaN-substituted with a fluorine tag for XPS analysis), and various omega-aminoacid derivatives. The most flexible compounds have shown a biological activity similar to that of the peptide reference (RGDS) in the platelet aggregation test. The compound 16a could be fitted (by modelisation) with DMP 728 and c(RGDfV), two cyclic peptides that are good ligands of integrins. The compound 16b has been covalently fixed on the surface of a poly(ethylene terephthalate) membrane used as support for mammalian cell cultivation. Copyright (C) 1998 Elsevier Science Ltd.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H21509N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: [1,4′-Bipiperidine]-1′-carbonyl chloride, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 103816-19-9, Name is [1,4′-Bipiperidine]-1′-carbonyl chloride, molecular formula is C11H19ClN2O. In a Patent, authors is ，once mentioned of 103816-19-9

New processes are disclosed for the preparation of camptothecin derivatives, such as, irinotecan and topotecan, as well as new intermediates and compounds related thereof.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H18707N – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 135632-53-0, molcular formula is C11H22N2O2, introducing its new discovery. category: piperidines

The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors. wherein A, Y, Z, X1, X2, X3, R1, R3, ‘m’, ‘n’ and ‘p’ have the meanings given in the specification and pharmaceutically acceptable salt or stereoisomer thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical composition comprising at least one of the compounds of compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H17292N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Computed Properties of C13H24N2O4, Which mentioned a new discovery about 139290-70-3

A series of substituted hydroxymethyl piperidine small molecule inhibitors of the protein-protein interaction between menin and mixed lineage leukemia 1 (MLL1) are described. Initial members of the series showed good inhibitory disruption of the menin-MLL1 interaction but demonstrated poor physicochemical and DMPK properties. Utilizing a structure-guided and iterative optimization approach key substituents were optimized leading to inhibitors with cell-based activity, improved in vitro DMPK parameters, and improved half-lives in rodent PK studies leading to MLPCN probe ML399. Ancillary off-target activity remains a parameter for further optimization.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H22105N – PubChem

Electric Literature of 27578-60-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 27578-60-5, Name is N-(2-Aminoethyl)piperidine,introducing its new discovery.

A series of structurally similar oxovanadium(V) complexes with analogous Schiff bases have been prepared and structurally characterized. The urease inhibitory activities of the complexes were investigated. The shorter the terminal groups of the Schiff base ligands are, the stronger the urease inhibitory activities of the oxovanadium(V) complexes.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H4712N – PubChem

Synthetic Route of 430461-56-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.430461-56-6, Name is (R)-3-Phenylpiperidine, molecular formula is C11H15N. In a article，once mentioned of 430461-56-6

The invention relates to compounds of the formulae (I), (II) and (III) in which R1, R2, R3, R4, Y, W1, W2, L, A, Alk, Cyc, Ar, Het1, Het2, Hal and n have the meaning indicated in claim 1, and/or physiologically acceptable salts, tautomers and stereo-isomers thereof, including mixtures thereof in all ratios. The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumours, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formulae (II) and (III) and optionally conversion of a base or acid of the compounds of the formula (I) into one of their salts.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H9234N – PubChem

Reference of 1121-89-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1121-89-7, Name is Piperidine-2,6-dione, molecular formula is C5H7NO2. In a Article，once mentioned of 1121-89-7

A new method of transamidation of carboxamides with amines catalyzed by benzotriazole has been developed.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H1540N – PubChem

Electric Literature of 309956-78-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.309956-78-3, Name is (R)-tert-Butyl piperidin-3-ylcarbamate, molecular formula is C10H20N2O2. In a Patent，once mentioned of 309956-78-3

A advantage Geleg sandbank industrial production method. In accordance with the molar ratio of the 8 […] -7 the […] (the 2 butyne […] ) – 3 the the methylxanthines […] the 2 […] methyl -4 the quinazoline methyl […] added to a dipolar aprotic organic solvent, then adding alkali and potassium iodide, crystallization, filtration dried to obtain the intermediate I; the intermediate body in accordance with the molar ratio of the I (R) – 3 the […] butoxycarbonyl amino piperidine is added to a dipolar aprotic organic solvent, then adding alkali, crystallization, filtration washing remove the inorganic salt, to remove solvent under reduced pressure to obtain crude products, after methanol and isopropanol crystallization get midbody II; than the intermediate II according to the volume of the deprotection reagent, by adding to the reaction solvent, a crystallization to obtain crude products, then recrystallized with ethanol, filter to obtain final product advantage Geleg sandbank. The method of the invention can greatly shorten the production cycle, save the production cost, can be high purity, impurity removing effect is better, the method is safe and reliable, is simple and easy to operate, has good repeatability. (by machine translation)

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H13515N – PubChem