Month: April 2021

Chemistry is an experimental science, SDS of cas: 179474-79-4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O, belongs to piperidines compound. In a document, author is Gomes do Nascimento, Michelle Nauara.

Antimicrobial and cytotoxic activities of Senna and Cassia species (Fabaceae) extracts

In Brazilian traditional medicine, botanical species belonging to the genera Senna and Cassia are widely used as laxative, analgesic, and antifungal agents to treat ringworm and other fungal skin infections. This has motivated us to select and to screen ten species of these genera for their antibacterial, antifungal, and cytotoxic activities. The leaf or flower ethanol extracts were investigated against aerobic and anaerobic oral bacteria and Candida spp.; the microdilution broth method was employed. Cytotoxicity was determined against Vero cells. Among the plant extracts evaluated herein, four extracts at 200.0-400.0 mu g mL(-1) presented moderate activities against at least two bacterial strains. Concerning the antifungal action, the S. macranthera flower ethanol extract exerted significant antifungal effect with MIC values ranging from 5.9 to 23.4 mu g mL(-1). This extract was submitted to liquid-liquid extraction, and the resulting fractions were tested. The ethyl acetate fraction showed better antifungal activity (MIC values of 5.9 mu g mL(-1) for C. glabrata and 23.4 mu g mL(-1) for C. albicans and C. tropicalis) as compared with amphotericin B (0.1-0.2 mu g mL(-1)), used as positive control. The bioactive metabolites of this fraction were identified by UHPLC-ESI/HRMS/MSn, which revealed the presence of eighteen compounds, including one organic acid (1), two flavan-3-ol (2 and 3), one flavone (4), two glycosylated flavonols (5 and 6), five proanthocyanidin dimers (7-11b), and seven proanthocyanidin trimers (12-18). The antimicrobial activities of some Senna or Cassia species studied here have been reported for the first time. The present results show that S. macranthera flowers are an interesting source of new antifungal agents.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 179474-79-4. SDS of cas: 179474-79-4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 41979-39-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 41979-39-9, Name is Piperidin-4-one hydrochloride, SMILES is O=C1CCNCC1.[H]Cl, belongs to piperidines compound. In a article, author is Kim, Simon J., introduce new discover of the category.

Enantioselective isoquinuclidine synthesis via sequential Diels-Alder/visible-light photoredox C-C bond cleavage: a formal synthesis of the indole alkaloid catharanthine

An enantioselective route to substituted chiral isoquinuclidines, present in alkaloids such as catharanthine, deserpidine, ibogamine and ibogaine, has been developed using a ketene equivalent approach. Organocatalyzed Diels-Alder reaction of an N-protected dihydropyridine with acrolein using a valine derived 1,2-aminoalcohol catalyst occurs with high er and dr. Subsequent Ru(Bipy)(3)Cl-2(H2O)(6) catalyzed photoredox cleavage generates an N-protected isoquinuclidinone, providing rapid access to the core structures of a variety of important indole alkaloids. Optimized conditions for the enamine mediated photocleavage employed the use of silica gel, acetic acid (1.5 equiv.) and piperidine (3.0 equiv.), a blue LED light source, and pure oxygen rather than air. The two-step sequence utilizes acrolein as a ketene dienophile equivalent providing a new approach to asymmetric ketene Diels-Alder reactions. Further elaboration of the resultant isoquinuclidines permitted an enantioselective route to intermediates previously employed in total syntheses of catharanthine and deserpidine.

Synthetic Route of 41979-39-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 41979-39-9.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine. In a document, author is De Angelis, Martina, introducing its new discovery. SDS of cas: 13925-07-0.

Stereodivergent synthesis of piperidine iminosugars 1-deoxy-D-nojirimycin and 1-deoxy-D-altronojirimycin

A stereodivergent approach for producing piperidine iminosugars has been developed employing a common optically active precursor. The key steps of the synthetic pathway are the double diastereoselection in the asymmetric dihydroxylation of the suitable chiral vinyl epoxy ester and the regio- and stereospecific opening of the epoxide ring with azide. The synthesis of two piperidine iminosugars, 1-deoxy-D-altronojirimycin and 1-deoxy-D-nojirimycin, was achieved by two related routes. (C) 2020 Elsevier Ltd. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 13925-07-0 help many people in the next few years. SDS of cas: 13925-07-0.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 120013-39-0, Name is 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride, SMILES is Cl.COC2=C(C=C1C(C(CC1=C2)CC3CCNCC3)=O)OC, belongs to piperidines compound. In a document, author is Wang, Meng, introduce the new discover, Safety of 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride.

Piperidine nitroxide Tempol enhances cisplatin-induced apoptosis in ovarian cancer cells

A nitroxide radical, Tempol (Tempol, TPL), is usually used as an antioxidative agent clinically, whereas the mechanism underlying its pro-oxidative effect has not been thoroughly investigated. The present study investigated the pro-oxidative effect of TPL on the inhibition of cellular proliferation and its role in enhancing the effect of anticancer drug cisplatin (DDP) on the induction of apoptosis in ovarian cancer cells. Cell viability and proliferation were evaluated by MTT assay. Cell apoptosis was analyzed by flow cytometry (FCM) following staining with Annexin V/propidium iodide. Western blot analysis was performed to determine the expression levels of anti-apoptotic protein B-cell lymphoma-2 (Bcl-2) and pro-apoptotic protein Bcl-2-associated X protein (Bax), and the Bcl-2:Bax expression ratio. Cellular reactive oxygen species (ROS) were labeled with dichlorofluorescin-diacetate and analyzed by FCM. The results revealed that cell viabilities of OVCAR3 and SKOV3 cells were decreased by TPL in dose-dependent manner at concentrations of 2 to 10 mM after 48 h incubation. The cell proliferation rates of OVCAR3 and SKOV3 cells were suppressed by TPL at lower toxic concentrations of 1.5 and 1 mM, respectively, compared with the control group. The MTT assay indicated that the combination therapy significantly inhibited the cell proliferation of OVCAR3 cells compared with treatment with DDP alone. FCM demonstrated that the combination treatment increased the proportion of early apoptotic cells in OVCAR3 cells compared with single DDP treatment. Western blot analysis revealed that the combination treatment markedly decreased the Bcl-2:Bax expression ratio compared with treatment with DDP alone. Detection of cellular ROS expression levels demonstrated that the combination therapy significantly increased cellular ROS generation compared with the DDP-only therapy. These data indicated that TPL increased the effect of DDP on inducing apoptosis in OVCAR3 cells.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 120013-39-0 is helpful to your research. Safety of 5,6-Dimethoxy-2-(4-piperidinylmethyl)-1-indanone hydrochloride.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Related Products of 41979-39-9, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 41979-39-9, Name is Piperidin-4-one hydrochloride, SMILES is O=C1CCNCC1.[H]Cl, belongs to piperidines compound. In a article, author is Periyannan, P., introduce new discover of the category.

Crystal structure, Hirshfeld surface analysis and DFT studies of 1-[r-2,c-6-diphenyl-t-3-(propan-2-yl)piperidin-1-yl]ethan-1-one

In the title compound, C22H27NO, the piperidine ring adopts a chair conformation. The dihedral angles between the mean plane of the piperidine ring and the phenyl rings are 89.78 (7) and 48.30 (8)degrees. In the crystal, molecules are linked into chains along the b-axis direction by C-H center dot center dot center dot O hydrogen bonds. The DFT/B3LYP/6-311 G(d,p) method was used to determine the HOMO-LUMO energy levels. The molecular electrostatic potential surfaces were investigated by Hirshfeld surface analysis and two-dimensional fingerprint plots were used to analyse the intermolecular interactions in the molecule.

Related Products of 41979-39-9, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 41979-39-9.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

188111-79-7, Name is (R)-1-Boc-3-Aminopiperidine, molecular formula is C10H20N2O2, belongs to piperidines compound, is a common compound. In a patnet, author is Oderinlo, Ogunyemi O., once mentioned the new application about 188111-79-7, Application In Synthesis of (R)-1-Boc-3-Aminopiperidine.

New thiazolidine-2,4-dione derivatives combined with organometallic ferrocene: Synthesis, structure and antiparasitic activity

Favourable physicochemical properties of an organometallic ferrocene and antiplasmodial potency of compounds containing the thiazolidine-2,4-dione framework (TZD-4) prompted us to explore compounds containing both the thiazolidine-2,4-dione core and the ferrocenyl unit with the primary aim of identifying compounds with promising antiprotozoal activities. Thus, a new series of rationally designed ferrocene-based thiazolidine-2,4-dione derivatives, containing a selection of secondary cyclic amines, was synthesised and fully characterised using standard spectroscopic techniques. The resulting compounds were screened for their antiplasmodial and antitrypanosomal activities against both the chloroquine-resistant (Dd2) strain of Plasmodium falciparum and the Nagana Trypanosoma brucei brucei 427. The general trend that emerged indicated that the target compounds were more selective towards T. b. brucei compared to the P. falciparum parasite. Moreover, the analogues bearing methylpiperazine (8a) and piperidine (8b) rings were more active against T. b. brucei compared to hit compound TZD-4. Except compound 8b, which appeared promising, none of the synthesised compounds showed better activity than TZD-4 against the P. falciparum parasite. All the synthesised compounds were non-toxic and often showed >90% viability of the HeLa cell line screened.

If you’re interested in learning more about 188111-79-7. The above is the message from the blog manager. Application In Synthesis of (R)-1-Boc-3-Aminopiperidine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 13925-07-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine, SMILES is CCC1=C(C)N=C(C)C=N1, belongs to piperidines compound. In a article, author is Becerra, Diana, introduce new discover of the category.

Synthesis of N -substituted 3-(2-aryl-2-oxoethyl) 3-hydroxyindolin-2-ones and their conversion to N -substituted (E)-3-(2-aryl-2-oxoethylidene)indolin-2-ones: synthetic sequence, spectroscopic characterization and structures of four 3-hydroxy compounds and five oxoethylidene products

An operationally simple and time -efficient approach has been developed for the synthesis of racemic N-substituted 3-(2-aryl-2-oxoethyl)-3-hydroxyindolin-2ones by a piperidine-catalysed aldol reaction between aryl methyl ketones and N-alkylisatins. These aldol products were used successfully as strategic intermediates for the preparation of N-substituted (E)-3-(2-hetary1-2-oxoethylidene)indolin-2-ones by a stereoselective dehydration reaction under acidic conditions. The products have all been fully characterized by ‘H and 13C NMR spectroscopy, by mass spectrometry and, for a representative selection, by crystal structure analysis. In each of (RS)-1-benzy1-3-hydroxy 3 [2 (4 methoxypheny1)-2-oxoethyl]indolin-2-one, C24H21N04, (Ic), and (RS)-1-benzy1-3-{214(dimethylamino)pheny11-2-oxoethyll-3-hydroxyindolin-2-one, C25H24N203, (Id), inversion -related pairs of molecules are linked by 0 H 0 hydrogen bonds to form R22(10) rings, which are further linked into chains of rings by a combination of C H 0 and C H -7r(arene) hydrogen bonds in (Ic) and by C H rr(arene) hydrogen bonds in (Id). The molecules of (RS)-1-benzy1-3-hydroxy-3[2-oxo-2-(pyridin-4-yl)ethyl]indolin-2-one, C22Hi8N203, (Ie), are linked into a three-dimensional framework structure by a combination of 0 H -N, C H- 0 and C H -7r(arene) hydrogen bonds. (RS)-342-(Benzo[d][1,3]dioxo1-5y1)-2-oxoethy11-1-benzyl-3-hydroxyindolin-2-one, C24Hi9N05, (If), crystallizes with Z = 2 in the space group Pi and the molecules are linked into complex sheets by a combination of 0 H -0, C H 0 and C H -7r(arene) hydrogen bonds. In each of (E)-1-benzyl 3 [2 (4 fluoropheny1)-2-oxoethylidene]indolin-2one, C23H16FN02, (Ha), and (E)-1-benzy1-342-oxo-2-(thiophen-2-yl)ethylidene1indolin-2-one, C2iH15NO2S, (llg), the molecules are linked into simple chains by a single C H 0 hydrogen bond, while those of (E)-1-benzy1-342-oxo-2-(pyriclin4-yl)ethylidenelindolin-2-one, C22Hi6N202, (He), are linked by three C H 0 hydrogen bonds to form sheets which are further linked into a three-dimensional structure by C H -7r(arene) hydrogen bonds. There are no hydrogen bonds in the structures of either (E)-1-benzy1-342-(4-methoxypheny1)-2-oxoethylidene1indolin-2-one, C24Hi9NO3, (IIc), or (E)-1-benzy1-5-chloro 3 [2 (4 chloropheny1)-2oxoethylidene]indolin-2-one, C23H15C12NO2, (IIh), but the molecules of (IIh) are linked into chains of rr-stacked dimers by a combination of C Cl -7r(arene) and aromatic 7r rr stacking interactions.

Synthetic Route of 13925-07-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 13925-07-0.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 10465-81-3, Name is Diazene-1,2-diylbis(piperidin-1-ylmethanone), molecular formula is , belongs to piperidines compound. In a document, author is Sattar, Almas, COA of Formula: C12H20N4O2.

Synthesis, biological evaluation, and in silico study of some unique multifunctional 1,2,4-triazole acetamides

The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a-6k, bearing multifunctional moieties. The target acetamides were derived from 4-phenyl-5-(1-tosylpiperidin-4-yl)-4H-1,2,4-triazole-3-thiol (3). The structural analysis was carried out using modern spectroscopic techniques including IR, NMR, and EIMS spectral analysis. The antibacterial activity was screened against five bacterial strains including three gram-negative and two gram-positive ones. Enzyme inhibition was carried out against lipoxygenase enzyme and results were supported by in silico study. The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 10465-81-3, in my other articles. COA of Formula: C12H20N4O2.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reference of 2873-29-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 2873-29-2, Name is (2R,3S,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate, SMILES is O=C(OC[C@@H]1[C@@H](OC(C)=O)[C@H](OC(C)=O)C=CO1)C, belongs to piperidines compound. In a article, author is Sharma, Rajni, introduce new discover of the category.

Khellinoflavanone, a Semisynthetic Derivative of Khellin, Overcomes Benzo[a] pyrene Toxicity in Human Normal and Cancer Cells That Express CYP1A1

Cytochrome P450 family 1 (CYP1) enzymes catalyze the metabolic activation of environmental procarcinogens such as benzo[a] pyrene, B[a] P, into carcinogens, which initiates the process of carcinogenesis. Thus, stopping the metabolic activation of procarcinogens can possibly prevent the onset of cancer. Several natural products have been reported to show unique ability in inhibiting CYP1 enzymes. We found that khellin, a naturally occurring furanochromone from Ammi visnaga, inhibits CYP1A1 enzyme with an IC50 value of 4.02 mu M in CYP1A1-overexpressing human HEK293 suspension cells. To further explore this natural product for discovery of more potent and selective CYP1A1 inhibitors, two sets of semisynthetic derivatives were prepared. Treatment of khellin with alkali results in opening of a pyrone ring, yielding khellinone (2). Claisen-Schmidt condensation of khellinone (2) with various aldehydes in presence of potassium hydroxide, at room temperature, provides a series of furanochalcones 3a-v (khellinochalcones). Treatment of khellinone (2) with aryl aldehydes in the presence of piperidine, under reflux, affords the flavanone series of compounds 4a-p (khellinoflavanones). The khellinoflavanone 4l potently inhibited CYP1A1 with an IC50 value of 140 nM in live cells, with 170fold selectivity over CYP1B1 (IC50 for CYP1B1 = 23.8 mu M). Compound 4l at 3x IC50 concentration for inhibition of CYP1A1 completely protected HEK293 cells from CYP1A1-mediated B[a] P toxicity. Lung cancer cells, A549 (p53+) and Calu-1 (p53null), blocked in growth at the S-phase by B[a] P were restored into the cell cycle by compound 4l. The results presented herein strongly indicate the potential of these khellin derivatives for further development as cancer chemopreventive agents.

Reference of 2873-29-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2873-29-2.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Huang, Huoming, once mentioned the application of 41556-26-7, Name is Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate, molecular formula is C30H56N2O4, molecular weight is 508.78, MDL number is MFCD00134706, category is piperidines. Now introduce a scientific discovery about this category, Application In Synthesis of Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate.

Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxypheny1)-N-phenylpiperidine-1-carboxamide as novel potent analgesic

Management of moderate to severe pain by clinically used opioid analgesics is associated with a plethora of side effects. Despite many efforts have been dedicated to reduce undesirable side effects, moderate progress has been made. In this work, starting from Tramadol, a series of 3-((dimethylamino)methyl)-4hydroxy-4-(3-methoxyphenyl)piperidine-1-carboxamide derivatives were designed and synthesized, and their in vitro and in vivo activities were evaluated. Our campaign afforded selective opioid receptor (MOR) ligand 2a (K-i (MOR): 7.3 +/- 0.5 nM; K-iDOR: 849.4 +/- 96.6 nM; K-i KOR: 49.1 +/- 6.9 nM) as potent analgesic with ED50 of 3.1 mg/kg in 55 degrees C hot plate model. Its antinociception effect was blocked by opioid antagonist naloxone. High binding affinity toward MOR of compound 2a was associated with water bridge, salt bridge, hydrogen bond and hydrophobic interaction with MOR. The high selectivity of compound 2a for MOR over delta opioid receptor (DOR) and kappa opioid receptor (KOR) was due to steric hindrance of compound 2a with DOR and KOR. 2a, a compound with novel scaffold, could serve as a lead for the development of novel opioid ligands. (C) 2020 Elsevier Masson SAS. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 41556-26-7, Application In Synthesis of Bis(1,2,2,6,6-pentamethylpiperidin-4-yl) decanedioate.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem