Day: March 24, 2021

Synthetic Route of 401566-79-8, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a article, author is Yamaguchi-Sasaki, Toru, introduce new discover of the category.

Design and Synthesis of 2-(1-Alkylaminoalkyl)pyrazolo[1,5-a]pyrimidines as New Respiratory Syncytial Virus Fusion Protein Inhibitors

Respiratory syncytial virus (RSV) is one of the most common causes of lower respiratory tract infections and a significant pathogen for both adults and children. Although two drugs have been approved for the treatment of RSV infections, the low therapeutic index of these drugs have led pharmaceutical companies to develop safe and effective small-molecule anti-RSV drugs. The pyrazolo[1,5-a]pyrimidine series of compounds containing a piperidine ring at the 2-position of the pyrazolo[1,5-a]pyrimidine scaffold are known as candidate RSV fusion (F) protein inhibitor drugs, such as presatovir and P3. The piperidine ring has been revealed to facilitate the formation of an appropriate dihedral angle between the pyrazolo[1,5-a]pyrimidine scaffold and the plane of the amide bond for exertion of anti-RSV activity. A molecular-dynamic study on newly designed compounds with an acyclic chain instead of the piperidine ring proposed and demonstrated a new series of pyrazolo[1,5-a]pyrimidine derivatives, such as 9c with a 1-methyaminopropyl moiety, showing similar dihedral angle distributions to those in presatovir. Compound 9c exhibited potent anti-RSV activity with an EC50 value of below 1 nM, which was similar to that of presatovir. A subsequent optimization study on the benzene ring of 9c led to the potent RSV F protein inhibitor 14f with an EC50 value of 0.15 nM. The possibility of improving the biological properties of anti-RSV agents by modification at the 7-position of pyrazolo[1,5-a]pyrimidine is also discussed.

Synthetic Route of 401566-79-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 401566-79-8 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O. In an article, author is Olsson, Joel S.,once mentioned of 179474-79-4, Product Details of 179474-79-4.

Functionalizing Polystyrene with N-Alicyclic Piperidine-Based Cations via Friedel-Crafts Alkylation for Highly Alkali-Stable Anion-Exchange Membranes

Different anion-exchange membranes (AEMs) based on polystyrene (PS)-carrying benzyltrimethyl ammonium cations are currently being developed for use in alkaline fuel cells and water electrolyzers. However, the stability in relation to these state-of-the-art cations needs to be further improved. Here, we introduce highly alkali-stable mono- and spirocyclic piperidine-based cations onto PS by first performing a superacid-mediated Friedel-Crafts alkylation using 2-(piperidine-4-yl)propane-2-ol. This is followed by quaternization of the piperidine rings either using iodomethane to produce N,N-dimethyl piperidinium cations or by cyclo-quaternizations using 1,5-dibromopentane and 1,4-dibromobutane, respectively, to obtain N-spirocyclic quaternary ammonium cations. Thus, it is possible to functionalize up to 27% of the styrene units with piperidine rings and subsequently achieve complete quaternization. The synthetic approach ensures that all of the sensitive beta-hydrogens of the cations are present in ring structures to provide high stability. AEMs based on these polymers show high alkaline stability and less than 5% ionic loss was observed by H-1 NMR spectroscopy after 30 days in 2 M aq NaOH at 90 degrees C. AEMs functionalized with N,N-dimethyl piperidinium cations show higher stability than the ones carrying N-spirocyclic quaternary ammonium. Careful analysis of the latter revealed that the rings formed in the cyclo-quaternization are more prone to degrade via Hofmann elimination than the rings introduced in the Friedel-Crafts reaction. AEMs with an ion-exchange capacity of 1.5 mequiv g(-1) reach a hydroxide conductivity of 106 mS cm(-1) at 80 degrees C under fully hydrated conditions. The AEMs are further tuned and improved by blending with polybenzimidazole (PBI). For example, an AEM containing 2 wt % PBI shows reduced water uptake and much improved robustness during handling and reaches 71 mS cm(-1) at 80 degrees C. The study demonstrates that the critical alkaline stability of PS-containing AEMs can be significantly enhanced by replacing the benchmark benzyltrimethyl ammonium cations with N-alicyclic piperidine-based cations.

Interested yet? Keep reading other articles of 179474-79-4, you can contact me at any time and look forward to more communication. Product Details of 179474-79-4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 19916-73-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 19916-73-5, Name is 6-(Benzyloxy)-7H-purin-2-amine, SMILES is C3=NC1=C(C(=NC(=N1)N)OCC2=CC=CC=C2)[NH]3, belongs to piperidines compound. In a article, author is Waddell, Lachlan J. N., introduce new discover of the category.

Asperidine B: Total synthesis and structure correction

A synthesis of the proposed structure of asperidine B is reported, involving a tandem hydroformylation-condensation reaction, a diastereoselective dihydroxylation and the addition of an organozinc reagent to an iminium ion. As the spectroscopic data for the synthetic material is not in agreement with that of the natural product, the structure of asperidine B is reassigned as (+)-preussin. (C) 2020 Elsevier Ltd. All rights reserved.

Electric Literature of 19916-73-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 19916-73-5.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 3056-33-5, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 3056-33-5, Name is N2,9-Diacetylguanine, SMILES is CC(=O)NC1=NC2=C(N=CN2C(C)=O)C(=O)N1, belongs to piperidines compound. In a article, author is Hussain, Javeena, introduce new discover of the category.

Synthesis and characterization of a new class of phenothiazine molecules with 10H-substituted morpholine & piperidine derivatives: A structural insight

A series of 10H-substituted phenothiazine-based molecules were prepared by the base-catalyzed reactions. The synthesized compounds are characterized by Mass spectroscopy, NMR, and SCXRD to examine the role of different functional groups involved in the intermolecular interactions and conformational geometries. The crystal packing of the compounds is governed by O-H center dot center dot center dot O, C-H center dot center dot center dot O, and pi-pi interactions. A complete understanding of the intermolecular interactions is studied employing the Hirshfeld analysis, 2D Fingerprint plot. Furthermore, the density functional theory (DFT/B3LYP) method at the 6-311++G(d,p) basis set was performed to support and compare experimental & theoretical geometrical parameters of phenothiazine derivatives. (C) 2020 Elsevier B.V. All rights reserved.

Application of 3056-33-5, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 3056-33-5 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Electric Literature of 13925-03-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 13925-03-6, Name is 2-Ethyl-6-methylpyrazine, SMILES is CC1=CN=CC(CC)=N1, belongs to piperidines compound. In a article, author is Akentieva, N. P., introduce new discover of the category.

Anticancer Activity of Spirocyclic Hydroxamic Acids (Derivatives of 1-Hydroxy-1,4,8-Triazaspiro[4,5]Decan-2-One), Histone Deacetylase Inhibitors

Ten racemic spirocyclic hydroxamic acids (CHA 1-10, 1-hydroxy-1,4,8-triazaspiro [4,5]decan-2-one derivatives) containing pharmacophore imidazolidine and piperidine fragments with various substituents were synthesized. It was shown that CHA (1-10) are inhibitors of the activity of the histone deacetylase enzyme in cultured breast cancer cells. The study of antitumor activity in vivo CHA (1-10) showed that in polychemotherapy with cisplatin and cyclophosphamide these compounds possess pronounced chemosensitizing antitumor activity and increase the life span of experimental animals. Thus, it is shown that spirocyclic hydroxamic acids possess therapeutic potential in polychemotherapy for the treatment of oncological diseases.

Electric Literature of 13925-03-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 13925-03-6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 22990-77-8, Name is 2-Piperidylmethylamine, SMILES is NCC1NCCCC1, belongs to piperidines compound. In a document, author is Ariffin, Eda Yuhana, introduce the new discover, Formula: C6H14N2.

Optical DNA Biosensor Based on Square-Planar Ethyl Piperidine Substituted Nickel(II) Salphen Complex for Dengue Virus Detection

A sensitive and selective optical DNA biosensor was developed for dengue virus detection based on novel square-planar piperidine side chain-functionalized N,N’-bis-4-(hydroxysalicylidene)-phenylenediamine-nickel(II), which was able to intercalate via nucleobase stacking within DNA and be functionalized as an optical DNA hybridization marker. 3-Aminopropyltriethoxysilane (APTS)-modified porous silica nanospheres (PSiNs), was synthesized with a facile mini-emulsion method to act as a high capacity DNA carrier matrix. The Schiff base salphen complexes-labelled probe to target nucleic acid on the PSiNs renders a colour change of the DNA biosensor to a yellow background colour, which could be quantified via a reflectance transduction method. The reflectometric DNA biosensor demonstrated a wide linear response range to target DNA over the concentration range of 1.0 x 10(-16)-1.0 x 10(-10) M (R-2 = 0.9879) with an ultralow limit of detection (LOD) at 0.2 aM. The optical DNA biosensor response was stable and maintainable at 92.8% of its initial response for up to seven days of storage duration with a response time of 90 min. The reflectance DNA biosensor obtained promising recovery values of close to 100% for the detection of spiked synthetic dengue virus serotypes 2 (DENV-2) DNA concentration in non-invasive human samples, indicating the high accuracy of the proposed DNA analytical method for early diagnosis of all potential infectious diseases or pathological genotypes.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 22990-77-8 is helpful to your research. Formula: C6H14N2.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is an experimental science, Safety of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14691-89-5, Name is 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl, molecular formula is C11H21N2O2*, belongs to piperidines compound. In a document, author is Nakhate, Akhil V..

Cu2O nanoparticles supported hydrothermal carbon microspheres as catalyst for propargylamine synthesis

Cu2O nanoparticles supported on hydrothermal carbon microsphere (HTC) have been synthesized by hydro thermal synthesis followed by chemical reduction method. The prepared catalyst was used for propargylamine synthesis from the coupling of phenyl acetylene with benzaldehyde and piperidine. In this protocol, biomass derived D-glucose was used as carbon source for the synthesis of carbon microspheres by hydrothermal treatment and CuCl2 center dot 6H(2)O as a copper precursor. The activity of Cu2O@HTC was compared with different catalysts such as CuFe2O4, CuCl2 center dot 2H(2)O, commercial CuO, and Cu2O. Among them Cu2O@HTC exhibited the best activity and selectivity for propargylamine synthesis. The catalyst was well characterized by several analytical techniques such as SEM, XRD, FTIR, TEM, ICP-AES, and XPS analysis before and after 5th reuse. The effect of various parameters was studied including solvent, catalyst loading, mole ratio and temperature of the reaction to achieve the best yield at 60 degrees C and 1.5 x 10 (-3)g/cm(3) catalyst loading. Notably, Cu2O@HTC was recycled five times and found to be robust.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14691-89-5, in my other articles. Safety of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C9H9N5O3, 3056-33-5, Name is N2,9-Diacetylguanine, molecular formula is C9H9N5O3, belongs to piperidines compound. In a document, author is Lin, Lan, introduce the new discover.

Novel artemisinin derivatives with potent anticancer activities and the anti-colorectal cancer effect by the mitochondria-mediated pathway

Many artemisinin derivatives have good inhibitory effects on malignant tumors. In this work, a novel series of artemisinin derivatives containing piperazine and fluorine groups were designed and synthesized and their structures were confirmed by H-1 NMR, C-13 NMR and HRMS technologies. The in vitro cytotoxicity against various cancer cell lines was evaluated. Among the derivatives, compound 12h was found to exhibit not only the best activity against HCT-116 cells (IC50 = 0.12 +/- 0.05 mu M), but also low toxicity against normal cell line L02 (IC50 = 12.46 +/- 0.10 mu W. The mechanisms study revealed that compound 12h caused the cell cycle arrest in G1 phase, induced apoptosis in a concentration-dependent manner, significantly reduced mitochondrial membrane potential, increased intracellular ROS and Ca2+ levels, up-regulated the expression of Bax, cleaved caspase-9, cleaved caspase-3, and down-regulated the expression of Bcl-2 protein. A series of analyses confirmed that 12h can inhibit HCT-116 cells migration and induce apoptosis by a mechanism of the mitochondria-mediated pathway in the HCT-116 cell line. The present work indicates that compound 12h may merit further investigation as a potential therapeutic agent for colorectal cancer.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 3056-33-5. Formula: C9H9N5O3.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine401566-79-8, Name is 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine, SMILES is CC1=NN(C2=CC=CC=C2)C(N3CCNCC3)=C1, belongs to piperidines compound. In a article, author is Jadhav, Manoj M., introduce new discover of the category.

Structure-efficiency relationship of newly synthesized 4-substituted donor-pi-acceptor coumarins for dye-sensitized solar cells

Four (MC1-MC4) 4-substituted coumarin dyes having N,N-diethyl aniline as donor and rhodanine-3-acetic acid as acceptor have been synthesized for use in nano-crystalline TiO2-based dye-sensitized solar cells (DSSCs). The alteration at the 4-position of coumarin was carried out by substituting H atom by chlorine (-Cl), piperidine (-NC5H10), and cyano group (-CN) to study the effect of substitution on the efficiency of the DSSCs. All the dyes were characterised by H-1-NMR and C-13-NMR spectroscopy and CHN analysis. The absorption and emission spectra of these coumarin dyes were recorded in eight different solvents and show positive solvatochromism. The TiO2-based DSSCs were fabricated using the four dyes and their photovoltaic properties were estimated. A maximum efficiency of 4.60% was obtained for the MC4 device, which has an electron-withdrawing cyano group at the 4-position of coumarin, while 2.64% efficiency was obtained for the MC1 device, which has only hydrogen at the 4-position. The efficiencies of the MC2 and MC3 devices lie between those of MC1 and MC4, suggesting the significance of substitution at the 4-position. The introduction of a cyano group, which acts as an electron trap, increases the electron-withdrawing capacity of the dye; thus, more electron density is withdrawn from the donor, resulting in enhanced efficiency. These dyes were studied by using density functional theory (DFT) and time dependent density functional theory (TD-DFT) to obtain the vertical excitation, HOMO-LUMO energy levels, band gap and electron distribution in the ground and excited state. The calculated values showed good correlation with the experimental values. Our results suggest that substitution at the 4-position is essential for enhancing the efficiency of coumarin-based DSSCs.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 401566-79-8. Application In Synthesis of 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Quality Control of 8-Chloroazatadine38092-89-6, Name is 8-Chloroazatadine, SMILES is CN1CC/C(CC1)=C2C3=CC=C(Cl)C=C3CCC4=CC=CN=C42, belongs to piperidines compound. In a article, author is Goel, Pallavi, introduce new discover of the category.

Recent advancement of piperidine moiety in treatment of cancer- A review

Piperidine is an important pharmacophore, a privileged scaffold and an excellent heterocyclic system in the field of drug discovery which provides numerous opportunities in studying/exploring this moiety as an anticancer agent by acting on various receptors of utmost importance. Cancer is an uncontrolled division of cells that results in the formation of tumour which have the potential to migrate to other parts of the body (metastasis) finally becoming a major threat to human population. Since piperidine displayed great potential in this area it is being further probed to get novel entities for the treatment of cancer. This review throws light on recent biological expansions of piperidine along with structure activity relationships to deliver association between various synthesized newer/novel derivatives and receptor sites. (C) 2018 Elsevier Masson SAS. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 38092-89-6. Quality Control of 8-Chloroazatadine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem