Day: March 4, 2021

Electric Literature of 6574-15-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.6574-15-8, Name is 1-(4-Nitrophenyl)piperidine, molecular formula is C11H14N2O2. In a article£¬once mentioned of 6574-15-8

Aromatic Nucleophilic Substitution of Halobenzenes with Amines under High Pressure

The nucleophilic substitution reactions of aromatic halides having electron-attracting groups on ortho or para position with various primary and secondary amines were accelerated by high pressure to give the corresponding N-substituted anilines in high yields.The bulkiness of amines affects its reactivity to lower the yields of the products.Although the secondary amines are usually less reactive than primary amines, cyclic secondary amines such as morpholine, piperidine, and pyrrolidine were found very reactive. 1,4-Diazabicyclo<2.2.2>octane and quinuclidine gave N-quarternary ammonium halides in high yields in contrast to the low reactivity of acyclic tertiary amines.Dichloro- and trichloro-nitrobenzenes also react with diethylamine, pyrrolidine, and morpholine to give mono-, di-, and trisubstitution products depending upon the amount of amine and the position of nitro group in these chlorides.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H15289N – PubChem

 

Electric Literature of 106-52-5, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 106-52-5, Name is 1-Methylpiperidin-4-ol, molecular formula is C6H13NO. In a Article£¬once mentioned of 106-52-5

Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies

Through virtual screening, we identified the lead compound MCL1020, which exhibited modest CHK1 inhibitory activity. Then a series of 5-(pyrimidin-2-ylamino)picolinonitrile derivatives as CHK1 inhibitors were discovered by further rational optimization. One promising molecule, (R)-17, whose potency was one of the best, had an IC50 of 0.4 nM with remarkable selectivity (>4300-fold CHK1 vs. CHK2). Compound (R)-17 effectively inhibited the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 muM) and displayed low affinity for hERG (IC50 > 40 muM). Moreover, (R)-17 significantly suppressed the tumor growth in Z-138 cell inoculated xenograft model (20 mg/kg I.V., TGI = 90.29%) as a single agent with body weight unaffected. Taken together, our data demonstrated compound (R)-17 could be a promising drug candidate for the treatment of hematologic malignancies.

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Piperidine – Wikipedia,
Piperidine | C5H2259N – PubChem

 

Related Products of 39546-32-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.39546-32-2, Name is Piperidine-4-carboxamide, molecular formula is C6H12N2O. In a Patent£¬once mentioned of 39546-32-2

AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR

A compound of the formula (I) wherein R1, R2, R3, X, and d are defined as above. The presently disclosed compounds are TPO agonists useful as promoters of thrombopoiesis and megakaryocytopoiesis.

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Piperidine – Wikipedia,
Piperidine | C5H3664N – PubChem

 

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NOVEL IMIDAZO[1,2-a]PYRIDINE CANNABINOID RECEPTOR LIGANDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to novel imidazo[1,2-a]pyridine cannabinoid receptor ligands, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2) receptor ligands, and uses thereof for treating diseases, conditions and/or disorders modulate by a cannabinoid receptors (such as pain, neurodegenerative disorders, eating disorders, weight loss or control, obesity and diabetes).

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Piperidine – Wikipedia,
Piperidine | C5H712N – PubChem

 

Electric Literature of 236406-39-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.236406-39-6, Name is 8-Boc-2,8-Diazaspiro[4.5]decane, molecular formula is C13H24N2O2. In a Article£¬once mentioned of 236406-39-6

Novel synthesis of heterocycle-containing adamantane derivatives

A novel approach to synthesize the of heterocycle-containing adamantane derivatives 1-{[(3-hydroxy-1-adamantyl)amino]acetyl}-2- cyano-(S)-pyrrolidine and N-{2-[4-(2-pyrimidinyl)-1-piperazinyl]ethyl}adamantane-1-carboxamide, which were effective in treatment of diabetes and depression respectively, have been described. The target compounds were synthesized by raw materials of inexpensive L-proline and available 1-(2-pyrimidinyl) piperazine respectively. Compared with traditional synthetic routes, the method provides several advantages such as inexpensive and readily available raw materials, convenient manipulation and high yield.

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Piperidine – Wikipedia,
Piperidine | C5H19879N – PubChem

 

Electric Literature of 236406-39-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 236406-39-6, Name is 8-Boc-2,8-Diazaspiro[4.5]decane, molecular formula is C13H24N2O2. In a Article£¬once mentioned of 236406-39-6

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines

We report the identification of a novel series of human epithelial sodium channel (ENaC) blockers that are structurally distinct from the pyrazinoyl guanidine chemotype found in prototypical ENaC blockers such as amiloride. Following a rational design hypothesis a series of quaternary amines were prepared and evaluated for their ability to block ion transport via ENaC in human bronchial epithelial cells (HBECs). Compound 11 has an IC50 of 200 nM and is efficacious in the Guinea-pig tracheal potential difference (TPD) model of ENaC blockade with an ED50 of 44 mug kg-1 at 1 h. As such, pyrazinoyl quaternary amines represent the first examples of a promising new class of human ENaC blockers.

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Piperidine – Wikipedia,
Piperidine | C5H19274N – PubChem

 

Application of 3433-37-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.3433-37-2, Name is 2-(Hydroxymethyl)piperidine, molecular formula is C6H13NO. In a article£¬once mentioned of 3433-37-2

beta-Hydroxypiperidinecarboxylates: Additions to the chiral pool from bakers’ yeast reductions of beta-ketopiperidinecarboxylates

Reduction of the piperidine keto esters 16-19 using fermenting bakers’ yeast provides high yields of the corresponding hydroxy esters 20, 26, 32 and 37 respectively, exclusively as the cis-diastereoisomers and with good levels (?80%) of enantiomeric enrichment. The relative stereochemistries of the products were deduced from NMR data while the absolute configurations were determined by degradation to known piperidinemethanol derivatives or, in the case of hydroxy ester 37, by homologation to (R)-3-quinuclidinol 41b.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 3433-37-2, and how the biochemistry of the body works.Application of 3433-37-2

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Piperidine – Wikipedia,
Piperidine | C5H2799N – PubChem

 

Application of 3466-80-6, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 3466-80-6, name is 2-Phenylpiperidine. In an article£¬Which mentioned a new discovery about 3466-80-6

Combined Imine Reductase and Amine Oxidase Catalyzed Deracemization of Nitrogen Heterocycles

A novel amine oxidase (AO)/imine reductase (IRED) system was developed for the deracemization of racemic amines. By combining (R)-6-hydroxy-d-nicotine oxidase (6-HDNO) with an (R)-IRED, a panel of racemic 2-substituted piperidines and pyrrolidines were deracemized to yield the (S)-amines in high yields and enantiomeric excess values. Other N-heterocycles were deracemized with monoamine oxidase (MAO-N) or 6-HDNO in combination with ammonia borane, which allowed comparison of the two enzyme deracemization approaches with that involving a chemical reducing agent.

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Piperidine – Wikipedia,
Piperidine | C5H9327N – PubChem

 

Electric Literature of 52722-86-8, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 52722-86-8, name is 1-(2-Hydroxyethyl)-2,2,6,6-tetramethylpiperidin-4-ol. In an article£¬Which mentioned a new discovery about 52722-86-8

High- k Gate Dielectrics for Emerging Flexible and Stretchable Electronics

Recent advances in flexible and stretchable electronics (FSE), a technology diverging from the conventional rigid silicon technology, have stimulated fundamental scientific and technological research efforts. FSE aims at enabling disruptive applications such as flexible displays, wearable sensors, printed RFID tags on packaging, electronics on skin/organs, and Internet-of-things as well as possibly reducing the cost of electronic device fabrication. Thus, the key materials components of electronics, the semiconductor, the dielectric, and the conductor as well as the passive (substrate, planarization, passivation, and encapsulation layers) must exhibit electrical performance and mechanical properties compatible with FSE components and products. In this review, we summarize and analyze recent advances in materials concepts as well as in thin-film fabrication techniques for high-k (or high-capacitance) gate dielectrics when integrated with FSE-compatible semiconductors such as organics, metal oxides, quantum dot arrays, carbon nanotubes, graphene, and other 2D semiconductors. Since thin-film transistors (TFTs) are the key enablers of FSE devices, we discuss TFT structures and operation mechanisms after a discussion on the needs and general requirements of gate dielectrics. Also, the advantages of high-k dielectrics over low-k ones in TFT applications were elaborated. Next, after presenting the design and properties of high-k polymers and inorganic, electrolyte, and hybrid dielectric families, we focus on the most important fabrication methodologies for their deposition as TFT gate dielectric thin films. Furthermore, we provide a detailed summary of recent progress in performance of FSE TFTs based on these high-k dielectrics, focusing primarily on emerging semiconductor types. Finally, we conclude with an outlook and challenges section.

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Piperidine – Wikipedia,
Piperidine | C5H14856N – PubChem

 

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Synthesis, structures, and DFT bonding analysis of new titanium hydrazido(2-) complexes

The reaction of 1,1-diphenylhydrazine with Ti(NMe2) 2Cl2 produced the monomeric terminal titanium hydrazido(2-) species Ti(NNPh2)Cl2(HNMe2) 2 (1) in near-quantitative yield. The reaction of Ti(NMe 2)2Cl2 with the less sterically demanding ligand precursors 1,1-dimethylhydrazine or N-aminopiperidine gave the dimeric mu-eta2,eta1-bridged compounds Ti 2(mu-eta2,eta1-NNMe2) 2Cl4(HNMe2)2 (2) and Ti 2{mu-eta2,eta1-NN(CH2) 5}2Cl4(HNMe2)3 (3). The X-ray structures of 2 and 3 showed the formation of N-H…Cl hydrogen bonded dimers or chains, respectively. The reaction of 1 with an excess of pyridine formed [Ti(NNPh2)Cl2(py)2]n (4, n = 1 or 2). The reaction of the tert-butyl imido complex Ti(N tBu)Cl2(py)3 with either 1,1-dimethylhydrazine or N-aminopiperidine again resulted in the formation of hydrazido-bridged dimeric complexes, namely Ti2(mu-eta2, eta1-NNMe2)2Cl4(py)2 (5, structurally characterized) and Ti2{mu-eta2, eta1-NN(CH2)5}2Cl 4(py)2 (6). Compounds 1 and 4 are potential new entry points into terminal hydrazido(2-) chemistry of titanium. Compound 1 reacted with neutral fac-N3 donor ligands to form Ti(NNPh2)Cl 2(Me3[9]aneN3) (7), Ti(NNPh2)Cl 2(Me3[6]aneN3) (8), Ti(NNPh2)Cl 2{HC(Me2pz)3} (9, structurally characterized), and Ti(NNPh2)Cl2{HC(nBupz)3} (10) in good yields (Me3[9]aneN3 = trimethyl-1,4,7- triazacyclononane, Me3[6]aneN3 = trimethyl-1,3,5- triazacyclohexane, HC(Me2pz)3 = tris(3,5- dimethylpyrazolyl)methane, and HC(nBupz)3 = tris(4- nbutylpyrazolyl)-methane). DFT calculations were performed on both the model terminal hydrazido compound Ti(NNPh2)Cl2{HC(pz) 3} (I) and the corresponding imido compounds Ti(NMe)Cl 2{HC(pz)3} (II) and Ti(NPh)Cl2{HC(pz) 3} (III). The NNPh2 ligand binds to the metal center in an analogous manner to that of terminal imido ligands (metal?ligand triple bond), but with one of the Ti=Nalpha pi components significantly destabilized by a pi* interaction with the lone pair of the N beta atom. The NR ligand sigma donor ability was found to be NMe > NPh > NNPh2, whereas the overall (sigma + pi) donor ability is NMe > NNPh2 > NPh, as judged by fragment orbital populations, Ti-N atom-atom overlap populations, and fragment-charge analysis. DFT calculations on the hydrazido ligand in a mu-eta2, eta1-bridging mode showed involvement of the N=N pi electrons in donation to one of the Ti centers. This TiN2 interaction is best represented as a metallocycle.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H671N – PubChem