Day: November 24, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.446302-83-6,1-Benzyl-3-phenylpiperidin-4-one,as a common compound, the synthetic route is as follows.

A solution of the compound (2.00 g) obtained in Process 3, hydrochloric acid (0.2 ml) and palladium carbon (10 wtpercent, 0.30 g) in ethanol (30 ml) was stirred at 40¡ãC for 3 hours under hydrogen atmosphere of 0.5 MPa. The catalyst was removed by filtration, and then the reaction solution was concentrated under reduced pressure to obtain crude 3-phenyl-4-piperidone as pale yellow powder. The obtained product was used in the next process without further purification.

446302-83-6, As the paragraph descriping shows that 446302-83-6 is playing an increasingly important role.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1553084; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.336191-17-4,tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate,as a common compound, the synthetic route is as follows.

The compound of formula 1-2 (methyl4-((4-bromo- 1 H-pyrrolo[2,3-b]pyridin- 1 -yi)methyl)benzoate) (0.700 g, 2.028 mmol), tert-butyl 2,8-diazabicyclo[4.5]decane-2-carboxylate (0.585 g, 2.433 mmol), Pd(t-Bu3P)2C12 (0.104 g, 0.203 mmol) and sodium tert-butoxide (0.234 g, 2.433 mmol) were dissolved in toluene (4 mL) at room temperature, and the solution was stirred at 120C for 17 hours, and then cooled to room temperature. After completion of the reaction, water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate, filtered, and then concentrated under reduced pressure. The concentrate was purified by column chromatography (Si02, 12 g cartridge; ethyl acetate/hexane = from 0% to 30%) to afford the desired compound of formula 18-1 (0.464 g, 45.3%) as a colorless oil., 336191-17-4

336191-17-4 tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate 34178604, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; LEE, Changsik; YANG, Hyun-mo; LEE, Changkon; BAE, Miseon; KIM, Soyoung; CHOI, Youngil; HA, Nina; LEE, Jaekwang; OH, Jungtaek; SONG, Hyeseung; KIM, Ilhyang; CHOI, Daekyu; MIN, Jaeki; LIM, Hyojin; BAE, Daekwon; WO2015/87151; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.,3970-68-1

A mixture of 11 (100 mg, 0.35 mmol), 4-methylpiperidin-4-ol (202 mg, 1.7mmol), and potassium carbonate (484 mg, 3.5 mmol) in anhydrous DMSO (3 mL) was stirred at 90 C overnight. The reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (3 ¡Á 50 mL). Combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The crude material was purified by flash chromatography using MeOH/DCM (1/100, v/v) to afford 13a as a yellow solid (80 mg, 60%).

3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Yang, Hao; Murigi, Francis N.; Wang, Zhijian; Li, Junfeng; Jin, Hongjun; Tu, Zhude; Bioorganic and Medicinal Chemistry Letters; vol. 25; 4; (2015); p. 919 – 924;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

To a solution of 0.04 g (0.1 mmol) of 4-[(S)-4-(3-chloro-phenylcarbamoyl)-3-methyl-2-oxo- piperazin-l-yl]-butyric acid (intermediate 19) and 0.04 ml of triethylamine (0.3 mmol) in 0.8 ml DMF was added 0.05 g (0.12 mmol) of HATU. The mixture was shaken for 10 minutes before being added to the appropriate amine (0.12 mmol) and the mixture shaken overnight. The mixture was then directly purified by preparative HPLC.

3970-68-1, As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; BINGGELI, Alfred; GREEN, Luke; HARTMANN, Guido; MAERKI, Hans P.; MATTEI, Patrizio; WO2011/48032; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22540-50-7,6-Oxopiperidine-3-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of intermediate 5b (100 mg, 0.248 mmol) in DCM (5 mL) was added 6-oxopiperidine-3-carboxylic acid (38 mg, 0.265 mmol), EDC (51 mg, 0.266 mmol) and DMAP (2.5 mg) and the solution was stirred at room temperature for 5 h. A second addition of 6-oxopiperidine-3-carboxylic acid (38 mg), EDC (51 mg), and DMAP (2.5 mg) was performed and it was stirred over night. A third addition of 6-oxopiperidine-3-carboxylic acid (38 mg) and EDC (51 mg) was performed and it was stirred over night. The reaction mixture was diluted with DCM (50 mL) and extracted twice with water, saturated sodium bicarbonate solution and with brine. The organic layer was dried over sodium sulfate and the solvent was removed under reduced pressure

22540-50-7, The synthetic route of 22540-50-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Santhera Pharmaceuticals (Schweiz) AG; EP2439197; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

25504-47-6, Methyl 2-oxopiperidine-4-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Add Lawesson’s reagent (9.2 g, 22.7 mmol) to a solution of methyl2-oxopiperidine-4-carboxylate (6.5 g, 41.4 mmol) in toluene (83 mL) and heat to reflux for 2 hours. Cool the solution and concentrate to dryness under reduced pressure. Purify the residue by flash chromatography on silica gel, eluting with ethyl acetate :dichloromethane (gradient 5-15percent) to afford the title compound (6.95 g). lH NMR (CDCI3) delta 1.97 (m, 1H), 2.17 (m, 1H), 2.78 (m, 1H), 3.03 (m, 1H), 3.24 (m, 1H), 3.39 (m, 1H), 3.49 (m, 1H), 3.72 (s, 3H), 8.48 (bs, 1H)., 25504-47-6

The synthetic route of 25504-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; PRIETO, Lourdes; TABOADA MARTINEZ, Lorena; WO2011/82010; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163271-08-7,tert-Butyl (4-methylpiperidin-4-yl)carbamate,as a common compound, the synthetic route is as follows.

To a solution of 3-(benzyloxy)-5-bromo-2-(2,3-dichlorophenyl)pyrazine (90.0 mg, 220 muetaiotaomicron, 1 equiv) in toluene (1 mL) was added ter/-butyl(4-methylpiperidin-4-yl)carbamate (70.5 mg, 329 muiotaetaomicron, 1.5 equiv), NaOt-Bu (42.2 mg, 439 muiotaetaomicron, 2 equiv), [l-(2- diphenylphosphanyl-l-naphthyl)-2-naphthyl]-diphenyl-phosphane (137 mg, 219 muiotaetaomicron, 1 equiv) and Pd2(dba)3 (10.0 mg, 11.0 mumol, 0.05 equiv). The reaction mixture was then warmed to 90 C and stirred for 1 hour. The reaction mixture was then filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give fer/-butyl(l-(6- (benzyloxy)-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)carbamate (100 mg, 184 mupiiotaomicron, 83.8% yield) as a white solid.

163271-08-7, 163271-08-7 tert-Butyl (4-methylpiperidin-4-yl)carbamate 19691370, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

167414-75-7, Benzyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

167414-75-7, Intermediate 5, 3.8 g (20 mmol), intermediate 3 7.99 g (24 mmol) was added to a 50 mL round bottom flask. Add 20 mL of acetic acid to dissolve, and react at 130 ¡ãC overnight. After the reaction is completed, the acetic acid is removed by rotary evaporation. 1M NaOH was added dropwise to precipitate a large amount of off-white solid, which was filtered. Washing with a small amount of MeOH gave a white solid M086. Yield 75.0percent.

The synthetic route of 167414-75-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kunming Xianghao Technology Co., Ltd.; Luo Huairong; Hong Xuechuan; Zhu Xi; Zhu Jinmei; Wu Guisheng; Deng Zixin; Zhu Yingmin; Lu Yungang; Deng Ke; Qu Chunrong; (25 pag.)CN103694242; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1029413-55-5,tert-Butyl 4-(4-amino-1H-pyrazol-1-yl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Compound 48-b (250 mg, 0.68 mmol) and compound 32-c (181 mg, 0.68 mmol) were dissolved in N,N-dimethylformamide (3 mL), and potassium carbonate (281 mg, 2.37 mmol), 2-dicyclohexylphosphino-2?,6?-diisopropoxy-1,1?-biphenyl (58 mg, 0.13 mmol) and tris(dibenzylideneacetone)dipalladium (136 mg, 0.24 mmol) were added. The reaction solution was heated to 110 C. and stirred for 16 hours under nitrogen gas atmosphere. After cooling to room temperature, the reaction mixture was partitioned between ethyl acetate (100 mL) and water (100 mL). The organic phase was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel TLC preparative plate (petroleum ether: ethyl acetate=1:1) to give 48-a as a pale yellow solid (75 mg, yield 18%). LC-MS (ESI): m/z=599[M+H]+.

1029413-55-5, As the paragraph descriping shows that 1029413-55-5 is playing an increasingly important role.

Reference£º
Patent; GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD.; XU, Zusheng; ZHANG, Nong; WANG, Tinghan; SUN, Qingrui; WANG, Yuguang; (90 pag.)US2018/208604; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

496807-97-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496807-97-7,3,3-Difluoropiperidine hydrochloride,as a common compound, the synthetic route is as follows.

To a dichloroethane (10 mL) solution of methyl (lS)-3- oxocyclopentanecarboxylate (0.28 mL, 2.2 mmol, step A), 3,3-difluoropiperidine hydrochloride (420 mg, 2.7 mmol, 1.2 equiv.), and triethylamine (0.43 mL, 3.1 mmol, 1.4 equiv.) were added sodium triacetoxyborohydride (940 mg, 4.4 mmol, 2.0 equiv.) and acetic acid (0.25 mL, 4.4 mmol, 2.0 equiv.). The reaction mixture was stirred at room temperature for 12 hours and quenched with IN aqueous sodium hydroxide. It was extracted with dichloroethane, dried (sodium sulfate), and concentrated in vacuo to afford a crude product. Chromatography over silica gel, eluting with hexanes/ethyl acetate, afforded the title compound as a diastereomeric mixture. LC/MS = 248 [M+l].

As the paragraph descriping shows that 496807-97-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ALI, Amjad; GALLO, Gioconda V.; HENDERSON, Timothy J.; KUANG, Rongze; LIM, Yeon-Hee; LO, Michael Man-Chu; METZGER, Edward; RUIZ, Manuel de Lera; STAMFORD, Andrew; TEMPEST, Paul; WHITEHEAD, Brent; WU, Heping; WO2015/27431; (2015); A1;; ; Patent; MERCK SHARP & DOHME CORP.; ALI, Amjad; GALLO, Gioconda, V.; HENDERSON, Timothy, J.; KUANG, Rongze; LIM, Yeon-Hee; LO, Michael Man-Chu; METZGER, Edward; RUIZ, Manuel de Lera; STAMFORD, Andrew; TEMPEST, Paul; WHITEHEAD, Brent; WU, Heping; WO2015/31221; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem