Day: November 12, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.71233-25-5,1-tert-Butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate,as a common compound, the synthetic route is as follows.,71233-25-5

Intermediate 1, Step a: tert-Butyl 4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate To a solution of 1-tert-butyl 4-ethyl 3-oxopiperidine-1,4-dicarboxylate (2.00 g, 7.39 mmol) in EtOH (37 mL) was added formamidine hydrochloride (910 mg, 11.08 mmol) followed by NaOEt (6.89 mL, 2.68 M in EtOH) dropwise. The mixture was then heated to reflux overnight. The mixture was concentrated in vacuo and then dissolved in a minimum amount of water. The pH was adjusted to pH 7 with 1 N HCl. The aqueous layer was then saturated with solid NaCl and extracted with a combination of EtOAc and DCM. The combined organic extracts were dried over Na2SO4, filtered and concentrated in vacuo. Chromatography on SiO2 eluting with IPA/EtOAc afforded the desired product as a white solid (993 mg, 53percent). MS (ESI) mass calcd. C12H12N3O3, 251.13. m/z found 252.1 [M+H]+. 1H NMR (500 MHz, CDCl3): 8.05 (s, 1H), 4.42 (s, 2H), 3.69-3.61 (m, 2H), 2.63 (s, 2H), 1.49 (s, 9H).

As the paragraph descriping shows that 71233-25-5 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; Alcazar Vaca, Manuel Jesus; Andres Gil, Jose Ignacio; Letavic, Michael A.; Rudolph, Dale A.; Shireman, Brock T.; Stenne, Brice M.; Ziff, Jeannie M.; US2014/275120; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 13.1; 1-(4-{2-[6-(4-Methoxy-phenyl)-py?dazin-3-yloxy1-ethoxy)-benzyl)-4-methyl-piperidin-4-ol; 100 mg (0.285 mmol) 4-{2-[6-(4-Methoxy-phenyl)-pyridazin-3-yloxy]-ethoxy}-benzaldehyde (educt XII.1 ) and 35 mg (0.30 mmol) 4-methyl-pipeiotadin-4-ol are dissolved in 10 ml of THF and 0.20 ml cone, acetic acid are added. After 10 minutes 180 mg (0.855 mmol) sodium triacetoxyborohydride are added and the mixture is stirred for 20 hours at RT. After that time the mixture is filtered and the solvent is evaporated. The residue is purified by silica gel column chromatography with methylene chloride/methanol/ammonia (10:1 :0.1 ) as eluent. Yield: 50 mg (39% of theory),Rf value: 0.25 (silica gel, methylene chloride/methanol/ammonia = 10:1 :0.1 )EII mass spectrum: m/z = 450 [M+H]+

3970-68-1, The synthetic route of 3970-68-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2007/48802; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1454-53-1,Ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

A suspension of ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (5a) (19.5 g, 68.7 mmol) and guanidine carbonate (19.5 g, 41.23 mmol) in ethanol (170 mL) was heated for 16 hours at 120C. The solvent was removed under reduced pressure, reconstituted in acetonitrile where the crude precipitated and was isolated by filtration. The solid was used as such in the next step without further purification. 1H NMR (300 MHz, DMSO-d6) d ppm 2.35 – 2.46 (m, 2 H), 2.57 – 2.65 (m, 2 H), 3.04 (s, 2 H), 3.60 (s, 2 H), 6.28 (br. s., 2 H), 7.27 (dt, J=8.7, 4.5 Hz, 1 H), 7.31 – 7.36 (m, 4 H), 10.74 (br. s., 1 H). MS m/z: 257 [M+H]+.

1454-53-1, The synthetic route of 1454-53-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; McGowan, David C.; Herschke, Florence; Khamlichi, Mourad D.; Rosauro, Mari Luz; Benedicto, Sara M. Perez; Pauwels, Frederik; Stoops, Bart; Pande, Vineet; Scholliers, Annick; Van Schoubroeck, Bertrand; Mostmans, Wendy; Van Dijck, Kris; Thone, Tine; Horton, Helen; Fanning, Gregory; Jonckers, Tim H.M.; Raboisson, Pierre; Bioorganic and Medicinal Chemistry Letters; vol. 28; 19; (2018); p. 3216 – 3221;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

138022-02-3, tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-{[(4-Cyano-benzoyl)-methyl-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester To a stirred solution of 4-cyanobenzoic acid (322 mg, 2.19 mmol) in CH2Cl2 (10 mL) was added TBTU (702 mg, 2.19 mmol) and N,N-diisopropylethylamine (1.14 mL, 6.54 mmol) and the reaction mixture stirred at RT for 10 min. 4-Methylaminomethyl-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 2.19 mmol) in DMF (4 mL) was added and the reaction mixture was stirred at RT for 2 h. The crude material was concentrated in vacuo and purified by silica gel column chromatography, eluting with isohexane and increasing the polarity to 100percent EtOAc to afford 4-{[(4-cyano-benzoyl)-methyl-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester as a orange solid (700 mg, 89percent). AnalpH2_MeOH-4 min(1): Rt 2.73 min; m/z 358 [M+1]+.

138022-02-3, The synthetic route of 138022-02-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ashworth, Alan; Lord, Christopher James; Elliot, Richard James Rowland; Niculescu-Duvaz, Dan; Porter, Roderick; Boffey, Raymond John; Bayford, Melanie Jayne; Firth-Clark, Stuart; Jarvis, Ashley Nicholas; Perrior, Trevor Robert; Key, Rebekah Elisabeth; US2015/99732; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

140645-23-4, (R)-1-Boc-3-(Aminomethyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(R)-tert-butyl 3-(((3-amino-6-bromopyrazine-2-yl)amino)methyl)piperidine- 1 -carboxylate._10239] (R)-tert-butyl 3-(aminomethyl)piperidine-1 -carboxylate (4.97 g, 22.40 mmol) was dissolved in DMSO (80 ml), and then 3,5-dibromopyrazine-2-amine (8.5 g, 33.60 mmol) and Et3N (6.3 ml) were added, followed by stirring at 130 C. overnight. Afier the completion of the reaction, the reaction mixture was extracted with H20, EA, and brine, followed by drying (Na2SO4), filtration, and concentration under reduced pressure, and the residue was purified by column chromatography (EA:Hex=1:1), to give (R)-tert-butyl 3-(((3-amino-6-bromopyrazine-2-yl)amino)methyl)piperi- dine-i-carboxylate (2.19 g, two steps: 26%).10240] ?H-NMR (300 MHz, CDC13) oe 7.39 (s, 1H), 4.64-4.23 (m, 2H), 3.79-2.92 (m, 5H), 2.25-1.19 (m, 4H), 1.46 (s, 9H)

140645-23-4, 140645-23-4 (R)-1-Boc-3-(Aminomethyl)piperidine 1502023, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.; Jung, Hee Jung; Ha, Jae Du; Cho, Sung Yun; Kim, Hyoung Rae; Lee, Kwang Ho; Lee, Chong Ock; Choi, Sang Un; Park, Chi Hoon; US2015/259350; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1465-76-5, 1-(tert-Butyl)piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1465-76-5, Step A: 1-tert-Butylpiperidin-4-ol To a 0 C. solution of 1.0 g of 1-tert-butylpiperidin-4-one (COMPOUND PPA-1) in 2 mL of TBF was added 6.4 mL of a 1M solution of lithium aluminum hydride in THF dropwise. The mixture was stirred 10 min at rt, then quenched by careful addition of 0.2 mL of water, 0.2 mL of 15% aqueous NaOH, and 0.6 mL of water. The mixture was stirred vigorously for 30 min, then filtered and concentrated to yield the title compound.

As the paragraph descriping shows that 1465-76-5 is playing an increasingly important role.

Reference£º
Patent; Doherty, James B.; Stelmach, John E.; Chen, Meng-Hsin; Liu, Luping; Hunt, Julianne A.; Ruzck, Rowena D.; Goulet, Joung L.; Wisnoski, David D.; Natarajan, Swaminathan Ravi; Rupprecht, Kathleen M.; Bao, Jianming; Miao, Shouwu; Hong, Xingfang; Sinclair, Peter J.; Kallashi, Florida; US2003/92712; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

479630-08-5, 1-Boc-4-(2-Ethoxycarbonyl-acetyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 47A Tert-butyl 4-[10-nitro-2-oxo-8-(trifluoromethyl)-1,2-dihydropyrimido[1,2-b]indazol-4-yl]piperidine-1-carboxylate Tert-butyl 4-(3-ethoxy-3-oxopropanoyl)piperidine-1-carboxylate (1.00 g, 3.34 mmol, 1.5 eq), 4-nitro-6-(trifluoromethyl)-1H-indazol-3-amine (548 mg, 2.23 mmol, 1 eq) and potassium phosphate (945 mg, 4.45 mmol, 2 eq) were suspended in 1-methoxy-2-propanol (10 mL) in a 20 mL microwave vial. The vial was capped and the mixture was heated in a microwave to 180 C. for 15 min After cooling to RT, the suspension was diluted with 20 mL dichloromethane/methanol (4:1), filtered through a short pad of silica gel with 100 mL dichloromethane/methanol (4:1) and evaporated in vacuo. The residue was purified by preparative HPLC (Method 1A). The combined product fractions were concentrated in vacuo to remove acetonitrile. The resulting suspension was filtered, the residue was washed with water (2 ml) and dried for 16 h at 50 C. in vacuo to give the title compound (90.8 mg, 8% of theory). LC-MS (Method 1B): Rt=1.16 min, MS (ESIPos): m/z=482 [M+H]+

479630-08-5, As the paragraph descriping shows that 479630-08-5 is playing an increasingly important role.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; Hassfeld, Jorma; KINZEL, Tom; Koebberling, Johannes; CANCHO GRANDE, Yolanda; BEYER, Kristin; Roehrig, Susanne; Koellnberger, Maria; SPERZEL, Michael; BURKHARDT, Nils; SCHLEMMER, Karl-Heinz; STEGMANN, Christian; SCHUHMACHER, Joachim; WERNER, Matthias; ELLERMANN, Manuel; US2015/126449; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.373603-88-4,3,3-Dimethylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

General procedure: In an oven-dried RB flask, compound 6c (250mg, 1.01mmol) and formaldehyde solution, 37-41wt.% in water (0.15mL, 2.02mmol) were mixed in glacial acetic acid (5mL). Morpholine (220.4mg, 2.53mmol) was added drop wise at 0C. The resulting mixture was stirred at room temperature for 12h. After completion of the reaction, the excess solvent was evaporated to dryness under reduced pressure. The residue was neutralized with 10% NaHCO3 solution, the solid formed was collected by filtration, washed with water and dried. The crude product was purified by silica gel column chromatography to provide title compound.

373603-88-4, The synthetic route of 373603-88-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jose, Gilish; Kumara, T. H. Suresha; Nagendrappa, Gopalpur; Sowmya; Jasinski, Jerry P.; Millikan, Sean P.; More, Sunil S.; Janardhan, Bhavya; Harish; Chandrika; Journal of Molecular Structure; vol. 1081; (2015); p. 85 – 95;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

336191-17-4, tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

336191-17-4, EXAMPLE 16; 8-(5-{[(4-Aminobiphenyl-3-yl)amino]carbonyl}pyridin-2-yl)-N-(2-phenylethyl)-2,8-diazaspiro[4.5]decane-2-carboxamide; To a solution of methyl 6-chloronicontinate (200 mg, 1.16 mmol) in DMSO/PhMe (2 mL of a 1:1 solution) was added t-butyl-2,8-diazaspiro[4.5]decane-2-carboxylate (700 mg, 2.91 mmol). The reaction mixture was heated at 85 C. for 6 hours and then diluted with EtOAc (10 mL). The organic layer was washed with NaHCO3 (1¡Á5 mL) and brine (1¡Á5 mL), dried over Na2SO4, and then concentrated. The crude residue was purified by reverse-phase flash chromatography (10-100% MeCN/H2O with 0.05% TFA) to give t-butyl 8-[5-(methoxycarbonyl)pyridin-2-yl]-2,8-diazaspiro[4.5]decane-2-carboxylate: MS (ESI+): cal’d [M+H]+ 376.2, obs’d 376.2.

336191-17-4 tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate 34178604, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Berk, Scott C.; Close, Joshua; Hamblett, Christopher; Heidebrecht, Richard W.; Kattar, Solomon D.; Kliman, Laura T.; Mampreian, Dawn M.; Methot, Joey L.; Miller, Thomas; Sloman, David L.; Stanton, Matthew G.; Tempest, Paul; Zabierek, Anna A.; US2007/117824; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

385425-15-0, 1-(4-Iodophenyl)piperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under room temperature, will be sequentially 1 – (piperidin-2-oxo-1-yl) – 4-iodophenylamino (2.5 g, 8.3 mmol), 1 – (3-fluoro-4-ethoxy phenyl) – 7-oxo -4, 5, 6, 7-tetrahydro -1H-pyrazolo [3,4-c] pyridine-3-carboxylic acid ethyl ester (2.4 g, 6.9 mmol) and potassium carbonate (2.1 g, 15.1 mmol) by adding DMSO in (35 ml). Under the protection of nitrogen is added in the mixture of the obtained CuI (650 mg, 3.4 mmol) and 1,10-phenanthrene (613 mg, 3.4 mmol). The obtained mixture is heated to 120 C, reaction 12 hours. After the completion of the reaction, the obtained cooling to room temperature the mixture, adding water. The resulting mixture is extracted with ethyl acetate. The resulting organic phase is concentrated under reduced pressure to obtain crude products. Crude product is purified by silica gel column chromatography (PE:EA=1:1) to obtain 1.0 g (yield: 26.7%) of the product., 385425-15-0

The synthetic route of 385425-15-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CSPC Weisheng Pharmaceutical Technology (Shijiahuang) Co., Ltd.; Shi, Ying; Gao, Qingzhi; Mi, Yi; Wang, Xuliang; (129 pag.)CN105384739; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem