Month: October 2020

6457-49-4, 4-Piperidinemethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6457-49-4, 1.1 Synthesis of ^Hydroxymethyl-piperidine-i-carboxylic tert-butyl ester 1Og of 4-piperidine methanol was dissolved in 10OmIs of dichloromethane and the solution treated with 14.5mls of triethylamine under nitrogen. The mixture was cooled to O0C using an ice bath and stirred. 19g of boc anhydride was added portionwise to the mixture over 15 minutes. The reaction mixture was then stirred overnight allowing the whole to warm to RT. The reaction mixture was diluted with a further 30OmIs dichloromethane and washed with 1 N HCI(aq) (250ml) followed by a wash with brine before drying over anhydrous magnesium sulphate. The dried organics were filtered and evaporated to dryness to give 17.8g of colourless crystalline solid.1H-NMR (400MHz, CD3OD) OH 4.88(2H s) 4.08(1 H d), 3.39(1 H d), 1.70(1 H d), 1.60(1 H m), 1.44(9H s), 1.08(2H m)

6457-49-4 4-Piperidinemethanol 420771, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; VERNALIS (R & D) LIMITED; WO2008/38011; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184637-48-7,tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,184637-48-7

[00585] To a stuffed solution of 2-[4-(3-fluoro-phenoxy)-phenoxy]-5-iodo-nicotinic acid methyl ester (1.50 g; 2.77 mmol; 1.00 eq.) in 1,4-dioxane (30.00 ml; 20.00 V) were added piperidin-3-yl-carbamic acid tert-butyl ester (0.72 g; 3.33 mmol; 1.20 eq.) and cesium carbonate (1.86 g; 5.55 mmol; 2.00 eq.) at RT under nitrogen atmosphere. The resulting reaction mixture was degassed with nitrogen for 20 mm and then treated with dicyclohexyl-(2?,6?-diisopropoxy-biphenyl-2-yl)-phosphane (0.07 g; 0.14 mmol; 0.05 eq.) andtris(dibenzylideneacetone)dipalladium(0) (0.26 g; 0.28 mmol; 0.10 eq.). The reaction mixture was heated in a sealed tube to 100 C for 16 h. Upon completion of the reaction (monitored by TLC), the reaction mixture was cooled to RT and filtered through Celite. The Celite was washed with EtOAc (50 mL). The filtrate was washed with water (lx 50 mL) and brine (1 x 20 mL), dried over sodium sulphate and concentrated under vacuum. The residue was purified by column chromatograpy over silica gel (60-120 mesh) by using (3:7) EtoAc:Pet ether as an eluent to afford tert-butoxycarbonylamino-6?- [4-(3-fluoro-phenoxy)-phenoxy] -3,4,5 ,6-tetrahydro-2H- [1,3?] bipyridinyl-5?-carboxylic acid methyl ester (1.20 g, 60.3 %) as a yellow solid. HPLC: 74.91 % purity. MS m/z = 538 [M+H]. ?H NMR (400 MHz, DMSO-d6) oe 8.04-8.02 (d, J= 4.3 Hz, 2H), 7.77-7.76 (d, J= 3.1 Hz, 1H), 7.43-7.37 (m, 1H), 7.09-7.06 (m, 4H), 6.97-6.91 (m, 2H), 6.86-6.79 (m, 2H), 3.8 (s, 3H), 3.54-3.48 (m, 3H), 2.74-2.59 (m, 2H), 1.8 1-1.72 (m, 1H), 1.6 (s, 1H),1.4 (s, 9H).

184637-48-7 tert-Butyl 3-aminopiperidine-1-carboxylate 545809, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GMBH; QIU, Hui; CALDWELL, Richard D.; NEAGU, Constantin; MOCHALKIN, Igor; LIU-BUJALSKI, Lesley; JONES, Reinaldo; TATE, Devon; JOHNSON, Theresa L.; GARDBERG, Anna; WO2015/61247; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

38646-68-3, 4,4-Dimethylpiperidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

DIPEA (1 .93ml, 1 1 .1 mmol) was added to a solution of Tricyclo[3.3.1.13,7]decane-1 – carbonyl chloride (1 ) (1 g, 5.5mmol) and 4,4-dimethylpiperidine hydrochloride (4) (828mg, 5.5mmol) in DCM (10ml) and the solution stirred at room temperature for 4 hours. At this time, TLC [15:85 EA:hexane, 20muIota_ aliquot into MTBE:1 N HCI (400muIota_:400muIota_)] showed the formation of a single chemical. The solution was washed with 0.1 N HCI (30ml), saturated NaHC03 (30ml), dried (Na2S04), filtered and the solvents removed to give crude product which was further purified by FC on silica gel using 15:85 EA:hexane to give the desired product as a crystalline white solid.

38646-68-3, As the paragraph descriping shows that 38646-68-3 is playing an increasingly important role.

Reference£º
Patent; UNILEVER PLC; UNILEVER N.V.; CONOPCO, INC., D/B/A UNILEVER; AU, Van; HARICHIAN, Bijan; CLOUDSDALE, Ian Stuart; BAJOR, John Steven; DICKSON, Jr, John Kenneth; WO2014/139965; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3433-37-2,2-(Hydroxymethyl)piperidine,as a common compound, the synthetic route is as follows.,3433-37-2

Example 8; 2-Hydroxymethyl-piperidine-l-carboxylic acid tert-butyl ester; Di-tert-butyl dicarbonate (8.3 g, 38.2 mmol) was added to a stirred solution of piperidinemethanol (4. 0g, 37.4 mmol) in CH2C12 (50 mL) and 1N NaOH (50 mL, 50 mmol) was added. The mixture was stirred at room temperature overnight. Reaction mixture was diluted with CH2C12 and the aqueous phase was separated. The aqueous phase was extracted with dichloromethane (3X30 mL). The combined organic phase was washed with water (30 mL) and brine (30 mL), dried (sodium sulfate), filtered and concentrated in-vacuo to give the crude product which was triturated with hexane to afford the title compound as white solid (4.8 g, 64percent).

As the paragraph descriping shows that 3433-37-2 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; NPS PHARMACEUTICALS, INC.; WO2005/80386; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

22990-34-7, 2-(4-Piperidyl)-2-propanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 209 [0728] cis-Methyl 4-((E)-2-(4-fluorobenzoylimino)-6-((4-(2- hydroxypropan-2-yl)piperidin-l-yl)methyl)-2,3-dihydro-lH-benzo[d]imidazol-l- yl)cyclohexanecarboxylate. To a 0C cooled solution of cis-methyl 4-((E)-2-(4- fluorobenzoylimino)-6-(hydroxymethyl)-2,3-dihydro-lH-benzo[d]imidazol-l- yl)cyclohexanecarboxylate (1 g, 2.350 mmol) in DCM (25 mL) was added thionyl chloride (0.858 mL, 11.75 mmol) dropwise, and the reaction was stirred at 0C for 30 minutes. After 30 minutes, the solvent was removed at reduced pressure, and the residue was suspended in ACN (5 mL) and re-concentrated to remove residual thionyl chloride. The residue was resuspended in ACN (15 mL), cooled to 0C, and 2-(piperidin-4- yl)propan-2-ol (1.010 g, 7.05 mmol) and TEA (0.655 mL, 4.70 mmol) were added. The reaction was stirred overnight at RT. After 16 hours, the reaction mixture was concentrated and partitioned between EtOAc and water. The organic layer was concentrated and the residual product was purified by column chromatography, eluting with 0-100% (90:9:1 DCM/MeOH/NH4OH)/DCM to provide cis-methyl 4-((E)-2-(4- fluorobenzoylimino)-6-((4-(2-hydroxypropan-2-yl)piperidin-l-yl)methyl)-2,3-dihydro- lH-benzo[d]imidazol-l-yl)cyclohexanecarboxylate as a white powder (1.05 g, 81 % yield). .H NMR (400 MHz, DMSO-d6) delta ppm 1.03 (s, 6 H), 1.09 – 1.35 (m, 3 H), 1.56 – 1.91 (m, 8 H), 2.21 – 2.29 (m, 2 H), 2.53 – 2.64 (m, 2 H), 2.77 – 2.95 (m, 3 H), 3.50 (s, 2 H), 3.77 (s, 3 H), 3.99 (s, 1 H), 4.74 (br. s., 1 H), 7.14 (d, J=6.9 Hz, 1 H), 7.26 (dd, J=8.8 Hz, 8.8 Hz, 2 H), 7.37 – 7.58 (m, 2 H), 8.26 (dd, J=8.7, 5.9 Hz, 2 H), 12.77 (s, 1 H). MS, m/z (C31H39FN4O4): calcd, 550.3; found, 551.1 [M+H].

22990-34-7, As the paragraph descriping shows that 22990-34-7 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; BODE, Christiane, M.; CHENG, Alan, C.; CHOQUETTE, Deborah; LEWIS, Richard, T.; POTASHMAN, Michele, H.; ROMERO, Karina; STELLWAGEN, John, C.; WHITTINGTON, Douglas, A.; WO2012/18668; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

64051-79-2,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64051-79-2,3-Hydroxypiperidine Hydrochloride,as a common compound, the synthetic route is as follows.

10 Step 4: preparation of 3-Hydroxy-piperidine-1-carboxylic acid benzyl ester. Tosuspension of piperidin-3-ol hydrochloride (134 g, 0.974 mol) and triethylamine (276 mL, 1.98 mol) in dichloromethane (2 L) at 0 C was added a solution of benzyl chloroformate (140 mL, 0.981 mol) in dichloromethane (100 mL) drop wise over 2.5 h. The reaction was allowed to stir for an additional 30 mm at 0 C, then allowed to warm15 to ambient temperature over 16 h, after which it was quenched with 1 N hydrochloric acid (3 L) and allowed to stir for 30 mm. The organic layer was separated, dried over sodium sulfate, and concentrated in vacuo to afford the title compound (218 g, 95 %).1H-NMR (CDCI3) 67.29-7.41 (m, 5H), 5.14 (s, 2H), 3.59-3.85 (m, 3H), 3.13-3.27 (m, 2H), 2.18 (bs, 1H), 1.74-1.94 (m, 2H), 1.38-1.61 (m, 2H).

64051-79-2 3-Hydroxypiperidine Hydrochloride 2723962, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; SPRINGER, John Robert; DEVADAS, Balekudru; GARLAND, Danny James; GRAPPERHAUS, Margaret Lanahan; HAN, Seungil; HOCKERMAN, Susan Landis; HUGHES, Robert Owen; SAIAH, Eddine; SCHNUTE, Mark Edward; SELNESS, Shaun Raj; WALKER, Daniel Patrick; WAN, Zhao-Kui; XING, Li; ZAPF, Christoph Wolfgang; SCHMIDT, Michelle, Ann; WO2014/68527; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

625471-18-3, (S)-tert-Butyl 3-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-Fluorophenylisocyanate (137 mg, 1 rnrnol) was slowly dropped into a solution of (S)-3-amino-l-N-Boc-piperidine (200 mg, 1 mmol) in DCM (2 mL). The reaction mixture was stirred at ambient temperature for 2h and then the solvent was evaporated under reduced pressure to afford a residue oil (337 mg), which was used for the next step without further purification. Yield: 100percent; LCMS (RT): 7.9 min (Method B); MS (ES+) gave m/z: 338.1., 625471-18-3

The synthetic route of 625471-18-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ADDEX PHARMACEUTICALS SA; WO2006/123244; (2006); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

41373-39-1,41373-39-1, (S)-Piperidin-2-ylmethanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 4-((6-ethoxy-6-oxohexyl)oxy)-5-methoxy-2-nitrobenzoic acid (16 ) (2.00 g, 5.60 mmol) in dichloromethane (40 mL) was charged with trimethyl amine (4.70 mL, 33.8 mmol) and 0-(7-azabenzotriazole-i-yl)-A V,A V-tetramethyluronium hexafluoro- phosphate (2.20 g, 5.90 mmol) and the resulting mixture was stirred for 2 h at room temperature. A solution of (S,)-piperidin-2-ylmethanol (647 mg, 5.63 mmol) in dichloromethane (10 mL) was then added and the resulting mixture was stirred for 16 h at room temperature. The reaction was quenched with a saturated aqueous solution of sodium hydrogen carbonate (40 mL), the phases were separated and the aqueous layer was further extracted with dichloromethane (20 mL). The combined organic extracts were washed with brine (40 mL), dried over magnesium sulfate, filtered and (1451) concentrated to give an amber oil. Purification was carried out by column (1452) chromatography (silica), eluting with ethyl acetate/ hexane (from 0percent to 100percent), to give the title compound (1.20 g, 48percent) as a colourless oil. (1453) NMR (400 MHz, CDCI3) delta 7.63-7.6o (m, iH), 6.77-6.75 (m, iH), 4.13-4.02 (m, 4H), 3-93 (s, 3H), 3-78-3-70 (m, iH), 3-68-3-39 (m, iH), 3-i8-3-H (m, 3H), 2.32 (t, J=7-6 Hz, 2H), 1.91-1.83 (m, 2H), 1.72-1.39 (m, 11H), 1.26 (t, J=7-i Hz, 3H); MS M/Z (EIMS) = 453 (M+H)+; LCMS (Method B): tR = 3.63 min.

The synthetic route of 41373-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FEMTOGENIX LIMITED; JACKSON, Paul Joseph Mark; THURSTON, David Edwin; RAHMAN, Khondaker Mirazur; (243 pag.)WO2017/194960; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.908245-03-4,Methyl 6-methylpiperidine-3-carboxylate,as a common compound, the synthetic route is as follows.

908245-03-4, To a dichloromethane solution (40 mL) of methyl 6-methylpiperidine-3-carboxylate (3.90 g) obtained in Step 1, triethylamine (2.64 g) was added, then, a dichloromethane solution (5 mL) of Boc2O (5.68 g) was added while stirring at room temperature. After stirred for 70 hours at room temperature, the reaction mixture was washed with 1 mol/L hydrochloric acid (100 mL). The organic layer was dried with anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, the residue was purified with silica gel column chromatography (hexane/ethyl acetate=100/0 to 13/87) to give 1-tert-butyl 3-methyl-cis-6-methylpiperidine-1,3-dicarboxylate (2.66 g, low polarity) and 1-tert-butyl 3-methyl-trans-6-methylpiperidine-1,3-dicarboxylate (1.39 g, high polarity) respectively as an oil. cis-isomer, 1H NMR (300 MHz, CDCl3) delta 1.13 (d, 3H), 1.46 (s, 9H), 1.50-1.95 (m, 4H), 2.30-2.45 (m, 1H), 2.80-3.00 (m, 1H), 3.69 (s, 3H), 4.15 (br, 1H), 4.40 (br, 1H); trans-isomer, 1H NMR (300 MHz, CDCl3) delta 1.14 (d, 3H), 1.30-1.40 (m, 1H), 1.46 (s, 9H), 1.72-1.96 (m, 2H), 1.96-2.06 (br, 1H), 2.58 (br, 1H), 3.04-3.10 (m, 1H), 3.68 (s, 3H), 4.30-4.45 (m, 2H)

908245-03-4 Methyl 6-methylpiperidine-3-carboxylate 42628698, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; SUMITOMO DAINIPPON PHARMA CO., LTD.; FUSANO, Akira; KOBAYASHI, Tomonori; SAITO, Yasuhiro; KANAI, Toshio; (55 pag.)US2016/221948; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21987-29-1,4,4-Difluoropiperidine,as a common compound, the synthetic route is as follows.

Example 1683-(4-Cyclohexylamino-1H-pyrazolo[4,3-c]pyridin-3-yl)-1-(4,4-drfluoro-piperidin-1-yl)-propan-1-oneTo a solution of Intermediate 23 (35 mg, 0.12 mmol) in DMF (1.5 ml) was added HATU (48 mg, 0.13 mmol) and Lambda/,Lambda/-diisopropylethylamine (126 mul, 0.73 mmol). 4,4-difluoro0 piperidine (19 mul, 0.18 mmol) was then added and the resulting solution was left to stir at room temperature overnight. The volatiles were removed under reduced pressure and the crude product was re-dissolved in 10percent MeOH/DCM and eluted though an Isolute-NH2 cartridge. The crude product purified by flash chromatography eluting with 10percent MeOH/DCM to give a yellow gum (28 mg, 61percent). 1H NMR (400 MHz, DMSO-Cf6) delta ppm-5 1.14 – 1.26 (m, 1 H), 1.30 – 1.46 (m, 4 H), 1.60 – 1.72 (m, 1 H), 1.71 – 2.01 (m, 8 H), 2.87 (t, 2 H), 3.21 (t, J=6.4 Hz, 2 H), 3.49 – 3.60 (m, 4 H), 4.01 (br. s., 1 H), 6.67 (br. s., 1 H), 7.62 (d, J=6.0 Hz, 1 H); m/z (ES+APCl)+: 392 [M + H]+., 21987-29-1

As the paragraph descriping shows that 21987-29-1 is playing an increasingly important role.

Reference£º
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; MCIVER, Edward, Giles; SMILJANIC, Ela; HARDING, Denise, Jamilla; HOUGH, Joanne; WO2010/106333; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem