Month: October 2020

150008-24-5, tert-Butyl 4-(hydroxyimino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a suspension of sodium hydride (0.268 g, 7.00 mmol) in DMF (3 ml_) the title compound from Step A above (0.500 g, 2.33 mmol) was added drop wise (dissolved in DMF 5 mL) at 0 (0833) C, then stirred at room temperature for 60 min. After that 2-fluoropyridine (0.340 g, 3.50 mmol) was added dropwise at 0 C (dissolved in DMF 2 mL) and then stirred at room temperature for 3 h. After completion of the reaction by TLC, the reaction mixture was quenched with ice water followed by extraction using ethyl acetate (30 mL). The organic layer was separated, dried over sodium sulphate, filtered and then concentrated to obtain tert-butyl 4-oxo-3-(2-oxo-1 ,2-dihydropyridin-3-yl)piperidine-1-carboxylate (300 mg, crude) as a pale brown solid. The crude product was taken as such for next step. (0834) MS: 293.2 (M+H)+., 150008-24-5

The synthetic route of 150008-24-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (220 pag.)WO2019/134978; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1001353-92-9, (R)-1-Methylpiperidin-3-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Int 13 (342 mg, 1 .001 mmol) and (R)-1 -methylpiperidin-3-amine (149 mg, 1 .301 mmol) in DMF (8 ml.) was added DIPEA (0.524 ml_, 3.00 mmol), HOBt (169 mg, 1 .101 mmol) and EDC (249 mg, 1 .301 mmol). The solution was stirred at RT overnight. The reaction mixture was diluted with 5% Na2CC>3 solution and extracted with EtOAc. The organic layer was washed twice with 5% Na2CC>3 solution, then brine. A white precipitate which formed between the layers was filtered off. The remaining organic extract was dried over Na2S04, filtered and evaporated to give an off-white solid after trituration with DCM. This crude product was combined with the first precipitate and further purified by crystallization from hot MEK to provide the title compound as white crystalline solid. 1 H NMR (400 MHz, DMSO-d6) d (ppm) 7.98 (d, J = 8.0 Hz, 1 H), 7.91 (s, 1 H), 7.53 (s, 1 H), 6.09 (s, 1 H), 4.54 (d, J = 1 .9 Hz, 2H), 3.81 – 3.66 (m, 1 H), 2.66 – 2.57 (m, 1 H), 2.48 – 2.45 (m, overlapping with DMSO signal, 1 H) 2.13 (s, 3H), 1 .98 – 1 .87 (m, 1 H), 1 .86 – 1 .76 (m, 1 H), 1 .71 – 1 .60 (m, 2H), 1 .58 (s, 6H), 1 .52 – 1 .38 (m, 1 H), 1 .27 – 1 .1 1 (m, 1 H). LC-MS: Rt = 0.69 min; MS m/z [M+H]+ 438.2

1001353-92-9, The synthetic route of 1001353-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; FARADY, Christopher; GOMMERMANN, Nina; JANSER, Philipp; MACKAY, Angela; MATTES, Henri; STIEFL, Nikolaus Johannes; VELCICKY, Juraj; (148 pag.)WO2020/21447; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

240401-22-3, Piperidine-4-carbonitrile hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a dry round bottom flask was placed 4-cyanopiperidinium chloride (13, 5g, 45.4 mmol) dichloromethane (150ml) and triethylamine (18.98ml, 136 mmol). To the reaction was added dropwise ethanesulfonyl chloride (4.56 ml, 45.4 mmol) and the solution stirred 1 hour and quenched with water (100 ml). The mixture was extracted with dichloromethane (3x 50 ml) and the combined organic fractions dried (MgSO4), filtered, and the solvent evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with EtOAc/Hexanes to give 1- (ethylsulfonyl)pirhoeridine-4-carbonitrile (14) as a white solid. MS 203 (M+l), 240401-22-3

240401-22-3 Piperidine-4-carbonitrile hydrochloride 22744637, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK & CO., INC.; MERCK SHARP & DOHME LIMITED; WO2007/53400; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1158759-03-5,tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate,as a common compound, the synthetic route is as follows.

Step b: To a solution of 6-chloro-1-methylpyridin-2(1H)-one (55 mg, 0.383 mmol), DIPEA (200 jiL, 1.15 mmol), and tert-butyl ((4-methylpiperidin-4-yl)methyl)carbamate (96 mg, 0.42 1 mmol) in DMF (1 mL) was radiated in a microwave reactor for 2 h at 140 C. After cooling to RT, the reaction mixture was diluted with EtOAc. The organic layer was washed with sat. aq. NH4C1 (2 x) followed by brine. The organic layer was dried over Mg504, filtered, and the volatiles were removed under reduced pressure. The residue was purified by silica chromatography (0 to 100% gradient of EtOAc/heptane) to give tert-butyl ((4-methyl-i -(1- methyl-6-oxo- 1 ,6-dihydropyridin-2-yl)piperidin-4-yl)methyl)carbamate (53 mg, 0.158 mmol). ?H NMR (400 MHz, DMSO-d6) oe ppm 7.33 (dd, J=8.9, 7.4 Hz, 1 H), 6.94 (t, J=6.3 Hz, 1 H), 6.10- 6.04 (m, 1 H), 3.35 (s, 3 H), 2.95-2.85 (m, 4 H), 2.77 (s, 2 H), 1.56-1.47 (m, 2 H), 1.42-1.30 (m, ii H), 0.89 (s, 3 H). MS m/z 336.6 (M+H)

1158759-03-5, As the paragraph descriping shows that 1158759-03-5 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

146093-46-1, 4-(Aminoethyl)-1-N-Boc-piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

146093-46-1, Example 14 (compound No. 234)2,2,2-Trifluoro-1 -(trifluoromethyl)ethyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine- 1 -carboxylate14.1 . ie f-Butyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine-1 -carboxylate; A mixture of 1.12 g (7.15 mmol) of 5-chloropyrazine-2-carboxamide, 1.95 g (8.58 mmol) of ie f-butyl 4-(2-aminoethyl)piperidine-1 -carboxylate and 1 .18 g (8.58 mmol) of potassium carbonate in 1 .4 ml of dimethyl sulphoxide is heated during 5 hours at 100C under an argon atmosphere and with stirring. After cooling to ambient temperature, 25 ml of ethyl acetate and 25 ml of water are added. The organic phase is separated by settling and washed 3 times with 25 ml of water and then 25 ml of a saturated aqueous sodium chloride solution. It is dried over sodium sulphate and evaporated to dryness. The residue is purified by chromatography on silica gel, elution being carried out with a 97:3, then 95:5 and 93:7 mixture of dichloromethane and methanol, in order to obtain 1 .99 g (5.69 mmol) of product in the form of a light-yellow paste.1H NMR (CDCI3, delta ppm, 200 MHz): 8.65 (s, 1 H), 8.10 (s, 1 H), 7.55 (m, 1 H), 5.75 (m, 1 H), 4.85 (m, 1 H), 4.15 (m, 2H), 3.45 (m, 2H), 2.75 (t, 2H), 1 .80-1 .60 (m, 5H), 1 .50 (s, 9H), 1 .35-1 .10 (m, 2H).

As the paragraph descriping shows that 146093-46-1 is playing an increasingly important role.

Reference£º
Patent; SANOFI; BARTSCH, Regine; CHEURET, Dorothee; EVEN, Luc; HOORNAERT, Christian; JEUNESSE, Jean; MARGUET, Frank; WO2011/151808; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.301221-79-4,tert-Butyl 4-(2-bromoacetyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

The bromomethylketone prepared as described in Step C (1.48 g, 4.83 mmol) was combined with thioformamide (295 mg, 4.83 mmol) in 10 mL of THF. The reaction mixture was warmed to 60 ¡ãC and stirred for 4 days. The reaction mixture was then diluted with ethyl acetate and washed with water, then brine, dried over anhydrous MgS04, filtered, and concentrated. Purification by MPLC (silica, 60percent ethyl acetate/hexane) afforded 627 mg of thiazole PRODUCT. 1H NMR (400 MHz, CDC13) : 8 8.75 (d, J = 2.0 Hz, 1H), 6.93 (d, J = 2.4 Hz, 1H), 4.19 (br s, 2H), 2.96 (m, 1H), 2.84 (BR M, 2H), 2.03 (m, 2H), 1.62 (m, 2H), 1.44 (s, 9H)., 301221-79-4

As the paragraph descriping shows that 301221-79-4 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2004/41279; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

496807-97-7, 3,3-Difluoropiperidine hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound 97 (1 equiv) in benzene (10 vol) was added TEA (1.5 equiv) and DPPA (1.2 equiv). The reaction mixture was stirred at 50 C for 1 h and then cooled to room temperature. 3,3-difluoropiperidine hydrochloride (4 equiv) and TEA (8 equiv) was added to the reaction mixture and stirred at 80 C for 16 h. After completion of the reaction, the reaction mixture was concentrated and the residue was purified by preparative HPLC to give compound 40. 1H MR (400 MHz, DMSO-de) delta 8.63 (s, 1H), 8.18 – 8.11 (s, 2H), 7.42 – 7.20 (m, 4H), 7.01 – 6.97 (m, 1H), 5.55 – 5.42 (m, 1H), 5.34 – 5.30 (m, 1H), 5.14 – 5.09 (m, 1H), 4.48 – 4.23 (m, 3H), 4.14 – 4.08 (m, 1H), 3.93 – 3.76 (m, 4H), 3.52 – 3.51 (m, 2H), 2.49 (s, 3H), 2.09 – 1.99 (m, 3H), 1.71 – 1.69 (m, 2H).

496807-97-7, The synthetic route of 496807-97-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (337 pag.)WO2017/35349; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54288-70-9,4-Bromopiperidine hydrobromide,as a common compound, the synthetic route is as follows.

54288-70-9, To a solution of 4-bromopiperidine hydrobromide (3.0 g, 12.2 mmol) in tetrahydrofuran (30 ml) were added 1-{[(benzyloxy)carbonyl]oxy}-2,5-pyrrolidinedione (3.20 g, 12.9 mmol), N-methylmorpholine (1.62 ml, 14.7 mmol) and 4-N,N-dimethylaminopyridine (30 mg) at room temperature, and stirred at room temperature for 16 hours. The reaction solution was poured into water and extracted with ethyl acetate. The organic layer was washed with a 1N-aqueous hydrochloric acid solution, dried over anhydrous magnesium sulfate and distilled under reduced pressure to remove the solvent, and the resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate = 1/1) to obtain benzyl 4-bromo-1-piperidinecarboxylate (3.58 g, 98percent).

The synthetic route of 54288-70-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1403255; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79099-07-3,1-Boc-4-Piperidone,as a common compound, the synthetic route is as follows.

79099-07-3, To a solution of /ert-butyl 4-oxopiperidine-l-carboxylate (50 g, 251 mmol) in pyridine (500 mL) is added molecular sieves (50 g) and the mixture is stirred at room temperature for 10 minutes, followed by the addition of NH2OH HCl (30.25 g, 427 mmol). The resulting reaction is stirred at room temperature overnight, and the reaction mixture filtered through a pad of celite to remove the molecular sieves. The filtrate is diluted with water, the layers separated and the aqueous phase extracted with more ethyl acetate. The combined organic phases are washed with brine, dried over EPO MgSO4, filtered, and concentrated in vacuo to provide the title compound. This material is used in the next step without further purification.1H NMR (300 MHz, DMSO-ddelta): 1.52 (s, 9H), 2.36 (t, J=6.0 Hz, 2H), 2.58 (t, J=6.0 Hz, 2H), 3.50-3.58 (m, 4H).

As the paragraph descriping shows that 79099-07-3 is playing an increasingly important role.

Reference£º
Patent; PHARMACIA & UPJOHN COMPANY LLC; WO2006/56877; (2006); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

454713-13-4, (R)-tert-Butyl (1-benzylpiperidin-3-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

R-3-(tert-butoxycarbonylamino)-1-benzylpiperidine (20g) was dissolved in 96g of absolute ethanol, added with 5 mass% Pd/C (2g), passed into 20MPa hydrogen, and reacted at 20-25 C. After 20 h, filtration and ethanol washing, the filtrate was combined and evaporated to dryness to give R-3-(tert-butoxycarbonylamino)piperidine (13.4 g), yield 97%., 454713-13-4

454713-13-4 (R)-tert-Butyl (1-benzylpiperidin-3-yl)carbamate 25417446, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Huzhou Fuhuachun Bio-pharmaceutical Technology Co., Ltd.; Feng Lichun; Yang Jianying; (18 pag.)CN110078657; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem