Day: October 22, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4138-26-5,Piperidine-3-carboxamide,as a common compound, the synthetic route is as follows.,4138-26-5

(1) 2-[(3RS)-3-Carbamoylpiperidin-1-yl]-2-iminoethylchloride hydrochloride 1.28 g of (3RS)-3-carbamoylpiperidine were added to a solution of 1.44 g of methyl 2-chloroacetimidate hydrochloride in 5 ml of anhydrous methanol, and the mixture was stirred at room temperature for 2 hours.

The synthetic route of 4138-26-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANKYO COMPANY LIMITED; EP202048; (1991); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.479195-19-2,2-Oxa-8-azaspiro[4.5]decane hydrochloride,as a common compound, the synthetic route is as follows.

To a solution 2-oxa-8-azaspiro[4.5]decane, HC1 (1 g, 5.63 mmol) and DIEA (2.9 mL, 16.9 mmol) in anhydrous CH3CN (35 mL) was added isopropyl 2-(5-bromo-4- chloro-2,6-dimethylpyridin-3-yl)-2-oxoacetate (1.9 g, 5.63 mmol) at rt. The resulting mixture was placed in a pre-heated oil bath (80 C) and stirred for 18 h; cooled, and concentrated. The crude product was charged (DCM) to a 80 g ISCO silica gel cartridge and gradient elution (5 – 35% EtOAc/hexanes) using an Isolera chromatography station to give isopropyl 2-(5-bromo-2,6-dimethyl-4-(2-oxa-8-azaspiro[4.5]decan-8-yl)pyridin-3- yl)-2-oxoacetate 990 mg (40%). 1H NMR (500 MHz, CDC13) delta 5.08-5.05 (m, 1H), 3.75 (t, J=7.3 Hz, 2H), 3.37 (s, 2H), 3.36-3.34 (m, 4H), 2.61 (s, 3H), 2.30 (s, 3H), 1.73-1.71 (m, 2H), 1.50 (br. s, 4H), 1.29 (d, J=6.2 Hz, 6H). UPLC (M+H) = 441.1.

479195-19-2, 479195-19-2 2-Oxa-8-azaspiro[4.5]decane hydrochloride 21955264, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; ROMINE, Jeffrey Lee; SIVAPRAKASAM, Prasanna; ST. LAURENT, Denis R.; (204 pag.)WO2017/25864; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.

Preparation of the amide: The acid chloride obtained above was dissolved in 3 ml of anhydrous THF, and 40 mg (0.340 mmol) of 4-methylpiperidine-4-ol [commercially available;Lit. example:.. JM McManus et al, J. Med Chem 1965, 8 (6), 766-776] and 100 mu (0.570 mmol) of N, N-diisopropylethylamine was added. Subsequently, the reaction mixture was stirred for about 16 h at RT.After the mixture was evaporated on a rotary evaporator to dryness, the crude product was purified by preparative HPLC (Method 5).After combining the product fractions, evaporation and drying of the residue under high vacuum, 113 mg (88% of theory..) Of the title compound, 3970-68-1

3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAERTER, MICHAEL; DELBECK, MARTINA; KALTHOF, BERND; LUSTIG, KLEMENS; LINDNER, NIELS; KAST, RAIMUND; WASNAIRE, PIERRE; SUESSMEIER, FRANK; (372 pag.)TW2016/7950; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1147423-01-5,tert-Butyl 7-acetyl-2,7-diazaspiro[3.5]nonane-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester (70 mg,0.309 mmol) in DCM (3 mL) were added acetyl chloride (32 muL, 0.450 mmol) and triethylamine (54 muL, 0.526 mmol). The resulting mixture was stirred at RT for 2 h. The reaction mixture was loaded onto an Isolute SCX-2 cartridge, and washed with MeOH then eluted with 2 M NH3 in MeOH to give 7-acetyl-2,7-diaza-spiro[3.5]nonane-2-carboxylic acid ester. To a solution of 7-acetyl-2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert- butyl ester in DCM (3 mL) was added TFA (1 mL) and the resulting mixture was stirred at RT for 1 h. The reaction mixture was loaded onto an Isolute SCX-2 cartridge, washed with MeOH then eluted with 2 M NH3 in MeOH to give the title compound as a colourless oil (41 mg, 79 %).1H NMR (400 MHz, CDCl3): delta 1.69-1.79 (m, 2 H), 1.78-1.83 (m, 2 H), 2.08 (s, 3 H), 3.32- 3.37 (m, 2 H), 3.39-3.45 (m, 2 H) and 3.37-3.57 (m, 4 H)., 1147423-01-5

The synthetic route of 1147423-01-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/53715; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3515-49-9,3-(Piperidin-4-ylmethyl)-1H-indole,as a common compound, the synthetic route is as follows.

EXAMPLE 6 3-Chloro-4-[(4-piperidyl)-methyl]-quinoline The operation is as in Example 1, but starting from 13.4 g of 4-(3-indolyl-methyl)-piperidine and 0.54 g of triethylbenzylammonium chloride in 130 ml of chloroform and 19.5 g of sodium hydroxide in solution in 39 ml of water. 4.2 g of 3-chloro-4-[(4-piperidyl)-methyl]-quinoline are finally obtained in the form of the dihydrochloride melting above 260 C.

3515-49-9, As the paragraph descriping shows that 3515-49-9 is playing an increasingly important role.

Reference£º
Patent; Pharmindustrie; US4405789; (1983); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A flask was charged with triphosgene (12.2 g, 41.1 mmol, 1.50 equiv), DCM (50 mL), l, l, l,3,3,3-hexafluoropropan-2-ol (20.6 g, 122 mmol, 4.50 equiv). N,N-diisopropylethylamine (17.6 g, 136 mmol, 5.00 equiv) was added dropwise at 0 C. The resulting solution was stirred for 2 h at 0 C. t-Butyl N-(4-methylpiperidin-4-yl)carbamate (5.84 g, 27.2 mmol, 1.00 equiv) was added. The resulting solution was stirred for 2 h at 0 C and quenched with water (100 mL), as described in Example 6, Step 4. The residue was chromatographed on a silica gel column to provide 4.90 g (44% yield) of l, l, l,3,3,3-hexafluoropropan-2-yl 4-((t-butoxycarbonyl)amino)-4- methylpiperidine-l-carboxylate as a yellow oil. LCMS (ESI, m/z): 409 [M+H]+.

163271-08-7, As the paragraph descriping shows that 163271-08-7 is playing an increasingly important role.

Reference£º
Patent; ABIDE THERAPEUTICS, INC.; GRICE, Cheryl A.; WEBER, Olivia D.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; JONES, Todd K.; (275 pag.)WO2019/46318; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78056-60-7,1-Acetyl-4-piperidineacetic acid,as a common compound, the synthetic route is as follows.

Reference Example 28 To a THF solution of (1-acetylpiperidin-4-yl)acetic acid were added under room temperature triethylamine and pivaloyl chloride, followed by stirring at room temperature for 1 hour. The reaction mixture was filtered and concentrated. Then, 3-cyclohexanecarbonyl-2-ethylamino-6-methylpyridine was added to the residue, followed bystirring at 150C for 14 hours. Ethanol and sodium methoxide were added to the product obtained by working up the reaction mixture, and the whole was heated under reflux for 1 hour. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain 3-(1-acetylpyridin-4-yl)-4-cyclohexyl-1-ethyl-7-methyl-1,8-naphthyridin-2(1H)-one as a colorless solid. MS: 396., 78056-60-7

The synthetic route of 78056-60-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; YAMANOUCHI PHARMACEUTICAL CO. LTD.; EP1225173; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1158759-03-5, tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 8: l-Benzyl-3-(2,3-dichlorophenyl)-5-methyl-l//-pyrazolo[3,4- 1158759-03-5, The synthetic route of 1158759-03-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; WALTERS, W., Patrick; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; TAYLOR, Alexander, M.; PIERCE, Levi Charles, Thomas; MURCKO, Mark, Andrew; GIORDANETTO, Fabrizio; GREISMAN, Jack, Benjamin; MARAGAKIS, Paul; BHAT, Sathesh; KONZE, Kyle; DAHLGREN, Markus, Kristofer; THERRIEN, Eric; (0 pag.)WO2019/165073; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79099-07-3, 1-Boc-4-Piperidone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

79099-07-3, In a reaction flask, 20 g (0.1 mol) of N-Boc-4-piperidone was added to 200 mL of toluene,Then 18 g (0.2 mol) of dimethyl carbonate and 22 g (0.2 mol) of potassium tert-butoxide were added, and the mixture was heated to 70 ¡ã C. for 1 hour,Cooled to room temperature, quenched with water 100mL,The reaction solution was adjusted to pH 7 with 1 mol / L HCl,Extracted with ethyl acetate, dried over anhydrous sodium sulfate,Dried to give N-Boc-3-methyl-4-piperidone as a yellow oil 25 g;

The synthetic route of 79099-07-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wang Erxia; (19 pag.)CN107266442; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.657-36-3,4-Trifluoromethylpiperidine,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of heterocyclic amines (1.1 mmol) and compound 23 (257.1 mg, 1 mmol) in anhydrous toluene (10 mL) wasadded Cs2CO3 (489.0 mg, 1.5 mmol), (¡À)-2,2′-Bis(diphenylphosphino)-1,1′-binaphthalene (62.0 mg, 0.1 mmol) and Palladium(II)acetate (25.0 mg, 0.1 mmol) at room temperature under argon. The mixture was refluxed for overnight, and then cooled to roomtemperature and filtered. The filtrate was diluted by EtOAc and washed with brine. The organic layer was concentrated and purified byFlash column chromatography (DCM/MeOH, 0-10%) to afford the crude target compounds 24b-j (50-64% yield).

657-36-3, As the paragraph descriping shows that 657-36-3 is playing an increasingly important role.

Reference£º
Article; Li; Wang; Wang, Bin; Liu, Mingliang; Lv, Kai; Tao, Zeyu; Ma, Chao; Ma; Han, Bing; Wang, Aoyu; Lu, Yu; Chinese Chemical Letters; (2019);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem