Day: October 19, 2020

239482-98-5, 2-(Aminoethyl)-1-N-Boc-piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2 EPO 2-r2-(5-Chloro-4-ethoxycarbonylmethyl-3,6-difluoro-pyridin-2-ylamino)-ethyl1- piperidine-1-carboxylic acid tert-butyl ester(3-Chloro-2,5,6-trifluoro-pyridin-4-yl)-acetic acid ethyl ester (667 mg, 2.63 mmol) and 2-(2-amino-ethy.)-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 2.19 mmol) are dissolved in 10 ml DMSO in a microwave vial. Sodium carbonate (4648 mg, 4.38 mmol) is added and the vial is closed. The reaction mixture is heated in the microvLambda/ave for 8 min at 120 C. A second batch is reacted in the same way.The solvent of the combined batches is evaporated by reduced pressure. The crude product is purified by column chromatography (silica gel, eluent = 5% to 50% EtOAc in cyclohexane).LC/MS (II) (5-95%, 5 min): 3.86, 484 (M+H+Na).

239482-98-5, As the paragraph descriping shows that 239482-98-5 is playing an increasingly important role.

Reference£º
Patent; SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH; WO2006/45459; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

832710-65-3, 2,8-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,832710-65-3

To a solution of 3-nitrosalicyclic acid (500 mg, 2.73 mmol) in dichloromethane (10 mL) is added oxalylchloride (2 M in dichloromethane, 1.50 ml, 3 mmol) and three drops of N,N-dimethylformamide. The mixture is stirred at room temperature overnight. The solvent is evaporated under vacuum to leave a crude residue, a portion of which (127 mg, 0.63 mmol) is dissolved in dichloromethane (5 mL) and the solution cooled to 0 C. Triethylamine (0.22 mL, 1.57 mmol) is added followed by 2,8-diaza-spiro[4.5]decan-1-one hydrochloride (100 mg, 0.52 mmol). The mixture is allowed to warm to room temperature and stirred overnight. Water is added, the phases separated, the organic layer dried over MgSO4 and evaporated under reduced pressure to give compound 1-1.Yield: 200 mgES mass spectrum: [M+H]+=320Retention time: 0.69 min (HPLC method 2)

832710-65-3 2,8-Diazaspiro[4.5]decan-1-one hydrochloride 42614558, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/329773; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

849928-30-9, 1-Boc-2-Phenyl-4-piperidinone is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A suspension of potassium tert-butoxide ( 1.25 g, 11.1 mmol) and methyltriphenylphosphonium bromide (3.86 g, 1.1 mmol) in tetrahydrofuran (100 mL) was stirred at 40 C for 30 minutes. The mixture was then cooled to room temperature and a solution of tert-butyl 4-oxo-2-phenylpiperidine-l-carboxylate (2.35 g, 8.5 mmol) in tetrahydrofuran (30 mL) was added slowly. The reaction mixture was stirred at 40 C for 24 hours. The mixture was cooled to room temperature and quenched by the addition of water and diluted with ethyl acetate (250 mL), The organic layer was separated then washed with water, 10% aqueous citric acid and brine, dried over anhydrous sodium sulfate, filtered and concentrated. Column chromatography on silica gel (hexane:ethyl acetate 95:5 to 9:1) provided tert-butyl 4-methylene-2-phenylpiperidine-l-carboxylate (2.24 g, 96%). NMR (400 MHz, CDCI3): 7.31 (m, 4H), 7.21 (m, 1H), 5.48 (br d, 1H), 4.84 (dd, 2H), 4.07 (br dd, 1H), 2.85 (br, t, 1H), 2.78 (dtr, 1H), 2.64 (dd, 1H), 2.28 (dtr, lH), 2.20 (br d, 1H), 1.42 (s, 9H). GC/MS (EI) for C7H23NO2: 273 (M+)., 849928-30-9

849928-30-9 1-Boc-2-Phenyl-4-piperidinone 44558601, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; EXELIXIS, INC.; RICE, Kenneth; WO2012/71509; (2012); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1158759-03-5, tert-Butyl ((4-methylpiperidin-4-yl)methyl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4d (0.35 g, 1.13 mmol), tert-butyl ((4-methylpiperidin-4-yl)methyl)carbamate (0.39 g, 1.70 mmol) DIEA (0.36 g, 2.83 mmol) was added to DMSO (10 mL) and stirred at 100 C for 2 h. The reaction solution was added water (10 mL), EA extraction (10 mL ¡Á 2), the combined organic phases were washed with brine (50 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure, the residue was purified by column chromatography to give compound 4e (0.15 g, 27%), 1158759-03-5

The synthetic route of 1158759-03-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; JACOBIO PHARMACEUTICALS CO., LTD; MA, CUNBO; GAO, PANLIANG; CHU, JIE; WU, XINPING; WEN, CHUNWEI; KANG, DI; BAI, JINLONG; PEI, XIAOYAN; (171 pag.)TW2019/25186; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.50534-49-1,N,N-Dimethylpiperidin-3-amine,as a common compound, the synthetic route is as follows.

EXAMPLE DDD86292 2,6-Dichloro-4-[2-(3-dimethylamino-pyrrolidin-1-yl)-pyridin-4-yl]-N-(1,3,5-trimethyl-1 H-pyrazol-4-yl)-benzenesulfonamide Prepared by heating the chloropyridine of intermediate 12 (250 mg, 0.58 mmol) with 3-dimethylaminopiperidine (200 mul) in EtOH (1.5 ml) at 155 C. for 1 h according to the method of DDD86213 to give the title compound as a white powder (150 mg, 0.29 mmol, 49%). deltaH (CDCl3, 300K) 8.48 (1H, d J 5.1 Hz), 7.49 (2H, s), 7.39 (1H, d J 4.7 Hz), 7.32 (1H, s), 3.76-3.46 (6H, s br), 3.63 (3H, s), 3.46-3.39 (1H, m), 2.75 (2H, s br), 2.28 (2H, s br), 2.05 (3H, s), 1.85 (3H, s), 1.56 (2H, s br). m/z (ES+, 70V) 523.2 (MH+)., 50534-49-1

As the paragraph descriping shows that 50534-49-1 is playing an increasingly important role.

Reference£º
Patent; Brand, Stephen; Wyatt, Paul; Thompson, Stephen; Smith, Victoria; Bayliss, Tracy; Harrison, Justin; Norcross, Neil; Cleghorn, Laura; Gilbert, Ian; Brenk, Ruth; US2011/312921; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3970-68-1

[00152] Step 2: (S)- 1 -Phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin- 1 -yl)-2- phenylacetate. To a solution of (S)-l -phenylethyl 2-bromo-2-phenylacetate (0.464 g, 1.45 mmol) in THF (8 mL) was added triethylamine (0.61 mL, 4.35 mmol), followed by tetrabutylammonium iodide (0.215 g, 0.58 mmol). The reaction mixture was stirred at room temperature for 5 minutes and then a solution of 4-methyl-4-hydroxypiperidine (0.251 g, 2.18 mmol) in THF (2 mL) was added. The mixture was stirred for 1 hour at room temperature and then it was heated at 55-60 C (oil bath temperature) for 4 hours. The cooled reaction mixture was then diluted with ethyl acetate (30 mL), washed (H20 x2, brine), dried (MgS04), filtered and concentrated. The residue was purified by silica gel chromatography (0-60% ethyl acetate-hexane) to provide first the (S,R)-isomer of the title compound (0.306 g, 60%) as a white solid and then the corresponding (S,S)-isomer (0.120 g, 23%), also as a white solid. (S,R)-isomer: ? NMR (CD3OD) delta 7.51-7.45 (m, 2H), 7.41-7.25 (m, 8H), 5.85 (q, J=6.6 Hz, 1H), 4.05 (s, 1H), 2.56-2.45 (m, 2H), 2.41- 2.29 (m, 2H), 1.71-1.49 (m, 4H), 1.38 (d, J=6.6 Hz, 3H), 1.18 (s, 3H). LC-MS: Anal. Calcd. for C22H27 03: 353; found: 354 (M+H)+. (S,S)-isomer: ‘H NMR (CD3OD) delta 7.41-7.30 (m, 5H), 7.20-7.14 (m, 3H), 7.06-7.00 (m, 2H), 5.85 (q, J=6.6 Hz, 1H), 4.06 (s, 1H), 2.70-2.60 (m, 1H), 2.51 (dt, J=6.6, 3.3 Hz, 1H), 2.44-2.31 (m, 2H), 1.75-1.65 (m, 1H), 1.65-1.54 (m, 3H), 1.50 (d, J=6.8 Hz, 3H), 1.20 (s, 3H). LC-MS: Anal. Calcd. for C22H27 03: 353; found: 354 (M+H)+.

3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BELEMA, Makonen; ROMINE, Jeffrey, Lee; NGUYEN, Van, N.; WANG, Gan; LOPEZ, Omar, D.; ST. LAURENT, Denis, R.; CHEN, Qi; BENDER, John, A.; YANG, Zhong; HEWAWASAM, Piyasena; XU, Ningning; MEANWELL, Nicholas, A.; EASTER, John, A.; SU, Bao-Ning; SMITH, Michael, J.; WO2011/75439; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

68947-43-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.68947-43-3,1-Methylpiperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.

A mixture of 1-methylpiperidine-4-carboxylic acid (1.72 g) obtained above, tert-butyl 2-hydroxyethyl(methyl)carbamate (1.75 g) obtained in Reference Synthetic Example 1, 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (2.30 g), 4-dimethylaminopyridine (0.24 g) and acetonitrile (50 mL) was stirred at room temperature for 16 hrs. The reaction solution was concentrated under reduced pressure, and to the residue was added saturated aqueous solution of sodium bicarbonate (50 mL), and extracted with ethyl acetate (100 mL). The ethyl acetate layeer was washed with saturated brine (50 mL), and dried over anhydrous magnesium sulfate, followed by concentrating under reduced pressure. The residue was purified with basic silica gel column chromatography (eluted with methanol : ethyl acetate = 50 : 50, then 80 : 20). To the purified material (2.73 g) was added 1 N hydrochloric acid (25 mL), and stirred at room temperature overnight. The reaction solution was concentrated under reduced pressure, and isopropanol was added, then, concentrated again under reduced pressure. The precipitated crystals were collected by filtration to give title compound as colorless solid (1.72 g).1H-NMR (DMSO-d6) : 1.70-2.20(4H,m), 2.40-3.50 (13H,m), 4.31(2H,m), 9.25(2H,br), 10.77 (1H,br).

The synthetic route of 68947-43-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Pharmaceutical Company Limited; EP1602362; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.73874-95-0,tert-Butyl piperidin-4-ylcarbamate,as a common compound, the synthetic route is as follows.

Step 1: To a solution of tert-butyl piperidin-4-ylcarbamate (10 g, 50 mmol) and TEA (10 mL, 775 mmol) in DCM (50 mL) was added acetic anhydride (5.1 g, 50 mmol) at 0C. The resulting mixture was stirred at 0C for 1.5 h. The reaction was quenched with water (30 mL), and the organic layer was washed with saturated aqueous sodium bicarbonate (50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to afford tert-butyl (1-acetylpiperidin-4-yl)carbamate as a solid, which was used in next step without further purification., 73874-95-0

As the paragraph descriping shows that 73874-95-0 is playing an increasingly important role.

Reference£º
Patent; CTxT PTY LIMITED; BERGMAN, Ylva Elisabet; CAMERINO, Michelle Ang; WALKER, Scott Raymond; STUPPLE, Paul Anthony; (135 pag.)WO2017/153513; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

3970-68-1, 4-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2; (S)- 1 -Phenylethyl (R)-2-(4-hydroxy-4-methylpiperidin- 1 -yl)- 2- phenylacetate: To a solution of (S)-I -phenylethyl 2-bromo-2-phenylacetate (0.464 g, 1.45 mmol) in THF (8 mL) was added triethylamine (0.61 mL, 4.35 mmol), followed by tetrabutylammonium iodide (0.215 g, 0.58 mmol). The reaction mixture was stirred at room temperature for 5 minutes and then a solution of 4-methyl-4- hydroxypiperidine (0.251 g, 2.18 mmol) in THF (2 mL) was added. The mixture was stirred for 1 hour at room temperature and then it was heated at 55-60 0C (oil bath temperature) for 4 hours. The cooled reaction mixture was then diluted with ethyl acetate (30 mL), washed (H2O x2, brine), dried (MgSO4), filtered and concentrated. The residue was purified by silica gel chromatography (0-60% ethyl acetate-hexane) to provide first the (S,R)-isomer of the title compound (0.306 g, 60%) as a white solid and then the corresponding (S,S)-isomer (0.120 g, 23%), also as a white solid. (S,R)-isomer: 1HNMR (CD3OD) delta 7.51-7.45 (m, 2H), 7.41-7.25 (m, 8H), 5.85 (q, J = 6.6 Hz, IH), 4.05 (s, IH), 2.56-2.45 (m, 2H), 2.41-2.29 (m, 2H), 1.71-1.49 (m, 4H), 1.38 (d, J = 6.6 Hz, 3H), 1.18 (s, 3H). LCMS: Anal. Calcd. for C22H27NO3: 353; found: 354 (M+H)+. (S,S)-isomer: 1HNMR (CD3OD) delta 7.41-7.30 (m, 5H), 7.20-7.14 (m, 3H), 7.06-7.00 (m, 2H), 5.85 (q, J = 6.6 Hz, IH), 4.06 (s, IH), 2.70- 2.60 (m, IH), 2.51 (dt, J = 6.6, 3.3 Hz, IH), 2.44-2.31 (m, 2H), 1.75-1.65 (m, IH), 1.65-1.54 (m, 3H), 1.50 (d, J = 6.8 Hz, 3H), 1.20 (s, 3H). LCMS: Anal. Calcd. for C22H27NO3: 353; found: 354 (M+H)+.

3970-68-1, As the paragraph descriping shows that 3970-68-1 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/102318; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.845909-49-1,Ethyl 4-fluoropiperidine-4-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.,845909-49-1

Intermediate B2(IIQ: 4-Fluoro-1 -(tetrahydro-pyran-4-yl)-piperidine-4-carboxylic acid ethyl esterTo a 250 mL RB were added compound B2(l) ethyl 4-fluoropiperidine-4- carboxylate, hydrochloride (1.25 g, 5.91 mmol, 1.0 eq), CH2CI2 (20 mL), 4- oxotetrahydropyranone B2(ll) (0.61 mL, 6.50 mmol, 1.10 eq), and glacial HOAc (0.340 mL, 5.91 mmol, 1.0 eq). After being stirred at rt for 5 to 10 min, sodium triacetoxyborohydride (2.02 g, 9.45 mmol, 1.60 eq) was added in one portion. A cloudy solution was obtained. After being stirred at rt for 12 h, the reaction mixture was diluted with 150 mL Et2O and 200 mL NaOH (1 M aqueous). The resulting suspension was stirred at rt for 1 h. The organic layer was collected, washed with 200 mL brine, dried over Na2SO4, filtered, and concentrated to afford 320 mg of the desired product, 4- fluoro-1-(tetrahydro-pyran-4-yl)-piperidine-4-carboxylic acid ethyl ester B2(IIO in 21 % yield as a colorless oil. 1H NNR (400 MHz, CDCI3, ppm) delta 1.30 (t, J = 7.08, 3H), 1.56- 1.66 (m, 2H), 1.74-1.78 (m, 2H), 1.94-2.21 (m, 4H), 2.46-2.55 (m, 3H), 2.82-2.85 (m, 2H), 3.38 (ddd, J = 1.52, 11.84, 11.84, 2H), 4.03 (dd, J = 4.28, 11.08, 2H), 4.24 (q, J = 7.05 Hz, 2H); 19F NMR (376 Hz, CDCI3, ppm) delta -166.94.

845909-49-1 Ethyl 4-fluoropiperidine-4-carboxylate hydrochloride 24729616, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER INC.; WO2008/125945; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem