Day: October 14, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37675-18-6,(S)-Ethyl piperidine-3-carboxylate,as a common compound, the synthetic route is as follows.,37675-18-6

[1495] LAH (118 mL, 1.0 M in Et2O, 1.0 eq.) was added to a solution of the product from Step A (18.5 g, 0.125 mmol) in THF (250 mL) at 0 C. over 20 minutes. The resulting solution was warmed slowly to room temperature and then heated at reflux 2 hours. The reaction was cooled to room temperature and quenched by the slow addition of saturated Na2SO4. The resulting slurry was dried by the addition of Na2SO4, filtered through Celite and concentrated to give a colorless oil (13.7 g, 98% crude yield). CIMS: MH+=116; [alpha]20D=-8.4 (5.0 mg in 2 mL MeOH).

The synthetic route of 37675-18-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhu, Hugh Y.; Njoroge, F. George; Cooper, Alan B.; Guzi, Timothy; Rane, Dinanath F.; Minor, Keith P.; Doll, Ronald J.; Girijavallabhan, Viyyoor M.; Santhanam, Bama; Pinto, Patrick A.; Vibulbhan, Bancha; Keertikar, Kartik M.; Alvarez, Carmen S.; Baldwin, John J.; Li, Ge; Huang, Chia-Yu; James, Ray A.; Bishop, W. Robert; Wang, James J-S; Desai, Jagdish A.; US2003/229099; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

625471-18-3, (S)-tert-Butyl 3-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

625471-18-3, 1,1-Dimethylethyl (3S)-3-AMINOPIPERIDINE-L-CARBOXYLATE (2. 1G, 10. 5MMOL), cyclopentanone (4.65mL, 52. 5MMOL), and 10percent palladium on carbon (0.2g) in methanol (80ML) were hydrogenated at 60psi overnight in a Parr hydrogenator. The catalyst was filtered off and the filtrate evaporated in vacuo. The resultant oil was purified by flash chromatography on silica, eluting with ethyl ACETATE/CYCLOHEXANE (15: 85 to 30: 70), to give the title compound as an oil.

625471-18-3 (S)-tert-Butyl 3-aminopiperidine-1-carboxylate 1501975, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/305; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1155-56-2, 1-Benzyl-N-phenylpiperidin-4-amine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Sodium borohydride (0.90 g, 23.9 mmol) was suspended in 20 mL of 1,2-dichloroethaneunder a nitrogen atmosphere and cooled in an ice water bath. Acetic acid (4.30 g,71.6 mmol) was added dropwise with an addition funnel. It was rinsed with 10 mL of 1,2-dichloroethane. The mixture was removed from the ice water bath and stirred atroom temperature for 16 h. A solution of 1-benzyl-4-piperidone (3.00 g, 15.9 mmol),aniline (2.62 g, 17.4 mmol), acetic acid (0.96 g, 15.9 mmol), and 12 mL of 1,2-dichloroethane was added dropwise with an addition funnel. It was rinsed with 10 mLof 1, 2 dichloroethane. The mixture was stirred for 24 h at room temperature. Thereaction mixture was poured over 100 mL of a 2 M aqueous sodium hydroxide solutionand extracted with chloroform (3 ? 100 mL). The combined organic extractswere dried with sodium sulfate, filtered, and the volatiles were evaporated providing4.40 grams of the reductive amination product. The residue was taken up in 120 mL1,2-dichloroethane and propionyl chloride (7.36 g, 79.5 mmol) was added with asyringe. The mixture was heated to reflux under a nitrogen atmosphere for 20 h. Thereaction mixture was allowed to cool to room temperature and the volatiles wereevaporated. The residue was taken up with 100 mL of saturated aqueous sodiumbicarbonate and 100 mL of chloroform. The organic layer was separated. The aqueouslayer was washed with chloroform (2 ? 100 mL). The combined organic extractswere dried with sodium sulfate, filtered, and the volatiles were evaporated providing5.70 g of a tan oil. The residue was dissolved in 15 mL of isopropanol and the solutionwas gently warmed. Oxalic acid (2.21 g, 17.5 mmol) in 5 mL of water was addedwith an addition funnel. It was rinsed with 2 mL of water followed by 3 mL of isopropanol.The mixture was allowed to cool to room temperature and was placed in are frigerator for 24 h. The white precipitate obtained was filtered, washed with icebath cooled isopropanol, and dried to provide 5.52 g of the oxalate salt 1 in 70%yield. An analytical sample was prepared by recrystallization from methanol. mp213-215C; 1H NMR (CD3OD) d 7.49-7.41 (m, 8 H), 7.19 (d, 2 H, J D 6.41 Hz),4.80-4.73 (m, 1 H), 4.22 (s, 2 H), 3.44 (br d, 2 H, J D 12.36 Hz), 3.10 (br t, 2 H, J D10.72 Hz), 2.04 (br d, 2 H, J D 13.23 Hz), 1.95 (q, 2 H, J D 7.33 Hz), 1.69-1.60 (m,2 H), 0.96 (t, 3 H, J D 7.33 Hz); 13C NMR (CD3OD) d 175.75, 165.21, 137.99,130.92, 129.97, 129.82, 129.60, 129.19, 128.97, 128.89, 59.97, 51.42, 49.98, 27.99,27.31, 8.51.Anal. Calcd for C23H28N2O5: C, 66.97; H, 6.84; N, 6.79. Found: C, 66.87; H, 6.99; N,6.76., 1155-56-2

As the paragraph descriping shows that 1155-56-2 is playing an increasingly important role.

Reference£º
Article; Walz, Andrew J.; Hsu, Fu-Lian; Organic Preparations and Procedures International; vol. 49; 5; (2017); p. 467 – 470;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

19889-77-1, Piperidine-2-carboxamide is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(d) I-Isobutylpiperidine-2-carboxamide. To a solution of piperidine-2-carboxamide (4.52 g, 35 mmol, Bionet-Inter) in DCE (100 mL) was added isobutyraldehyde (9.6 mL, 106 mmol, Aldrich). The mixture was stirred at room temperature for 10 min, sodium triacetoxyborohydride (22.26 g, 105 mmol, Aldrich) was added, and the stirring was continued for 1 h. The reaction mixture was evaporated in vacuo and the residue was dissolved in EtOAc. The EtOAc solution was washed with sat. aqueous solution of NaHCO3, H2O and brine, dried over Na2SO4, filtered, and evaporated under reduced pressure. Purification of the residue by silica gel column chromatography [gradient: 0-2% (2 N NH3 in MeOH)/DCM] afforded the title compound as yellow oil. (ESI, pos. ion.) m/z: 185 (M+1).

19889-77-1, As the paragraph descriping shows that 19889-77-1 is playing an increasingly important role.

Reference£º
Patent; Doherty, Elizabeth M.; Liao, Hongyu; Norman, Mark H.; Retz, Daniel M.; US2006/235036; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

79421-45-7, 1-(4-Nitrophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

79421-45-7, The 4-hydroxy-N-(4-nitrophenyl)piperidine (11.1 g, 50 mmol) obtained in Example 1(1) was dissolved in methanol (100 ml) and tetrahydrofuran (50 ml), and 10% palladium-carbon (8.0 g) was added thereto, followed by stirring at room temperature in an atmosphere of hydrogen gas for 7 hours. After the insoluble material was filtered with Celite, the filtrate was concentrated under reduced pressure, diethyl ether was added to the obtained residue, and the precipitate was collected by filtration, thereby obtaining 4-hydroxy-N-(4-aminophenyl)piperidine (9.25 g, 94%) as a reddish-purple solid.1H-NMR (CDCl3): delta (ppm) 1.65-1.77 (m, 2H), 1.94-2.11 (m, 2H), 2.71-2.85 (m, 2H), 3.23-3.92 (m, 5H), 6.64 (d, J=8.9 Hz, 2H), 6.83 (d, J=8.9 Hz, 2H)

79421-45-7 1-(4-Nitrophenyl)piperidin-4-ol 613768, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; TAIHO PHARMACEUTICAL CO., LTD.; US2011/319413; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

675-20-7, Piperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The preparation was carried out in an inert atmosphere (argon). Ethyl 6-(4-iodophenyl)-l-(4- methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate (536 mg; 1.04 mmol) was dissolved in 5 ml of cyclopentyl methyl ether in a 10 ml sealable pressure container. Piperidin-2-one (128 mg; 1.30 mmol), Cul (10 mg; 0.052 mmol), K3PO4 (440 mg; 2,1 mmol) and N,N’-dimethylethylenediamine (37 mg; 0.42 mmol) were added. A stirrer was inserted in the container and it was closed under an inert atmosphere. Being stirred by a magnetic stirrer the mixture was heated up in an oil bath to 110 C for 6 h. After cooling the reaction mixture was diluted with a solvent, the solid salts were isolated by filtration and thoroughly washed on the filter. The filtrate was concentrated and the crude product was obtained in the yield of 84%.

675-20-7, 675-20-7 Piperidin-2-one 12665, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef; WO2014/75648; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

37675-20-0, (R)-(Piperidin-3-yl)methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

TEA (1.76 g, 17.4 mmol, 2.42 mL) was added to a solution of [(3R)-3 -piped dyl]methanol (1.0 g, 8.68 mmol) in THF (25.0 mL), followed by the addition of a solution of B0C2O (1.89 g, 8.68 mmol, 1.99 mL) in THF (5 mL) at 15 C. The mixture was stirred at 15 C for 12 hours. The solvent was removed under vacuum and the residue dissolved in ethyl acetate (50 ml) and H2O (30 mL). The solution was acidified with HC1 (6 M) to pH~6 and the layers separated. The organics were washed with brine (3 x 50 mL) and the combined organics concentrated to dryness to give tert- butyl (3R)-3-(hydroxymethyl)piperidine-l-carboxylate (1.68 g, 7.80 mmol, 89.9% yield, 100% purity) as colorless crystals. MR (400MHz, chloroform-d) delta = 3.73 (br s, 2H), 3.51 (br d, J = 6.8 Hz, 2H), 3.05 (br s, 2H), 1.83 – 1.71 (m, 2H), 1.62 (br s, 1H), 1.46 (s, 9H), 1.44 – 1.37 (m, 1H), 1.35 – 1.22 (m, 1H).

37675-20-0, The synthetic route of 37675-20-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

5325-94-0, Ethyl piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In nitrogen atmosphere, to a 500 ml three-neck flask, 16.7 g (77.6 mmol) of 4-bromo-2,6-dimethylanisole, and 150 ml of dehydrated diethyl ether were added. While the mixture was cooled in a methanol/dry ice bath, 49.7 ml (81.5 mmol) of a n-butyllithium/hexane solution (1.64 M) was gradually added. While the temperature was gradually elevated to room temperature, the mixture was stirred for 16 hours. While the mixture was cooled in an ice bath, a solution composed of 4.83 g (30.7 mmol) of N-carboethoxypiperidine and 50 ml of dehydrated diethyl ether was gradually added with a dropping funnel over a period of 20 minutes. The mixture was stirred for 1 hour at room temperature, and stirred for 2 hours under heating to reflux. Thereto, in an ice bath, 100 ml of 2N hydrochloric acid was gradually added. The resultant two-layer solution was transferred to a 500 ml separating funnel. The resultant solution was shaken several times. Thereafter, the aqueous layer was removed. Subsequently, the organic layer was washed two times with 100 ml of water, one time with 100 ml of a saturated aqueous sodium bicarbonate solution, and one time with 100 ml of a saturated saline solution, and dried over anhydrous magnesium sulfate for 30 minutes. After the solvent was distilled off under reduced pressure, a small amount of hexane was added to perform recrystallization to give a solid. This solid was washed with a small amount of hexane, and dried under reduced pressure. As a result, 6.83 g (22.9 mmol, 74.5%) of 4,4′-dimethoxy-3,3′,5,5′-tetramethylbenzophenone was obtained as a white solid. 4,4′-Dimethoxy-3,3′,5,5′-tetramethylbenzophenone was identified by 1H NMR spectrum. Measured values thereof are shown below. 1H NMR spectrum (270 MHz, CDCl3): delta/ppm 7.44 (s, 4H), 3.77 (s, 6H), 2.31 (s, 12H), 5325-94-0

5325-94-0 Ethyl piperidine-1-carboxylate 21399, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MITSUI CHEMICALS, INC.; Endo, Koji; Hiwara, Mayumi; Matsuura, Sadahiko; Kosugi, Yoko; Yamamura, Yuichi; Mizobuchi, Yusuke; (50 pag.)US9969827; (2018); B2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.336191-17-4,tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate,as a common compound, the synthetic route is as follows.

tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate (7.21 g, 30.0 mmol) is dissolved in TEA (7.69 mL) in DCM (200 mL) at 0 C. and treated dropwise with cyclobutanone (2.92 mL, 38.9 mmol). The mixture is stirred for 30 min and sodium triacetoxyborohydride (9.53 g, 4.56 mmol) is added in portions. The reaction mixture is stirred at rt overnight, basified with 1N NaOH solution and extracted with DCM (2¡Á100 mL). The combined extracts are washed with water, brine, dried over anhydrous Na2SO4 and concentrated in vacuo to afford the title compound. LC-MS (Method 1): 295.4.

336191-17-4, 336191-17-4 tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate 34178604, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Xu, Yuelian; Caldwell, Timothy M.; Xie, Linghong; Chenard, Bertrand L.; US2008/247964; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.188869-05-8,tert-Butyl 3-bromo-4-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

tert-Butyl 3-bromor4-oxopiperidine-l-carboxylate (1.0 g, 3.6 mmol) and benzothioamide (490 mg, 3.6 mmol) were heated neat at 1400C for 10 minutes. After cooling down, the resulting brown solid was sonicated in AcOEt for 10 minutes. Filtration and drying yielded 2-phenyl-4, 5, 6, 7- tetrahydrothiazolo [5, 4-c] pyridine hydrobromide as a brown solid (829 mg, 78percent): 1H NMR (400 MHz, DMSO-d6) delta 3.06-3.12 (m, 2H), 3.49-3.57 (m, 2H), 4.46-4.53 (m, 2H), 7.50-7.56 (m, 3H), 7.90-7.94 (m, 2H), 9.35 (br, 2H); m/z (APCI pos) 217.1 (10percent) [M+H] .

188869-05-8, The synthetic route of 188869-05-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/11130; (2008); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem