Day: October 12, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138163-07-2,1-Benzyl 4-methyl piperidine-1,4-dicarboxylate,as a common compound, the synthetic route is as follows.

Step (iii): Benzyl 4-formylpiperidine-1-carboxylate A solution of 1-benzyl 4-methyl piperidine-1,4-dicarboxylate (10 g) in toluene (100 ml) under nitrogen was cooled to -78 C. DIBAL-H (60.9 ml) was then added dropwise at -78 C. and the mixture was stirred at this temperature for 1 h (TLC control). Because the reaction was incomplete, a further 0.2 eq. of DIBAL-H was added and the mixture was stirred for a further 30 min (TLC control: some educt and the corresponding alcohol were to be detected). Methanol (40 ml), followed by sat. sodium chloride solution (40 ml) were added slowly to the reaction mixture at -78 C. The mixture was filtered over Celite and the solvent was removed in vacuo. The residue was extracted with ethyl acetate (3*75 ml) and the extract was dried (Na2SO4) and concentrated in vacuo. The crude product obtained in this way was purified by column chromatography (silica gel, 20% ethyl acetate/hexane). Yield: 4.3 g (49%)

138163-07-2, The synthetic route of 138163-07-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gruenenthal GmbH; US2010/249095; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24666-56-6,3-Aminopiperidine-2,6-dione hydrochloride,as a common compound, the synthetic route is as follows.

[00409j Step 3: A mechanically stirred mixture of 4-bromo-2-bromomethyl-benzoic acid methyl ester (121 g, 390 mmol) and 3-amino-piperidine-2,6-dione hydrochloride (64.2 g, 390 mmol) in DMF (400 mL) was treated dropwise with triethylamine (98.5 g, 980 mmol) over75 minutes. After the addition was completed, the reaction mixture was stirred at room temperature overnight. The mixture was quenched sequentially with acetic acid (50 mL), water (2500 mL) and a 1:1 mixture of ethyl acetate and hexanes (600 mL). After stirring the mixture for 20 minutes, the solid was filtered, washed with water, and air dried overnight. The solid was stirred in acetic acid (200 mL) and refluxed for 2 hours. The mixture was cooled to room temperature and filtered. The solid was washed with additional acetic acid, hexanes, and air dried overnight to give 25.4 g of 3 -(5-bromo- 1 -oxo- 1 ,3-dihydro-isoindol-2-yl)-piperidine-2,6- dione as a grey solid, in 20% yield; 1H NMR (DMSO-d6) oe 1.97-2.04 (m, 1H), 2.32-2.46 (m, 1H), 2.56-2.63 (m, 1H), 2.85-2.97 (m, 1H), 4.34 (d, J = 17.7 Hz, 1H), 4.47 (d, J = 17.7 Hz, 1H),5.11 (dd,J= 13.2Hz,J5.1 Hz, 1H),7.67(d,J8.1 Hz, 1H),7.72(dd,J=8.1 Hz,J= 1.5Hz, 1H), 7.89 (d, J = 0.9 Hz, 1H), 11.00 (s, 1H).

24666-56-6, As the paragraph descriping shows that 24666-56-6 is playing an increasingly important role.

Reference£º
Patent; CELGENE CORPORATION; LOPEZ-GIRONA, Antonia; CATHERS, Brian, E.; LU, Gang; JACKSON, Pilgrim; HANDA, Hiroshi; (184 pag.)WO2016/57503; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

51304-64-4, 4-Hydrazinyl-1-methylpiperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,51304-64-4

Example 6 Trans-6-[2-(4-methoxyphenyl)ethenyl]-2-(1-methyl-4-piperidinyl)phthalazin-1(2H)-one 1-Methyl-4-hydrazinopiperidine (41.2 gm) was dissolved in 1000 ml of ethanol. To this was added 90 gm trans-5-[2-(4-methoxyphenyl)ethenyl]-3-hydroxyphthalide (refer to U.S. patent 4,665,181). The resulting mixture was refluxed for 5 hours, then concentrated to dryness and the product taken up in 2000 ml of 2.5 normal HCl and extracted three times with 700 ml ethyl acetate. The product was basified, extracted into chloroform, and concentrated to dryness. The product was dissolved in isopropanol, acidified with HCl, heated to reflux, charcoaled and allowed to cool and crystallize. After three more crystallizations 3.7 gm of pure material was obtained melting at 297 to 298C.

51304-64-4 4-Hydrazinyl-1-methylpiperidine 10920535, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; FISONS CORPORATION; EP309765; (1990); A3;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39945-51-2,Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 8 Synthesis of 3-formyl-piperidine-1-carboxylic acid benzyl ester (9) To a stirring, 0 C. solution of 0.303 g (1.20 mmol) of 3-hydroxymethyl-piperidine-1-carboxylic acid benzyl ester (8) in CH2Cl2 (4.0 mL) was added 0.630g (1.44 mmol) of Dess-Martin periodinane, and the solution was stirred under N2. When the reaction was complete by TLC (about 30 min.), the reaction was concentrated, and then Et2O was added. After standing for about 15 min., the reaction was filtered through Celite wet with Et2O, rinsed with Et2O, and concentrated. The crude reaction was purified by column chromatography (florisil, 100-200 mesh, 2:1 Hexane: EtOAc) to achieve pure 9.

39945-51-2, The synthetic route of 39945-51-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Aquila, Brian M.; Bannister, Thomas D.; Cuny, Gregory C.; Hauske, James R.; Heffernan, Michele L.R.; Hoemann, Michael Z.; Kessler, Donald W.; Shao, Liming; Wu, Xinhe; Xie, Roger L.; US2002/177721; (2002); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1032903-63-1, tert-Butyl 4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 6 (1.0 equiv.) was added to a solution of trisubstituted aniline 49 (5.0 g) in 100 mL CH3CN at room temperature. The resulting reaction mixture was heated to 80C and stirred for 8 h. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The mixture was stirred at 0C for 2 h and filtered. The crude product 7 was used in the next step without further purification. A small sample of 7 was recrystallised to give a brown solid, m.p. 220-221C (CH3CN/MTBE); 1H NMR delta 11.3 (s, 1H), 9.21 (s, 1H), 8.01 (m, 3H), 7.87 (m, 1H), 7.65 (m, 1H), 7.45 (m,1H), 6.73 (s, 1H), 4,59 (m, 1H), 4.28 (m, 2H), 3.27 (m, 1H), 2,79 (m,3H), 2.07 (s, 1H), 1.93 (m, 2H). 1.41-1.75 (m, 25H); 13C NMR delta 154.9,136.5, 134.2, 131.4, 125.8, 79.6, 71.7, 55.0, 38.4, 32.5, 28.5, 22.2, 18.8,15.4; HRMS (m/z) [M+Na]+ calcd for C33H44N6O7SNa 691.2890, found 691.2885., 1032903-63-1

1032903-63-1 tert-Butyl 4-(4-amino-5-isopropoxy-2-methylphenyl)piperidine-1-carboxylate 59764580, apiperidines compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Haidong; Li, Yuan; Wang, Dongdong; Qin, Yu; Ji, Min; Journal of Chemical Research; vol. 39; 8; (2015); p. 475 – 477;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

58333-75-8, 4-(2-Methoxyphenyl)piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

58333-75-8, 4-(2-Methoxyphenyl)piperidine (200 mg, 1 mmol), the product from Example 1A (228 mg, 1 mmol) and N,N-diisopropylethylamine (0.185 mL, 1.1 mmol) in toluene (8 mL) were stirred at 60 C. for 18 hours. The reaction mixture was poured into water (30 mL) and extracted with ethyl acetate (30 mL). The organic layer was washed with brine (230 mL), dried over MgSO4, filtered and the filtrate concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (elution with dichloromethane:methanol, 9.5:0.5) to provide the title compound 177 mg (52.3%). 1H NMR (300 MHz, DMSO-d6) ? 1.71 (m, 4H), 2.28 (m, 5H), 2.89 (m, 1H), 2.96 (m, 2H), 3.13 (s, 2H), 3.78 (s, 3H), 6.91 (m, 3H), 7.20 (m, 3H), 7.45 (m, 2H), 8.69 (s, 1H); MS (DCI/NH3) m/e 339 (M+H)+. Anal. calcd for C21H26N2O2: C, 74.52; H, 7.74; N, 8.28. Found: C, 74.23, H, 7.71, N, 8.26.

The synthetic route of 58333-75-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Stewart, Andrew O.; Kolasa, Teodozyj; US2003/232836; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-53-3,1-N-Boc-3-Cyanopiperidine,as a common compound, the synthetic route is as follows.

91419-53-3, Step 4. Piperidine-3-carbonitrile hydrochloride; A 250-mL 3-necked round-bottomed flask was charged with tert-butyl 3-cyanopiperidine-1-carboxylate (5.8 g, 27.07 mmol, 1.00 equiv, 98%) in 1,4-dioxane (60 mL). The mixture was cooled down to at 0 C. and treated with HCl (g). The mixture was stirred for 2 hours at 0 C. resulting in a precipitate that was collected by filtration to afford piperidine-3-carbonitrile hydrochloride as white solid (1.9 g, 48%).

91419-53-3 1-N-Boc-3-Cyanopiperidine 2756785, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Kalypsys, Inc; US8080566; (2011); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.98977-34-5,1-tert-Butyl 3-ethyl 4-oxopiperidine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

98977-34-5, To a stirred solution of 4-oxo-piperidine-1 ,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (14 g) in MeOH (300 mL) was added NaBhU (12 g) in 12 lots over 1 h period. After completion of addition, the reaction mixture was stirred for 30 min. Removed solvent under reduced pressure, to the residue was added saturated NH4CI solution (300 mL) and was extracted with EtOAc (300 mL). The organic layer was dried, filtered and concentrated under reduced pressure. The residue was purified by flash silica gel column chromatography by eluting with ethyl acetate to give 4-hydroxy-3-hydroxymethyl- piperidine-1-carboxylic acid tert-butyl ester (10.1 g, cis/trans mixture).

As the paragraph descriping shows that 98977-34-5 is playing an increasingly important role.

Reference£º
Patent; TRANSTECH PHARMA, INC.; GOHIMUKKULA, Devi, Reddy; JONES, David; QABAJA, Ghassan; ZHU, Jeff, Jiqun; COOPER, Jeremy, T.; BANNER, William, Kenneth; SUNDERMANN, Kurt; BONDLELA, Muralidhar; RAO, Mohan; WANG, Pingzhen; GOWDA, Raju, Bore; ANDREWS, Robert, C.; GUPTA, Suparna; HARI, Anitha; WO2011/103091; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5382-17-2,Piperidin-4-ol hydrochloride,as a common compound, the synthetic route is as follows.

a 4-Benzyl-5-bromo-2-(4-hydroxypiperidino)pyridine A mixture of 550 mg of 4-benzyl-5-bromo-2-pyridyl trifluoromethanesulfonate (Production Example 1), 600 mg of 4-hydroxypiperidine hydrochloride, 1 ml of triethylamine and 2 ml of N,N-dimethylformamide was heated under stirring for 3 hours in an oil bath kept at 100 C. in a nitrogen atmosphere. After cooling as it was, the reaction mixture was extracted with ethyl acetate/water. The organic phase was washed with water and brine, dried over anhydrous magnesium sulfate and evaporated. The residue was subjected to silica gel column chromatography and eluted with 50% ethyl acetate/hexane, to give 270 mg of the target compound. 1H-NMR (CDCl3) delta=1.44-1.60 (2H, m), 1.88-1.97 (2H, m), 3.03-3.12 (2H, m), 3.75-3.96 (3H, m), 3.99 (2H, s), 6.41 (1H, s), 7.19 (2H, d, J=7 Hz), 7.25 (1H, t, J=7 Hz), 7.32 (2H, t, J=7 Hz), 8.20 (1H, s)., 5382-17-2

The synthetic route of 5382-17-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eisai Co., Ltd.; US6599917; (2003); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

106-52-5, 1-Methylpiperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Methyl-4-piperidyl para-toluenesulphonate may be obtained in the following manner: para-toluenesulphonyl chloride (19.60 g) is added in the course of approximately 1 hour 30 minutes to a solution, cooled to 0 C., of 4-hydroxy-1-methylpiperidine (11.50 g) in pyridine (50 cc), and the mixture is stirred for 4 hours at 0 C. and then 12 hours at a temperature in the region of 20 C. After the addition of triethylamine (14.10 g) and stirring for a further 15 minutes, distilled water (300 cc) and ethyl acetate (300 cc) are added., 106-52-5

As the paragraph descriping shows that 106-52-5 is playing an increasingly important role.

Reference£º
Patent; Rhone-Poulenc Sante; US5086051; (1992); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem